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Storage of hydrogen spin polarization in long-lived 13C2 singlet order and implications for hyperpolarized magnetic resonance imaging.

Publication ,  Journal Article
Feng, Y; Theis, T; Liang, X; Wang, Q; Zhou, P; Warren, WS
Published in: J Am Chem Soc
July 3, 2013

Hyperpolarized magnetic resonance imaging (MRI) is a powerful technique enabling real-time monitoring of metabolites at concentration levels not accessible by standard MRI techniques. A considerable challenge this technique faces is the T1 decay of the hyperpolarization upon injection into the system under study. Here we show that A(n)A'(n)XX' spin systems such as (13)C2-1,2-diphenylacetylene ((13)C2-DPA) sustain long-lived polarization for both (13)C and (1)H spins with decay constants of almost 4.5 min at high magnetic fields of up to 16.44 T without spin-locking; the T1 of proton polarization is only 3.8 s. Therefore, storage of the proton polarization in a (13)C2-singlet state causes a 69-fold extension of the spin lifetime. Notably, this extension is demonstrated with proton-only pulse sequences, which can be readily implemented on standard clinical scanners.

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Published In

J Am Chem Soc

DOI

EISSN

1520-5126

Publication Date

July 3, 2013

Volume

135

Issue

26

Start / End Page

9632 / 9635

Location

United States

Related Subject Headings

  • Magnetic Resonance Imaging
  • Hydrogen
  • General Chemistry
  • Carbon Isotopes
  • Acetylene
  • 40 Engineering
  • 34 Chemical sciences
  • 03 Chemical Sciences
 

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Feng, Y., Theis, T., Liang, X., Wang, Q., Zhou, P., & Warren, W. S. (2013). Storage of hydrogen spin polarization in long-lived 13C2 singlet order and implications for hyperpolarized magnetic resonance imaging. J Am Chem Soc, 135(26), 9632–9635. https://doi.org/10.1021/ja404936p
Feng, Yesu, Thomas Theis, Xiaofei Liang, Qiu Wang, Pei Zhou, and Warren S. Warren. “Storage of hydrogen spin polarization in long-lived 13C2 singlet order and implications for hyperpolarized magnetic resonance imaging.J Am Chem Soc 135, no. 26 (July 3, 2013): 9632–35. https://doi.org/10.1021/ja404936p.
Feng Y, Theis T, Liang X, Wang Q, Zhou P, Warren WS. Storage of hydrogen spin polarization in long-lived 13C2 singlet order and implications for hyperpolarized magnetic resonance imaging. J Am Chem Soc. 2013 Jul 3;135(26):9632–5.
Feng, Yesu, et al. “Storage of hydrogen spin polarization in long-lived 13C2 singlet order and implications for hyperpolarized magnetic resonance imaging.J Am Chem Soc, vol. 135, no. 26, July 2013, pp. 9632–35. Pubmed, doi:10.1021/ja404936p.
Feng Y, Theis T, Liang X, Wang Q, Zhou P, Warren WS. Storage of hydrogen spin polarization in long-lived 13C2 singlet order and implications for hyperpolarized magnetic resonance imaging. J Am Chem Soc. 2013 Jul 3;135(26):9632–9635.
Journal cover image

Published In

J Am Chem Soc

DOI

EISSN

1520-5126

Publication Date

July 3, 2013

Volume

135

Issue

26

Start / End Page

9632 / 9635

Location

United States

Related Subject Headings

  • Magnetic Resonance Imaging
  • Hydrogen
  • General Chemistry
  • Carbon Isotopes
  • Acetylene
  • 40 Engineering
  • 34 Chemical sciences
  • 03 Chemical Sciences