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Pei Zhou

Professor of Biochemistry
Duke Box 3711, Durham, NC 27710
270 Sands Building, Research Drive, Durham, NC 27710


The Zhou lab focuses on the elucidation of the structure and dynamics of protein–protein and protein–ligand interactions and their functions in various cellular processes. Our current efforts are directed at enzymes and protein complexes involved in bacterial membrane biosynthesis, translesion DNA synthesis, co-transcriptional regulation, and host-pathogen interactions. Our investigations of these important cellular machineries have led to the development of novel antibiotics and cancer therapeutics, as well as the establishment of new biotechnology adventures.


The Zhou lab integrates a variety of biochemical and biophysical tools, including NMR, X-ray crystallography, cryo-EM, and enzymology. The lab has played a major role in the development and application of innovative NMR technologies, including high-resolution, high-dimensional spectral reconstruction techniques.

Current Appointments & Affiliations

Professor of Biochemistry · 2015 - Present Biochemistry, Basic Science Departments
Professor of Chemistry · 2015 - Present Chemistry, Trinity College of Arts & Sciences
Member of the Duke Cancer Institute · 2001 - Present Duke Cancer Institute, Institutes and Centers

Education, Training & Certifications

Harvard University · 1998 Ph.D.