Andrey V Bortsov
Assistant Professor in Anesthesiology
Dr. Andrey Bortsov is an Assistant Professor in the Department of Anesthesiology and holds a faculty position in the Center for Translational Pain Medicine
(CTPM). He earned his Doctor of Medicine degree (1999) from Pavlov State Medical University, Saint Petersburg, Russia, and his PhD in Epidemiology (2010) from the University of South Carolina at Columbia.
In 2010, he joined the faculty at UNC Department of Anesthesiology as a Research Assistant Professor, where he studied genetics and non-genetic risk factors of chronic pain development after traumatic stressful events. Dr. Bortsov has published more than 30 peer-reviewed articles and presented his work at major and national and international conferences.
Dr. Bortsov joined the faulty at Duke University in 2016, where he continues his work on pain genomics. His major area of interest is application of novel computational and statistical methods to big genomic datasets to develop prediction models for disease risk and treatment outcomes.
In 2010, he joined the faculty at UNC Department of Anesthesiology as a Research Assistant Professor, where he studied genetics and non-genetic risk factors of chronic pain development after traumatic stressful events. Dr. Bortsov has published more than 30 peer-reviewed articles and presented his work at major and national and international conferences.
Dr. Bortsov joined the faulty at Duke University in 2016, where he continues his work on pain genomics. His major area of interest is application of novel computational and statistical methods to big genomic datasets to develop prediction models for disease risk and treatment outcomes.
Current Appointments & Affiliations
- Assistant Professor in Anesthesiology, Anesthesiology, Pain Management, Anesthesiology 2021
Contact Information
- Background
-
Education, Training, & Certifications
- Ph.D., University of South Carolina, Columbia 2010
- M.D., St. Petersburg State University (Russia) 1999
-
Duke Appointment History
- Assistant Professor in Anesthesiology, Anesthesiology, Pain Management, Anesthesiology 2016 - 2020
- Recognition
-
Awards & Honors
- Best Abstracts for Basic Science. American Society of Anesthesiologist, Annual Meeting in Washington, DC. 2013
- Best Abstracts for Basic Science. American Society of Anesthesiologists, Annual Meeting in Washington, DC. 2012
- Best Abstracts for Basic Science. American Society of Anesthesiologists, Annual Meeting in Chicago, IL. 2011
- Arnold School of Public Health Doctoral Achievement Award. University of South Carolina, Columbia, SC. 2010
- Norman J. Arnold Fellowship Award. Arnold School of Public Health, University of South Carolina. 2008
- Research
-
Selected Grants
- Vestibulodynia: Understanding Pathophysiology and Determining Appropriate Treatments (Vestibulodynia: UPDATe) awarded by National Institutes of Health 2018 - 2023
- Role of Preoperative Baroreflex Sensitivity on Persistent Postoperative Pain and Opioid Consumption after Thoracic Surgery awarded by National Institutes of Health 2019 - 2021
- Analgesic effects of perioperative propranolol administration for spine surgery awarded by Foundation for Anesthesia Education and Research 2020
- Royal Institution for the Advancement of Leanring/McGill University Research Service Agreement (Salary Support Dr. Bortsov) awarded by Mcgill University, Montreal 2016 - 2019
- Publications & Artistic Works
-
Selected Publications
-
Academic Articles
-
Chandra, Sharat, Zilong Wang, Xueshu Tao, Ouyang Chen, Xin Luo, Ru-Rong Ji, and Andrey V. Bortsov. “Computer-aided Discovery of a New Nav1.7 Inhibitor for Treatment of Pain and Itch.” Anesthesiology 133, no. 3 (September 2020): 611–27. https://doi.org/10.1097/ALN.0000000000003427.Full Text Link to Item
-
Zorina-Lichtenwalter, Katerina, Ryan N. Lichtenwalter, Dima V. Zaykin, Marc Parisien, Simon Gravel, Andrey Bortsov, and Luda Diatchenko. “A study in scarlet: MC1R as the main predictor of red hair and exemplar of the flip-flop effect.” Hum Mol Genet 28, no. 12 (June 15, 2019): 2093–2106. https://doi.org/10.1093/hmg/ddz018.Full Text Link to Item
-
Beaudoin, Francesca L., Anthony J. Rosellini, Andrey Bortsov, and Samuel A. McLean. “Health care utilization following motor vehicle collision is poorly stratified by chronic pain risk: Lessons from the CRASH study.” Am J Emerg Med 37, no. 3 (March 2019): 534–35. https://doi.org/10.1016/j.ajem.2018.07.019.Full Text Link to Item
-
Bortsov, Andrey V., Marshall Devor, Mari A. Kaunisto, Eija Kalso, Adam Brufsky, Henrik Kehlet, Eske Aasvang, Reinhard Bittner, Luda Diatchenko, and Inna Belfer. “CACNG2 polymorphisms associate with chronic pain after mastectomy.” Pain 160, no. 3 (March 2019): 561–68. https://doi.org/10.1097/j.pain.0000000000001432.Full Text Link to Item
-
Zhang, Xin, Jane E. Hartung, Andrey V. Bortsov, Seungtae Kim, Sandra C. O’Buckley, Julia Kozlowski, and Andrea G. Nackley. “Sustained stimulation of β2- and β3-adrenergic receptors leads to persistent functional pain and neuroinflammation.” Brain Behav Immun 73 (October 2018): 520–32. https://doi.org/10.1016/j.bbi.2018.06.017.Full Text Link to Item
-
Sigurdsson, Martin I., Nathan H. Waldron, Andrey V. Bortsov, Shad B. Smith, and William Maixner. “Genomics of Cardiovascular Measures of Autonomic Tone.” J Cardiovasc Pharmacol 71, no. 3 (March 2018): 180–91. https://doi.org/10.1097/FJC.0000000000000559.Full Text Link to Item
-
Mauck, Matthew C., Jennifer Smith, Jeffrey W. Shupp, Mark A. Weaver, Andrea Liu, Andrey V. Bortsov, Bilal Lateef, et al. “Pain and itch outcome trajectories differ among European American and African American survivors of major thermal burn injury.” Pain 158, no. 11 (November 2017): 2268–76. https://doi.org/10.1097/j.pain.0000000000001029.Full Text Link to Item
-
Linnstaedt, Sarah D., Margaret G. Walker, Kyle D. Riker, Jennifer E. Nyland, JunMei Hu, Catherine Rossi, Robert A. Swor, et al. “Genetic variant rs3750625 in the 3'UTR of ADRA2A affects stress-dependent acute pain severity after trauma and alters a microRNA-34a regulatory site.” Pain 158, no. 2 (February 2017): 230–39. https://doi.org/10.1097/j.pain.0000000000000742.Full Text Open Access Copy Link to Item
-
Meloto, Carolina B., Andrey V. Bortsov, Eric Bair, Erika Helgeson, Cara Ostrom, Shad B. Smith, Ronald Dubner, et al. “Modification of COMT-dependent pain sensitivity by psychological stress and sex.” Pain 157, no. 4 (April 2016): 858–67. https://doi.org/10.1097/j.pain.0000000000000449.Full Text Link to Item
-
Hu, JunMei, Andrey V. Bortsov, Lauren Ballina, Danielle C. Orrey, Robert A. Swor, David Peak, Jeffrey Jones, et al. “Chronic widespread pain after motor vehicle collision typically occurs through immediate development and nonrecovery: results of an emergency department-based cohort study.” Pain 157, no. 2 (February 2016): 438–44. https://doi.org/10.1097/j.pain.0000000000000388.Full Text Link to Item
-
Platts-Mills, Timothy F., Sean A. Flannigan, Andrey V. Bortsov, Samantha Smith, Robert M. Domeier, Robert A. Swor, Phyllis L. Hendry, et al. “Persistent Pain Among Older Adults Discharged Home From the Emergency Department After Motor Vehicle Crash: A Prospective Cohort Study.” Ann Emerg Med 67, no. 2 (February 2016): 166-176.e1. https://doi.org/10.1016/j.annemergmed.2015.05.003.Full Text Link to Item
-
Auvergne, Lauriane, Andrey V. Bortsov, Jacob C. Ulirsch, David A. Peak, Jeffrey S. Jones, Robert A. Swor, Robert M. Domeier, et al. “Association of Epidemiologic Factors and Genetic Variants Influencing Hypothalamic-Pituitary-Adrenocortical Axis Function With Postconcussive Symptoms After Minor Motor Vehicle Collision.” Psychosom Med 78, no. 1 (January 2016): 68–78. https://doi.org/10.1097/PSY.0000000000000253.Full Text Link to Item
-
Linnstaedt, Sarah D., Andrey V. Bortsov, April C. Soward, Robert Swor, David A. Peak, Jeffrey Jones, Niels Rathlev, et al. “CRHBP polymorphisms predict chronic pain development following motor vehicle collision.” Pain 157, no. 1 (January 2016): 273–79. https://doi.org/10.1097/j.pain.0000000000000374.Full Text Link to Item
-
Phelps, Janey R., Ali Russell, Maria C. Lupa, Peggy McNaull, Sara Pittenger, Karene Ricketts, Jennifer Ditto, and Andrey V. Bortsov. “High-dose dexmedetomidine for noninvasive pediatric procedural sedation and discharge readiness.” Paediatr Anaesth 25, no. 9 (September 2015): 877–82. https://doi.org/10.1111/pan.12569.Full Text Link to Item
-
Qadri, Yawar J., Andrey V. Bortsov, Danielle C. Orrey, Robert A. Swor, David A. Peak, Jeffrey S. Jones, Niels K. Rathlev, et al. “Genetic Polymorphisms in the Dopamine Receptor 2 Predict Acute Pain Severity After Motor Vehicle Collision.” Clin J Pain 31, no. 9 (September 2015): 768–75. https://doi.org/10.1097/AJP.0000000000000167.Full Text Link to Item
-
Linnstaedt, Sarah D., JunMei Hu, Andrey V. Bortsov, April C. Soward, Robert Swor, Jeffrey Jones, David Lee, et al. “μ-Opioid Receptor Gene A118 G Variants and Persistent Pain Symptoms Among Men and Women Experiencing Motor Vehicle Collision.” J Pain 16, no. 7 (July 2015): 637–44. https://doi.org/10.1016/j.jpain.2015.03.011.Full Text Link to Item
-
Phillips, Michael R., Amal L. Khoury, Andrey V. Bortsov, Amy Marzinsky, Kathy A. Short, Bruce A. Cairns, Anthony G. Charles, Benny L. Joyner, and Sean E. McLean. “A noninvasive hemoglobin monitor in the pediatric intensive care unit.” J Surg Res 195, no. 1 (May 1, 2015): 257–62. https://doi.org/10.1016/j.jss.2014.12.051.Full Text Link to Item
-
Orrey, Danielle C., Omar I. Halawa, Andrey V. Bortsov, Jeffrey W. Shupp, Samuel W. Jones, Linwood R. Haith, Janelle M. Hoskins, et al. “Results of a pilot multicenter genotype-based randomized placebo-controlled trial of propranolol to reduce pain after major thermal burn injury.” Clin J Pain 31, no. 1 (January 2015): 21–29. https://doi.org/10.1097/AJP.0000000000000086.Full Text Link to Item
-
Ulirsch, Jacob C., Mark A. Weaver, Andrey V. Bortsov, April C. Soward, Robert A. Swor, David A. Peak, Jeffrey S. Jones, et al. “No man is an island: living in a disadvantaged neighborhood influences chronic pain development after motor vehicle collision.” Pain 155, no. 10 (October 2014): 2116–23. https://doi.org/10.1016/j.pain.2014.07.025.Full Text Link to Item
-
Bortsov, Andrey V., Timothy F. Platts-Mills, David A. Peak, Jeffrey S. Jones, Robert A. Swor, Robert M. Domeier, David C. Lee, et al. “Effect of pain location and duration on life function in the year after motor vehicle collision.” Pain 155, no. 9 (September 2014): 1836–45. https://doi.org/10.1016/j.pain.2014.06.013.Full Text Link to Item
-
Kumar, Priya A., Andrey V. Bortsov, and Harendra Arora. “In reply.” Anesthesiology 121, no. 2 (August 2014): 430–31. https://doi.org/10.1097/ALN.0000000000000311.Full Text Link to Item
-
McLean, Samuel A., Jacob C. Ulirsch, and Andrey V. Bortsov. “Response to letter to the Editor.” Pain 155, no. 7 (July 2014): 1416–18. https://doi.org/10.1016/j.pain.2014.04.014.Full Text Link to Item
-
Bortsov, Andrey V., Luda Diatchenko, and Samuel A. McLean. “Complex multilocus effects of catechol-O-methyltransferase haplotypes predict pain and pain interference 6 weeks after motor vehicle collision.” Neuromolecular Med 16, no. 1 (March 2014): 83–93. https://doi.org/10.1007/s12017-013-8255-9.Full Text Link to Item
-
McLean, Samuel A., Jacob C. Ulirsch, Gary D. Slade, April C. Soward, Robert A. Swor, David A. Peak, Jeffrey S. Jones, et al. “Incidence and predictors of neck and widespread pain after motor vehicle collision among US litigants and nonlitigants.” Pain 155, no. 2 (February 2014): 309–21. https://doi.org/10.1016/j.pain.2013.10.016.Full Text Link to Item
-
Ferrero, Natalie A., Andrey V. Bortsov, Harendra Arora, Susan M. Martinelli, Lavinia M. Kolarczyk, Emily C. Teeter, David A. Zvara, and Priya A. Kumar. “Simulator training enhances resident performance in transesophageal echocardiography.” Anesthesiology 120, no. 1 (January 2014): 149–59. https://doi.org/10.1097/ALN.0000000000000063.Full Text Link to Item
-
Joseph, Julie A., Chris M. Terry, Eva J. Waller, Andrey V. Bortsov, David A. Zvara, David C. Mayer, and Susan M. Martinelli. “Enhancement of anesthesiology in-training exam performance with institution of an academic improvement policy.” J Educ Perioper Med 16, no. 6 (January 2014): E072.Link to Item
-
Bortsov, A. V., T. F. Platts-Mills, D. A. Peak, J. S. Jones, R. A. Swor, R. M. Domeier, D. C. Lee, et al. “Pain distribution and predictors of widespread pain in the immediate aftermath of motor vehicle collision.” Eur J Pain 17, no. 8 (September 2013): 1243–51. https://doi.org/10.1002/j.1532-2149.2013.00285.x.Full Text Link to Item
-
Bortsov, Andrey V., Jennifer E. Smith, Luda Diatchenko, April C. Soward, Jacob C. Ulirsch, Catherine Rossi, Robert A. Swor, et al. “Polymorphisms in the glucocorticoid receptor co-chaperone FKBP5 predict persistent musculoskeletal pain after traumatic stress exposure.” Pain 154, no. 8 (August 2013): 1419–26. https://doi.org/10.1016/j.pain.2013.04.037.Full Text Link to Item
-
Willis, Monte S., Bruce A. Cairns, Ashley Purdy, Andrey V. Bortsov, Samuel W. Jones, Shiara M. Ortiz-Pujols, Tina M Schade Willis, and Benny L. Joyner. “Persistent lactic acidosis after chronic topical application of silver sulfadiazine in a pediatric burn patient: a review of the literature.” Int J Burns Trauma 3, no. 1 (2013): 1–8.Link to Item
-
Spiegel, Gail, Andrey Bortsov, Franziska K. Bishop, Darcy Owen, Georgeanna J. Klingensmith, Elizabeth J. Mayer-Davis, and David M. Maahs. “Randomized nutrition education intervention to improve carbohydrate counting in adolescents with type 1 diabetes study: is more intensive education needed?” J Acad Nutr Diet 112, no. 11 (November 2012): 1736–46. https://doi.org/10.1016/j.jand.2012.06.001.Full Text Link to Item
-
Platts-Mills, Timothy F., Denise A. Esserman, D Levin Brown, Andrey V. Bortsov, Philip D. Sloane, and Samuel A. McLean. “Older US emergency department patients are less likely to receive pain medication than younger patients: results from a national survey.” Ann Emerg Med 60, no. 2 (August 2012): 199–206. https://doi.org/10.1016/j.annemergmed.2011.09.014.Full Text Link to Item
-
Orrey, Danielle C., Andrey V. Bortsov, Janelle M. Hoskins, Jeffrey W. Shupp, Samuel W. Jones, Bryan J. Cicuto, James Hwang, et al. “Catechol-O-methyltransferase genotype predicts pain severity in hospitalized burn patients.” J Burn Care Res 33, no. 4 (July 2012): 518–23. https://doi.org/10.1097/BCR.0b013e31823746ed.Full Text Link to Item
-
Platts-Mills, Timothy F., Katie M. Hunold, Andrey V. Bortsov, April C. Soward, David A. Peak, Jeffrey S. Jones, Robert A. Swor, et al. “More educated emergency department patients are less likely to receive opioids for acute pain.” Pain 153, no. 5 (May 2012): 967–73. https://doi.org/10.1016/j.pain.2012.01.013.Full Text Link to Item
-
Bortsov, Andrey V., Robert C. Millikan, Inna Belfer, Richard L. Boortz-Marx, Harendra Arora, and Samuel A. McLean. “μ-Opioid receptor gene A118G polymorphism predicts survival in patients with breast cancer.” Anesthesiology 116, no. 4 (April 2012): 896–902. https://doi.org/10.1097/ALN.0b013e31824b96a1.Full Text Link to Item
-
Tomecka, Maggie J., Andrey V. Bortsov, Natalie R. Miller, Natalie Solano, John Narron, Peggy P. McNaull, Karene J. Ricketts, Concetta M. Lupa, and Samuel A. McLean. “Substantial postoperative pain is common among children undergoing laparoscopic appendectomy.” Paediatr Anaesth 22, no. 2 (February 2012): 130–35. https://doi.org/10.1111/j.1460-9592.2011.03711.x.Full Text Link to Item
-
Bortsov, Andrey V., Angela D. Liese, Ronny A. Bell, Dana Dabelea, Ralph B. D’Agostino, Richard F. Hamman, Georgeanna J. Klingensmith, et al. “Sugar-sweetened and diet beverage consumption is associated with cardiovascular risk factor profile in youth with type 1 diabetes.” Acta Diabetol 48, no. 4 (December 2011): 275–82. https://doi.org/10.1007/s00592-010-0246-9.Full Text Link to Item
-
Platts-Mills, Timothy F., Lauren Ballina, Andrey V. Bortsov, April Soward, Robert A. Swor, Jeffrey S. Jones, David C. Lee, et al. “Using emergency department-based inception cohorts to determine genetic characteristics associated with long term patient outcomes after motor vehicle collision: methodology of the CRASH study.” Bmc Emerg Med 11 (September 26, 2011): 14. https://doi.org/10.1186/1471-227X-11-14.Full Text Link to Item
-
Bortsov, A., A. D. Liese, R. A. Bell, D. Dabelea, R. B. D’Agostino, R. F. Hamman, G. J. Klingensmith, et al. “Response to insulin regimen-associated differences in diets of preadolescents with type 1 diabetes.” Journal of Nutrition Education and Behavior 43, no. 3 (May 1, 2011). https://doi.org/10.1016/j.jneb.2011.03.009.Full Text
-
Liese, Angela D., Andrey Bortsov, Anke L. B. Günther, Dana Dabelea, Kristi Reynolds, Debra A. Standiford, Lenna Liu, et al. “Association of DASH diet with cardiovascular risk factors in youth with diabetes mellitus: the SEARCH for Diabetes in Youth study.” Circulation 123, no. 13 (April 5, 2011): 1410–17. https://doi.org/10.1161/CIRCULATIONAHA.110.955922.Full Text Link to Item
-
Bortsov, Andrey, Angela D. Liese, Ronny A. Bell, Dana Dabelea, Ralph B. D’Agostino, Richard F. Hamman, Georgeanna J. Klingensmith, et al. “Correlates of dietary intake in youth with diabetes: results from the SEARCH for diabetes in youth study.” J Nutr Educ Behav 43, no. 2 (March 2011): 123–29. https://doi.org/10.1016/j.jneb.2009.12.007.Full Text Link to Item
-
Bishop, F. K., D. M. Maahs, G. Spiegel, D. Owen, G. J. Klingensmith, A. Bortsov, J. Thomas, and E. J. Mayer-Davis. “The carbohydrate counting in adolescents with type 1 diabetes (CCAT) study.” Diabetes Spectrum 22, no. 1 (January 1, 2009): 56–62. https://doi.org/10.2337/diaspect.22.1.56.Full Text
-
Krupitskiĭ, E. M., and A. V. Bortsov. “[A paradigm of evidence-based medicine: principles of clinical study].” Zh Nevrol Psikhiatr Im S S Korsakova 108, no. 2 (2008): 31–37.Link to Item
-
Neznanov, N. G., and A. V. Bortsov. “[A new quality of the therapy of anxiety and depression--escitalopram].” Zh Nevrol Psikhiatr Im S S Korsakova 105, no. 2 (2005): 79–84.Link to Item
-
-
Book Sections
-
Bortsov, A. V., R. C. Millikan, I. Belfer, R. L. Boortz-Marx, H. Arora, and S. A. Mc Lean. “Genetic Polymorphisms in the m -Opioid Receptor Gene and Breast Cancer Survival.” In Morphine and Metastasis, 95–112, 2013. https://doi.org/10.1007/978-94-007-5678-6_7.Full Text
-
-
Conference Papers
-
Musey, Paul I., Sarah D. Linnstaedt, Timothy F. Platts-Mills, James R. Miner, Andrey V. Bortsov, Basmah Safdar, Polly Bijur, et al. “Gender differences in acute and chronic pain in the emergency department: results of the 2014 Academic Emergency Medicine consensus conference pain section.” In Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine, 21:1421–30, 2014. https://doi.org/10.1111/acem.12529.Full Text
-
-
Some information on this profile has been compiled automatically from Duke databases and external sources. (Our About page explains how this works.) If you see a problem with the information, please write to Scholars@Duke and let us know. We will reply promptly.