Andrey V Bortsov | Scholars@Duke

Andrey V Bortsov
Assistant Professor in Anesthesiology

Dr. Andrey Bortsov is an Assistant Professor in the Department of Anesthesiology and holds a faculty position in the Center for Translational Pain Medicine (CTPM). He earned his Doctor of Medicine degree (1999) from Pavlov State Medical University, Saint Petersburg, Russia, and his PhD in Epidemiology (2010) from the University of South Carolina at Columbia.

In 2010, he joined the faculty at UNC Department of Anesthesiology as a Research Assistant Professor, where he studied genetics and non-genetic risk factors of chronic pain development after traumatic stressful events. Dr. Bortsov has published more than 30 peer-reviewed articles and presented his work at major and national and international conferences.

Dr. Bortsov joined the faulty at Duke University in 2016, where he continues his work on pain genomics. His major area of interest is application of novel computational and statistical methods to big genomic datasets to develop prediction models for disease risk and treatment outcomes.

Current Appointments & Affiliations

Assistant Professor in Anesthesiology, Anesthesiology, Pain Management, Anesthesiology 2016

Contact Information

andrey.bortsov@duke.edu

Background
Education, Training, & Certifications
- Ph.D., University of South Carolina at Columbia 2010
- M.D., St. Petersburg State University (Russia) 1999
Recognition
Awards & Honors
Research
Selected Grants
- Vestibulodynia: Understanding Pathophysiology and Determining Appropriate Treatments (Vestibulodynia: UPDATe) awarded by National Institutes of Health 2018 - 2023
- Royal Institution for the Advancement of Leanring/McGill University Research Service Agreement (Salary Support Dr. Bortsov) awarded by Mcgill University, Montreal 2016 - 2019
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Zhang, X, Hartung, JE, Bortsov, AV, Kim, S, O'Buckley, SC, Kozlowski, J, and Nackley, AG. "Sustained stimulation of β2- and β3-adrenergic receptors leads to persistent functional pain and neuroinflammation." Brain, Behavior, and Immunity 73 (October 2018): 520-532. Full Text
  - Sigurdsson, MI, Waldron, NH, Bortsov, AV, Smith, SB, and Maixner, W. "Genomics of Cardiovascular Measures of Autonomic Tone." Journal of Cardiovascular Pharmacology 71, no. 3 (March 2018): 180-191. Full Text
  - Mauck, MC, Smith, J, Shupp, JW, Weaver, MA, Liu, A, Bortsov, AV, Lateef, B, Jones, SW, Williams, F, Hwang, J, Karlnoski, R, Smith, DJ, Cairns, BA, and McLean, SA. "Pain and itch outcome trajectories differ among European American and African American survivors of major thermal burn injury." Pain 158, no. 11 (November 2017): 2268-2276. Full Text
  - Linnstaedt, SD, Walker, MG, Riker, KD, Nyland, JE, Hu, J, Rossi, C, Swor, RA, Jones, JS, Diatchenko, L, Bortsov, AV, Peak, DA, and McLean, SA. "Genetic variant rs3750625 in the 3'UTR of ADRA2A affects stress-dependent acute pain severity after trauma and alters a microRNA-34a regulatory site." Pain 158, no. 2 (February 2017): 230-239. Full Text Open Access Copy
  - Meloto, CB, Bortsov, AV, Bair, E, Helgeson, E, Ostrom, C, Smith, SB, Dubner, R, Slade, GD, Fillingim, RB, Greenspan, JD, Ohrbach, R, Maixner, W, McLean, SA, and Diatchenko, L. "Modification of COMT-dependent pain sensitivity by psychological stress and sex." Pain 157, no. 4 (April 2016): 858-867. Full Text
  - Hu, J, Bortsov, AV, Ballina, L, Orrey, DC, Swor, RA, Peak, D, Jones, J, Rathlev, N, Lee, DC, Domeier, R, Hendry, P, Parry, BA, and McLean, SA. "Chronic widespread pain after motor vehicle collision typically occurs through immediate development and nonrecovery: results of an emergency department-based cohort study." Pain 157, no. 2 (February 2016): 438-444. Full Text
  - Platts-Mills, TF, Flannigan, SA, Bortsov, AV, Smith, S, Domeier, RM, Swor, RA, Hendry, PL, Peak, DA, Rathlev, NK, Jones, JS, Lee, DC, Keefe, FJ, Sloane, PD, and McLean, SA. "Persistent Pain Among Older Adults Discharged Home From the Emergency Department After Motor Vehicle Crash: A Prospective Cohort Study." Annals of emergency medicine 67, no. 2 (February 2016): 166-176.e1. Full Text
  - Auvergne, L, Bortsov, AV, Ulirsch, JC, Peak, DA, Jones, JS, Swor, RA, Domeier, RM, Lee, DC, Rathlev, NK, Hendry, PL, and McLean, SA. "Association of Epidemiologic Factors and Genetic Variants Influencing Hypothalamic-Pituitary-Adrenocortical Axis Function With Postconcussive Symptoms After Minor Motor Vehicle Collision." Psychosomatic medicine 78, no. 1 (January 2016): 68-78. Full Text
  - Linnstaedt, SD, Bortsov, AV, Soward, AC, Swor, R, Peak, DA, Jones, J, Rathlev, N, Lee, DC, Domeier, R, Hendry, PL, and McLean, SA. "CRHBP polymorphisms predict chronic pain development following motor vehicle collision." Pain 157, no. 1 (January 2016): 273-279. Full Text
  - Phelps, JR, Russell, A, Lupa, MC, McNaull, P, Pittenger, S, Ricketts, K, Ditto, J, and Bortsov, AV. "High-dose dexmedetomidine for noninvasive pediatric procedural sedation and discharge readiness." Paediatric anaesthesia 25, no. 9 (September 2015): 877-882. Full Text
  - Qadri, YJ, Bortsov, AV, Orrey, DC, Swor, RA, Peak, DA, Jones, JS, Rathlev, NK, Lee, DC, Domeier, RM, Hendry, PL, and Mclean, SA. "Genetic Polymorphisms in the Dopamine Receptor 2 Predict Acute Pain Severity After Motor Vehicle Collision." The Clinical journal of pain 31, no. 9 (September 2015): 768-775. Full Text
  - Linnstaedt, SD, Hu, J, Bortsov, AV, Soward, AC, Swor, R, Jones, J, Lee, D, Peak, D, Domeier, R, Rathlev, N, Hendry, P, and McLean, SA. "μ-Opioid Receptor Gene A118 G Variants and Persistent Pain Symptoms Among Men and Women Experiencing Motor Vehicle Collision." The journal of pain : official journal of the American Pain Society 16, no. 7 (July 2015): 637-644. Full Text
  - Phillips, MR, Khoury, AL, Bortsov, AV, Marzinsky, A, Short, KA, Cairns, BA, Charles, AG, Joyner, BL, and McLean, SE. "A noninvasive hemoglobin monitor in the pediatric intensive care unit." The Journal of surgical research 195, no. 1 (May 2015): 257-262. Full Text
  - Orrey, DC, Halawa, OI, Bortsov, AV, Shupp, JW, Jones, SW, Haith, LR, Hoskins, JM, Jordan, MH, Bangdiwala, SI, Roane, BR, Platts-Mills, TF, Holmes, JH, Hwang, J, Cairns, BA, and McLean, SA. "Results of a pilot multicenter genotype-based randomized placebo-controlled trial of propranolol to reduce pain after major thermal burn injury." The Clinical journal of pain 31, no. 1 (January 2015): 21-29. Full Text
  - Ulirsch, JC, Weaver, MA, Bortsov, AV, Soward, AC, Swor, RA, Peak, DA, Jones, JS, Rathlev, NK, Lee, DC, Domeier, RM, Hendry, PL, and McLean, SA. "No man is an island: living in a disadvantaged neighborhood influences chronic pain development after motor vehicle collision." Pain 155, no. 10 (October 2014): 2116-2123. Full Text
  - Bortsov, AV, Platts-Mills, TF, Peak, DA, Jones, JS, Swor, RA, Domeier, RM, Lee, DC, Rathlev, NK, Hendry, PL, Fillingim, RB, and McLean, SA. "Effect of pain location and duration on life function in the year after motor vehicle collision." Pain 155, no. 9 (September 2014): 1836-1845. Full Text
  - Kumar, PA, Bortsov, AV, and Arora, H. "In reply." Anesthesiology 121, no. 2 (August 2014): 430-431. (Letter) Full Text
  - McLean, SA, Ulirsch, JC, and Bortsov, AV. "Response to letter to the Editor." Pain 155, no. 7 (July 2014): 1416-1418. (Letter) Full Text
  - Bortsov, AV, Diatchenko, L, and McLean, SA. "Complex multilocus effects of catechol-O-methyltransferase haplotypes predict pain and pain interference 6 weeks after motor vehicle collision." Neuromolecular medicine 16, no. 1 (March 2014): 83-93. Full Text
  - McLean, SA, Ulirsch, JC, Slade, GD, Soward, AC, Swor, RA, Peak, DA, Jones, JS, Rathlev, NK, Lee, DC, Domeier, RM, Hendry, PL, Bortsov, AV, and Bair, E. "Incidence and predictors of neck and widespread pain after motor vehicle collision among US litigants and nonlitigants." Pain 155, no. 2 (February 2014): 309-321. Full Text
  - Ferrero, NA, Bortsov, AV, Arora, H, Martinelli, SM, Kolarczyk, LM, Teeter, EC, Zvara, DA, and Kumar, PA. "Simulator training enhances resident performance in transesophageal echocardiography." Anesthesiology 120, no. 1 (January 2014): 149-159. Full Text
  - Joseph, JA, Terry, CM, Waller, EJ, Bortsov, AV, Zvara, DA, Mayer, DC, and Martinelli, SM. "Enhancement of anesthesiology in-training exam performance with institution of an academic improvement policy." The journal of education in perioperative medicine : JEPM 16, no. 6 (January 2014): E072-.
  - Bortsov, AV, Platts-Mills, TF, Peak, DA, Jones, JS, Swor, RA, Domeier, RM, Lee, DC, Rathlev, NK, Hendry, PL, Fillingim, RB, and McLean, SA. "Pain distribution and predictors of widespread pain in the immediate aftermath of motor vehicle collision." European journal of pain (London, England) 17, no. 8 (September 2013): 1243-1251. Full Text
  - Bortsov, AV, Smith, JE, Diatchenko, L, Soward, AC, Ulirsch, JC, Rossi, C, Swor, RA, Hauda, WE, Peak, DA, Jones, JS, Holbrook, D, Rathlev, NK, Foley, KA, Lee, DC, Collette, R, Domeier, RM, Hendry, PL, and McLean, SA. "Polymorphisms in the glucocorticoid receptor co-chaperone FKBP5 predict persistent musculoskeletal pain after traumatic stress exposure." Pain 154, no. 8 (August 2013): 1419-1426. Full Text
  - Willis, MS, Cairns, BA, Purdy, A, Bortsov, AV, Jones, SW, Ortiz-Pujols, SM, Willis, TMS, and Joyner, BL. "Persistent lactic acidosis after chronic topical application of silver sulfadiazine in a pediatric burn patient: a review of the literature." International journal of burns and trauma 3, no. 1 (January 24, 2013): 1-8.
  - Spiegel, G, Bortsov, A, Bishop, FK, Owen, D, Klingensmith, GJ, Mayer-Davis, EJ, and Maahs, DM. "Randomized nutrition education intervention to improve carbohydrate counting in adolescents with type 1 diabetes study: is more intensive education needed?." Journal of the Academy of Nutrition and Dietetics 112, no. 11 (November 2012): 1736-1746. Full Text
  - Platts-Mills, TF, Esserman, DA, Brown, DL, Bortsov, AV, Sloane, PD, and McLean, SA. "Older US emergency department patients are less likely to receive pain medication than younger patients: results from a national survey." Annals of Emergency Medicine 60, no. 2 (August 2012): 199-206. Full Text
  - Orrey, DC, Bortsov, AV, Hoskins, JM, Shupp, JW, Jones, SW, Cicuto, BJ, Hwang, J, Jordan, MH, Holmes, JH, Haith, LR, Roane, BM, Diatchenko, L, Cairns, BA, and McLean, SA. "Catechol-O-methyltransferase genotype predicts pain severity in hospitalized burn patients." Journal of burn care & research : official publication of the American Burn Association 33, no. 4 (July 2012): 518-523. Full Text
  - Platts-Mills, TF, Hunold, KM, Bortsov, AV, Soward, AC, Peak, DA, Jones, JS, Swor, RA, Lee, DC, Domeier, RM, Hendry, PL, Rathlev, NK, and McLean, SA. "More educated emergency department patients are less likely to receive opioids for acute pain." Pain 153, no. 5 (May 2012): 967-973. Full Text
  - Bortsov, AV, Millikan, RC, Belfer, I, Boortz-Marx, RL, Arora, H, and McLean, SA. "μ-Opioid receptor gene A118G polymorphism predicts survival in patients with breast cancer." Anesthesiology 116, no. 4 (April 2012): 896-902. Full Text
  - Tomecka, MJ, Bortsov, AV, Miller, NR, Solano, N, Narron, J, McNaull, PP, Ricketts, KJ, Lupa, CM, and McLean, SA. "Substantial postoperative pain is common among children undergoing laparoscopic appendectomy." Paediatric Anaesthesia 22, no. 2 (February 2012): 130-135. Full Text
  - Bortsov, AV, Liese, AD, Bell, RA, Dabelea, D, D'Agostino, RB, Hamman, RF, Klingensmith, GJ, Lawrence, JM, Maahs, DM, McKeown, R, Marcovina, SM, Thomas, J, Williams, DE, and Mayer-Davis, EJ. "Sugar-sweetened and diet beverage consumption is associated with cardiovascular risk factor profile in youth with type 1 diabetes." Acta Diabetologica 48, no. 4 (December 2011): 275-282. Full Text
  - Platts-Mills, TF, Ballina, L, Bortsov, AV, Soward, A, Swor, RA, Jones, JS, Lee, DC, Peak, DA, Domeier, RM, Rathlev, NK, Hendry, PL, and McLean, SA. "Using emergency department-based inception cohorts to determine genetic characteristics associated with long term patient outcomes after motor vehicle collision: methodology of the CRASH study." BMC emergency medicine 11 (September 26, 2011): 14-. Full Text
  - Bortsov, A, Liese, AD, Bell, RA, Dabelea, D, D'Agostino, RB, Hamman, RF, Klingensmith, GJ, Lawrence, JM, Maahs, DM, McKeown, R, Marcovina, SM, Thomas, J, and Mayer-Davis, EJ. "Response to Insulin Regimen-associated Differences in Diets of Preadolescents with Type 1 Diabetes." Journal of Nutrition Education and Behavior 43, no. 3 (May 2011): e6-e6. Full Text
  - Liese, AD, Bortsov, A, Günther, ALB, Dabelea, D, Reynolds, K, Standiford, DA, Liu, L, Williams, DE, Mayer-Davis, EJ, D'Agostino, RB, Bell, R, and Marcovina, S. "Association of DASH diet with cardiovascular risk factors in youth with diabetes mellitus: the SEARCH for Diabetes in Youth study." Circulation 123, no. 13 (April 2011): 1410-1417. Full Text
  - Bortsov, A, Liese, AD, Bell, RA, Dabelea, D, D'Agostino, RB, Hamman, RF, Klingensmith, GJ, Lawrence, JM, Maahs, DM, McKeown, R, Marcovina, SM, Thomas, J, and Mayer-Davis, EJ. "Correlates of dietary intake in youth with diabetes: results from the SEARCH for diabetes in youth study." Journal of nutrition education and behavior 43, no. 2 (March 2011): 123-129. Full Text
  - Bishop, FK, Maahs, DM, Spiegel, G, Owen, D, Klingensmith, GJ, Bortsov, A, Thomas, J, and Mayer-Davis, EJ. "The Carbohydrate Counting in Adolescents With Type 1 Diabetes (CCAT) Study." Diabetes Spectrum 22, no. 1 (January 1, 2009): 56-62. Full Text
  - Krupitskiĭ, EM, and Bortsov, AV. "[A paradigm of evidence-based medicine: principles of clinical study]." Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 108, no. 2 (January 2008): 31-37. (Review)
  - Neznanov, NG, and Bortsov, AV. "[A new quality of the therapy of anxiety and depression--escitalopram]." Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 105, no. 2 (January 2005): 79-84. (Review)
- Book Sections
  - Bortsov, AV, Millikan, RC, Belfer, I, Boortz-Marx, RL, Arora, H, and Mc Lean, SA. "Genetic Polymorphisms in the m -Opioid Receptor Gene and Breast Cancer Survival." In Morphine and Metastasis, 95-112. January 1, 2013. Full Text
- Conference Papers
  - Musey, PI, Linnstaedt, SD, Platts-Mills, TF, Miner, JR, Bortsov, AV, Safdar, B, Bijur, P, Rosenau, A, Tsze, DS, Chang, AK, Dorai, S, Engel, KG, Feldman, JA, Fusaro, AM, Lee, DC, Rosenberg, M, Keefe, FJ, Peak, DA, Nam, CS, Patel, RG, Fillingim, RB, and McLean, SA. "Gender differences in acute and chronic pain in the emergency department: results of the 2014 Academic Emergency Medicine consensus conference pain section." December 2014. Full Text

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Education, Training, & Certifications

Awards & Honors

Selected Grants

Selected Publications

Academic Articles

Book Sections

Conference Papers