Selected Grants
Interferon-inducible cell-autonomous immunity to cytosolic bacterial pathogens
ResearchCo Investigator · Awarded by National Institute of Allergy and Infectious Diseases · 2024 - 2028Inhibiting Rev1-mediated DNA translesion synthesis for cancer therapy
ResearchCo-Principal Investigator · Awarded by National Cancer Institute · 2024 - 2028Structural and Functional Analysis of Nucleocytoplasmic Protein O-Glycosyltransferases in Plants
ResearchPrincipal Investigator · Awarded by National Institute of General Medical Sciences · 2023 - 2027Duke ACS Institutional Research Grant
ResearchSignificant Contributor · Awarded by American Cancer Society, Inc. · 2024 - 2026Mechanistic Insights into the Plant Disease Resistance Mediated by NPR1
ResearchPrincipal Investigator · Awarded by National Institute of General Medical Sciences · 2022 - 2026Molecular mechanism of cephalosporin resistance of N. gonorrhoeae conferred by mutated PBP2
ResearchPrincipal Investigator · Awarded by University of South Alabama · 2022 - 2026MRI: Acquisition of a Microscale Thermophoresis System
EquipmentMajor User · Awarded by National Science Foundation · 2022 - 2025Mechanism of carbon skeleton formation in molybdenum cofactor biosynthesis
ResearchCollaborating Investigator · Awarded by National Institutes of Health · 2020 - 2025Method development for automatic assignment and structure determination in protein NMR
ResearchPrincipal Investigator · Awarded by Rensselaer Polytechnic Institute · 2022 - 2024Biochemical and functional investigation of the novel enzymatic activities of Mesh1
ResearchCo-Principal Investigator · Awarded by National Institutes of Health · 2018 - 2024Therapeutic targeting of MESH1 in renal cell carcinoma
ResearchCo Investigator · Awarded by Department of Defense · 2020 - 2023The regulation dephosphorylated-CoA-capped RNA and innate immunity by MESH1
ResearchCo Investigator · Awarded by National Institutes of Health · 2020 - 2023Discovery and validation of broadly effective LpxH inhibitors as novel therapeutics against multi-drug resistant Gram-negative pathogens
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2019 - 2023Testing D5 compounds in a human version of a published ELISA system
ResearchPrincipal Investigator · Awarded by D5 Therapeutics, Inc · 2021 - 2022IND-enabling studies of the potent LpxC inhibitor LPC-233 as a novel antibiotic against Gram-negative pathogens
ResearchCo Investigator · Awarded by Valanbio Therapeutics, Inc. · 2020 - 2022Deep Topological Sampling of Protein Structures - non-competing renewal for Year 4
ResearchCo Investigator · Awarded by National Institutes of Health · 2017 - 2022Structure-Function Analysis of Chlamydia Secretion Chaperones
ResearchCo-Principal Investigator · Awarded by National Institutes of Health · 2016 - 2022Organization and Function of Cellular Structure
Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 1975 - 2020Biochemistry and Structure of Lipid A Enzymes
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2016 - 2020Molecular targets in peptidoglycan synthesis
ResearchPrincipal Investigator · Awarded by Medical University of South Carolina · 2016 - 2020Discovery and validation of broadly effective LpxH inhibitors as novel therapeutics against multi-drug resistant Gram-negative pathogens
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2018 - 2019Targeting Rev1-mediated Translesion Synthesis for Cancer Therapy
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2015 - 2017LpxC inhibitors as a novel class of antibiotics against N. gonorrhoeae
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2011 - 2017Preliminary Safety Screening of Duke PlxC inhibitors as Novel Antibiotics against Gram-negative Pathogens
ResearchPrincipal Investigator · Awarded by North Carolina Biotechnology Center · 2015 - 2016Structural Biology and Biophysics Training Program
Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 1994 - 2015Biosynthesis And Function Of Lipopolysaccharides
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 1994 - 2015High sensitivity multi-purpose electron paramagnetic resonance spectroscopy for biotechnological and biomedical research
EquipmentCollaborating Investigator · Awarded by North Carolina Biotechnology Center · 2014 - 2015Automated detection of protein crystals in high-throughput crystallography experiments
ResearchMajor User · Awarded by North Carolina Biotechnology Center · 2014 - 2015New Console and Cold Probe for the Duke 600 MHz NMR Spectrometer System
EquipmentMajor User · Awarded by National Institutes of Health · 2013 - 2014Structural and Biochemical Studies of LpxC Inhibition
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2003 - 2014Lipid A Modification Systems in Gram-Negative Bacteria
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 1995 - 2013Automated NMR Assignment and Protein Structure Determination
ResearchCo-Principal Investigator · Awarded by National Institutes of Health · 2006 - 2012Structural, Biochemical and Functional Studies of RNAPII CTD Interacting Proteins
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2008 - 2012Replacement Equipment Components for an 800 MHz NMR Spectrometer
EquipmentMajor User · Awarded by National Institutes of Health · 2010 - 2011Regulation of Germline Stem Cell Division in Drosophila
ResearchConsultant · Awarded by National Institutes of Health · 1996 - 2006Structure and Regulation of hsp90 Chaperones
ResearchConsultant · Awarded by National Institutes of Health · 2005 - 2005External Relationships
- D5 Therapeutics
- LVM Biosciences
- Valanbio Therapeutics
This faculty member (or a member of their immediate family) has reported outside activities with the companies, institutions, or organizations listed above. This information is available to institutional leadership and, when appropriate, management plans are in place to address potential conflicts of interest.