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Complex multilocus effects of catechol-O-methyltransferase haplotypes predict pain and pain interference 6 weeks after motor vehicle collision.

Publication ,  Journal Article
Bortsov, AV; Diatchenko, L; McLean, SA
Published in: Neuromolecular Med
March 2014

Catechol-O-methyltransferase, encoded by COMT gene, is the primary enzyme that metabolizes catecholamines. COMT haplotypes have been associated with vulnerability to persistent non-traumatic pain. In this prospective observational study, we investigated the influence of COMT on persistent pain and pain interference with life functions after motor vehicle collision (MVC) in 859 European American adults for whom overall pain (0-10 numeric rating scale) and pain interference (Brief Pain Inventory) were assessed at week 6 after MVC. Ten single nucleotide polymorphisms spanning the COMT gene were successfully genotyped, and nine were present in three haploblocks: block 1 (rs2020917, rs737865, rs1544325), block 2 (rs4633, rs4818, rs4680, rs165774), and block 3 (rs174697, rs165599). After adjustment for multiple comparisons, haplotype TCG from block 1 predicted decreased pain interference (p = 0.004). The pain-protective effect of the low pain sensitivity (CGGG) haplotype from block 2 was only observed if at least one TCG haplotype was present in block 1 (haplotype × haplotype interaction p = 0.002 and <0.0001 for pain and pain interference, respectively). Haplotype AG from block 3 was associated with pain and interference in males only (sex × haplotype interaction p = 0.005 and 0.0005, respectively). These results suggest that genetic variants in the distal promoter are important contributors to the development of persistent pain after MVC, directly and via the interaction with haplotypes in the coding region of the gene.

Duke Scholars

Published In

Neuromolecular Med

DOI

EISSN

1559-1174

Publication Date

March 2014

Volume

16

Issue

1

Start / End Page

83 / 93

Location

United States

Related Subject Headings

  • Young Adult
  • Time Factors
  • Sex Factors
  • Prospective Studies
  • Promoter Regions, Genetic
  • Polymorphism, Single Nucleotide
  • Pain Measurement
  • Neurology & Neurosurgery
  • Musculoskeletal Pain
  • Middle Aged
 

Citation

APA
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ICMJE
MLA
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Bortsov, A. V., Diatchenko, L., & McLean, S. A. (2014). Complex multilocus effects of catechol-O-methyltransferase haplotypes predict pain and pain interference 6 weeks after motor vehicle collision. Neuromolecular Med, 16(1), 83–93. https://doi.org/10.1007/s12017-013-8255-9
Bortsov, Andrey V., Luda Diatchenko, and Samuel A. McLean. “Complex multilocus effects of catechol-O-methyltransferase haplotypes predict pain and pain interference 6 weeks after motor vehicle collision.Neuromolecular Med 16, no. 1 (March 2014): 83–93. https://doi.org/10.1007/s12017-013-8255-9.
Bortsov, Andrey V., et al. “Complex multilocus effects of catechol-O-methyltransferase haplotypes predict pain and pain interference 6 weeks after motor vehicle collision.Neuromolecular Med, vol. 16, no. 1, Mar. 2014, pp. 83–93. Pubmed, doi:10.1007/s12017-013-8255-9.
Journal cover image

Published In

Neuromolecular Med

DOI

EISSN

1559-1174

Publication Date

March 2014

Volume

16

Issue

1

Start / End Page

83 / 93

Location

United States

Related Subject Headings

  • Young Adult
  • Time Factors
  • Sex Factors
  • Prospective Studies
  • Promoter Regions, Genetic
  • Polymorphism, Single Nucleotide
  • Pain Measurement
  • Neurology & Neurosurgery
  • Musculoskeletal Pain
  • Middle Aged