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Results of a pilot multicenter genotype-based randomized placebo-controlled trial of propranolol to reduce pain after major thermal burn injury.

Publication ,  Journal Article
Orrey, DC; Halawa, OI; Bortsov, AV; Shupp, JW; Jones, SW; Haith, LR; Hoskins, JM; Jordan, MH; Bangdiwala, SI; Roane, BR; Platts-Mills, TF ...
Published in: Clin J Pain
January 2015

BACKGROUND: Results of previous studies suggest that β-adrenoreceptor activation may augment pain, and that β-adrenoreceptor antagonists may be effective in reducing pain, particularly in individuals not homozygous for the catechol-O-methyltransferase (COMT) high-activity haplotype. MATERIALS AND METHODS: Consenting patients admitted for thermal burn injury at participating burn centers were genotyped; those who were not high-activity COMT homozygotes were randomized to propranolol 240 mg/d or placebo. Primary outcomes were study feasibility (consent rate, protocol completion rate) and pain scores on study days 5 to 19. Secondary outcomes assessed pain and posttraumatic stress disorder symptoms 6 weeks postinjury. RESULTS: Seventy-seven percent (61/79) of eligible patients were consented and genotyped, and 77% (47/61) were genotype eligible and randomized. Ninety-one percent (43/47) tolerated study drug and completed primary outcome assessments. In intention-to-treat and per-protocol analyses, patients randomized to propranolol had worse pain scores on study days 5 to 19. CONCLUSIONS: Genotype-specific pain medication interventions are feasible in hospitalized burn patients. Propranolol is unlikely to be a useful analgesic during the first few weeks after burn injury.

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Published In

Clin J Pain

DOI

EISSN

1536-5409

Publication Date

January 2015

Volume

31

Issue

1

Start / End Page

21 / 29

Location

United States

Related Subject Headings

  • Young Adult
  • Treatment Outcome
  • Time Factors
  • Propranolol
  • Polymorphism, Single Nucleotide
  • Pilot Projects
  • Patient Compliance
  • Pain Measurement
  • Pain
  • Male
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Orrey, D. C., Halawa, O. I., Bortsov, A. V., Shupp, J. W., Jones, S. W., Haith, L. R., … McLean, S. A. (2015). Results of a pilot multicenter genotype-based randomized placebo-controlled trial of propranolol to reduce pain after major thermal burn injury. Clin J Pain, 31(1), 21–29. https://doi.org/10.1097/AJP.0000000000000086
Orrey, Danielle C., Omar I. Halawa, Andrey V. Bortsov, Jeffrey W. Shupp, Samuel W. Jones, Linwood R. Haith, Janelle M. Hoskins, et al. “Results of a pilot multicenter genotype-based randomized placebo-controlled trial of propranolol to reduce pain after major thermal burn injury.Clin J Pain 31, no. 1 (January 2015): 21–29. https://doi.org/10.1097/AJP.0000000000000086.
Orrey DC, Halawa OI, Bortsov AV, Shupp JW, Jones SW, Haith LR, et al. Results of a pilot multicenter genotype-based randomized placebo-controlled trial of propranolol to reduce pain after major thermal burn injury. Clin J Pain. 2015 Jan;31(1):21–9.
Orrey, Danielle C., et al. “Results of a pilot multicenter genotype-based randomized placebo-controlled trial of propranolol to reduce pain after major thermal burn injury.Clin J Pain, vol. 31, no. 1, Jan. 2015, pp. 21–29. Pubmed, doi:10.1097/AJP.0000000000000086.
Orrey DC, Halawa OI, Bortsov AV, Shupp JW, Jones SW, Haith LR, Hoskins JM, Jordan MH, Bangdiwala SI, Roane BR, Platts-Mills TF, Holmes JH, Hwang J, Cairns BA, McLean SA. Results of a pilot multicenter genotype-based randomized placebo-controlled trial of propranolol to reduce pain after major thermal burn injury. Clin J Pain. 2015 Jan;31(1):21–29.

Published In

Clin J Pain

DOI

EISSN

1536-5409

Publication Date

January 2015

Volume

31

Issue

1

Start / End Page

21 / 29

Location

United States

Related Subject Headings

  • Young Adult
  • Treatment Outcome
  • Time Factors
  • Propranolol
  • Polymorphism, Single Nucleotide
  • Pilot Projects
  • Patient Compliance
  • Pain Measurement
  • Pain
  • Male