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UVB radiation generates sunburn pain and affects skin by activating epidermal TRPV4 ion channels and triggering endothelin-1 signaling.

Publication ,  Journal Article
Moore, C; Cevikbas, F; Pasolli, HA; Chen, Y; Kong, W; Kempkes, C; Parekh, P; Lee, SH; Kontchou, N-A; Yeh, I; Jokerst, NM; Fuchs, E ...
Published in: Proc Natl Acad Sci U S A
August 20, 2013

At our body surface, the epidermis absorbs UV radiation. UV overexposure leads to sunburn with tissue injury and pain. To understand how, we focus on TRPV4, a nonselective cation channel highly expressed in epithelial skin cells and known to function in sensory transduction, a property shared with other transient receptor potential channels. We show that following UVB exposure mice with induced Trpv4 deletions, specifically in keratinocytes, are less sensitive to noxious thermal and mechanical stimuli than control animals. Exploring the mechanism, we find that epidermal TRPV4 orchestrates UVB-evoked skin tissue damage and increased expression of the proalgesic/algogenic mediator endothelin-1. In culture, UVB causes a direct, TRPV4-dependent Ca(2+) response in keratinocytes. In mice, topical treatment with a TRPV4-selective inhibitor decreases UVB-evoked pain behavior, epidermal tissue damage, and endothelin-1 expression. In humans, sunburn enhances epidermal expression of TRPV4 and endothelin-1, underscoring the potential of keratinocyte-derived TRPV4 as a therapeutic target for UVB-induced sunburn, in particular pain.

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Published In

Proc Natl Acad Sci U S A

DOI

EISSN

1091-6490

Publication Date

August 20, 2013

Volume

110

Issue

34

Start / End Page

E3225 / E3234

Location

United States

Related Subject Headings

  • Ultraviolet Rays
  • TRPV Cation Channels
  • Sunburn
  • Skin
  • Signal Transduction
  • Pain
  • Microscopy, Electron
  • Mice, Transgenic
  • Mice
  • Immunohistochemistry
 

Citation

APA
Chicago
ICMJE
MLA
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Moore, C., Cevikbas, F., Pasolli, H. A., Chen, Y., Kong, W., Kempkes, C., … Liedtke, W. B. (2013). UVB radiation generates sunburn pain and affects skin by activating epidermal TRPV4 ion channels and triggering endothelin-1 signaling. Proc Natl Acad Sci U S A, 110(34), E3225–E3234. https://doi.org/10.1073/pnas.1312933110
Moore, Carlene, Ferda Cevikbas, H Amalia Pasolli, Yong Chen, Wei Kong, Cordula Kempkes, Puja Parekh, et al. “UVB radiation generates sunburn pain and affects skin by activating epidermal TRPV4 ion channels and triggering endothelin-1 signaling.Proc Natl Acad Sci U S A 110, no. 34 (August 20, 2013): E3225–34. https://doi.org/10.1073/pnas.1312933110.
Moore C, Cevikbas F, Pasolli HA, Chen Y, Kong W, Kempkes C, et al. UVB radiation generates sunburn pain and affects skin by activating epidermal TRPV4 ion channels and triggering endothelin-1 signaling. Proc Natl Acad Sci U S A. 2013 Aug 20;110(34):E3225–34.
Moore, Carlene, et al. “UVB radiation generates sunburn pain and affects skin by activating epidermal TRPV4 ion channels and triggering endothelin-1 signaling.Proc Natl Acad Sci U S A, vol. 110, no. 34, Aug. 2013, pp. E3225–34. Pubmed, doi:10.1073/pnas.1312933110.
Moore C, Cevikbas F, Pasolli HA, Chen Y, Kong W, Kempkes C, Parekh P, Lee SH, Kontchou N-A, Yeh I, Jokerst NM, Fuchs E, Steinhoff M, Liedtke WB. UVB radiation generates sunburn pain and affects skin by activating epidermal TRPV4 ion channels and triggering endothelin-1 signaling. Proc Natl Acad Sci U S A. 2013 Aug 20;110(34):E3225–E3234.
Journal cover image

Published In

Proc Natl Acad Sci U S A

DOI

EISSN

1091-6490

Publication Date

August 20, 2013

Volume

110

Issue

34

Start / End Page

E3225 / E3234

Location

United States

Related Subject Headings

  • Ultraviolet Rays
  • TRPV Cation Channels
  • Sunburn
  • Skin
  • Signal Transduction
  • Pain
  • Microscopy, Electron
  • Mice, Transgenic
  • Mice
  • Immunohistochemistry