Scholars@Duke
Amreen Dinani

Amreen Dinani

Associate Professor of Medicine
Medicine, Gastroenterology
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Selected Publications

Integrated Hepatitis C-Opioid Use Disorder Care Through Facilitated Telemedicine: A Randomized Trial.

Journal Article JAMA · April 23, 2024 IMPORTANCE: Facilitated telemedicine may promote hepatitis C virus elimination by mitigating geographic and temporal barriers. OBJECTIVE: To compare sustained virologic responses for hepatitis C virus among persons with opioid use disorder treated through ... Full text Link to item Cite

A Real-World Experience Utilizing the FAST Score to Identify Patients With Nonalcoholic Steatohepatitis Fibrosis

Conference Gastro Hep Advances · January 1, 2024 Background and Aims: We aimed to test the performance of the Fibroscan-aspartate aminotransferase (FAST) score, a noninvasive test, to identify nonalcoholic steatohepatitis (NASH) and significant fibrosis (NASH + ≥F2) in a cohort of patients with a histolo ... Full text Cite

Advanced Fibrosis in Metabolic Dysfunction-Associated Steatotic Liver Disease Is Independently Associated With Reduced Renal Function.

Journal Article Gastro Hep Adv · 2024 BACKGROUND AND AIMS: The large global population of patients with metabolic dysfunction-associated steatotic liver disease (MASLD) has recently been shown to have an association with chronic kidney disease (CKD) due to a host of proposed mechanisms, one of ... Full text Link to item Cite

Modification of the diabetes prevention program for the treatment of nonalcoholic fatty liver disease: A pilot study.

Journal Article Obes Sci Pract · June 2023 OBJECTIVE: The Diabetes Prevention Program (DPP) is the gold standard lifestyle modification program that reduces incident type 2 diabetes mellitus. Patients with prediabetes and patients with non-alcoholic fatty liver disease (NAFLD) often share metabolic ... Full text Link to item Cite

Environmental exposures are important risk factors for advanced liver fibrosis in African American adults.

Journal Article JHEP Rep · April 2023 BACKGROUND & AIMS: The prevalence and aetiology of liver fibrosis vary over time and impact racial/ethnic groups unevenly. This study measured time trends and identified factors associated with advanced liver fibrosis in the United States. METHODS: Standar ... Full text Link to item Cite

The Delta Delta: Gaps in screening and patient assessment for hepatitis D virus infection.

Journal Article J Viral Hepat · March 2023 Hepatitis D virus (HDV) infection is highly prevalent in patients with chronic hepatitis B (CHB). AASLD guidelines recommend a risk-based screening approach. Our aim was to ascertain if the risk-based approach leads to appropriate HDV screening, identify t ... Full text Link to item Cite

Patient-centered HCV care via telemedicine for individuals on medication for opioid use disorder: Telemedicine for Evaluation, Adherence and Medication for Hepatitis C (TEAM-C).

Journal Article Contemp Clin Trials · January 2022 BACKGROUND: Telemedicine has the potential to increase healthcare access especially for vulnerable populations. Telemedicine for Evaluation, Adherence, and Medication for Hepatitis C (TEAM-C) is comparing telemedicine access to specialty medical care to us ... Full text Link to item Cite

COVID-19 Vaccine-Induced Liver Injury: A Case Series

Conference AMERICAN JOURNAL OF GASTROENTEROLOGY · 2022 Cite

A Digital Case-Finding Algorithm for Diagnosed but Untreated Hepatitis C: A Tool for Increasing Linkage to Treatment and Cure.

Journal Article Hepatology · December 2021 BACKGROUND AND AIMS: Although chronic HCV infection increases mortality, thousands of patients remain diagnosed-but-untreated (DBU). We aimed to (1) develop a DBU phenotyping algorithm, (2) use it to facilitate case finding and linkage to care, and (3) ide ... Full text Link to item Cite

Application of Artificial Intelligence for Diagnosis and Risk Stratification in NAFLD and NASH: The State of the Art.

Journal Article Hepatology · October 2021 The diagnosis of nonalcoholic fatty liver disease and associated fibrosis is challenging given the lack of signs, symptoms and nonexistent diagnostic test. Furthermore, follow up and treatment decisions become complicated with a lack of a simple reproducib ... Full text Link to item Cite

Facilitating engagement of persons with opioid use disorder in treatment for hepatitis C virus infection via telemedicine: Stories of onsite case managers.

Journal Article J Subst Abuse Treat · August 2021 Although hepatitis C virus (HCV) infection has high prevalence and incidence in persons with opioid use disorder (PWOUD), their engagement in HCV care has been limited due to a variety of factors. In an ongoing multisite study at 12 opioid treatment progra ... Full text Link to item Cite

The association of impaired lung function and nonalcoholic fatty liver disease: a systematic review.

Journal Article Eur J Gastroenterol Hepatol · May 1, 2021 BACKGROUND AND AIMS: Nonalcoholic fatty liver disease (NAFLD) and impaired lung function share similar risk factors and phenotypes, such as obesity and type 2 diabetes. The study is an updated meta-analysis to evaluate the association between NAFLD and imp ... Full text Link to item Cite

Nontargeted Hepatitis C Screening in an Urban Emergency Department in New York City.

Journal Article J Emerg Med · March 2021 BACKGROUND: Previously the Centers for Disease Control and Prevention (CDC) recommended targeted hepatitis C virus (HCV) screening for adults born between 1945 and 1965 and individuals with HCV risk factors. In April 2020, the CDC updated their recommendat ... Full text Link to item Cite

Basic science to clinical trials in non-alcoholic fatty liver disease and alcohol-related liver disease: Collaboration with industry

Journal Article Translational Gastroenterology and Hepatology · January 21, 2021 Non-alcoholic fatty liver disease (NAFLD) and alcohol-related liver disease (ALD) are highly prevalent forms of chronic liver diseases globally, associated with rising all-cause morbidity and mortality. While distinct diseases, NAFLD and ALD share several ... Full text Cite

Emerging prevalence of fatty liver disease in HIV

Journal Article Future Virology · January 1, 2021 Fatty liver disease is a growing concern in people living with HIV, the main drivers are alcoholic liver disease and nonalcoholic fatty liver disease. It has shown to negatively impact HIV care continuum and result in notable non-HIV related morbidity and ... Full text Cite

Working Up an Incidental Finding of Hepatic Steatosis on Imaging

Journal Article Clinical Liver Disease · August 1, 2020 Full text Cite

Integrated Hepatitis C-Opioid Use Disorder Care Through Facilitated Telemedicine: A Randomized Trial.

Journal Article JAMA · April 23, 2024 IMPORTANCE: Facilitated telemedicine may promote hepatitis C virus elimination by mitigating geographic and temporal barriers. OBJECTIVE: To compare sustained virologic responses for hepatitis C virus among persons with opioid use disorder treated through ... Full text Link to item Cite

A Real-World Experience Utilizing the FAST Score to Identify Patients With Nonalcoholic Steatohepatitis Fibrosis

Conference Gastro Hep Advances · January 1, 2024 Background and Aims: We aimed to test the performance of the Fibroscan-aspartate aminotransferase (FAST) score, a noninvasive test, to identify nonalcoholic steatohepatitis (NASH) and significant fibrosis (NASH + ≥F2) in a cohort of patients with a histolo ... Full text Cite

Advanced Fibrosis in Metabolic Dysfunction-Associated Steatotic Liver Disease Is Independently Associated With Reduced Renal Function.

Journal Article Gastro Hep Adv · 2024 BACKGROUND AND AIMS: The large global population of patients with metabolic dysfunction-associated steatotic liver disease (MASLD) has recently been shown to have an association with chronic kidney disease (CKD) due to a host of proposed mechanisms, one of ... Full text Link to item Cite

Modification of the diabetes prevention program for the treatment of nonalcoholic fatty liver disease: A pilot study.

Journal Article Obes Sci Pract · June 2023 OBJECTIVE: The Diabetes Prevention Program (DPP) is the gold standard lifestyle modification program that reduces incident type 2 diabetes mellitus. Patients with prediabetes and patients with non-alcoholic fatty liver disease (NAFLD) often share metabolic ... Full text Link to item Cite

Environmental exposures are important risk factors for advanced liver fibrosis in African American adults.

Journal Article JHEP Rep · April 2023 BACKGROUND & AIMS: The prevalence and aetiology of liver fibrosis vary over time and impact racial/ethnic groups unevenly. This study measured time trends and identified factors associated with advanced liver fibrosis in the United States. METHODS: Standar ... Full text Link to item Cite

The Delta Delta: Gaps in screening and patient assessment for hepatitis D virus infection.

Journal Article J Viral Hepat · March 2023 Hepatitis D virus (HDV) infection is highly prevalent in patients with chronic hepatitis B (CHB). AASLD guidelines recommend a risk-based screening approach. Our aim was to ascertain if the risk-based approach leads to appropriate HDV screening, identify t ... Full text Link to item Cite

Patient-centered HCV care via telemedicine for individuals on medication for opioid use disorder: Telemedicine for Evaluation, Adherence and Medication for Hepatitis C (TEAM-C).

Journal Article Contemp Clin Trials · January 2022 BACKGROUND: Telemedicine has the potential to increase healthcare access especially for vulnerable populations. Telemedicine for Evaluation, Adherence, and Medication for Hepatitis C (TEAM-C) is comparing telemedicine access to specialty medical care to us ... Full text Link to item Cite

COVID-19 Vaccine-Induced Liver Injury: A Case Series

Conference AMERICAN JOURNAL OF GASTROENTEROLOGY · 2022 Cite

A Digital Case-Finding Algorithm for Diagnosed but Untreated Hepatitis C: A Tool for Increasing Linkage to Treatment and Cure.

Journal Article Hepatology · December 2021 BACKGROUND AND AIMS: Although chronic HCV infection increases mortality, thousands of patients remain diagnosed-but-untreated (DBU). We aimed to (1) develop a DBU phenotyping algorithm, (2) use it to facilitate case finding and linkage to care, and (3) ide ... Full text Link to item Cite

Application of Artificial Intelligence for Diagnosis and Risk Stratification in NAFLD and NASH: The State of the Art.

Journal Article Hepatology · October 2021 The diagnosis of nonalcoholic fatty liver disease and associated fibrosis is challenging given the lack of signs, symptoms and nonexistent diagnostic test. Furthermore, follow up and treatment decisions become complicated with a lack of a simple reproducib ... Full text Link to item Cite

Facilitating engagement of persons with opioid use disorder in treatment for hepatitis C virus infection via telemedicine: Stories of onsite case managers.

Journal Article J Subst Abuse Treat · August 2021 Although hepatitis C virus (HCV) infection has high prevalence and incidence in persons with opioid use disorder (PWOUD), their engagement in HCV care has been limited due to a variety of factors. In an ongoing multisite study at 12 opioid treatment progra ... Full text Link to item Cite

The association of impaired lung function and nonalcoholic fatty liver disease: a systematic review.

Journal Article Eur J Gastroenterol Hepatol · May 1, 2021 BACKGROUND AND AIMS: Nonalcoholic fatty liver disease (NAFLD) and impaired lung function share similar risk factors and phenotypes, such as obesity and type 2 diabetes. The study is an updated meta-analysis to evaluate the association between NAFLD and imp ... Full text Link to item Cite

Nontargeted Hepatitis C Screening in an Urban Emergency Department in New York City.

Journal Article J Emerg Med · March 2021 BACKGROUND: Previously the Centers for Disease Control and Prevention (CDC) recommended targeted hepatitis C virus (HCV) screening for adults born between 1945 and 1965 and individuals with HCV risk factors. In April 2020, the CDC updated their recommendat ... Full text Link to item Cite

Basic science to clinical trials in non-alcoholic fatty liver disease and alcohol-related liver disease: Collaboration with industry

Journal Article Translational Gastroenterology and Hepatology · January 21, 2021 Non-alcoholic fatty liver disease (NAFLD) and alcohol-related liver disease (ALD) are highly prevalent forms of chronic liver diseases globally, associated with rising all-cause morbidity and mortality. While distinct diseases, NAFLD and ALD share several ... Full text Cite

Emerging prevalence of fatty liver disease in HIV

Journal Article Future Virology · January 1, 2021 Fatty liver disease is a growing concern in people living with HIV, the main drivers are alcoholic liver disease and nonalcoholic fatty liver disease. It has shown to negatively impact HIV care continuum and result in notable non-HIV related morbidity and ... Full text Cite

Working Up an Incidental Finding of Hepatic Steatosis on Imaging

Journal Article Clinical Liver Disease · August 1, 2020 Full text Cite

Lifestyle interventions beyond diet and exercise for patients with nonalcoholic fatty liver disease

Journal Article Gastroenterology and Hepatology · March 1, 2020 Nonalcoholic fatty liver disease (NAFLD) is a growing worldwide concern, affecting approximately 30% of the US adult population. Developing pharmacologic therapies for NAFLD is crucial, especially as there are currently no treatments approved by the US Foo ... Cite

Liver transplant for hepatocellular carcinoma in the United States: Evolving trends over the last three decades.

Journal Article Am J Transplant · January 2020 Hepatitis C virus infection has been the most common etiology in HCC-related liver transplantation (LT). Since 2014, direct-acting antivirals (DAAs) have dramatically improved HCV cure. We aimed to study the changing pattern of etiologies and impact in out ... Full text Link to item Cite

Nonalcoholic fatty liver disease: Implications for cardiovascular risk

Journal Article Cardiovascular Endocrinology · January 1, 2017 Nonalcoholic fatty liver disease (NAFLD) is a growing epidemic in the USA affecting ∼30% of the population. It has been closely linked to metabolic syndrome and type 2 diabetes, with strong implications for cardiovascular disease (CVD). This review focuses ... Full text Cite

Endoscopic Devices for Obesity.

Journal Article Curr Obes Rep · June 2016 The obesity epidemic, recognized by the World Health Organization in 1997, refers to the rising incidence of obesity worldwide. Lifestyle modification and pharmacotherapy are often ineffective long-term solutions; bariatric surgery remains the gold standar ... Full text Link to item Cite

Predictors of Outcome in Ulcerative Colitis.

Journal Article Inflamm Bowel Dis · September 2015 BACKGROUND: Approximately 80% of patients with ulcerative colitis (UC) have intermittently active disease and up to 20% will require a colectomy, but little data available on predictors of poor disease course. The aim of this study was to identify clinical ... Full text Link to item Cite

Preoperative biological therapy and short-term outcomes of abdominal surgery in patients with inflammatory bowel disease.

Journal Article Gut · March 2013 OBJECTIVE: Previous investigations of short-term outcomes after preoperative exposure to biological therapy in inflammatory bowel disease (IBD) were conflicting. The authors aimed to assess postoperative outcomes in patients who underwent abdominal surgery ... Full text Link to item Cite

Patients with autoimmune hepatitis who have antimitochondrial antibodies need long-term follow-up to detect late development of primary biliary cirrhosis.

Journal Article Clin Gastroenterol Hepatol · June 2012 Patients with autoimmune hepatitis (AIH) who have antibodies against mitochondrial proteins (AMA positive) are believed to have an autoimmune syndrome that should be managed as AIH. Of patients with AMA-positive AIH, we report on 3 individuals to demonstra ... Full text Link to item Cite

High rates of advanced gastric cancer in community of Flushing, New York.

Conference J Gastrointest Cancer · March 2012 BACKGROUND: Gastric cancer remains a major public health issue and is a leading cause of death worldwide, accounting for 600,000 deaths annually. Over the last decades, there has been a steady decline in the incidence rates of gastric cancer. Furthermore, ... Full text Link to item Cite

Community-acquired multi-drug resistant Escherichia coli in a patient presenting with pyelonephritis

Journal Article Infectious Diseases in Clinical Practice · January 1, 2011 TEM and SHV extended-spectrum β-lactamases (ESBLs) used to be the dominant ESBLs in the 1990s, but more recently, the emergence of CTX-M enzymes have been increasingly recognized worldwide. Gram-negative rods harboring these β-lactamases represent a signif ... Full text Cite

Endoscopic management and outcomes of pregnant women hospitalized for nonvariceal upper GI bleeding: a nationwide analysis.

Journal Article Gastrointest Endosc · November 2010 BACKGROUND: Upper GI endoscopy has an important diagnostic and therapeutic role in the management of nonvariceal upper GI bleeding (NVUGB). OBJECTIVE: To characterize nationwide patterns of utilization of upper GI endoscopy in pregnant women with NVUGB and ... Full text Link to item Cite

Rifaximin therapy for metronidazole-unresponsive Clostridium difficile infection: A prospective pilot trial

Journal Article Therapeutic Advances in Gastroenterology · January 1, 2010 Background: Clostridium difficile infection (CDI) is a recent epidemic in the United States, particularly in the hospital setting. Oral metronidazole is standard therapy for C. difficile infection, but resistance to metronidazole is becoming a clinical cha ... Full text Cite

Levofloxacin-resistant-Streptococcus mitis endophthalmitis: a unique presentation of bacterial endocarditis.

Journal Article J Med Microbiol · October 2009 Endogenous endophthalmitis is a rare complication of infective endocarditis and has been decreasing due to the availability of effective antibiotics. We highlight a case of endogenous endophthalmitis due to levofloxacin-resistant Streptococcus mitis presen ... Full text Link to item Cite