Scholars@Duke
Andrey V Bortsov

Andrey V Bortsov

Assistant Professor in Anesthesiology
Anesthesiology

Selected Publications

A mouse model of chronic primary pain that integrates clinically relevant genetic vulnerability, stress, and minor injury.

Journal Article Sci Transl Med · April 10, 2024 Chronic primary pain conditions (CPPCs) affect over 100 million Americans, predominantly women. They remain ineffectively treated, in large part because of a lack of valid animal models with translational relevance. Here, we characterized a CPPC mouse mode ... Full text Link to item Cite

Higher Cardiovagal Baroreflex Sensitivity Predicts Increased Pain Outcomes After Cardiothoracic Surgery.

Conference The journal of pain · January 2024 Excessive postoperative pain can lead to extended hospitalization and increased expenses, but factors that predict its severity are still unclear. Baroreceptor function could influence postoperative pain by modulating nociceptive processing and vagal-media ... Full text Cite

Biopsychosocial Factors Associated With Pain and Pain-Related Outcomes in Adults and Children With Sickle Cell Disease: A Multivariable Analysis of the GRNDaD Multicenter Registry.

Journal Article J Pain · January 2024 Pain is the primary symptomatic manifestation of sickle cell disease (SCD), an inherited hemoglobinopathy. The characteristics that influence pain experiences and outcomes in SCD are not fully understood. The primary objective of this study was to use mult ... Full text Link to item Cite

Higher Cardiovagal Baroreflex Sensitivity Predicts Increased Pain Outcomes After Cardiothoracic Surgery.

Conference J Pain · January 2024 Excessive postoperative pain can lead to extended hospitalization and increased expenses, but factors that predict its severity are still unclear. Baroreceptor function could influence postoperative pain by modulating nociceptive processing and vagal-media ... Full text Link to item Cite

Immunotherapies in chronic pain through modulation of neuroimmune interactions.

Journal Article Pharmacol Ther · August 2023 It is generally believed that immune activation can elicit pain through production of inflammatory mediators that can activate nociceptive sensory neurons. Emerging evidence suggests that immune activation may also contribute to the resolution of pain by p ... Full text Link to item Cite

Intrathecal administration of conditioned serum from different species resolves Chemotherapy-Induced neuropathic pain in mice via secretory exosomes.

Journal Article Brain Behav Immun · July 2023 Chemotherapy-induced peripheral neuropathy (CIPN) is the most prevalent neurological complication of chemotherapy for cancer, and has limited effective treatment options. Autologous conditioned serum (ACS) is an effective biologic therapy used by intra-art ... Full text Link to item Cite

Sensory Neuron-TRPV4 Modulates Temporomandibular Disorder Pain Via CGRP in Mice.

Journal Article J Pain · May 2023 Temporomandibular disorder (TMD) pain that involves inflammation and injury in the temporomandibular joint (TMJ) and/or masticatory muscle is the most common form of orofacial pain. We recently found that transient receptor potential vanilloid-4 (TRPV4) in ... Full text Open Access Link to item Cite

Rationale and design of a multicenter randomized clinical trial of vestibulodynia: understanding pathophysiology and determining appropriate treatments (vestibulodynia: UPDATe).

Journal Article Ann Med · December 2022 BACKGROUND: Limited data are available to establish evidence-based management protocols for vestibulodynia (VBD), a chronic vulvar pain condition that affects approximately 14 million women in the U.S. For the purposes of the study, our group subdivided VB ... Full text Open Access Link to item Cite

Brain-specific genes contribute to chronic but not to acute back pain.

Journal Article Pain Rep · 2022 INTRODUCTION: Back pain is the leading cause of disability worldwide. Although most back pain cases are acute, 20% of acute pain patients experience chronic back pain symptoms. It is unclear whether acute pain and chronic pain have similar or distinct unde ... Full text Link to item Cite

Repurposing cancer drugs identifies kenpaullone which ameliorates pathologic pain in preclinical models via normalization of inhibitory neurotransmission.

Journal Article Nat Commun · October 27, 2021 Inhibitory GABA-ergic neurotransmission is fundamental for the adult vertebrate central nervous system and requires low chloride concentration in neurons, maintained by KCC2, a neuroprotective ion transporter that extrudes intracellular neuronal chloride. ... Full text Link to item Cite

IL-23/IL-17A/TRPV1 axis produces mechanical pain via macrophage-sensory neuron crosstalk in female mice.

Journal Article Neuron · September 1, 2021 Although sex dimorphism is increasingly recognized as an important factor in pain, female-specific pain signaling is not well studied. Here we report that administration of IL-23 produces mechanical pain (mechanical allodynia) in female but not male mice, ... Full text Link to item Cite

Epithelia-Sensory Neuron Cross Talk Underlies Cholestatic Itch Induced by Lysophosphatidylcholine.

Journal Article Gastroenterology · July 2021 BACKGROUND & AIMS: Limited understanding of pruritus mechanisms in cholestatic liver diseases hinders development of antipruritic treatments. Previous studies implicated lysophosphatidic acid (LPA) as a potential mediator of cholestatic pruritus. METHODS: ... Full text Link to item Cite

Phenotypic profile clustering pragmatically identifies diagnostically and mechanistically informative subgroups of chronic pain patients.

Journal Article Pain · May 1, 2021 Traditional classification and prognostic approaches for chronic pain conditions focus primarily on anatomically based clinical characteristics not based on underlying biopsychosocial factors contributing to perception of clinical pain and future pain traj ... Full text Open Access Link to item Cite

Sex- and age-specific genetic analysis of chronic back pain.

Journal Article Pain · April 1, 2021 Sex differences for chronic back pain (cBP) have been reported, with females usually exhibiting greater morbidity, severity, and poorer response to treatment. Genetic factors acting in an age-specific manner have been implicated but never comprehensively e ... Full text Link to item Cite

Activation of GPR37 in macrophages confers protection against infection-induced sepsis and pain-like behaviour in mice.

Journal Article Nat Commun · March 17, 2021 GPR37 was discovered more than two decades ago, but its biological functions remain poorly understood. Here we report a protective role of GPR37 in multiple models of infection and sepsis. Mice lacking Gpr37 exhibited increased death and/or hypothermia fol ... Full text Link to item Cite

Multi-ethnic GWAS and meta-analysis of sleep quality identify MPP6 as a novel gene that functions in sleep center neurons.

Journal Article Sleep · March 12, 2021 Poor sleep quality can have harmful health consequences. Although many aspects of sleep are heritable, the understandings of genetic factors involved in its physiology remain limited. Here, we performed a genome-wide association study (GWAS) using the Pitt ... Full text Open Access Link to item Cite

Computer-aided Discovery of a New Nav1.7 Inhibitor for Treatment of Pain and Itch.

Journal Article Anesthesiology · September 2020 BACKGROUND: Voltage-gated sodium channel Nav1.7 has been validated as a perspective target for selective inhibitors with analgesic and anti-itch activity. The objective of this study was to discover new candidate compounds with Nav1.7 inhibitor properties. ... Full text Link to item Cite

Vitamin D insufficiency increases risk of chronic pain among African Americans experiencing motor vehicle collision.

Journal Article Pain · February 2020 African Americans experience an increased burden of motor vehicle collision (MVC), post-MVC musculoskeletal pain, and vitamin D insufficiency. In this prospective multicenter study, we tested the hypothesis that African Americans (n = 133) presenting to th ... Full text Link to item Cite

A study in scarlet: MC1R as the main predictor of red hair and exemplar of the flip-flop effect.

Journal Article Hum Mol Genet · June 15, 2019 Genetic variation in melanocortin-1 receptor (MC1R) is a known contributor to disease-free red hair in humans. Three loss-of-function single-nucleotide variants (rs1805007, rs1805008 and rs1805009) have been established as strongly correlated with red hair ... Full text Link to item Cite

CACNG2 polymorphisms associate with chronic pain after mastectomy.

Journal Article Pain · March 2019 Chronic postmastectomy pain (PMP) imposes a major burden on the quality of life of the ever-increasing number of long-term survivors of breast cancer. An earlier report by Nissenbaum et al. claimed that particular polymorphisms in the gene CACNG2 are assoc ... Full text Link to item Cite

Sustained stimulation of β2- and β3-adrenergic receptors leads to persistent functional pain and neuroinflammation.

Journal Article Brain Behav Immun · October 2018 Functional pain syndromes, such as fibromyalgia and temporomandibular disorder, are associated with enhanced catecholamine tone and decreased levels of catechol-O-methyltransferase (COMT; an enzyme that metabolizes catecholamines). Consistent with clinical ... Full text Link to item Cite

Genomics of Cardiovascular Measures of Autonomic Tone.

Journal Article J Cardiovasc Pharmacol · March 2018 The autonomic nervous system exerts broad control over the involuntary functions of the human body through complex equilibrium between sympathetic and parasympathetic tone. Imbalance in this equilibrium is associated with a multitude of cardiovascular outc ... Full text Link to item Cite

Pain and itch outcome trajectories differ among European American and African American survivors of major thermal burn injury.

Journal Article Pain · November 2017 More than half of individuals experiencing major thermal burn injury (MThBI) receive an autologous skin graft (autograft), in which skin is removed from a healthy "donor" site and transplanted to the burn site. Persistent pain and itch at the graft site ar ... Full text Link to item Cite

Genetic variant rs3750625 in the 3'UTR of ADRA2A affects stress-dependent acute pain severity after trauma and alters a microRNA-34a regulatory site.

Journal Article Pain · February 2017 α2A adrenergic receptor (α2A-AR) activation has been shown in animal models to play an important role in regulating the balance of acute pain inhibition vs facilitation after both physical and psychological stress. To our knowledge, the influence of geneti ... Full text Open Access Link to item Cite

Modification of COMT-dependent pain sensitivity by psychological stress and sex.

Journal Article Pain · April 2016 Catecholamine-O-methyltransferase (COMT) is a polymorphic gene whose variants affect enzymatic activity and pain sensitivity via adrenergic pathways. Although COMT represents one of the most studied genes in human pain genetics, findings regarding its asso ... Full text Link to item Cite

Persistent Pain Among Older Adults Discharged Home From the Emergency Department After Motor Vehicle Crash: A Prospective Cohort Study.

Journal Article Ann Emerg Med · February 2016 STUDY OBJECTIVE: Motor vehicle crashes are the second most common form of trauma among older adults. We seek to describe the incidence, risk factors, and consequences of persistent pain among older adults evaluated in the emergency department (ED) after a ... Full text Link to item Cite

Chronic widespread pain after motor vehicle collision typically occurs through immediate development and nonrecovery: results of an emergency department-based cohort study.

Journal Article Pain · February 2016 Motor vehicle collision (MVC) can trigger chronic widespread pain (CWP) development in vulnerable individuals. Whether such CWP typically develops through the evolution of pain from regional to widespread or through the early development of widespread pain ... Full text Link to item Cite

Association of Epidemiologic Factors and Genetic Variants Influencing Hypothalamic-Pituitary-Adrenocortical Axis Function With Postconcussive Symptoms After Minor Motor Vehicle Collision.

Journal Article Psychosom Med · January 2016 OBJECTIVES: To determine the influence of epidemiologic factors and the influence of genetic variants affecting FKBP5, a protein known to modulate hypothalamic-pituitary-adrenocortical axis function, on the severity of somatic symptoms commonly termed "pos ... Full text Link to item Cite

CRHBP polymorphisms predict chronic pain development following motor vehicle collision.

Journal Article Pain · January 2016 Musculoskeletal pain (MSP) is a common sequela of traumatic stress exposure. While biological factors contributing to chronic MSP after motor vehicle collision (MVC) have traditionally focused on tissue injury, increasing evidence suggests that neuro/stres ... Full text Link to item Cite

High-dose dexmedetomidine for noninvasive pediatric procedural sedation and discharge readiness.

Journal Article Paediatr Anaesth · September 2015 BACKGROUND: The University of North Carolina's (UNC) Pediatric Sedation Service adopted a noninvasive procedural sedation protocol that uses dexmedetomidine in children based on review of literature that reported fast recovery times and low morbidity. This ... Full text Link to item Cite

Genetic Polymorphisms in the Dopamine Receptor 2 Predict Acute Pain Severity After Motor Vehicle Collision.

Journal Article Clin J Pain · September 2015 OBJECTIVES: Dopaminergic signaling is implicated in nociceptive pathways. These effects are mediated largely through dopamine receptors and modulated in part by dopamine transporters. This study tested the hypothesis that genetic variants in the genes enco ... Full text Link to item Cite

μ-Opioid Receptor Gene A118 G Variants and Persistent Pain Symptoms Among Men and Women Experiencing Motor Vehicle Collision.

Journal Article J Pain · July 2015 UNLABELLED: The μ-opioid receptor 1 (OPRM1) binds endogenous opioids. Increasing evidence suggests that endogenous OPRM1 agonists released at the time of trauma may contribute to the development of posttraumatic musculoskeletal pain (MSP). In this prospect ... Full text Link to item Cite

A noninvasive hemoglobin monitor in the pediatric intensive care unit.

Journal Article J Surg Res · May 1, 2015 BACKGROUND: Critically ill pediatric patients frequently require hemoglobin monitoring. Accurate noninvasive Hb (SpHb) would allow practitioners to decrease anemia from repeated blood draws, traumatic blood draws, and a decreased number of laboratory Hb (L ... Full text Link to item Cite

Results of a pilot multicenter genotype-based randomized placebo-controlled trial of propranolol to reduce pain after major thermal burn injury.

Journal Article Clin J Pain · January 2015 BACKGROUND: Results of previous studies suggest that β-adrenoreceptor activation may augment pain, and that β-adrenoreceptor antagonists may be effective in reducing pain, particularly in individuals not homozygous for the catechol-O-methyltransferase (COM ... Full text Link to item Cite

Gender differences in acute and chronic pain in the emergency department: results of the 2014 Academic Emergency Medicine consensus conference pain section.

Conference Acad Emerg Med · December 2014 Pain is a leading public health problem in the United States, with an annual economic burden of more than $630 billion, and is one of the most common reasons that individuals seek emergency department (ED) care. There is a paucity of data regarding sex dif ... Full text Link to item Cite

No man is an island: living in a disadvantaged neighborhood influences chronic pain development after motor vehicle collision.

Journal Article Pain · October 2014 Living in a lower socioeconomic status neighborhood has been shown to alter stress system function and is associated with a number of adverse health outcomes, but its influence on musculoskeletal pain (MSP) outcomes after traumatic stress exposures such as ... Full text Link to item Cite

Effect of pain location and duration on life function in the year after motor vehicle collision.

Journal Article Pain · September 2014 Persistent musculoskeletal pain is common after motor vehicle collision (MVC) and often results in substantial disability. The objective of this study was to identify distributions of post-MVC pain that most interfere with specific life functions and that ... Full text Link to item Cite

In reply.

Journal Article Anesthesiology · August 2014 Full text Link to item Cite

Complex multilocus effects of catechol-O-methyltransferase haplotypes predict pain and pain interference 6 weeks after motor vehicle collision.

Journal Article Neuromolecular Med · March 2014 Catechol-O-methyltransferase, encoded by COMT gene, is the primary enzyme that metabolizes catecholamines. COMT haplotypes have been associated with vulnerability to persistent non-traumatic pain. In this prospective observational study, we investigated th ... Full text Link to item Cite

Incidence and predictors of neck and widespread pain after motor vehicle collision among US litigants and nonlitigants.

Journal Article Pain · February 2014 Debate continues regarding the influence of litigation on pain outcomes after motor vehicle collision (MVC). In this study we enrolled European Americans presenting to the emergency department (ED) in the hours after MVC (n=948). Six weeks later, participa ... Full text Link to item Cite

Simulator training enhances resident performance in transesophageal echocardiography.

Journal Article Anesthesiology · January 2014 BACKGROUND: Standardized training via simulation as an educational adjunct may lead to a more rapid and complete skill achievement. The authors hypothesized that simulation training will also enhance performance in transesophageal echocardiography image ac ... Full text Link to item Cite

Enhancement of anesthesiology in-training exam performance with institution of an academic improvement policy.

Journal Article J Educ Perioper Med · 2014 BACKGROUND: Anesthesiology resident physicians across the United States complete an annual in-training examination (ITE). The ITE evaluates resident knowledge and provides personalized feedback to guide future study in low scoring sections(1). Performance ... Link to item Cite

Pain distribution and predictors of widespread pain in the immediate aftermath of motor vehicle collision.

Journal Article Eur J Pain · September 2013 BACKGROUND: Musculoskeletal pain is common after motor vehicle collision (MVC). The study objective was to evaluate distribution of pain and predictors of widespread musculoskeletal pain in the early aftermath (within 48 h) of collision. METHODS: European ... Full text Link to item Cite

Polymorphisms in the glucocorticoid receptor co-chaperone FKBP5 predict persistent musculoskeletal pain after traumatic stress exposure.

Journal Article Pain · August 2013 Individual vulnerability factors influencing the function of the hypothalamic-pituitary-adrenal axis may contribute to the risk of the development of persistent musculoskeletal pain after traumatic stress exposure. The objective of the study was to evaluat ... Full text Link to item Cite

Persistent lactic acidosis after chronic topical application of silver sulfadiazine in a pediatric burn patient: a review of the literature.

Journal Article Int J Burns Trauma · 2013 A 3-year old male who sustained 2(nd) and 3(rd) degree burns that covered approximately 60% TBSA presented to a large adult and pediatric verified burn center. On hospital day (HD) 26 of his stay, Candida fungemia was identified by blood culture, delaying ... Link to item Cite

Genetic Polymorphisms in the m -Opioid Receptor Gene and Breast Cancer Survival

Chapter · January 1, 2013 Preclinical studies suggest that endogenous opioids and/or opioid medications may contribute to tumor growth. However, endogenous and exogenous opioids have not been modulated over time in cancer patients, who often need opioids for pain control. Most of t ... Full text Cite

Randomized nutrition education intervention to improve carbohydrate counting in adolescents with type 1 diabetes study: is more intensive education needed?

Journal Article J Acad Nutr Diet · November 2012 BACKGROUND: Youth with type 1 diabetes do not count carbohydrates accurately, yet it is an important strategy in blood glucose control. OBJECTIVE: The study objective was to determine whether a nutrition education intervention would improve carbohydrate co ... Full text Link to item Cite

Older US emergency department patients are less likely to receive pain medication than younger patients: results from a national survey.

Journal Article Ann Emerg Med · August 2012 STUDY OBJECTIVE: The purpose of this study is to determine whether older adults presenting to the emergency department (ED) with pain are less likely to receive pain medication than younger adults. METHODS: Pain-related visits to US EDs were identified wit ... Full text Link to item Cite

More educated emergency department patients are less likely to receive opioids for acute pain.

Journal Article Pain · May 2012 Inadequate treatment of pain in United States emergency departments (EDs) is common, in part because of the limited and idiosyncratic use of opioids by emergency providers. This study sought to determine the relationship between patient socioeconomic chara ... Full text Link to item Cite

μ-Opioid receptor gene A118G polymorphism predicts survival in patients with breast cancer.

Journal Article Anesthesiology · April 2012 BACKGROUND: Preclinical studies suggest that opioids may promote tumor growth. Genetic polymorphisms have been shown to affect opioid receptor function and to modify the clinical effects of morphine. In this study we assessed the association between six co ... Full text Link to item Cite

Substantial postoperative pain is common among children undergoing laparoscopic appendectomy.

Journal Article Paediatr Anaesth · February 2012 BACKGROUND: Laparoscopic appendectomy is one of the most common surgical procedures performed in children. However, to our knowledge, the postoperative pain experience of children undergoing laparoscopic appendectomy has never been described. In this study ... Full text Link to item Cite

Catechol-O-methyltransferase genotype predicts pain severity in hospitalized burn patients.

Journal Article J Burn Care Res · 2012 Increasing evidence suggests that stress system activation after burn injury may contribute to burn-related pain. If this is the case, then genetic variations influencing the function of important stress system components, such as the enzyme catechol-O-met ... Full text Link to item Cite

Sugar-sweetened and diet beverage consumption is associated with cardiovascular risk factor profile in youth with type 1 diabetes.

Journal Article Acta Diabetol · December 2011 The prevalence of cardiovascular disease (CVD) risk factors among youth with type 1 diabetes is high and associated with age, gender, and race/ethnicity. It has also been shown that youth with type 1 diabetes often do not follow dietary recommendations. Th ... Full text Link to item Cite

Using emergency department-based inception cohorts to determine genetic characteristics associated with long term patient outcomes after motor vehicle collision: methodology of the CRASH study.

Journal Article BMC Emerg Med · September 26, 2011 BACKGROUND: Persistent musculoskeletal pain and psychological sequelae following minor motor vehicle collision (MVC) are common problems with a large economic cost. Prospective studies of pain following MVC have demonstrated that demographic characteristic ... Full text Link to item Cite

Response to insulin regimen-associated differences in diets of preadolescents with type 1 diabetes

Journal Article Journal of Nutrition Education and Behavior · May 1, 2011 Full text Cite

Association of DASH diet with cardiovascular risk factors in youth with diabetes mellitus: the SEARCH for Diabetes in Youth study.

Journal Article Circulation · April 5, 2011 BACKGROUND: We have shown that adherence to the Dietary Approaches to Stop Hypertension (DASH) diet is related to blood pressure in youth with type 1 and type 2 diabetes mellitus. We explored the impact of the DASH diet on other cardiovascular disease risk ... Full text Link to item Cite

Correlates of dietary intake in youth with diabetes: results from the SEARCH for diabetes in youth study.

Journal Article J Nutr Educ Behav · 2011 OBJECTIVE: To explore demographic, socioeconomic, diabetes-related, and behavioral correlates of dietary intake of dairy, fruit, vegetables, sweetened soda, fiber, calcium, and saturated fat in youth with diabetes. METHODS: Cross-sectional study of youth 1 ... Full text Link to item Cite

The carbohydrate counting in adolescents with type 1 diabetes (CCAT) study

Journal Article Diabetes Spectrum · January 1, 2009 This article reports pilot study results evaluating the accuracy of carbohydrate counting among adolescents with type 1 diabetes. This cross-sectional observational study included 48 adolescents ages 12-18 years (mean 15.2 ± 1.8 years) with type 1 diabetes ... Full text Cite

[A paradigm of evidence-based medicine: principles of clinical study].

Journal Article Zh Nevrol Psikhiatr Im S S Korsakova · 2008 Link to item Cite

[A new quality of the therapy of anxiety and depression--escitalopram].

Journal Article Zh Nevrol Psikhiatr Im S S Korsakova · 2005 Link to item Cite