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Genomics of Cardiovascular Measures of Autonomic Tone.

Publication ,  Journal Article
Sigurdsson, MI; Waldron, NH; Bortsov, AV; Smith, SB; Maixner, W
Published in: J Cardiovasc Pharmacol
March 2018

The autonomic nervous system exerts broad control over the involuntary functions of the human body through complex equilibrium between sympathetic and parasympathetic tone. Imbalance in this equilibrium is associated with a multitude of cardiovascular outcomes, including mortality. The cardiovascular static state of this equilibrium can be quantified using physiological parameters such as heart rate (HR), blood pressure, and by spectral analysis of HR variability. Here, we review the current state of knowledge of the genetic background of cardiovascular measurements of autonomic tone. For most parameters of autonomic tone, a large portion of variability is explained by genetic heritability. Many of the static parameters of autonomic tone have also been studied through candidate-gene approach, yielding some insight into how genotypes of adrenergic receptors affect variables such as HR. Genome-wide approaches in large cohorts similarly exist for static variables such as HR and blood pressure but less is known about the genetic background of the dynamic and more specific measurements, such as HR variability. Furthermore, because most autonomic measures are likely polygenic, pathway analyses and modeling of polygenic effects are critical. Future work will hopefully explain the control of autonomic tone and guide individualized therapeutic interventions.

Duke Scholars

Published In

J Cardiovasc Pharmacol

DOI

EISSN

1533-4023

Publication Date

March 2018

Volume

71

Issue

3

Start / End Page

180 / 191

Location

United States

Related Subject Headings

  • Risk Factors
  • Prognosis
  • Phenotype
  • Pedigree
  • Multifactorial Inheritance
  • Humans
  • Heredity
  • Heart Rate
  • Genomics
  • Genome, Human
 

Citation

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Sigurdsson, M. I., Waldron, N. H., Bortsov, A. V., Smith, S. B., & Maixner, W. (2018). Genomics of Cardiovascular Measures of Autonomic Tone. J Cardiovasc Pharmacol, 71(3), 180–191. https://doi.org/10.1097/FJC.0000000000000559
Sigurdsson, Martin I., Nathan H. Waldron, Andrey V. Bortsov, Shad B. Smith, and William Maixner. “Genomics of Cardiovascular Measures of Autonomic Tone.J Cardiovasc Pharmacol 71, no. 3 (March 2018): 180–91. https://doi.org/10.1097/FJC.0000000000000559.
Sigurdsson MI, Waldron NH, Bortsov AV, Smith SB, Maixner W. Genomics of Cardiovascular Measures of Autonomic Tone. J Cardiovasc Pharmacol. 2018 Mar;71(3):180–91.
Sigurdsson, Martin I., et al. “Genomics of Cardiovascular Measures of Autonomic Tone.J Cardiovasc Pharmacol, vol. 71, no. 3, Mar. 2018, pp. 180–91. Pubmed, doi:10.1097/FJC.0000000000000559.
Sigurdsson MI, Waldron NH, Bortsov AV, Smith SB, Maixner W. Genomics of Cardiovascular Measures of Autonomic Tone. J Cardiovasc Pharmacol. 2018 Mar;71(3):180–191.

Published In

J Cardiovasc Pharmacol

DOI

EISSN

1533-4023

Publication Date

March 2018

Volume

71

Issue

3

Start / End Page

180 / 191

Location

United States

Related Subject Headings

  • Risk Factors
  • Prognosis
  • Phenotype
  • Pedigree
  • Multifactorial Inheritance
  • Humans
  • Heredity
  • Heart Rate
  • Genomics
  • Genome, Human