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Immunotherapies in chronic pain through modulation of neuroimmune interactions.

Publication ,  Journal Article
Zhao, J; Huh, Y; Bortsov, A; Diatchenko, L; Ji, R-R
Published in: Pharmacol Ther
August 2023

It is generally believed that immune activation can elicit pain through production of inflammatory mediators that can activate nociceptive sensory neurons. Emerging evidence suggests that immune activation may also contribute to the resolution of pain by producing distinct pro-resolution/anti-inflammatory mediators. Recent research into the connection between the immune and nervous systems has opened new avenues for immunotherapy in pain management. This review provides an overview of the most utilized forms of immunotherapies (e.g., biologics) and highlight their potential for immune and neuronal modulation in chronic pain. Specifically, we discuss pain-related immunotherapy mechanisms that target inflammatory cytokine pathways, the PD-L1/PD-1 pathway, and the cGAS/STING pathway. This review also highlights cell-based immunotherapies targeting macrophages, T cells, neutrophils and mesenchymal stromal cells for chronic pain management.

Duke Scholars

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Published In

Pharmacol Ther

DOI

EISSN

1879-016X

Publication Date

August 2023

Volume

248

Start / End Page

108476

Location

England

Related Subject Headings

  • Pharmacology & Pharmacy
  • Neurons
  • Neuroimmunomodulation
  • Immunotherapy
  • Humans
  • Cytokines
  • Chronic Pain
  • 3214 Pharmacology and pharmaceutical sciences
  • 1115 Pharmacology and Pharmaceutical Sciences
 

Citation

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Zhao, J., Huh, Y., Bortsov, A., Diatchenko, L., & Ji, R.-R. (2023). Immunotherapies in chronic pain through modulation of neuroimmune interactions. Pharmacol Ther, 248, 108476. https://doi.org/10.1016/j.pharmthera.2023.108476
Zhao, Junli, Yul Huh, Andrey Bortsov, Luda Diatchenko, and Ru-Rong Ji. “Immunotherapies in chronic pain through modulation of neuroimmune interactions.Pharmacol Ther 248 (August 2023): 108476. https://doi.org/10.1016/j.pharmthera.2023.108476.
Zhao J, Huh Y, Bortsov A, Diatchenko L, Ji R-R. Immunotherapies in chronic pain through modulation of neuroimmune interactions. Pharmacol Ther. 2023 Aug;248:108476.
Zhao, Junli, et al. “Immunotherapies in chronic pain through modulation of neuroimmune interactions.Pharmacol Ther, vol. 248, Aug. 2023, p. 108476. Pubmed, doi:10.1016/j.pharmthera.2023.108476.
Zhao J, Huh Y, Bortsov A, Diatchenko L, Ji R-R. Immunotherapies in chronic pain through modulation of neuroimmune interactions. Pharmacol Ther. 2023 Aug;248:108476.
Journal cover image

Published In

Pharmacol Ther

DOI

EISSN

1879-016X

Publication Date

August 2023

Volume

248

Start / End Page

108476

Location

England

Related Subject Headings

  • Pharmacology & Pharmacy
  • Neurons
  • Neuroimmunomodulation
  • Immunotherapy
  • Humans
  • Cytokines
  • Chronic Pain
  • 3214 Pharmacology and pharmaceutical sciences
  • 1115 Pharmacology and Pharmaceutical Sciences