Scholars@Duke
Aditya Pratapa

Current Duke Appointments & Affiliations

Assist Research Professor Cell Biology, Basic Science Departments

Recent Scholarly Works

Spatial proteomic analysis in human Alzheimer's disease brains enables identification of microenvironment-dependent microglial cell states.

Journal article Nature neuroscience · July 2026 Disease-associated microglial states are thought to contribute to Alzheimer's disease (AD) progression, but characterizing them and their relationships to pathology remains challenging. Here we introduce CODEX-CNS-a multiplexed protein imaging technology w ... Full text Cite

TP53-mediated bidirectional lineage plasticity drives alveolar epithelial cell extrusion and tissue remodeling

Preprint · 2026 Cell extrusion contributes to epithelial homeostasis, but its dysregulation can lead to tumorigenesis or degeneration. A fine balance in this process is therefore essential for tissue integrity. Yet the cell types and states vulnerable to extrusion, and th ... Full text Cite

The Immunoregulatory Architecture of the Adult Oral Cavity.

Preprint · September 18, 2025 The immunoregulatory architecture of human oral tissues remains poorly defined despite their central role as barrier interfaces. We present the first integrated single cell and dual platform spatial proteotranscriptomic atlas of oral tissues, profiling >25 ... Full text Link to item Cite
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