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Establishing a framework to implement 4D XCAT phantom for 4D radiotherapy research.

Publication ,  Journal Article
Panta, RK; Segars, P; Yin, F-F; Cai, J
Published in: J Cancer Res Ther
2012

AIMS: To establish a framework to implement the 4D integrated extended cardiac torso (XCAT) digital phantom for 4D radiotherapy (RT) research. MATERIALS AND METHODS: A computer program was developed to facilitate the characterization and implementation of the 4D XCAT phantom. The program can (1) generate 4D XCAT images with customized parameter files; (2) review 4D XCAT images; (3) generate composite images from 4D XCAT images; (4) track motion of selected region-of-interested (ROI); (5) convert XCAT raw binary images into DICOM format; (6) analyse clinically acquired 4DCT images and real-time position management (RPM) respiratory signal. Motion tracking algorithm was validated by comparing with manual method. Major characteristics of the 4D XCAT phantom were studied. RESULTS: The comparison between motion tracking and manual measurements of lesion motion trajectory showed a small difference between them (mean difference in motion amplitude: 1.2 mm). The maximum lesion motion decreased nearly linearly (R 2 = 0.97) as its distance to the diaphragm (DD) increased. At any given DD, lesion motion amplitude increased nearly linearly (R 2 range: 0.89 to 0.95) as the inputted diaphragm motion increased. For a given diaphragm motion, the lesion motion is independent of the lesion size at any given DD. The 4D XCAT phantom can closely reproduce irregular breathing profile. The end-to-end test showed that clinically comparable treatment plans can be generated successfully based on 4D XCAT images. CONCLUSIONS: An integrated computer program has been developed to generate, review, analyse, process, and export the 4D XCAT images. A framework has been established to implement the 4D XCAT phantom for 4D RT research.

Duke Scholars

Published In

J Cancer Res Ther

DOI

EISSN

1998-4138

Publication Date

2012

Volume

8

Issue

4

Start / End Page

565 / 570

Location

India

Related Subject Headings

  • Software
  • Radiotherapy, Computer-Assisted
  • Radiation Dosage
  • Phantoms, Imaging
  • Oncology & Carcinogenesis
  • Humans
  • Biomedical Research
  • 3211 Oncology and carcinogenesis
  • 11 Medical and Health Sciences
 

Citation

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Panta, R. K., Segars, P., Yin, F.-F., & Cai, J. (2012). Establishing a framework to implement 4D XCAT phantom for 4D radiotherapy research. J Cancer Res Ther, 8(4), 565–570. https://doi.org/10.4103/0973-1482.106539
Panta, Raj K., Paul Segars, Fang-Fang Yin, and Jing Cai. “Establishing a framework to implement 4D XCAT phantom for 4D radiotherapy research.J Cancer Res Ther 8, no. 4 (2012): 565–70. https://doi.org/10.4103/0973-1482.106539.
Panta RK, Segars P, Yin F-F, Cai J. Establishing a framework to implement 4D XCAT phantom for 4D radiotherapy research. J Cancer Res Ther. 2012;8(4):565–70.
Panta, Raj K., et al. “Establishing a framework to implement 4D XCAT phantom for 4D radiotherapy research.J Cancer Res Ther, vol. 8, no. 4, 2012, pp. 565–70. Pubmed, doi:10.4103/0973-1482.106539.
Panta RK, Segars P, Yin F-F, Cai J. Establishing a framework to implement 4D XCAT phantom for 4D radiotherapy research. J Cancer Res Ther. 2012;8(4):565–570.

Published In

J Cancer Res Ther

DOI

EISSN

1998-4138

Publication Date

2012

Volume

8

Issue

4

Start / End Page

565 / 570

Location

India

Related Subject Headings

  • Software
  • Radiotherapy, Computer-Assisted
  • Radiation Dosage
  • Phantoms, Imaging
  • Oncology & Carcinogenesis
  • Humans
  • Biomedical Research
  • 3211 Oncology and carcinogenesis
  • 11 Medical and Health Sciences