Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • Ph.D., University of South Carolina, Columbia 2010
  • M.D., St. Petersburg State University (Russia) 1999
• 

  Previous Appointments & Affiliations

  • Assistant Professor in Anesthesiology, Anesthesiology, Pain Management, Anesthesiology 2016 - 2020
• Recognition
• 

  Awards & Honors

  • Best Abstracts for Basic Science. American Society of Anesthesiologist, Annual Meeting in Washington, DC. 2013
  • Best Abstracts for Basic Science. American Society of Anesthesiologists, Annual Meeting in Washington, DC. 2012
  • Best Abstracts for Basic Science. American Society of Anesthesiologists, Annual Meeting in Chicago, IL. 2011
  • Arnold School of Public Health Doctoral Achievement Award. University of South Carolina, Columbia, SC. 2010
  • Norman J. Arnold Fellowship Award. Arnold School of Public Health, University of South Carolina. 2008
• Research
• 

  Selected Grants

  • Developing non-opiate GPCR signaling biased agents for pain management awarded by Department of Defense 2022 - 2026
  • Pain Management in Critical Combat Casualty Environments using Resorbable Poly(ester urea) Films for Sustained Delivery of Meloxicam and Bupivacaine awarded by Department of Defense 2022 - 2026
  • A novel clinically- relevant mouse model of chronic overlapping pain conditions for screening analgesics awarded by National Institutes of Health 2022 - 2023
  • Role of Preoperative Baroreflex Sensitivity on Persistent Postoperative Pain and Opioid Consumption after Thoracic Surgery awarded by National Institutes of Health 2019 - 2022
  • Analgesic effects of perioperative propranolol administration for spine surgery awarded by Foundation for Anesthesia Education and Research 2020
  • Royal Institution for the Advancement of Leanring/McGill University Research Service Agreement (Salary Support Dr. Bortsov) awarded by Mcgill University, Montreal 2016 - 2019
• Publications & Artistic Works
• 

  Selected Publications

  • Academic Articles

    • Bortsov, Andrey V., Marc Parisien, Samar Khoury, Amy E. Martinsen, Marie Udnesseter Lie, Ingrid Heuch, Kristian Hveem, John-Anker Zwart, Bendik S. Winsvold, and Luda Diatchenko. “Brain-specific genes contribute to chronic but not to acute back pain.” Pain Rep 7, no. 5 (September 2022): e1018. https://doi.org/10.1097/PR9.0000000000001018.
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    • Yeo, Michele, Yong Chen, Changyu Jiang, Gang Chen, Kaiyuan Wang, Sharat Chandra, Andrey Bortsov, et al. “Repurposing cancer drugs identifies kenpaullone which ameliorates pathologic pain in preclinical models via normalization of inhibitory neurotransmission.” Nat Commun 12, no. 1 (October 27, 2021): 6208. https://doi.org/10.1038/s41467-021-26270-3.
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    • Luo, Xin, Ouyang Chen, Zilong Wang, Sangsu Bang, Jasmine Ji, Sang Hoon Lee, Yul Huh, et al. “IL-23/IL-17A/TRPV1 axis produces mechanical pain via macrophage-sensory neuron crosstalk in female mice.” Neuron 109, no. 17 (September 1, 2021): 2691-2706.e5. https://doi.org/10.1016/j.neuron.2021.06.015.
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    • Chen, Yong, Zi-Long Wang, Michele Yeo, Qiao-Juan Zhang, Ana E. López-Romero, Hui-Ping Ding, Xin Zhang, et al. “Epithelia-Sensory Neuron Cross Talk Underlies Cholestatic Itch Induced by Lysophosphatidylcholine.” Gastroenterology 161, no. 1 (July 2021): 301-317.e16. https://doi.org/10.1053/j.gastro.2021.03.049.
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    • Gaynor, Sheila M., Andrey Bortsov, Eric Bair, Roger B. Fillingim, Joel D. Greenspan, Richard Ohrbach, Luda Diatchenko, et al. “Phenotypic profile clustering pragmatically identifies diagnostically and mechanistically informative subgroups of chronic pain patients.” Pain 162, no. 5 (May 1, 2021): 1528–38. https://doi.org/10.1097/j.pain.0000000000002153.
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    • Freidin, Maxim B., Yakov A. Tsepilov, Ian B. Stanaway, Weihua Meng, Caroline Hayward, Blair H. Smith, Samar Khoury, et al. “Sex- and age-specific genetic analysis of chronic back pain.” Pain 162, no. 4 (April 1, 2021): 1176–87. https://doi.org/10.1097/j.pain.0000000000002100.
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    • Bang, Sangsu, Christopher R. Donnelly, Xin Luo, Maria Toro-Moreno, Xueshu Tao, Zilong Wang, Sharat Chandra, Andrey V. Bortsov, Emily R. Derbyshire, and Ru-Rong Ji. “Activation of GPR37 in macrophages confers protection against infection-induced sepsis and pain-like behaviour in mice.” Nat Commun 12, no. 1 (March 17, 2021): 1704. https://doi.org/10.1038/s41467-021-21940-8.
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    • Khoury, Samar, Qiao-Ping Wang, Marc Parisien, Pavel Gris, Andrey V. Bortsov, Sarah D. Linnstaedt, Samuel A. McLean, et al. “Multi-ethnic GWAS and meta-analysis of sleep quality identify MPP6 as a novel gene that functions in sleep center neurons.” Sleep 44, no. 3 (March 12, 2021). https://doi.org/10.1093/sleep/zsaa211.
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    • Chandra, Sharat, Zilong Wang, Xueshu Tao, Ouyang Chen, Xin Luo, Ru-Rong Ji, and Andrey V. Bortsov. “Computer-aided Discovery of a New Nav1.7 Inhibitor for Treatment of Pain and Itch.” Anesthesiology 133, no. 3 (September 2020): 611–27. https://doi.org/10.1097/ALN.0000000000003427.
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    • Mauck, Matthew C., Sarah D. Linnstaedt, Andrey Bortsov, Michael Kurz, Phyllis L. Hendry, Christopher Lewandowski, Marc-Anthony Velilla, et al. “Vitamin D insufficiency increases risk of chronic pain among African Americans experiencing motor vehicle collision.” Pain 161, no. 2 (February 2020): 274–80. https://doi.org/10.1097/j.pain.0000000000001728.
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    • Zorina-Lichtenwalter, Katerina, Ryan N. Lichtenwalter, Dima V. Zaykin, Marc Parisien, Simon Gravel, Andrey Bortsov, and Luda Diatchenko. “A study in scarlet: MC1R as the main predictor of red hair and exemplar of the flip-flop effect.” Hum Mol Genet 28, no. 12 (June 15, 2019): 2093–2106. https://doi.org/10.1093/hmg/ddz018.
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    • Beaudoin, Francesca L., Anthony J. Rosellini, Andrey Bortsov, and Samuel A. McLean. “Health care utilization following motor vehicle collision is poorly stratified by chronic pain risk: Lessons from the CRASH study.” Am J Emerg Med 37, no. 3 (March 2019): 534–35. https://doi.org/10.1016/j.ajem.2018.07.019.
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    • Bortsov, Andrey V., Marshall Devor, Mari A. Kaunisto, Eija Kalso, Adam Brufsky, Henrik Kehlet, Eske Aasvang, Reinhard Bittner, Luda Diatchenko, and Inna Belfer. “CACNG2 polymorphisms associate with chronic pain after mastectomy.” Pain 160, no. 3 (March 2019): 561–68. https://doi.org/10.1097/j.pain.0000000000001432.
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    • Zhang, Xin, Jane E. Hartung, Andrey V. Bortsov, Seungtae Kim, Sandra C. O’Buckley, Julia Kozlowski, and Andrea G. Nackley. “Sustained stimulation of β2- and β3-adrenergic receptors leads to persistent functional pain and neuroinflammation.” Brain Behav Immun 73 (October 2018): 520–32. https://doi.org/10.1016/j.bbi.2018.06.017.
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    • Sigurdsson, Martin I., Nathan H. Waldron, Andrey V. Bortsov, Shad B. Smith, and William Maixner. “Genomics of Cardiovascular Measures of Autonomic Tone.” J Cardiovasc Pharmacol 71, no. 3 (March 2018): 180–91. https://doi.org/10.1097/FJC.0000000000000559.
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    • Mauck, Matthew C., Jennifer Smith, Jeffrey W. Shupp, Mark A. Weaver, Andrea Liu, Andrey V. Bortsov, Bilal Lateef, et al. “Pain and itch outcome trajectories differ among European American and African American survivors of major thermal burn injury.” Pain 158, no. 11 (November 2017): 2268–76. https://doi.org/10.1097/j.pain.0000000000001029.
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    • Linnstaedt, Sarah D., Margaret G. Walker, Kyle D. Riker, Jennifer E. Nyland, JunMei Hu, Catherine Rossi, Robert A. Swor, et al. “Genetic variant rs3750625 in the 3'UTR of ADRA2A affects stress-dependent acute pain severity after trauma and alters a microRNA-34a regulatory site.” Pain 158, no. 2 (February 2017): 230–39. https://doi.org/10.1097/j.pain.0000000000000742.
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    • Meloto, Carolina B., Andrey V. Bortsov, Eric Bair, Erika Helgeson, Cara Ostrom, Shad B. Smith, Ronald Dubner, et al. “Modification of COMT-dependent pain sensitivity by psychological stress and sex.” Pain 157, no. 4 (April 2016): 858–67. https://doi.org/10.1097/j.pain.0000000000000449.
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    • Hu, JunMei, Andrey V. Bortsov, Lauren Ballina, Danielle C. Orrey, Robert A. Swor, David Peak, Jeffrey Jones, et al. “Chronic widespread pain after motor vehicle collision typically occurs through immediate development and nonrecovery: results of an emergency department-based cohort study.” Pain 157, no. 2 (February 2016): 438–44. https://doi.org/10.1097/j.pain.0000000000000388.
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    • Platts-Mills, Timothy F., Sean A. Flannigan, Andrey V. Bortsov, Samantha Smith, Robert M. Domeier, Robert A. Swor, Phyllis L. Hendry, et al. “Persistent Pain Among Older Adults Discharged Home From the Emergency Department After Motor Vehicle Crash: A Prospective Cohort Study.” Ann Emerg Med 67, no. 2 (February 2016): 166-176.e1. https://doi.org/10.1016/j.annemergmed.2015.05.003.
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    • Auvergne, Lauriane, Andrey V. Bortsov, Jacob C. Ulirsch, David A. Peak, Jeffrey S. Jones, Robert A. Swor, Robert M. Domeier, et al. “Association of Epidemiologic Factors and Genetic Variants Influencing Hypothalamic-Pituitary-Adrenocortical Axis Function With Postconcussive Symptoms After Minor Motor Vehicle Collision.” Psychosom Med 78, no. 1 (January 2016): 68–78. https://doi.org/10.1097/PSY.0000000000000253.
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    • Linnstaedt, Sarah D., Andrey V. Bortsov, April C. Soward, Robert Swor, David A. Peak, Jeffrey Jones, Niels Rathlev, et al. “CRHBP polymorphisms predict chronic pain development following motor vehicle collision.” Pain 157, no. 1 (January 2016): 273–79. https://doi.org/10.1097/j.pain.0000000000000374.
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    • Qadri, Yawar J., Andrey V. Bortsov, Danielle C. Orrey, Robert A. Swor, David A. Peak, Jeffrey S. Jones, Niels K. Rathlev, et al. “Genetic Polymorphisms in the Dopamine Receptor 2 Predict Acute Pain Severity After Motor Vehicle Collision.” Clin J Pain 31, no. 9 (September 2015): 768–75. https://doi.org/10.1097/AJP.0000000000000167.
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    • Phelps, Janey R., Ali Russell, Maria C. Lupa, Peggy McNaull, Sara Pittenger, Karene Ricketts, Jennifer Ditto, and Andrey V. Bortsov. “High-dose dexmedetomidine for noninvasive pediatric procedural sedation and discharge readiness.” Paediatr Anaesth 25, no. 9 (September 2015): 877–82. https://doi.org/10.1111/pan.12569.
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    • Linnstaedt, Sarah D., JunMei Hu, Andrey V. Bortsov, April C. Soward, Robert Swor, Jeffrey Jones, David Lee, et al. “μ-Opioid Receptor Gene A118 G Variants and Persistent Pain Symptoms Among Men and Women Experiencing Motor Vehicle Collision.” J Pain 16, no. 7 (July 2015): 637–44. https://doi.org/10.1016/j.jpain.2015.03.011.
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    • Phillips, Michael R., Amal L. Khoury, Andrey V. Bortsov, Amy Marzinsky, Kathy A. Short, Bruce A. Cairns, Anthony G. Charles, Benny L. Joyner, and Sean E. McLean. “A noninvasive hemoglobin monitor in the pediatric intensive care unit.” J Surg Res 195, no. 1 (May 1, 2015): 257–62. https://doi.org/10.1016/j.jss.2014.12.051.
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    • Orrey, Danielle C., Omar I. Halawa, Andrey V. Bortsov, Jeffrey W. Shupp, Samuel W. Jones, Linwood R. Haith, Janelle M. Hoskins, et al. “Results of a pilot multicenter genotype-based randomized placebo-controlled trial of propranolol to reduce pain after major thermal burn injury.” Clin J Pain 31, no. 1 (January 2015): 21–29. https://doi.org/10.1097/AJP.0000000000000086.
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    • Ulirsch, Jacob C., Mark A. Weaver, Andrey V. Bortsov, April C. Soward, Robert A. Swor, David A. Peak, Jeffrey S. Jones, et al. “No man is an island: living in a disadvantaged neighborhood influences chronic pain development after motor vehicle collision.” Pain 155, no. 10 (October 2014): 2116–23. https://doi.org/10.1016/j.pain.2014.07.025.
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    • Bortsov, Andrey V., Timothy F. Platts-Mills, David A. Peak, Jeffrey S. Jones, Robert A. Swor, Robert M. Domeier, David C. Lee, et al. “Effect of pain location and duration on life function in the year after motor vehicle collision.” Pain 155, no. 9 (September 2014): 1836–45. https://doi.org/10.1016/j.pain.2014.06.013.
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    • Kumar, Priya A., Andrey V. Bortsov, and Harendra Arora. “In reply.” Anesthesiology 121, no. 2 (August 2014): 430–31. https://doi.org/10.1097/ALN.0000000000000311.
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    • McLean, Samuel A., Jacob C. Ulirsch, and Andrey V. Bortsov. “Response to letter to the Editor.” Pain 155, no. 7 (July 2014): 1416–18. https://doi.org/10.1016/j.pain.2014.04.014.
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    • Bortsov, Andrey V., Luda Diatchenko, and Samuel A. McLean. “Complex multilocus effects of catechol-O-methyltransferase haplotypes predict pain and pain interference 6 weeks after motor vehicle collision.” Neuromolecular Med 16, no. 1 (March 2014): 83–93. https://doi.org/10.1007/s12017-013-8255-9.
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    • McLean, Samuel A., Jacob C. Ulirsch, Gary D. Slade, April C. Soward, Robert A. Swor, David A. Peak, Jeffrey S. Jones, et al. “Incidence and predictors of neck and widespread pain after motor vehicle collision among US litigants and nonlitigants.” Pain 155, no. 2 (February 2014): 309–21. https://doi.org/10.1016/j.pain.2013.10.016.
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    • Ferrero, Natalie A., Andrey V. Bortsov, Harendra Arora, Susan M. Martinelli, Lavinia M. Kolarczyk, Emily C. Teeter, David A. Zvara, and Priya A. Kumar. “Simulator training enhances resident performance in transesophageal echocardiography.” Anesthesiology 120, no. 1 (January 2014): 149–59. https://doi.org/10.1097/ALN.0000000000000063.
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    • Joseph, Julie A., Chris M. Terry, Eva J. Waller, Andrey V. Bortsov, David A. Zvara, David C. Mayer, and Susan M. Martinelli. “Enhancement of anesthesiology in-training exam performance with institution of an academic improvement policy.” J Educ Perioper Med 16, no. 6 (January 2014): E072.
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    • Bortsov, A. V., T. F. Platts-Mills, D. A. Peak, J. S. Jones, R. A. Swor, R. M. Domeier, D. C. Lee, et al. “Pain distribution and predictors of widespread pain in the immediate aftermath of motor vehicle collision.” Eur J Pain 17, no. 8 (September 2013): 1243–51. https://doi.org/10.1002/j.1532-2149.2013.00285.x.
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    • Bortsov, Andrey V., Jennifer E. Smith, Luda Diatchenko, April C. Soward, Jacob C. Ulirsch, Catherine Rossi, Robert A. Swor, et al. “Polymorphisms in the glucocorticoid receptor co-chaperone FKBP5 predict persistent musculoskeletal pain after traumatic stress exposure.” Pain 154, no. 8 (August 2013): 1419–26. https://doi.org/10.1016/j.pain.2013.04.037.
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    • Willis, Monte S., Bruce A. Cairns, Ashley Purdy, Andrey V. Bortsov, Samuel W. Jones, Shiara M. Ortiz-Pujols, Tina M Schade Willis, and Benny L. Joyner. “Persistent lactic acidosis after chronic topical application of silver sulfadiazine in a pediatric burn patient: a review of the literature.” Int J Burns Trauma 3, no. 1 (2013): 1–8.
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    • Spiegel, Gail, Andrey Bortsov, Franziska K. Bishop, Darcy Owen, Georgeanna J. Klingensmith, Elizabeth J. Mayer-Davis, and David M. Maahs. “Randomized nutrition education intervention to improve carbohydrate counting in adolescents with type 1 diabetes study: is more intensive education needed?” J Acad Nutr Diet 112, no. 11 (November 2012): 1736–46. https://doi.org/10.1016/j.jand.2012.06.001.
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    • Platts-Mills, Timothy F., Denise A. Esserman, D Levin Brown, Andrey V. Bortsov, Philip D. Sloane, and Samuel A. McLean. “Older US emergency department patients are less likely to receive pain medication than younger patients: results from a national survey.” Ann Emerg Med 60, no. 2 (August 2012): 199–206. https://doi.org/10.1016/j.annemergmed.2011.09.014.
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    • Orrey, Danielle C., Andrey V. Bortsov, Janelle M. Hoskins, Jeffrey W. Shupp, Samuel W. Jones, Bryan J. Cicuto, James Hwang, et al. “Catechol-O-methyltransferase genotype predicts pain severity in hospitalized burn patients.” J Burn Care Res 33, no. 4 (July 2012): 518–23. https://doi.org/10.1097/BCR.0b013e31823746ed.
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    • Platts-Mills, Timothy F., Katie M. Hunold, Andrey V. Bortsov, April C. Soward, David A. Peak, Jeffrey S. Jones, Robert A. Swor, et al. “More educated emergency department patients are less likely to receive opioids for acute pain.” Pain 153, no. 5 (May 2012): 967–73. https://doi.org/10.1016/j.pain.2012.01.013.
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    • Bortsov, Andrey V., Robert C. Millikan, Inna Belfer, Richard L. Boortz-Marx, Harendra Arora, and Samuel A. McLean. “μ-Opioid receptor gene A118G polymorphism predicts survival in patients with breast cancer.” Anesthesiology 116, no. 4 (April 2012): 896–902. https://doi.org/10.1097/ALN.0b013e31824b96a1.
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    • Tomecka, Maggie J., Andrey V. Bortsov, Natalie R. Miller, Natalie Solano, John Narron, Peggy P. McNaull, Karene J. Ricketts, Concetta M. Lupa, and Samuel A. McLean. “Substantial postoperative pain is common among children undergoing laparoscopic appendectomy.” Paediatr Anaesth 22, no. 2 (February 2012): 130–35. https://doi.org/10.1111/j.1460-9592.2011.03711.x.
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    • Bortsov, Andrey V., Angela D. Liese, Ronny A. Bell, Dana Dabelea, Ralph B. D’Agostino, Richard F. Hamman, Georgeanna J. Klingensmith, et al. “Sugar-sweetened and diet beverage consumption is associated with cardiovascular risk factor profile in youth with type 1 diabetes.” Acta Diabetol 48, no. 4 (December 2011): 275–82. https://doi.org/10.1007/s00592-010-0246-9.
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    • Platts-Mills, Timothy F., Lauren Ballina, Andrey V. Bortsov, April Soward, Robert A. Swor, Jeffrey S. Jones, David C. Lee, et al. “Using emergency department-based inception cohorts to determine genetic characteristics associated with long term patient outcomes after motor vehicle collision: methodology of the CRASH study.” Bmc Emerg Med 11 (September 26, 2011): 14. https://doi.org/10.1186/1471-227X-11-14.
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    • Bortsov, A., A. D. Liese, R. A. Bell, D. Dabelea, R. B. D’Agostino, R. F. Hamman, G. J. Klingensmith, et al. “Response to insulin regimen-associated differences in diets of preadolescents with type 1 diabetes.” Journal of Nutrition Education and Behavior 43, no. 3 (May 1, 2011). https://doi.org/10.1016/j.jneb.2011.03.009.
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    • Liese, Angela D., Andrey Bortsov, Anke L. B. Günther, Dana Dabelea, Kristi Reynolds, Debra A. Standiford, Lenna Liu, et al. “Association of DASH diet with cardiovascular risk factors in youth with diabetes mellitus: the SEARCH for Diabetes in Youth study.” Circulation 123, no. 13 (April 5, 2011): 1410–17. https://doi.org/10.1161/CIRCULATIONAHA.110.955922.
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    • Bortsov, Andrey, Angela D. Liese, Ronny A. Bell, Dana Dabelea, Ralph B. D’Agostino, Richard F. Hamman, Georgeanna J. Klingensmith, et al. “Correlates of dietary intake in youth with diabetes: results from the SEARCH for diabetes in youth study.” J Nutr Educ Behav 43, no. 2 (March 2011): 123–29. https://doi.org/10.1016/j.jneb.2009.12.007.
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    • Bishop, F. K., D. M. Maahs, G. Spiegel, D. Owen, G. J. Klingensmith, A. Bortsov, J. Thomas, and E. J. Mayer-Davis. “The carbohydrate counting in adolescents with type 1 diabetes (CCAT) study.” Diabetes Spectrum 22, no. 1 (January 1, 2009): 56–62. https://doi.org/10.2337/diaspect.22.1.56.
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    • Krupitskiĭ, E. M., and A. V. Bortsov. “[A paradigm of evidence-based medicine: principles of clinical study].” Zh Nevrol Psikhiatr Im S S Korsakova 108, no. 2 (2008): 31–37.
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    • Neznanov, N. G., and A. V. Bortsov. “[A new quality of the therapy of anxiety and depression--escitalopram].” Zh Nevrol Psikhiatr Im S S Korsakova 105, no. 2 (2005): 79–84.
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  • Book Sections

    • Bortsov, A. V., R. C. Millikan, I. Belfer, R. L. Boortz-Marx, H. Arora, and S. A. Mc Lean. “Genetic Polymorphisms in the m -Opioid Receptor Gene and Breast Cancer Survival.” In Morphine and Metastasis, 95–112, 2013. https://doi.org/10.1007/978-94-007-5678-6_7.
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  • Conference Papers

    • Musey, Paul I., Sarah D. Linnstaedt, Timothy F. Platts-Mills, James R. Miner, Andrey V. Bortsov, Basmah Safdar, Polly Bijur, et al. “Gender differences in acute and chronic pain in the emergency department: results of the 2014 Academic Emergency Medicine consensus conference pain section.” In Acad Emerg Med, 21:1421–30, 2014. https://doi.org/10.1111/acem.12529.
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