Pei Zhou
Professor of Biochemistry
Protein-protein interactions play a pivotal role in the regulation of various cellular processes. The formation of higher order protein complexes is frequently accompanied by extensive structural remodeling of the individual components, varying from domain re-orientation to induced folding of unstructured elements. Nuclear Magnetic Resonance (NMR) spectroscopy is a powerful tool for macromolecular structure determination in solution. It has the unique advantage of being capable of elucidating the dynamic behavior of proteins during the process of recognition. Recent advances in NMR techniques have enabled the study of significantly larger proteins and protein complexes. These innovations have also led to faster and more accurate structure determination. My research interests focus on the exploration of molecular recognition and conformation variability of protein complexes in crucial biomedical processes using state-of-the-art NMR techniques.
Current Appointments & Affiliations
- Professor of Biochemistry, Biochemistry, Basic Science Departments 2015
- Member of the Duke Cancer Institute, Duke Cancer Institute, Institutes and Centers 2001
Contact Information
- 270 Sands Building, Research Drive, Durham, NC 27710
- Duke Box 3711, Durham, NC 27710
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peizhou@biochem.duke.edu
(919) 668-6409
- Background
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Education, Training, & Certifications
- Post-Doct Fellow, Biological Chemistry, Harvard University 1998 - 2001
- Ph.D., Harvard University 1998
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Previous Appointments & Affiliations
- Professor of Chemistry, Chemistry, Trinity College of Arts & Sciences 2015 - 2020
- Associate Professor of Biochemistry, Biochemistry, Basic Science Departments 2008 - 2015
- Associate Professor in the Department of Chemistry, Chemistry, Trinity College of Arts & Sciences 2010 - 2015
- Associate Professor of Chemistry, Chemistry, Trinity College of Arts & Sciences 2008 - 2009
- Assistant Professor of Biochemistry, Biochemistry, Basic Science Departments 2001 - 2008
- Assistant Professor of Chemistry, Chemistry, Trinity College of Arts & Sciences 2007 - 2008
- Assistant Professor of Chemistry, Chemistry, Trinity College of Arts & Sciences 2002 - 2007
- Instructor, Temporary in the Department of Biochemistry, Biochemistry, Basic Science Departments 2001
- Research
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Selected Grants
- Mechanistic Insights into the Plant Disease Resistance Mediated by NPR1 awarded by National Institutes of Health 2022 - 2026
- MRI: Acquisition of a Microscale Thermophoresis System awarded by National Science Foundation 2022 - 2025
- Mechanism of carbon skeleton formation in molybdenum cofactor biosynthesis awarded by National Institutes of Health 2021 - 2024
- Therapeutic targeting of MESH1 in renal cell carcinoma awarded by Department of Defense 2020 - 2023
- Method development for automatic assignment and structure determination in protein NMR awarded by Rensselaer Polytechnic Institute 2022 - 2023
- Biochemical and functional investigation of the novel enzymatic activities of Mesh1 awarded by National Institutes of Health 2018 - 2023
- Molecular mechanism of cephalosporin resistance of N. gonorrhoeae conferred by mutated PBP2 awarded by University of South Alabama 2022 - 2023
- The regulation dephosphorylated-CoA-capped RNA and innate immunity by MESH1 awarded by National Institutes of Health 2020 - 2023
- Discovery and validation of broadly effective LpxH inhibitors as novel therapeutics against multi-drug resistant Gram-negative pathogens awarded by National Institutes of Health 2019 - 2023
- Testing D5 compounds in a human version of a published ELISA system awarded by D5 Therapeutics, Inc 2021 - 2022
- IND-enabling studies of the potent LpxC inhibitor LPC-233 as a novel antibiotic against Gram-negative pathogens awarded by Valanbio Therapeutics, Inc. 2020 - 2022
- Deep Topological Sampling of Protein Structures - non-competing renewal for Year 4 awarded by National Institutes of Health 2017 - 2022
- Structure-Function Analysis of Chlamydia Secretion Chaperones awarded by National Institutes of Health 2016 - 2022
- Organization and Function of Cellular Structure awarded by National Institutes of Health 1975 - 2020
- Biochemistry and Structure of Lipid A Enzymes awarded by National Institutes of Health 2016 - 2020
- Molecular targets in peptidoglycan synthesis awarded by Medical University of South Carolina 2016 - 2020
- Discovery and validation of broadly effective LpxH inhibitors as novel therapeutics against multi-drug resistant Gram-negative pathogens awarded by National Institutes of Health 2018 - 2019
- Targeting Rev1-mediated Translesion Synthesis for Cancer Therapy awarded by National Institutes of Health 2015 - 2017
- LpxC inhibitors as a novel class of antibiotics against N. gonorrhoeae awarded by National Institutes of Health 2011 - 2017
- Preliminary Safety Screening of Duke PlxC inhibitors as Novel Antibiotics against Gram-negative Pathogens awarded by North Carolina Biotechnology Center 2015 - 2016
- Structural Biology and Biophysics Training Program awarded by National Institutes of Health 1994 - 2015
- Biosynthesis And Function Of Lipopolysaccharides awarded by National Institutes of Health 1994 - 2015
- High sensitivity multi-purpose electron paramagnetic resonance spectroscopy for biotechnological and biomedical research awarded by North Carolina Biotechnology Center 2014 - 2015
- Automated detection of protein crystals in high-throughput crystallography experiments awarded by North Carolina Biotechnology Center 2014 - 2015
- New Console and Cold Probe for the Duke 600 MHz NMR Spectrometer System awarded by National Institutes of Health 2013 - 2014
- Structural and Biochemical Studies of LpxC Inhibition awarded by National Institutes of Health 2003 - 2014
- Lipid A Modification Systems in Gram-Negative Bacteria awarded by National Institutes of Health 1995 - 2013
- Automated NMR Assignment and Protein Structure Determination awarded by National Institutes of Health 2006 - 2012
- Structural, Biochemical and Functional Studies of RNAPII CTD Interacting Proteins awarded by National Institutes of Health 2008 - 2012
- Replacement Equipment Components for an 800 MHz NMR Spectrometer awarded by National Institutes of Health 2010 - 2011
- Regulation of Germline Stem Cell Division in Drosophila awarded by National Institutes of Health 1996 - 2006
- Structure and Regulation of hsp90 Chaperones awarded by National Institutes of Health 2005
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External Relationships
- D5 Therapeutics
- LVM Biosciences
- Valanbio Therapeutics
- Publications & Artistic Works
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Selected Publications
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Academic Articles
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Kumar, Shivesh, Raul Zavaliev, Qinglin Wu, Ye Zhou, Jie Cheng, Lucas Dillard, Jordan Powers, et al. “Structural basis of NPR1 in activating plant immunity.” Nature 605, no. 7910 (May 2022): 561–66. https://doi.org/10.1038/s41586-022-04699-w.Full Text
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Victor, Joshua, Tristan Jordan, Erica Lamkin, Kanayo Ikeh, Anthony March, Justin Frere, Andrew Crompton, et al. “SARS-CoV-2 hijacks host cell genome instability pathways.” Res Sq, April 14, 2022. https://doi.org/10.21203/rs.3.rs-1556634/v1.Full Text Link to Item
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Sun, Tianai, Chien-Kuang Cornelia Ding, Yuning Zhang, Yang Zhang, Chao-Chieh Lin, Jianli Wu, Yasaman Setayeshpour, et al. “MESH1 knockdown triggers proliferation arrest through TAZ repression.” Cell Death Dis 13, no. 3 (March 10, 2022): 221. https://doi.org/10.1038/s41419-022-04663-6.Full Text Link to Item
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Mestre, Alexander A., Pei Zhou, and Jen-Tsan Chi. “Metazoan stringent-like response mediated by MESH1 phenotypic conservation via distinct mechanisms.” Comput Struct Biotechnol J 20 (2022): 2680–84. https://doi.org/10.1016/j.csbj.2022.05.001.Full Text Link to Item
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Wüllner, Dominik, Maren Gesper, Annika Haupt, Xiaofei Liang, Pei Zhou, Pascal Dietze, Franz Narberhaus, and Julia E. Bandow. “Adaptive Responses of Pseudomonas aeruginosa to Treatment with Antibiotics.” Antimicrobial Agents and Chemotherapy 66, no. 1 (January 2022): e0087821. https://doi.org/10.1128/aac.00878-21.Full Text
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Victor, Joshua, Jamie Deutsch, Annalis Whitaker, Erica N. Lamkin, Anthony March, Pei Zhou, Jason W. Botten, and Nimrat Chatterjee. “SARS-CoV-2 triggers DNA damage response in Vero E6 cells.” Biochem Biophys Res Commun 579 (November 19, 2021): 141–45. https://doi.org/10.1016/j.bbrc.2021.09.024.Full Text Link to Item
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Ikeh, Kanayo E., Erica N. Lamkin, Andrew Crompton, Jamie Deutsch, Kira J. Fisher, Mark Gray, David J. Argyle, et al. “REV1 Inhibition Enhances Radioresistance and Autophagy.” Cancers (Basel) 13, no. 21 (October 21, 2021). https://doi.org/10.3390/cancers13215290.Full Text Link to Item
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Fenton, Benjamin A., Joshua Tomberg, Carly A. Sciandra, Robert A. Nicholas, Christopher Davies, and Pei Zhou. “Mutations in PBP2 from ceftriaxone-resistant Neisseria gonorrhoeae alter the dynamics of the β3-β4 loop to favor a low-affinity drug-binding state.” J Biol Chem 297, no. 4 (October 2021): 101188. https://doi.org/10.1016/j.jbc.2021.101188.Full Text Link to Item
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Yoo, Chan Yul, Jiangman He, Qing Sang, Yongjian Qiu, Lingyun Long, Ruth Jean-Ae Kim, Emily G. Chong, et al. “Direct photoresponsive inhibition of a p53-like transcription activation domain in PIF3 by Arabidopsis phytochrome B.” Nat Commun 12, no. 1 (September 23, 2021): 5614. https://doi.org/10.1038/s41467-021-25909-5.Full Text Link to Item
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Ikeh, Kanayo, Erica Lamkin, Andrew Crompton, Jamie Deutsch, Kira Fisher, Mark E. Gray, David Argyle, et al. “REV1 Inhibition Enhances Radioresistance and Autophagy,” September 13, 2021. https://doi.org/10.20944/preprints202109.0202.v1.Full Text
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Adhikari, Hema, Walaa E. Kattan, Shivesh Kumar, Pei Zhou, John F. Hancock, and Christopher M. Counter. “Oncogenic KRAS is dependent upon an EFR3A-PI4KA signaling axis for potent tumorigenic activity.” Nat Commun 12, no. 1 (September 9, 2021): 5248. https://doi.org/10.1038/s41467-021-25523-5.Full Text Link to Item
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Lin, Chao-Chieh, Chien-Kuang Cornelia Ding, Tianai Sun, Jianli Wu, Kai-Yuan Chen, Pei Zhou, and Jen-Tsan Chi. “The regulation of ferroptosis by MESH1 through the activation of the integrative stress response.” Cell Death Dis 12, no. 8 (July 22, 2021): 727. https://doi.org/10.1038/s41419-021-04018-7.Full Text Link to Item
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Chin, Chui-Yoke, Jinshi Zhao, Anna C. Llewellyn, Igor Golovliov, Anders Sjöstedt, Pei Zhou, and David S. Weiss. “Francisella FlmX broadly affects lipopolysaccharide modification and virulence.” Cell Rep 35, no. 11 (June 15, 2021): 109247. https://doi.org/10.1016/j.celrep.2021.109247.Full Text Link to Item
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Zhou, Pei, and Jiyong Hong. “Structure- and Ligand-Dynamics-Based Design of Novel Antibiotics Targeting Lipid A Enzymes LpxC and LpxH in Gram-Negative Bacteria.” Acc Chem Res 54, no. 7 (April 6, 2021): 1623–34. https://doi.org/10.1021/acs.accounts.0c00880.Full Text Link to Item
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Martorana, Alessandra M., Elisabete C. C. M. Moura, Paola Sperandeo, Flavia Di Vincenzo, Xiaofei Liang, Eric Toone, Pei Zhou, and Alessandra Polissi. “Degradation of Components of the Lpt Transenvelope Machinery Reveals LPS-Dependent Lpt Complex Stability in Escherichia coli.” Front Mol Biosci 8 (2021): 758228. https://doi.org/10.3389/fmolb.2021.758228.Full Text Open Access Copy Link to Item
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Chatterjee, Nimrat, Matthew A. Whitman, Cynthia A. Harris, Sophia M. Min, Oliver Jonas, Evan C. Lien, Alba Luengo, et al. “REV1 inhibitor JH-RE-06 enhances tumor cell response to chemotherapy by triggering senescence hallmarks.” Proc Natl Acad Sci U S A 117, no. 46 (November 17, 2020): 28918–21. https://doi.org/10.1073/pnas.2016064117.Full Text Link to Item
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Vassel, Faye-Marie, Ke Bian, Graham C. Walker, and Michael T. Hemann. “Rev7 loss alters cisplatin response and increases drug efficacy in chemotherapy-resistant lung cancer.” Proc Natl Acad Sci U S A 117, no. 46 (November 17, 2020): 28922–24. https://doi.org/10.1073/pnas.2016067117.Full Text Link to Item
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Kwak, Seung-Hwa, C Skyler Cochrane, Amanda F. Ennis, Won Young Lim, Caroline G. Webster, Jae Cho, Benjamin A. Fenton, Pei Zhou, and Jiyong Hong. “Synthesis and evaluation of sulfonyl piperazine LpxH inhibitors.” Bioorg Chem 102 (September 2020): 104055. https://doi.org/10.1016/j.bioorg.2020.104055.Full Text Link to Item
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Ding, Chien-Kuang Cornelia, Joshua Rose, Tianai Sun, Jianli Wu, Po-Han Chen, Chao-Chieh Lin, Wen-Hsuan Yang, et al. “MESH1 is a cytosolic NADPH phosphatase that regulates ferroptosis.” Nature Metabolism 2, no. 3 (March 2020): 270–77. https://doi.org/10.1038/s42255-020-0181-1.Full Text Open Access Copy
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Cho, Jae, Minhee Lee, C Skyler Cochrane, Caroline G. Webster, Benjamin A. Fenton, Jinshi Zhao, Jiyong Hong, and Pei Zhou. “Structural basis of the UDP-diacylglucosamine pyrophosphohydrolase LpxH inhibition by sulfonyl piperazine antibiotics.” Proc Natl Acad Sci U S A 117, no. 8 (February 25, 2020): 4109–16. https://doi.org/10.1073/pnas.1912876117.Full Text Link to Item
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Ji, Yuhyun, Jinsu An, Dohyeon Hwang, Da Hui Ha, Sang Min Lim, Chankyu Lee, Jinshi Zhao, et al. “Metabolic engineering of Escherichia coli to produce a monophosphoryl lipid A adjuvant.” Metab Eng 57 (January 2020): 193–202. https://doi.org/10.1016/j.ymben.2019.11.009.Full Text Open Access Copy Link to Item
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Zhao, Jinshi, Jinsu An, Dohyeon Hwang, Qinglin Wu, Su Wang, Robert A. Gillespie, Eun Gyeong Yang, Ziqiang Guan, Pei Zhou, and Hak Suk Chung. “The Lipid A 1-Phosphatase, LpxE, Functionally Connects Multiple Layers of Bacterial Envelope Biogenesis.” Mbio 10, no. 3 (June 18, 2019). https://doi.org/10.1128/mBio.00886-19.Full Text Open Access Copy Link to Item
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Yang, Emily J., Chan Yul Yoo, Jiangxin Liu, He Wang, Jun Cao, Fay-Wei Li, Kathleen M. Pryer, et al. “NCP activates chloroplast transcription by controlling phytochrome-dependent dual nuclear and plastidial switches.” Nat Commun 10, no. 1 (June 14, 2019): 2630. https://doi.org/10.1038/s41467-019-10517-1.Full Text Open Access Copy Link to Item
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Wojtaszek, Jessica L., Nimrat Chatterjee, Javaria Najeeb, Azucena Ramos, Minhee Lee, Ke Bian, Jenny Y. Xue, et al. “A Small Molecule Targeting Mutagenic Translesion Synthesis Improves Chemotherapy.” Cell 178, no. 1 (June 2019): 152-159.e11. https://doi.org/10.1016/j.cell.2019.05.028.Full Text
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Lee, Minhee, Jinshi Zhao, Seung-Hwa Kwak, Jae Cho, Myungju Lee, Robert A. Gillespie, Do-Yeon Kwon, et al. “Structure-Activity Relationship of Sulfonyl Piperazine LpxH Inhibitors Analyzed by an LpxE-Coupled Malachite Green Assay.” Acs Infect Dis 5, no. 4 (April 12, 2019): 641–51. https://doi.org/10.1021/acsinfecdis.8b00364.Full Text Link to Item
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Cristillo, Anthony D., Claire C. Bristow, Elizabeth Torrone, Jo-Anne Dillon, Robert D. Kirkcaldy, Huan Dong, Yonatan H. Grad, et al. “Antimicrobial Resistance in Neisseria gonorrhoeae: Proceedings of the STAR Sexually Transmitted Infection-Clinical Trial Group Programmatic Meeting.” Sex Transm Dis 46, no. 3 (March 2019): e18–25. https://doi.org/10.1097/OLQ.0000000000000929.Full Text Link to Item
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Yang, E. J., C. Y. Yoo, J. Liu, H. Wang, J. Cao, F. Li, K. M. Pryer, T. Sun, D. Weigel, and P. Zhou. “NCP activates chloroplast transcription by controlling phytochrome-dependent dual nuclear and plastidial switches.” Nature Communications 10, no. 1 (2019): 1–13.Open Access Copy
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Wang, Tao, Yonghui Yu, Xiaofei Liang, Shengdong Luo, Zemin He, Zhihui Sun, Yongqiang Jiang, Anders Omsland, Pei Zhou, and Lihua Song. “Lipid A Has Significance for Optimal Growth of Coxiella burnetii in Macrophage-Like THP-1 Cells and to a Lesser Extent in Axenic Media and Non-phagocytic Cells.” Front Cell Infect Microbiol 8 (2018): 192. https://doi.org/10.3389/fcimb.2018.00192.Full Text Link to Item
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Liu, Yixiang, Joshua Rose, Shaojia Huang, Yangbo Hu, Qiong Wu, Dan Wang, Conggang Li, Maili Liu, Pei Zhou, and Ling Jiang. “A pH-gated conformational switch regulates the phosphatase activity of bifunctional HisKA-family histidine kinases.” Nat Commun 8, no. 1 (December 13, 2017): 2104. https://doi.org/10.1038/s41467-017-02310-9.Full Text Link to Item
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Zhou, Pei, and Jinshi Zhao. “Structure, inhibition, and regulation of essential lipid A enzymes.” Biochim Biophys Acta Mol Cell Biol Lipids 1862, no. 11 (November 2017): 1424–38. https://doi.org/10.1016/j.bbalip.2016.11.014.Full Text Open Access Copy Link to Item
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Wu, Qinglin, Benjamin A. Fenton, Jessica L. Wojtaszek, and Pei Zhou. “Probing the excited-state chemical shifts and exchange parameters by nitrogen-decoupled amide proton chemical exchange saturation transfer (HNdec-CEST).” Chem Commun (Camb) 53, no. 61 (July 27, 2017): 8541–44. https://doi.org/10.1039/c7cc05021f.Full Text Open Access Copy Link to Item
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Lemaître, Nadine, Xiaofei Liang, Javaria Najeeb, Chul-Jin Lee, Marie Titecat, Emmanuelle Leteurtre, Michel Simonet, Eric J. Toone, Pei Zhou, and Florent Sebbane. “Curative Treatment of Severe Gram-Negative Bacterial Infections by a New Class of Antibiotics Targeting LpxC.” Mbio 8, no. 4 (July 25, 2017). https://doi.org/10.1128/mBio.00674-17.Full Text Open Access Copy Link to Item
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Zentella, Rodolfo, Ning Sui, Benjamin Barnhill, Wen-Ping Hsieh, Jianhong Hu, Jeffrey Shabanowitz, Michael Boyce, et al. “The Arabidopsis O-fucosyltransferase SPINDLY activates nuclear growth repressor DELLA.” Nature Chemical Biology 13, no. 5 (May 2017): 479–85. https://doi.org/10.1038/nchembio.2320.Full Text Open Access Copy
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Titecat, Marie, Xiaofei Liang, Chul-Jin Lee, Audrey Charlet, Didier Hocquet, Thierry Lambert, Jean-Marie Pagès, et al. “High susceptibility of MDR and XDR Gram-negative pathogens to biphenyl-diacetylene-based difluoromethyl-allo-threonyl-hydroxamate LpxC inhibitors.” J Antimicrob Chemother 71, no. 10 (October 2016): 2874–82. https://doi.org/10.1093/jac/dkw210.Full Text Open Access Copy Link to Item
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Cho, Jae, Chul-Jin Lee, Jinshi Zhao, Hayley E. Young, and Pei Zhou. “Structure of the essential Haemophilus influenzae UDP-diacylglucosamine pyrophosphohydrolase LpxH in lipid A biosynthesis.” Nat Microbiol 1, no. 11 (August 15, 2016): 16154. https://doi.org/10.1038/nmicrobiol.2016.154.Full Text Open Access Copy Link to Item
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Wu, Qinglin, Brian E. Coggins, and Pei Zhou. “Unbiased measurements of reconstruction fidelity of sparsely sampled magnetic resonance spectra.” Nat Commun 7 (July 27, 2016): 12281. https://doi.org/10.1038/ncomms12281.Full Text Open Access Copy Link to Item
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Liang, Xiaofei, Ramesh Gopalaswamy, Frank Navas, Eric J. Toone, and Pei Zhou. “A Scalable Synthesis of the Difluoromethyl-allo-threonyl Hydroxamate-Based LpxC Inhibitor LPC-058.” J Org Chem 81, no. 10 (May 20, 2016): 4393–98. https://doi.org/10.1021/acs.joc.6b00589.Full Text Open Access Copy Link to Item
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Young, Hayley E., Jinshi Zhao, Jeffrey R. Barker, Ziqiang Guan, Raphael H. Valdivia, and Pei Zhou. “Discovery of the Elusive UDP-Diacylglucosamine Hydrolase in the Lipid A Biosynthetic Pathway in Chlamydia trachomatis.” Mbio 7, no. 2 (March 22, 2016): e00090. https://doi.org/10.1128/mBio.00090-16.Full Text Open Access Copy Link to Item
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Lee, Chul-Jin, Xiaofei Liang, Qinglin Wu, Javaria Najeeb, Jinshi Zhao, Ramesh Gopalaswamy, Marie Titecat, et al. “Drug design from the cryptic inhibitor envelope.” Nat Commun 7 (February 25, 2016): 10638. https://doi.org/10.1038/ncomms10638.Full Text Open Access Copy Link to Item
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Deis, Lindsay N., Qinglin Wu, You Wang, Yang Qi, Kyle G. Daniels, Pei Zhou, and Terrence G. Oas. “Suppression of conformational heterogeneity at a protein-protein interface.” Proc Natl Acad Sci U S A 112, no. 29 (July 21, 2015): 9028–33. https://doi.org/10.1073/pnas.1424724112.Full Text Open Access Copy Link to Item
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Martin, Jeffrey W., Pei Zhou, and Bruce R. Donald. “Systematic solution to homo-oligomeric structures determined by NMR.” Proteins 83, no. 4 (April 2015): 651–61. https://doi.org/10.1002/prot.24768.Full Text Link to Item
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Wojtaszek, Jessica L., Su Wang, Hyungjin Kim, Qinglin Wu, Alan D. D’Andrea, and Pei Zhou. “Ubiquitin recognition by FAAP20 expands the complex interface beyond the canonical UBZ domain.” Nucleic Acids Res 42, no. 22 (December 16, 2014): 13997–5. https://doi.org/10.1093/nar/gku1153.Full Text Open Access Copy Link to Item
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Emptage, Ryan P., Nam K. Tonthat, John D. York, Maria A. Schumacher, and Pei Zhou. “Structural basis of lipid binding for the membrane-embedded tetraacyldisaccharide-1-phosphate 4'-kinase LpxK.” J Biol Chem 289, no. 35 (August 29, 2014): 24059–68. https://doi.org/10.1074/jbc.M114.589986.Full Text Link to Item
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Sampson, Timothy R., Brooke A. Napier, Max R. Schroeder, Rogier Louwen, Jinshi Zhao, Chui-Yoke Chin, Hannah K. Ratner, et al. “A CRISPR-Cas system enhances envelope integrity mediating antibiotic resistance and inflammasome evasion.” Proc Natl Acad Sci U S A 111, no. 30 (July 29, 2014): 11163–68. https://doi.org/10.1073/pnas.1323025111.Full Text Link to Item
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Wang, Su, and Pei Zhou. “Sparsely-sampled, high-resolution 4-D omit spectra for detection and assignment of intermolecular NOEs of protein complexes.” J Biomol Nmr 59, no. 2 (June 2014): 51–56. https://doi.org/10.1007/s10858-014-9834-2.Full Text Link to Item
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Lee, Chul-Jin, Xiaofei Liang, Ramesh Gopalaswamy, Javaria Najeeb, Eugene D. Ark, Eric J. Toone, and Pei Zhou. “Structural basis of the promiscuous inhibitor susceptibility of Escherichia coli LpxC.” Acs Chem Biol 9, no. 1 (January 17, 2014): 237–46. https://doi.org/10.1021/cb400067g.Full Text Link to Item
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Masoudi, Ali, Christian R. H. Raetz, Pei Zhou, and Charles W. Pemble. “Chasing acyl carrier protein through a catalytic cycle of lipid A production.” Nature 505, no. 7483 (January 16, 2014): 422–26. https://doi.org/10.1038/nature12679.Full Text Link to Item
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Masoudi, A., C. R. H. Raetz, P. Zhou, and C. W. Pemble IV. “Chasing acyl carrier protein through a catalytic cycle of lipid A production.” Nature 505, no. 7483 (January 1, 2014): 422–26. https://doi.org/10.1038/nature12679.Full Text
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Young, Hayley E., Matthew P. Donohue, Tatyana I. Smirnova, Alex I. Smirnov, and Pei Zhou. “The UDP-diacylglucosamine pyrophosphohydrolase LpxH in lipid A biosynthesis utilizes Mn2+ cluster for catalysis.” J Biol Chem 288, no. 38 (September 20, 2013): 26987–1. https://doi.org/10.1074/jbc.M113.497636.Full Text Link to Item
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Liang, Xiaofei, Chul-Jin Lee, Jinshi Zhao, Eric J. Toone, and Pei Zhou. “Synthesis, structure, and antibiotic activity of aryl-substituted LpxC inhibitors.” J Med Chem 56, no. 17 (September 12, 2013): 6954–66. https://doi.org/10.1021/jm4007774.Full Text Link to Item
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Chung, Ben C., Jinshi Zhao, Robert A. Gillespie, Do-Yeon Kwon, Ziqiang Guan, Jiyong Hong, Pei Zhou, and Seok-Yong Lee. “Crystal structure of MraY, an essential membrane enzyme for bacterial cell wall synthesis.” Science 341, no. 6149 (August 30, 2013): 1012–16. https://doi.org/10.1126/science.1236501.Full Text Link to Item
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Feng, Yesu, Thomas Theis, Xiaofei Liang, Qiu Wang, Pei Zhou, and Warren S. Warren. “Storage of hydrogen spin polarization in long-lived 13C2 singlet order and implications for hyperpolarized magnetic resonance imaging.” J Am Chem Soc 135, no. 26 (July 3, 2013): 9632–35. https://doi.org/10.1021/ja404936p.Full Text Link to Item
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Liu, Jiangxin, Shilong Fan, Chul-Jin Lee, Arno L. Greenleaf, and Pei Zhou. “Specific interaction of the transcription elongation regulator TCERG1 with RNA polymerase II requires simultaneous phosphorylation at Ser2, Ser5, and Ser7 within the carboxyl-terminal domain repeat.” J Biol Chem 288, no. 15 (April 12, 2013): 10890–901. https://doi.org/10.1074/jbc.M113.460238.Full Text Link to Item
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Tripathy, C., A. K. Yan, P. Zhou, and B. R. Donald. “Extracting structural information from residual chemical shift anisotropy: Analytic solutions for peptide plane orientations and applications to determine protein structure.” Lecture Notes in Computer Science (Including Subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) 7821 LNBI (April 3, 2013): 271–84. https://doi.org/10.1007/978-3-642-37195-0_25.Full Text
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Emptage, Ryan P., Charles W. Pemble, John D. York, Christian R. H. Raetz, and Pei Zhou. “Mechanistic characterization of the tetraacyldisaccharide-1-phosphate 4'-kinase LpxK involved in lipid A biosynthesis.” Biochemistry 52, no. 13 (April 2, 2013): 2280–90. https://doi.org/10.1021/bi400097z.Full Text Link to Item
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Zeng, Daina, Jinshi Zhao, Hak Suk Chung, Ziqiang Guan, Christian R. H. Raetz, and Pei Zhou. “Mutants resistant to LpxC inhibitors by rebalancing cellular homeostasis.” J Biol Chem 288, no. 8 (February 22, 2013): 5475–86. https://doi.org/10.1074/jbc.M112.447607.Full Text Link to Item
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Chung, B. C., J. Zhao, R. A. Gillespie, D. Y. Kwon, Z. Guan, J. Hong, P. Zhou, and S. Y. Lee. “Crystal structure of MraY, an essential membrane enzyme for bacterial cell wall synthesis.” Science 341, no. 6149 (2013): 1012–16. https://doi.org/10.1126/science.1240985.Full Text
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Zeng, Jianyang, Pei Zhou, and Bruce Randall Donald. “HASH: a program to accurately predict protein Hα shifts from neighboring backbone shifts.” J Biomol Nmr 55, no. 1 (January 2013): 105–18. https://doi.org/10.1007/s10858-012-9693-7.Full Text Link to Item
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Coggins, Brian E., Jonathan W. Werner-Allen, Anthony Yan, and Pei Zhou. “Rapid protein global fold determination using ultrasparse sampling, high-dynamic range artifact suppression, and time-shared NOESY.” J Am Chem Soc 134, no. 45 (November 14, 2012): 18619–30. https://doi.org/10.1021/ja307445y.Full Text Link to Item
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Wojtaszek, Jessica, Chul-Jin Lee, Sanjay D’Souza, Brenda Minesinger, Hyungjin Kim, Alan D. D’Andrea, Graham C. Walker, and Pei Zhou. “Structural basis of Rev1-mediated assembly of a quaternary vertebrate translesion polymerase complex consisting of Rev1, heterodimeric polymerase (Pol) ζ, and Pol κ.” J Biol Chem 287, no. 40 (September 28, 2012): 33836–46. https://doi.org/10.1074/jbc.M112.394841.Full Text Link to Item
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Wojtaszek, Jessica, Jiangxin Liu, Sanjay D’Souza, Su Wang, Yaohua Xue, Graham C. Walker, and Pei Zhou. “Multifaceted recognition of vertebrate Rev1 by translesion polymerases ζ and κ.” J Biol Chem 287, no. 31 (July 27, 2012): 26400–408. https://doi.org/10.1074/jbc.M112.380998.Full Text Link to Item
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Wen, Jie, Pei Zhou, and Jihui Wu. “Efficient acquisition of high-resolution 4-D diagonal-suppressed methyl-methyl NOESY for large proteins.” J Magn Reson 218 (May 2012): 128–32. https://doi.org/10.1016/j.jmr.2012.02.021.Full Text Link to Item
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Young, Hayley E., Louis E. Metzger, John K. Lee, Robert M. Stroud, Pei Zhou, and Christian R. H. Raetz. “Enzymatic and structural studies of UDP-2,3-diacylglucosamine hydrolysis in lipid A biosynthesis.” Faseb Journal 26 (April 1, 2012).Link to Item
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Werner-Allen, Jon W., and Pei Zhou. “¹H, ¹³C and ¹⁵N backbone and side-chain resonance assignments of Drosophila melanogaster Ssu72.” Biomol Nmr Assign 6, no. 1 (April 2012): 57–61. https://doi.org/10.1007/s12104-011-9325-2.Full Text Link to Item
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Tripathy, Chittaranjan, Jianyang Zeng, Pei Zhou, and Bruce Randall Donald. “Protein loop closure using orientational restraints from NMR data.” Proteins 80, no. 2 (February 2012): 433–53. https://doi.org/10.1002/prot.23207.Full Text Link to Item
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Moss, Marcia L., Gary Powell, Miles A. Miller, Lori Edwards, Bin Qi, Qing-Xiang Amy Sang, Bart De Strooper, et al. “ADAM9 inhibition increases membrane activity of ADAM10 and controls α-secretase processing of amyloid precursor protein.” J Biol Chem 286, no. 47 (November 25, 2011): 40443–51. https://doi.org/10.1074/jbc.M111.280495.Full Text Link to Item
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Martin, Jeffrey W., Anthony K. Yan, Chris Bailey-Kellogg, Pei Zhou, and Bruce R. Donald. “A geometric arrangement algorithm for structure determination of symmetric protein homo-oligomers from NOEs and RDCs.” J Comput Biol 18, no. 11 (November 2011): 1507–23. https://doi.org/10.1089/cmb.2011.0173.Full Text Link to Item
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Zeng, Jianyang, Kyle E. Roberts, Pei Zhou, and Bruce Randall Donald. “A Bayesian approach for determining protein side-chain rotamer conformations using unassigned NOE data.” J Comput Biol 18, no. 11 (November 2011): 1661–79. https://doi.org/10.1089/cmb.2011.0172.Full Text Link to Item
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Zeng, Jianyang, Pei Zhou, and Bruce Randall Donald. “Protein side-chain resonance assignment and NOE assignment using RDC-defined backbones without TOCSY data.” J Biomol Nmr 50, no. 4 (August 2011): 371–95. https://doi.org/10.1007/s10858-011-9522-4.Full Text Link to Item
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Nguyen, Bidong D., Doreen Cunningham, Xiaofei Liang, Xin Chen, Eric J. Toone, Christian R. H. Raetz, Pei Zhou, and Raphael H. Valdivia. “Lipooligosaccharide is required for the generation of infectious elementary bodies in Chlamydia trachomatis.” Proc Natl Acad Sci U S A 108, no. 25 (June 21, 2011): 10284–89. https://doi.org/10.1073/pnas.1107478108.Full Text Link to Item
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Martin, Jeffrey W., Anthony K. Yan, Chris Bailey-Kellogg, Pei Zhou, and Bruce R. Donald. “A graphical method for analyzing distance restraints using residual dipolar couplings for structure determination of symmetric protein homo-oligomers.” Protein Sci 20, no. 6 (June 2011): 970–85. https://doi.org/10.1002/pro.620.Full Text Link to Item
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Chen, J., Q. Li, C. C. Liu, P. Zhou, G. Bu, and J. Wang. “Erratum to: NMR structure note: Solution structure of the core domain of MESD that is essential for proper folding of LRP5/6 (Journal of Biomolecular NMR (2010) 47 (283-288) DOI:10.1007/s10858-010-9426-8).” Journal of Biomolecular Nmr 50, no. 1 (May 1, 2011): 101. https://doi.org/10.1007/s10858-011-9476-6.Full Text
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Wen, Jie, Jihui Wu, and Pei Zhou. “Sparsely sampled high-resolution 4-D experiments for efficient backbone resonance assignment of disordered proteins.” J Magn Reson 209, no. 1 (March 2011): 94–100. https://doi.org/10.1016/j.jmr.2010.12.012.Full Text Link to Item
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Werner-Allen, Jon W., Chul-Jin Lee, Pengda Liu, Nathan I. Nicely, Su Wang, Arno L. Greenleaf, and Pei Zhou. “cis-Proline-mediated Ser(P)5 dephosphorylation by the RNA polymerase II C-terminal domain phosphatase Ssu72.” J Biol Chem 286, no. 7 (February 18, 2011): 5717–26. https://doi.org/10.1074/jbc.M110.197129.Full Text Link to Item
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Lee, Chul-Jin, Xiaofei Liang, Xin Chen, Daina Zeng, Sang Hoon Joo, Hak Suk Chung, Adam W. Barb, et al. “Species-specific and inhibitor-dependent conformations of LpxC: implications for antibiotic design.” Chem Biol 18, no. 1 (January 28, 2011): 38–47. https://doi.org/10.1016/j.chembiol.2010.11.011.Full Text Link to Item
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Liang, Xiaofei, Chul-Jin Lee, Xin Chen, Hak Suk Chung, Daina Zeng, Christian R. H. Raetz, Yaoxian Li, Pei Zhou, and Eric J. Toone. “Syntheses, structures and antibiotic activities of LpxC inhibitors based on the diacetylene scaffold.” Bioorg Med Chem 19, no. 2 (January 15, 2011): 852–60. https://doi.org/10.1016/j.bmc.2010.12.017.Full Text Link to Item
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Martin, J. W., A. K. Yan, C. Bailey-Kellogg, P. Zhou, and B. R. Donald. “A Geometric Arrangement Algorithm for Structure Determination of Symmetric Protein Homo-oligomers from NOEs and RDCs.” Lecture Notes in Computer Science (Including Subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) 6577 LNBI (January 1, 2011): 222–37. https://doi.org/10.1007/978-3-642-20036-6_21.Full Text
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Tripathy, C., J. Zeng, P. Zhou, and B. R. Donald. “Protein Loop Closure Using Orientational Restraints from NMR Data.” Lecture Notes in Computer Science (Including Subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) 6577 LNBI (January 1, 2011): 483–98. https://doi.org/10.1007/978-3-642-20036-6_43.Full Text
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Zeng, J., K. E. Roberts, P. Zhou, and B. R. Donald. “A Bayesian Approach for Determining Protein Side-Chain Rotamer Conformations Using Unassigned NOE Data.” Lecture Notes in Computer Science (Including Subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) 6577 LNBI (January 1, 2011): 563–78. https://doi.org/10.1007/978-3-642-20036-6_49.Full Text
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Zeng, J., P. Zhou, and B. R. Donald. “A Markov random field framework for protein side-chain resonance assignment.” Lecture Notes in Computer Science (Including Subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) 6044 LNBI (December 23, 2010): 550–70. https://doi.org/10.1007/978-3-642-12683-3_36.Full Text
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Hard, Ryan L., Jiangxin Liu, Juan Shen, Pei Zhou, and Dehua Pei. “HDAC6 and Ubp-M BUZ domains recognize specific C-terminal sequences of proteins.” Biochemistry 49, no. 50 (December 21, 2010): 10737–46. https://doi.org/10.1021/bi101014s.Full Text Open Access Copy Link to Item
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Yershova, A., C. Tripathy, P. Zhou, and B. R. Donald. “Algorithms and analytic solutions using sparse residual dipolar couplings for high-resolution automated protein backbone structure determination by NMR.” Springer Tracts in Advanced Robotics 68, no. STAR (December 20, 2010): 355–72. https://doi.org/10.1007/978-3-642-17452-0_21.Full Text
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Woodruff, Rachel V., Martha G. Bomar, Sanjay D’Souza, Pei Zhou, and Graham C. Walker. “The unusual UBZ domain of Saccharomyces cerevisiae polymerase η.” Dna Repair (Amst) 9, no. 11 (November 10, 2010): 1130–41. https://doi.org/10.1016/j.dnarep.2010.08.001.Full Text Link to Item
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Coggins, Brian E., Ronald A. Venters, and Pei Zhou. “Radial sampling for fast NMR: Concepts and practices over three decades.” Prog Nucl Magn Reson Spectrosc 57, no. 4 (November 2010): 381–419. https://doi.org/10.1016/j.pnmrs.2010.07.001.Full Text Link to Item
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Chen, Jianglei, Qianqian Li, Chia-Chen Liu, Pei Zhou, Guojun Bu, and Jianjun Wang. “NMR structure note: solution structure of the core domain of MESD that is essential for proper folding of LRP5/6.” J Biomol Nmr 47, no. 4 (August 2010): 283–88. https://doi.org/10.1007/s10858-010-9426-8.Full Text Link to Item
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Werner-Allen, Jon W., Brian E. Coggins, and Pei Zhou. “Fast acquisition of high resolution 4-D amide-amide NOESY with diagonal suppression, sparse sampling and FFT-CLEAN.” J Magn Reson 204, no. 1 (May 2010): 173–78. https://doi.org/10.1016/j.jmr.2010.02.017.Full Text Link to Item
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Lee, Chul-Jin, Xiaofei Liang, Eugene Park, Daina Zeng, Shauna Swanson, Xin Chen, Robert A. Nicholas, Christian R. H. Raetz, Eric J. Toone, and Pei Zhou. “Structure-activity relationships of diacetylene-based LpxC inhibitors.” Faseb Journal 24 (April 2010).Link to Item
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Zeng, Daina, Pei Zhou, and Christian R. H. Raetz. “Characterization of E. coli mutants resistant to LpxC inhibitors.” Faseb Journal 24 (April 2010).Link to Item
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Barb, Adam W., Ling Jiang, Christian R. H. Raetz, and Pei Zhou. “Assignment of 1H, 13C and 15N backbone resonances of Escherichia coli LpxC bound to L-161,240.” Biomol Nmr Assign 4, no. 1 (April 2010): 37–40. https://doi.org/10.1007/s12104-009-9201-5.Full Text Link to Item
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Bomar, Martha G., Sanjay D’Souza, Marzena Bienko, Ivan Dikic, Graham C. Walker, and Pei Zhou. “Unconventional ubiquitin recognition by the ubiquitin-binding motif within the Y family DNA polymerases iota and Rev1.” Mol Cell 37, no. 3 (February 12, 2010): 408–17. https://doi.org/10.1016/j.molcel.2009.12.038.Full Text Link to Item
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Zhou, Pei, and Gerhard Wagner. “Overcoming the solubility limit with solubility-enhancement tags: successful applications in biomolecular NMR studies.” J Biomol Nmr 46, no. 1 (January 2010): 23–31. https://doi.org/10.1007/s10858-009-9371-6.Full Text Link to Item
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Zeng, Jianyang, Jeffrey Boyles, Chittaranjan Tripathy, Lincong Wang, Anthony Yan, Pei Zhou, and Bruce Randall Donald. “High-resolution protein structure determination starting with a global fold calculated from exact solutions to the RDC equations.” J Biomol Nmr 45, no. 3 (November 2009): 265–81. https://doi.org/10.1007/s10858-009-9366-3.Full Text Link to Item
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Barb, A. W., T. M. Leavy, L. I. Robins, Z. Guan, D. A. Six, P. Zhou, M. J. Hangauer, C. R. Bertozzi, and C. Raetz. “Correction to uridine-based inhibitors as new leads for antibiotics targeting Escherichia coli LpxC (Biochemistry (2009) 48, (3068) DOI: 10.1021/bi900167q).” Biochemistry 48, no. 32 (August 18, 2009): 7776. https://doi.org/10.1021/bi9012066.Full Text
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Barb, Adam W., Tanya M. Leavy, Lori I. Robins, Ziqiang Guan, David A. Six, Pei Zhou, Matthew J. Hangauer, Carolyn R. Bertozzi, and Christian R. H. Raetz. “Uridine-based inhibitors as new leads for antibiotics targeting Escherichia coli LpxC.” Biochemistry 48, no. 14 (April 14, 2009): 3068–77. https://doi.org/10.1021/bi900167q.Full Text Link to Item
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Coggins, Brian E., and Pei Zhou. “High resolution 4-D spectroscopy with sparse concentric shell sampling and FFT-CLEAN.” J Biomol Nmr 42, no. 4 (December 2008): 225–39. https://doi.org/10.1007/s10858-008-9275-x.Full Text Link to Item
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Barb, Adam W., and Pei Zhou. “Mechanism and inhibition of LpxC: an essential zinc-dependent deacetylase of bacterial lipid A synthesis.” Curr Pharm Biotechnol 9, no. 1 (February 2008): 9–15. https://doi.org/10.2174/138920108783497668.Full Text Link to Item
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Zeng, Jianyang Michael, Chittaranjan Tripathy, Pei Zhou, and Bruce R. Donald. “A HAUSDORFF-BASED NOE ASSIGNMENT ALGORITHM USING PROTEIN BACKBONE DETERMINED FROM RESIDUAL DIPOLAR COUPLINGS AND ROTAMER PATTERNS.” Comput Syst Bioinformatics Conf 2008 (2008): 169–81.Link to Item
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Zeng, Jianyang, Chittaranjan Tripathy, Pei Zhou, and Bruce R. Donald. “A Hausdorff-based NOE assignment algorithm using protein backbone determined from residual dipolar couplings and rotamer patterns.” Comput Syst Bioinformatics Conf 7 (2008): 169–81.Link to Item
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Barb, A. W., L. Jiang, C. R. H. Raetz, and P. Zhou. “Structure of the deacetylase LpxC bound to the antibiotic CHIR-090: Time-dependent inhibition and specificity in ligand binding (Proceedings of National Academy of Sciences of the United States of America (November 20, 2007) 104, 47, (18433-18438) DOI:10.1073/pnas0709412104)).” Proceedings of the National Academy of Sciences of the United States of America 104, no. 52 (December 26, 2007): 21020. https://doi.org/10.1073/pnas.0711056105.Full Text
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Moss, Marcia L., Martha Bomar, Qian Liu, Harvey Sage, Peter Dempsey, Patricia M. Lenhart, Patricia A. Gillispie, et al. “The ADAM10 prodomain is a specific inhibitor of ADAM10 proteolytic activity and inhibits cellular shedding events.” J Biol Chem 282, no. 49 (December 7, 2007): 35712–21. https://doi.org/10.1074/jbc.M703231200.Full Text Link to Item
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Barb, Adam W., Ling Jiang, Christian R. H. Raetz, and Pei Zhou. “Structure of the deacetylase LpxC bound to the antibiotic CHIR-090: Time-dependent inhibition and specificity in ligand binding.” Proc Natl Acad Sci U S A 104, no. 47 (November 20, 2007): 18433–38. https://doi.org/10.1073/pnas.0709412104.Full Text Link to Item
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Brower-Toland, Brent, Seth D. Findley, Ling Jiang, Li Liu, Hang Yin, Monica Dus, Pei Zhou, Sarah C. R. Elgin, and Haifan Lin. “Drosophila PIWI associates with chromatin and interacts directly with HP1a.” Genes Dev 21, no. 18 (September 15, 2007): 2300–2311. https://doi.org/10.1101/gad.1564307.Full Text Link to Item
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Pai, Ming-Tao, Shiou-Ru Tzeng, Jeffrey J. Kovacs, Mignon A. Keaton, Shawn S-C Li, Tso-Pang Yao, and Pei Zhou. “Solution structure of the Ubp-M BUZ domain, a highly specific protein module that recognizes the C-terminal tail of free ubiquitin.” J Mol Biol 370, no. 2 (July 6, 2007): 290–302. https://doi.org/10.1016/j.jmb.2007.04.015.Full Text Link to Item
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Lemieux, George A., Fernando Blumenkron, Nolan Yeung, Pei Zhou, Jason Williams, Amrie C. Grammer, Robert Petrovich, Peter E. Lipsky, Marcia L. Moss, and Zena Werb. “The low affinity IgE receptor (CD23) is cleaved by the metalloproteinase ADAM10.” J Biol Chem 282, no. 20 (May 18, 2007): 14836–44. https://doi.org/10.1074/jbc.M608414200.Full Text Link to Item
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Barb, Adam W., Amanda L. McClerren, Karnem Snehelatha, C Michael Reynolds, Pei Zhou, and Christian R. H. Raetz. “Inhibition of lipid A biosynthesis as the primary mechanism of CHIR-090 antibiotic activity in Escherichia coli.” Biochemistry 46, no. 12 (March 27, 2007): 3793–3802. https://doi.org/10.1021/bi6025165.Full Text Link to Item
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Bomar, Martha G., Ming-Tao Pai, Shiou-Ru Tzeng, Shawn Shun-Cheng Li, and Pei Zhou. “Structure of the ubiquitin-binding zinc finger domain of human DNA Y-polymerase eta.” Embo Rep 8, no. 3 (March 2007): 247–51. https://doi.org/10.1038/sj.embor.7400901.Full Text Link to Item
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Coggins, Brian E., and Pei Zhou. “Sampling of the NMR time domain along concentric rings.” J Magn Reson 184, no. 2 (February 2007): 207–21. https://doi.org/10.1016/j.jmr.2006.10.002.Full Text Link to Item
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Coggins, Brian E., and Pei Zhou. “Polar Fourier transforms of radially sampled NMR data.” J Magn Reson 182, no. 1 (September 2006): 84–95. https://doi.org/10.1016/j.jmr.2006.06.016.Full Text Link to Item
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Werner-Allen, Jon W., Ling Jiang, and Pei Zhou. “A 'just-in-time' HN(CA)CO experiment for the backbone assignment of large proteins with high sensitivity.” J Magn Reson 181, no. 1 (July 2006): 177–80. https://doi.org/10.1016/j.jmr.2006.04.001.Full Text Link to Item
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Ban, Yih-En Andrew, Johannes Rudolph, Pei Zhou, and Herbert Edelsbrunner. “Evaluating the quality of NMR structures by local density of protons.” Proteins 62, no. 4 (March 1, 2006): 852–64. https://doi.org/10.1002/prot.20811.Full Text Link to Item
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Coggins, Brian E., and Pei Zhou. “PR-CALC: a program for the reconstruction of NMR spectra from projections.” J Biomol Nmr 34, no. 3 (March 2006): 179–95. https://doi.org/10.1007/s10858-006-0020-z.Full Text Link to Item
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Li, Ming, Hemali P. Phatnani, Arno L. Greenleaf, and Pei Zhou. “NMR assignment of the SRI domain of human Set2/HYPB.” J Biomol Nmr 36 Suppl 1 (2006): 5. https://doi.org/10.1007/s10858-005-4690-8.Full Text Link to Item
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Li, Ming, Hemali P. Phatnani, Ziqiang Guan, Harvey Sage, Arno L. Greenleaf, and Pei Zhou. “Solution structure of the Set2-Rpb1 interacting domain of human Set2 and its interaction with the hyperphosphorylated C-terminal domain of Rpb1.” Proc Natl Acad Sci U S A 102, no. 49 (December 6, 2005): 17636–41. https://doi.org/10.1073/pnas.0506350102.Full Text Link to Item
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He, Chuan, Jean-Christophe Hus, Li Jing Sun, Pei Zhou, Derek P. G. Norman, Volker Dötsch, Hua Wei, et al. “A methylation-dependent electrostatic switch controls DNA repair and transcriptional activation by E. coli ada.” Mol Cell 20, no. 1 (October 7, 2005): 117–29. https://doi.org/10.1016/j.molcel.2005.08.013.Full Text Link to Item
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Coggins, Brian E., Ronald A. Venters, and Pei Zhou. “Filtered backprojection for the reconstruction of a high-resolution (4,2)D CH3-NH NOESY spectrum on a 29 kDa protein.” J Am Chem Soc 127, no. 33 (August 24, 2005): 11562–63. https://doi.org/10.1021/ja053110k.Full Text Link to Item
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Jiang, Ling, Brian E. Coggins, and Pei Zhou. “Rapid assignment of protein side chain resonances using projection-reconstruction of (4,3)D HC(CCO)NH and intra-HC(C)NH experiments.” J Magn Reson 175, no. 1 (July 2005): 170–76. https://doi.org/10.1016/j.jmr.2005.03.014.Full Text Link to Item
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Venters, Ronald A., Brian E. Coggins, Doug Kojetin, John Cavanagh, and Pei Zhou. “(4,2)D Projection--reconstruction experiments for protein backbone assignment: application to human carbonic anhydrase II and calbindin D(28K).” J Am Chem Soc 127, no. 24 (June 22, 2005): 8785–95. https://doi.org/10.1021/ja0509580.Full Text Link to Item
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Coggins, Brian E., Amanda L. McClerren, Ling Jiang, Xuechen Li, Johannes Rudolph, Ole Hindsgaul, Christian R. H. Raetz, and Pei Zhou. “Refined solution structure of the LpxC-TU-514 complex and pKa analysis of an active site histidine: insights into the mechanism and inhibitor design.” Biochemistry 44, no. 4 (February 1, 2005): 1114–26. https://doi.org/10.1021/bi047820z.Full Text Link to Item
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McClerren, Amanda L., Pei Zhou, Ziqiang Guan, Christian R. H. Raetz, and Johannes Rudolph. “Kinetic analysis of the zinc-dependent deacetylase in the lipid A biosynthetic pathway.” Biochemistry 44, no. 4 (February 1, 2005): 1106–13. https://doi.org/10.1021/bi048001h.Full Text Link to Item
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Coggins, Brian E., Ronald A. Venters, and Pei Zhou. “Generalized reconstruction of n-D NMR spectra from multiple projections: application to the 5-D HACACONH spectrum of protein G B1 domain.” J Am Chem Soc 126, no. 4 (February 4, 2004): 1000–1001. https://doi.org/10.1021/ja039430q.Full Text Link to Item
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Coggins, Brian E., Xuechen Li, Ole Hindsgaul, Christian R. H. Raetz, and Pei Zhou. “Assignment of the 1H, 13C and 15N resonances of the LpxC deacetylase from Aquifex aeolicus in complex with the substrate-analog inhibitor TU-514.” J Biomol Nmr 28, no. 2 (February 2004): 201–2. https://doi.org/10.1023/B:JNMR.0000013817.29493.87.Full Text Link to Item
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Coggins, Brian E., Xuechen Li, Amanda L. McClerren, Ole Hindsgaul, Christian R. H. Raetz, and Pei Zhou. “Structure of the LpxC deacetylase with a bound substrate-analog inhibitor.” Nat Struct Biol 10, no. 8 (August 2003): 645–51. https://doi.org/10.1038/nsb948.Full Text Link to Item
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Coggins, Brian E., and Pei Zhou. “PACES: Protein sequential assignment by computer-assisted exhaustive search.” J Biomol Nmr 26, no. 2 (June 2003): 93–111. https://doi.org/10.1023/a:1023589029301.Full Text Link to Item
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Blackshear, Perry J., Wi S. Lai, Elizabeth A. Kennington, Gary Brewer, Gerald M. Wilson, Xiaoju Guan, and Pei Zhou. “Characteristics of the interaction of a synthetic human tristetraprolin tandem zinc finger peptide with AU-rich element-containing RNA substrates.” J Biol Chem 278, no. 22 (May 30, 2003): 19947–55. https://doi.org/10.1074/jbc.M301290200.Full Text Link to Item
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Lugovskoy, Alexey A., Alexei I. Degterev, Amr F. Fahmy, Pei Zhou, John D. Gross, Junying Yuan, and Gerhard Wagner. “A novel approach for characterizing protein ligand complexes: molecular basis for specificity of small-molecule Bcl-2 inhibitors.” J Am Chem Soc 124, no. 7 (February 20, 2002): 1234–40. https://doi.org/10.1021/ja011239y.Full Text Link to Item
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Zhou, P., A. A. Lugovskoy, J. S. McCarty, P. Li, and G. Wagner. “Solution structure of DFF40 and DFF45 N-terminal domain complex and mutual chaperone activity of DFF40 and DFF45.” Proc Natl Acad Sci U S A 98, no. 11 (May 22, 2001): 6051–55. https://doi.org/10.1073/pnas.111145098.Full Text Link to Item
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Zhou, P., A. A. Lugovskoy, and G. Wagner. “A solubility-enhancement tag (SET) for NMR studies of poorly behaving proteins.” J Biomol Nmr 20, no. 1 (May 2001): 11–14. https://doi.org/10.1023/a:1011258906244.Full Text Link to Item
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Lugovskoy, A. A., P. Zhou, J. J. Chou, J. S. McCarty, P. Li, and G. Wagner. “Solution structure of the CIDE-N domain of CIDE-B and a model for CIDE-N/CIDE-N interactions in the DNA fragmentation pathway of apoptosis.” Cell 99, no. 7 (December 23, 1999): 747–55. https://doi.org/10.1016/s0092-8674(00)81672-4.Full Text Link to Item
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Zhou, P., J. Chou, R. S. Olea, J. Yuan, and G. Wagner. “Solution structure of Apaf-1 CARD and its interaction with caspase-9 CARD: a structural basis for specific adaptor/caspase interaction.” Proc Natl Acad Sci U S A 96, no. 20 (September 28, 1999): 11265–70. https://doi.org/10.1073/pnas.96.20.11265.Full Text Link to Item
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Zhou, P., L. J. Sun, V. Dötsch, G. Wagner, and G. L. Verdine. “Solution structure of the core NFATC1/DNA complex.” Cell 92, no. 5 (March 6, 1998): 687–96. https://doi.org/10.1016/s0092-8674(00)81136-8.Full Text Link to Item
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Wolfe, S. A., P. Zhou, V. Dötsch, L. Chen, A. You, S. N. Ho, G. R. Crabtree, G. Wagner, and G. L. Verdine. “Unusual Rel-like architecture in the DNA-binding domain of the transcription factor NFATc.” Nature 385, no. 6612 (January 9, 1997): 172–76. https://doi.org/10.1038/385172a0.Full Text Link to Item
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Book Sections
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Coggins, B. E., and P. Zhou. “CLEAN.” In New Developments in NMR, 2017-January:169–219, 2017. https://doi.org/10.1039/9781782628361-00169.Full Text
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Coggins, B. E., and P. Zhou. “Backprojection and Related Methods.” In New Developments in NMR, 2017-January:119–68, 2017. https://doi.org/10.1039/9781782628361-00119.Full Text
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Conference Papers
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An, Jinsu, Jinshi Zhao, Dohyeon Hwang, Robert A. Gillespie, Eun Gyeong Yang, Pei Zhou, and Hak Suk Chung. “The lipid A 1-phosphatase, LpxE, play multiple roles in bacteria envelope biogenesis.” In Faseb Journal, Vol. 32. FEDERATION AMER SOC EXP BIOL, 2018.Link to Item
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Lee, Minhee, Jinshi Zhao, Jae Cho, Do-Yeon Kwon, Pei Zhou, and Jiyong Hong. “Synthesis and biological evaluation of sulfonyl piperazine derivatives for LpxH inhibition.” In Abstracts of Papers of the American Chemical Society, Vol. 253. AMER CHEMICAL SOC, 2017.Link to Item
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Chung, Ben C., Jinshi Zhao, Robert Gillespie, Do Yeon Kwon, Ziqiang Guan, Jiyong Hong, Pei Zhou, and Seok-Yong Lee. “Crystal Structure of MraY, an Essential Membrane Enzyme for Bacterial Cell Wall Synthesis.” In Biophysical Journal, 106:14a-14a. Elsevier BV, 2014. https://doi.org/10.1016/j.bpj.2013.11.131.Full Text
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Liu, Jiangxin, Shilong Fan, Chul-Jin Lee, Arno L. Greenleaf, and Pei Zhou. “Specific interaction of the TCERG1 FF4-6 tandem repeat domains with RNA polymerase II requires simultaneous phosphorylation at Ser2, Ser5 and Ser7 of the CTD.” In Faseb Journal, Vol. 27. FEDERATION AMER SOC EXP BIOL, 2013.Link to Item
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Masoudi, Ali, Charles W. Pemble, Christian R. H. Raetz, and Pei Zhou. “Structural Basis for Acyl-substrate Delivery and Product Release by ACP in the Biosynthesis of Lipid A.” In Faseb Journal, Vol. 27. FEDERATION AMER SOC EXP BIOL, 2013.Link to Item
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Lee, Chul-Jin, Xiaofei Liang, Eugene Park, Daina Zeng, Shauna Swanson, Xin Chen, Robert A. Nicholas, Christian R. H. Raetz, Eric J. Toone, and Pei Zhou. “Structure-activity relationships of diacetylene-based LpxC inhibitors.” In Faseb Journal, Vol. 26. FEDERATION AMER SOC EXP BIOL, 2012.Link to Item
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Zeng, Daina, Pei Zhou, and Christian R. H. Raetz. “Characterization of E. coli mutants resistant to LpxC inhibitors.” In Faseb Journal, Vol. 26. FEDERATION AMER SOC EXP BIOL, 2012.Link to Item
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Young, Hayley E., Louis E. Metzger, John K. Lee, Robert M. Stroud, Pei Zhou, and Christian R. H. Raetz. “Enzymatic and structural studies of UDP-2,3-diacylglucosamine hydrolysis in lipid A biosynthesis.” In Faseb Journal, Vol. 26, 2012.Link to Item
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Greenleaf, A. L., H. P. Phatnani, M. Li, and P. Zhou. “Structure and CTD phosphorylation pattern-binding specificity of the SRI domain of Set2.” In Faseb Journal, 20:A467–A467. FEDERATION AMER SOC EXP BIOL, 2006.Link to Item
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McClerren, A., J. Rudolph, P. Zhou, and C. R. H. Raetz. “Mechanistic studies of the deacetylase LpxC, a novel target for drug design in gram-negative bacteria.” In Faseb Journal, 18:C54–C54. FEDERATION AMER SOC EXP BIOL, 2004.Link to Item
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- CBB 659: Structural Biochemistry II 2022
- CELLBIO 659: Structural Biochemistry II 2022
- SBB 659: Structural Biochemistry II 2022
- UPGEN 659: Structural Biochemistry II 2022
- BIOCHEM 393: Research Independent Study 2021
- BIOCHEM 593: Research Independent Study 2021
- BIOCHEM 659: Structural Biochemistry II 2021
- CBB 659: Structural Biochemistry II 2021
- CELLBIO 659: Structural Biochemistry II 2021
- SBB 659: Structural Biochemistry II 2021
- UPGEN 659: Structural Biochemistry II 2021
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