Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • Fellowship, Cardiology, Penn State Milton S. Hershey Medical Center 2007 - 2010
  • Residency, Internal Medicine, Wake Forest University School Of Medicine 2004 - 2007
  • M.B.B.S., University of Mysore (India) 1995
• Publications & Artistic Works
• 

  Selected Publications

  • Books

    • Upadhya, Bharathi. The Aging Cardiovascular System Hazzard's, Geriatric Medicine and Gerontology. McGraw-Hill., 2022.
    • Upadhya, Bharathi. Effects of Aging on Cardiovascular Structure and Function. McGraw-Hill, 2017.
    • Upadhya, Bharathi. The Atlas of Cardiovascular Emergencies: Transthoracic Echocardiography For Emergency medicine. McGraw-Hill, New York, NY, 2015.
    • Upadhya, Bharathi. The Management of Patients with HF and Preserved Ejection Fraction. An Essential Clinical Guide. Heart failure by Taylor & Francis, n.d.
    • Upadhya, Bharathi. Exercise Training for Prevention and Treatment of Heart Failure with Preserved Ejection Fraction. Springer Nature book project on sports & exercise cardiology, n.d.
    • Upadhya, Bharathi. Heart failure with preserved ejection fraction in older adults. Tresch and Aronow's Cardiovascular Disease in the Elderly,, n.d.

  • Academic Articles

    • Ghazi, Lama, Rahul V. Annabathula, Natalie A. Bello, Li Zhou, Richard Brandon Stacey, and Bharathi Upadhya. “Hypertension Across a Woman's Life Cycle.” Curr Hypertens Rep 24, no. 12 (December 2022): 723–33. https://doi.org/10.1007/s11906-022-01230-4.
       Full Text  Link to Item
    • Peters, Anthony E., Dalane W. Kitzman, Haiying Chen, M Benjamin Nelson, Amy M. Pastva, Pamela W. Duncan, Gordon R. Reeves, Bharathi Upadhya, David J. Whellan, and Robert J. Mentz. “Obesity Status and Physical Rehabilitation in Older Patients Hospitalized With Acute HF: Insights From REHAB-HF.” Jacc Heart Fail 10, no. 12 (December 2022): 918–27. https://doi.org/10.1016/j.jchf.2022.07.008.
       Full Text  Link to Item
    • Ye, Fan, M Benjamin Nelson, Alain G. Bertoni, Grace L. Ditzenberger, Pamela Duncan, Robert J. Mentz, Gordon Reeves, et al. “Severity of functional impairments by race and sex in older patients hospitalized with acute decompensated heart failure.” J Am Geriatr Soc 70, no. 12 (December 2022): 3447–57. https://doi.org/10.1111/jgs.18006.
       Full Text  Link to Item
    • Brubaker, Peter H., Barbara J. Nicklas, Denise K. Houston, W Gregory Hundley, Haiying Chen, M Anthony J. A. Molina, W Mary Lyles, et al. “A Randomized, Controlled Trial of Resistance Training Added to Caloric Restriction Plus Aerobic Exercise Training in Obese Heart Failure with Preserved Ejection Fraction.” Circulation: Heart Failure, October 31, 2022. https://doi.org/10.1161/circheartfailure.122.010161.
       Full Text
    • Bloomer, Chance H., Rahul V. Annabathula, Vanya Aggarwal, Bharathi Upadhya, and Thomas W. Lycan. “A Case Report of Immune Checkpoint Inhibitor-Induced Aortitis Treated with Tocilizumab.” Edited by Rajni Rani. Case Reports in Immunology 2022 (October 12, 2022): 1–3. https://doi.org/10.1155/2022/7971169.
       Full Text
    • Skipina, Travis M., Nikhil Patel, Bharathi Upadhya, and Elsayed Z. Soliman. “Cannabis use is associated with prevalent coronary artery disease.” Am J Med Sci 364, no. 3 (September 2022): 304–8. https://doi.org/10.1016/j.amjms.2022.04.005.
       Full Text  Link to Item
    • Zaidi, Danish, Derek Williams, David Zhao, Bharathi Upadhya, and Olivia Gilbert. “Interatrial Stent to Treat Stiff Left Atrium Syndrome.” Cardiovasc Revasc Med 40S (July 2022): 337–40. https://doi.org/10.1016/j.carrev.2022.01.004.
       Full Text  Link to Item
    • Skipina, Travis M., Bharathi Upadhya, and Elsayed Z. Soliman. “Cannabis Use Is Associated with Prevalent Angina in Individuals with Diabetes.” Cannabis and Cannabinoid Research, June 29, 2022. https://doi.org/10.1089/can.2021.0175.
       Full Text
    • Annabathula, Rahul V., Li Zhou, Edward H. Kincaid, Richard B. Stacey, Sujethra Vasu, and Bharathi Upadhya. “An Unusual Cause of Acute Abdominal Pain and Unexplained Dyspnea in a Young Man: A Sinus of Valsalva Aneurysm.” Case 6, no. 4 (June 2022): 167–72. https://doi.org/10.1016/j.case.2022.02.005.
       Full Text
    • Singleton, Matthew J., M Benjamin Nelson, T Jake Samuel, Dalane W. Kitzman, Peter Brubaker, Mark J. Haykowsky, Bharathi Upadhya, Haiying Chen, and Michael D. Nelson. “Left Atrial Stiffness Index Independently Predicts Exercise Intolerance and Quality of Life in Older, Obese Patients With Heart Failure With Preserved Ejection Fraction.” J Card Fail 28, no. 4 (April 2022): 567–75. https://doi.org/10.1016/j.cardfail.2021.10.010.
       Full Text  Link to Item
    • Skipina, T. M., N. Patel, B. Upadhya, and E. Z. Soliman. “Secondhand smoke exposure is associated with abnormal P-wave axis.” Public Health 205 (April 2022): 79–82. https://doi.org/10.1016/j.puhe.2022.01.026.
       Full Text  Link to Item
    • Md, Matthew Anderson, Clifton Forrest Parrott, Mark J Haykowsky Ph D, Peter H Brubaker Ph D, Fan Ye Md, and Bharathi Upadhya Md. “Skeletal muscle abnormalities in heart failure with preserved ejection fraction.” Heart Fail Rev, March 30, 2022. https://doi.org/10.1007/s10741-022-10219-9.
       Full Text  Link to Item
    • Shah, Sanjiv J., Barry A. Borlaug, Eugene S. Chung, Donald E. Cutlip, Philippe Debonnaire, Peter S. Fail, Qi Gao, et al. “Atrial shunt device for heart failure with preserved and mildly reduced ejection fraction (REDUCE LAP-HF II): a randomised, multicentre, blinded, sham-controlled trial.” Lancet 399, no. 10330 (March 19, 2022): 1130–40. https://doi.org/10.1016/S0140-6736(22)00016-2.
       Full Text  Link to Item
    • Skipina, Travis M., Nikhil Patel, Bharathi Upadhya, and Elsayed Z. Soliman. “Relation of Cannabis Use to Elevated Atherosclerotic Cardiovascular Disease Risk Score.” Am J Cardiol 165 (February 15, 2022): 46–50. https://doi.org/10.1016/j.amjcard.2021.10.051.
       Full Text  Link to Item
    • Gjini, P., J. F. Kenes, M. Chandrasekhar, R. Hansen, A. Dharod, S. C. Smith, M. Pu, B. Upadhya, and R. B. Stacey. “Prevalence and clinical associations of mitral and aortic regurgitation in patients with aortic stenosis.” Echocardiography, January 1, 2022. https://doi.org/10.1111/echo.15503.
       Full Text
    • Upadhya, Bharathi, Patrick M. Kozak, Richard Brandon Stacey, and Ramachandran S. Vasan. “Newer Drugs to Reduce High Blood Pressure and Mitigate Hypertensive Target Organ Damage.” Curr Hypertens Rep 24, no. 1 (January 2022): 1–20. https://doi.org/10.1007/s11906-022-01166-9.
       Full Text  Link to Item
    • Upadhya, Bharathi, James J. Willard, Laura C. Lovato, Michael V. Rocco, Cora E. Lewis, Suzanne Oparil, William C. Cushman, et al. “Incidence and Outcomes of Acute Heart Failure With Preserved Versus Reduced Ejection Fraction in SPRINT.” Circ Heart Fail 14, no. 12 (December 2021): e008322. https://doi.org/10.1161/CIRCHEARTFAILURE.121.008322.
       Full Text  Link to Item
    • Amjad, Aysha, Peter H. Brubaker, and Bharathi Upadhya. “Exercise training for prevention and treatment of older adults with heart failure with preserved ejection fraction.” Exp Gerontol 155 (November 2021): 111559. https://doi.org/10.1016/j.exger.2021.111559.
       Full Text  Link to Item
    • Mentz, Robert J., David J. Whellan, Gordon R. Reeves, Amy M. Pastva, Pamela Duncan, Bharathi Upadhya, M Benjamin Nelson, et al. “Rehabilitation Intervention in Older Patients With Acute Heart Failure With Preserved Versus Reduced Ejection Fraction.” Jacc Heart Fail 9, no. 10 (October 2021): 747–57. https://doi.org/10.1016/j.jchf.2021.05.007.
       Full Text  Link to Item
    • Skipina, T. M., B. Upadhya, and E. Z. Soliman. “Secondhand Smoke Exposure is Associated with Prevalent Heart Failure: Longitudinal Examination of the National Health and Nutrition Examination Survey.” Nicotine Tob Res 23, no. 9 (August 18, 2021): 1512–17. https://doi.org/10.1093/ntr/ntab047.
       Full Text  Link to Item
    • Anderson, Theresa, Thomas M. Cascino, Todd M. Koelling, Daniel Perry, Gillian Grafton, Denise K. Houston, Bharathi Upadhya, Dalane W. Kitzman, and Scott L. Hummel. “Measured Versus Estimated Resting Metabolic Rate in Heart Failure With Preserved Ejection Fraction.” Circ Heart Fail 14, no. 8 (August 2021): e007962. https://doi.org/10.1161/CIRCHEARTFAILURE.120.007962.
       Full Text  Link to Item
    • Kitzman, Dalane W., David J. Whellan, Pamela Duncan, Amy M. Pastva, Robert J. Mentz, Gordon R. Reeves, M Benjamin Nelson, et al. “Physical Rehabilitation for Older Patients Hospitalized for Heart Failure.” N Engl J Med 385, no. 3 (July 15, 2021): 203–16. https://doi.org/10.1056/NEJMoa2026141.
       Full Text  Link to Item
    • Skipina, Travis M., Bharathi Upadhya, and Elsayed Z. Soliman. “Cannabis Use and Electrocardiographic Myocardial Injury.” Am J Cardiol 151 (July 15, 2021): 100–104. https://doi.org/10.1016/j.amjcard.2021.03.058.
       Full Text  Link to Item
    • Berdy, Andrew E., Bharathi Upadhya, Sonia Ponce, Katrina Swett, Richard B. Stacey, Robert Kaplan, Priscilla M. Vasquez, et al. “Associations between physical activity, sedentary behaviour and left ventricular structure and function from the Echocardiographic Study of Latinos (ECHO-SOL).” Open Heart 8, no. 2 (July 2021). https://doi.org/10.1136/openhrt-2021-001647.
       Full Text  Open Access Copy  Link to Item
    • Raby, Kirsten, Michael Rocco, Suzanne Oparil, Olivia N. Gilbert, and Bharathi Upadhya. “Heart Failure Primary Prevention: What Does SPRINT Add?: Recent Advances in Hypertension.” Hypertension 77, no. 6 (June 2021): 1804–14. https://doi.org/10.1161/HYPERTENSIONAHA.121.16503.
       Full Text  Link to Item
    • Skipina, T. M., B. Upadhya, and E. Z. Soliman. “Exposure to secondhand smoke is associated with increased left ventricular mass.” Tobacco Induced Diseases 19, no. June (June 1, 2021). https://doi.org/10.18332/TID/136415.
       Full Text
    • Skipina, T. M., B. Upadhya, and E. Z. Soliman. “Exposure to secondhand smoke is associated with increased left ventricular mass.” Korean Circulation Journal 51 (May 27, 2021).
    • Upadhya, Bharathi, Nicholas M. Pajewski, Michael V. Rocco, W Gregory Hundley, Gerard Aurigemma, Craig A. Hamilton, Jeffrey T. Bates, et al. “Effect of Intensive Blood Pressure Control on Aortic Stiffness in the SPRINT-HEART.” Hypertension 77, no. 5 (May 5, 2021): 1571–80. https://doi.org/10.1161/HYPERTENSIONAHA.120.16676.
       Full Text  Link to Item
    • Samuel, T Jake, Dalane W. Kitzman, Mark J. Haykowsky, Bharathi Upadhya, Peter Brubaker, M Benjamin Nelson, W Gregory Hundley, and Michael D. Nelson. “Left ventricular diastolic dysfunction and exercise intolerance in obese heart failure with preserved ejection fraction.” Am J Physiol Heart Circ Physiol 320, no. 4 (April 1, 2021): H1535–42. https://doi.org/10.1152/ajpheart.00610.2020.
       Full Text  Link to Item
    • Park, Carolyn J., Bharathi Upadhya, Min Pu, and Li Zhou. “Diagnosis of Persistent Left Superior Vena Cava: Lessons Learned from a Recurrent Stroke Case.” Case 4, no. 5 (October 2020): 320–23. https://doi.org/10.1016/j.case.2020.05.019.
       Full Text
    • Skipina, Travis M., Elsayed Z. Soliman, and Bharathi Upadhya. “Association between secondhand smoke exposure and hypertension: nearly as large as smoking.” J Hypertens 38, no. 10 (October 2020): 1899–1908. https://doi.org/10.1097/HJH.0000000000002478.
       Full Text  Link to Item
    • Xu, Jiaqian, Adrian L. Lata, Li Zhou, Bharathi Upadhya, and Min Pu. “Anticoagulation for coexisting bioprosthetic aortic valve thrombosis and anticoagulant-related bleeding: "A double edge sword".” Echocardiography 37, no. 10 (October 2020): 1687–90. https://doi.org/10.1111/echo.14857.
       Full Text  Link to Item
    • Mayl, Jonathan J., Charles A. German, Alain G. Bertoni, Bharathi Upadhya, Prashant D. Bhave, Joseph Yeboah, and Matthew J. Singleton. “Association of Alcohol Intake With Hypertension in Type 2 Diabetes Mellitus: The ACCORD Trial.” J Am Heart Assoc 9, no. 18 (September 15, 2020): e017334. https://doi.org/10.1161/JAHA.120.017334.
       Full Text  Link to Item
    • Hicklin, Harry E., Olivia N. Gilbert, Fan Ye, Jeremy E. Brooks, and Bharathi Upadhya. “Hypertension as a Road to Treatment of Heart Failure with Preserved Ejection Fraction.” Curr Hypertens Rep 22, no. 10 (September 3, 2020): 82. https://doi.org/10.1007/s11906-020-01093-7.
       Full Text  Link to Item
    • Dhaliwal, Karanpreet K., Bharathi Upadhya, Elsayed Z. Soliman, Elijah H. Beaty, Joseph Yeboah, Prashant D. Bhave, Sean P. Whalen, and Matthew J. Singleton. “Association of P-Wave Axis With Incident Atrial Fibrillation in Diabetes Mellitus (from the ACCORD Trial).” Am J Cardiol 128 (August 1, 2020): 191–95. https://doi.org/10.1016/j.amjcard.2020.05.009.
       Full Text  Link to Item
    • Kitzman, Dalane W., Bharathi Upadhya, and G Michael Felker. “A Biomarker Approach to Understanding HFpEF.” J Am Coll Cardiol 75, no. 11 (March 24, 2020): 1296–98. https://doi.org/10.1016/j.jacc.2020.01.020.
       Full Text  Link to Item
    • Upadhya, Bharathi, and Dalane W. Kitzman. “Beta-Blockers for Primary Therapy of Heart Failure With Preserved Ejection Fraction: An Idea Whose Time Has Gone?” J Card Fail 26, no. 3 (March 2020): 283–84. https://doi.org/10.1016/j.cardfail.2020.01.006.
       Full Text  Link to Item
    • Upadhya, Bharathi, Aysha Amjad, and Richard Brandon Stacey. “Optimizing The Management of Obese HFpEF Phenotype: Can We Mind Both The Heart and The Kidney?” J Card Fail 26, no. 2 (February 2020): 108–11. https://doi.org/10.1016/j.cardfail.2019.11.018.
       Full Text  Link to Item
    • Upadhya, Bharathi, and Dalane W. Kitzman. “Heart failure with preserved ejection fraction: New approaches to diagnosis and management.” Clin Cardiol 43, no. 2 (February 2020): 145–55. https://doi.org/10.1002/clc.23321.
       Full Text  Open Access Copy  Link to Item
    • Ehrhardt-Humbert, Lauren, Bharathi Upadhya, Prashant D. Bhave, Elsayed Z. Soliman, Elijah H. Beaty, Joseph Yeboah, and Matthew J. Singleton. “P-wave axis is associated with all-cause mortality in diabetes: The ACCORD trial.” J Electrocardiol 60 (2020): 184–87. https://doi.org/10.1016/j.jelectrocard.2020.04.023.
       Full Text  Link to Item
    • Kitzman, Dalane W., and Bharathi Upadhya. “Age-Related Divergence of Risk-Benefit Relationship of Spironolactone Treatment for Heart Failure With Preserved Ejection Fraction.” Jacc Heart Fail 7, no. 12 (December 2019): 1029–31. https://doi.org/10.1016/j.jchf.2019.09.006.
       Full Text  Link to Item
    • Pandey, Ambarish, Dalane Kitzman, David J. Whellan, Pamela W. Duncan, Robert J. Mentz, Amy M. Pastva, M Benjamin Nelson, Bharathi Upadhya, Haiying Chen, and Gordon R. Reeves. “Frailty Among Older Decompensated Heart Failure Patients: Prevalence, Association With Patient-Centered Outcomes, and Efficient Detection Methods.” Jacc Heart Fail 7, no. 12 (December 2019): 1079–88. https://doi.org/10.1016/j.jchf.2019.10.003.
       Full Text  Link to Item
    • Saffarzadeh, Mona, James P. Gaewsky, Joshua Tan, Ryan Lahm, Bharathi Upadhya, Geoffrey T. Jao, and Ashley A. Weaver. “Cardiothoracic Morphology Measures in Heart Failure Patients to Inform Device Designs.” Cardiovasc Eng Technol 10, no. 4 (December 2019): 543–52. https://doi.org/10.1007/s13239-019-00436-z.
       Full Text  Link to Item
    • Upadhya, Bharathi, Laura C. Lovato, Michael Rocco, Cora E. Lewis, Suzanne Oparil, William C. Cushman, John B. Kostis, et al. “Heart Failure Prevention in Older Patients Using Intensive Blood Pressure Reduction: Potential Role of Diuretics.” Jacc Heart Fail 7, no. 12 (December 2019): 1032–41. https://doi.org/10.1016/j.jchf.2019.08.018.
       Full Text  Link to Item
    • Kitzman, Dalane W., Bharathi Upadhya, and Pamela Duncan. “Falls, Subclinical Cardiovascular Disease, and a Nonagenarian's Sage Advice.” J Am Geriatr Soc 67, no. 9 (September 2019): 1774–76. https://doi.org/10.1111/jgs.16042.
       Full Text  Link to Item
    • Kitzman, Dalane W., Bharathi Upadhya, Peter H. Brubaker, Mark J. Haykowsky, and Michael D. Nelson. “Reply: Heart Failure With Preserved Ejection Fraction: Types 1 and 2?” Jacc Heart Fail 7, no. 7 (July 2019): 632–33. https://doi.org/10.1016/j.jchf.2019.02.013.
       Full Text  Link to Item
    • Upadhya, Bharathi, Michael V. Rocco, Nicholas M. Pajewski, Tim Morgan, Joseph Blackshear, William Greg Hundley, Suzanne Oparil, et al. “Effect of Intensive Blood Pressure Reduction on Left Ventricular Mass, Structure, Function, and Fibrosis in the SPRINT-HEART.” Hypertension, July 1, 2019, HYPERTENSIONAHA11913073. https://doi.org/10.1161/HYPERTENSIONAHA.119.13073.
       Full Text  Link to Item
    • Jogu, Hanumantha R., Sameer Arora, Muthiah Vaduganathan, Arman Qamar, Ambarish Pandey, Parag A. Chevli, Tusharkumar H. Pansuriya, et al. “Wake Forest University long-term follow-up of type 2 myocardial infarction: The Wake-Up T2MI Registry.” Clin Cardiol 42, no. 6 (June 2019): 592–604. https://doi.org/10.1002/clc.23182.
       Full Text  Link to Item
    • Brooks, Jeremy Earl, Elsayed Z. Soliman, and Bharathi Upadhya. “Is Left Ventricular Hypertrophy a Valid Therapeutic Target?” Curr Hypertens Rep 21, no. 6 (May 20, 2019): 47. https://doi.org/10.1007/s11906-019-0952-9.
       Full Text  Link to Item
    • Upadhya, Bharathi, Richard B. Stacey, and Dalane W. Kitzman. “Preventing Heart Failure by Treating Systolic Hypertension: What Does the SPRINT Add?” Curr Hypertens Rep 21, no. 1 (January 18, 2019): 9. https://doi.org/10.1007/s11906-019-0913-3.
       Full Text  Link to Item
    • Applegate, William B., Bharathi Upadhya, and K. Patrick Ober. “Paint by Numbers.” J Am Geriatr Soc 67, no. 1 (January 2019): 7–8. https://doi.org/10.1111/jgs.15693.
       Full Text  Link to Item
    • Upadhya, Bharathi, Mark J. Haykowsky, and Dalane W. Kitzman. “Therapy for heart failure with preserved ejection fraction: current status, unique challenges, and future directions.” Heart Fail Rev 23, no. 5 (September 2018): 609–29. https://doi.org/10.1007/s10741-018-9714-z.
       Full Text  Link to Item
    • Haykowsky, Mark J., Barbara J. Nicklas, Peter H. Brubaker, W Gregory Hundley, Tina E. Brinkley, Bharathi Upadhya, J Thomas Becton, Michael D. Nelson, Haiying Chen, and Dalane W. Kitzman. “Regional Adipose Distribution and its Relationship to Exercise Intolerance in Older Obese Patients Who Have Heart Failure With Preserved Ejection Fraction.” Jacc Heart Fail 6, no. 8 (August 2018): 640–49. https://doi.org/10.1016/j.jchf.2018.06.002.
       Full Text  Link to Item
    • Upadhya, Bharathi, Peter H. Brubaker, Timothy M. Morgan, Joel D. Eggebeen, Geoffrey T. Jao, Kathryn P. Stewart, and Dalane W. Kitzman. “The effect of Aliskiren on exercise capacity in older patients with heart failure and preserved ejection fraction: A randomized, placebo-controlled, double-blind trial.” Am Heart J 201 (July 2018): 164–67. https://doi.org/10.1016/j.ahj.2018.03.019.
       Full Text  Link to Item
    • Prasada, Sahil, Olivia N. Gilbert, Sanjay K. Gandhi, Bharathi Upadhya, and Richard Brandon Stacey. “Asymptomatic Pulmonary Artery Aneurysm with a Bicuspid Pulmonic Valve.” Tex Heart Inst J 45, no. 3 (June 2018): 190–91. https://doi.org/10.14503/THIJ-17-6347.
       Full Text  Link to Item
    • Upadhya, Bharathi, Barbara Pisani, and Dalane W. Kitzman. “Evolution of a Geriatric Syndrome: Pathophysiology and Treatment of Heart Failure with Preserved Ejection Fraction.” J Am Geriatr Soc 65, no. 11 (November 2017): 2431–40. https://doi.org/10.1111/jgs.15141.
       Full Text  Link to Item
    • Upadhya, Bharathi, William G. Hundley, Peter H. Brubaker, Timothy M. Morgan, Kathryn P. Stewart, and Dalane W. Kitzman. “Effect of Spironolactone on Exercise Tolerance and Arterial Function in Older Adults with Heart Failure with Preserved Ejection Fraction.” J Am Geriatr Soc 65, no. 11 (November 2017): 2374–82. https://doi.org/10.1111/jgs.14940.
       Full Text  Link to Item
    • Upadhya, Bharathi, and Dalane W. Kitzman. “Management of Heart Failure with Preserved Ejection Fraction: Current Challenges and Future Directions.” Am J Cardiovasc Drugs 17, no. 4 (August 2017): 283–98. https://doi.org/10.1007/s40256-017-0219-2.
       Full Text  Link to Item
    • Upadhya, Bharathi, and Dalane W. Kitzman. “Heart Failure with Preserved Ejection Fraction in Older Adults.” Heart Fail Clin 13, no. 3 (July 2017): 485–502. https://doi.org/10.1016/j.hfc.2017.02.005.
       Full Text  Link to Item
    • Kitzman, Dalane W., Bharathi Upadhya, and David Zhao. “New Concepts in an Old Disease: Exercise Intolerance in Moderate Mitral Stenosis.” Jacc Cardiovasc Imaging 10, no. 6 (June 2017): 634–36. https://doi.org/10.1016/j.jcmg.2016.09.011.
       Full Text  Link to Item
    • Upadhya, Bharathi, Michael Rocco, Cora E. Lewis, Suzanne Oparil, Laura C. Lovato, William C. Cushman, Jeffrey T. Bates, et al. “Effect of Intensive Blood Pressure Treatment on Heart Failure Events in the Systolic Blood Pressure Reduction Intervention Trial.” Circ Heart Fail 10, no. 4 (April 2017). https://doi.org/10.1161/CIRCHEARTFAILURE.116.003613.
       Full Text  Link to Item
    • Brandon Stacey, R., Meng Meng, Graham V. Byrum Iii, Olivia N. Gilbert, Bharathi Upadhya, Carlos Rodriguez, David Zhao, and Min Pu. “Clinical Outcomes in Different Types of Aortic Stenosis as Assessed by Doppler Echocardiography.” J Heart Valve Dis 25, no. 6 (November 2016): 672–78.
       Link to Item
    • Ohara, Takahiro, Hiroyuki Iwano, Vinay Thohan, Dalane W. Kitzman, Bharathi Upadhya, Min Pu, and William C. Little. “Role of Diastolic Function in Preserved Exercise Capacity in Patients with Reduced Ejection Fractions.” J Am Soc Echocardiogr 28, no. 10 (October 2015): 1184–93. https://doi.org/10.1016/j.echo.2015.06.004.
       Full Text  Link to Item
    • Stacey, Brandon R., Wesley M. Milks, Christian Deutsch, Bharathi Upadhya, Gregory W. Hundley, and Vinay Thohan. “Clinical signifi cance of intermediate left ventricular trabeculations in cardiac magnetic resonance.” Acta Cardiologica 70, no. 5 (October 2015): 588–93. https://doi.org/10.1080/ac.70.5.3110520.
       Full Text
    • Stacey, R Brandon, M Wesley Milks, Christian Deutsch, Bharathi Upadhya, W Gregory Hundley, and Vinay Thohan. “Clinical significance of intermediate left ventricular trabeculations in cardiac magnetic resonance.” Acta Cardiol 70, no. 5 (October 2015): 588–93. https://doi.org/10.2143/AC.70.5.3110520.
       Full Text  Link to Item
    • Kitzman, Dalane W., Bharthi Upadhya, and Gordon Reeves. “Hospitalizations and Prognosis in Elderly Patients With Heart Failure and Preserved Ejection Fraction: Time to Treat the Whole Patient.” Jacc Heart Fail 3, no. 6 (June 2015): 442–44. https://doi.org/10.1016/j.jchf.2015.01.009.
       Full Text  Link to Item
    • Upadhya, Bharathi, George E. Taffet, Che Ping Cheng, and Dalane W. Kitzman. “Heart failure with preserved ejection fraction in the elderly: scope of the problem.” J Mol Cell Cardiol 83 (June 2015): 73–87. https://doi.org/10.1016/j.yjmcc.2015.02.025.
       Full Text  Link to Item
    • Upadhya, Bharathi, Mark J. Haykowsky, Joel Eggebeen, and Dalane W. Kitzman. “Sarcopenic obesity and the pathogenesis of exercise intolerance in heart failure with preserved ejection fraction.” Curr Heart Fail Rep 12, no. 3 (June 2015): 205–14. https://doi.org/10.1007/s11897-015-0257-5.
       Full Text  Link to Item
    • Kitzman, Dalane W., Bharathi Upadhya, and Sujethra Vasu. “What the dead can teach the living: systemic nature of heart failure with preserved ejection fraction.” Circulation 131, no. 6 (February 10, 2015): 522–24. https://doi.org/10.1161/CIRCULATIONAHA.114.014420.
       Full Text  Link to Item
    • Milks, Michael Wesley, Bharathi Upadhya, Michael E. Hall, Sujethra Vasu, William Gregory Hundley, and Richard Brandon Stacey. “Right ventricular stress-induced perfusion defects and late gadolinium enhancement in coronary artery disease.” J Comput Assist Tomogr 39, no. 2 (2015): 185–88. https://doi.org/10.1097/RCT.0000000000000175.
       Full Text  Link to Item
    • Upadhya, B., M. J. Haykowsky, J. Eggebeen, and D. W. Kitzman. “Exercise intolerance in heart failure with preserved ejection fraction: More than a heart problem.” Journal of Geriatric Cardiology 12, no. 3 (January 1, 2015): 294–304. https://doi.org/10.11909/j.issn.1671-5411.2015.03.013.
       Full Text
    • Upadhya, Bharathi. “Exercise Intolerance in Heart Failure with Preserved Ejection Fraction: More than a heart problem.” Journal of Geriatric Cardiology 3 (2015): 442–44.
    • Lin, T., M. W. Milks, B. Upadhya, W. G. Hundley, and R. B. Stacey. “Improvement in systolic function in left ventricular non-compaction cardiomyopathy: A case report.” Journal of Cardiology Cases 10, no. 6 (December 1, 2014): 231–34. https://doi.org/10.1016/j.jccase.2014.08.004.
       Full Text
    • Gomadam, P. S., R. B. Stacey, A. E. Johnsen, D. W. Kitzman, N. D. Kon, and B. Upadhya. “Papillary fibroelastoma of the mitral valve chordae with systemic embolization.” Journal of Cardiology Cases 10, no. 4 (October 1, 2014): 125–28. https://doi.org/10.1016/j.jccase.2014.06.004.
       Full Text
    • Stacey, R Brandon, Jason Haag, Michael E. Hall, George McLeod, Bharathi Upadhya, W Gregory Hundley, and Vinay Thohan. “Mitral regurgitation in left ventricular noncompaction cardiomyopathy assessed by cardiac MRI.” J Heart Valve Dis 23, no. 5 (September 2014): 591–97.
       Link to Item
    • Stacey, Richard Brandon, Mousumi Andersen, Jason Haag, Michael E. Hall, George McLeod, Bharathi Upadhya, William Gregory Hundley, and Vinay Thohan. “Right ventricular morphology and systolic function in left ventricular noncompaction cardiomyopathy.” Am J Cardiol 113, no. 6 (March 15, 2014): 1018–23. https://doi.org/10.1016/j.amjcard.2013.12.008.
       Full Text  Link to Item
    • Kitzman, Dalane W., and Bharathi Upadhya. “Heart failure with preserved ejection fraction: a heterogenous disorder with multifactorial pathophysiology.” J Am Coll Cardiol 63, no. 5 (February 11, 2014): 457–59. https://doi.org/10.1016/j.jacc.2013.10.007.
       Full Text  Link to Item
    • Kitzman, Dalane W., and Bharathi Upadhya. “Heart Failure With Preserved Ejection Fraction.” Journal of the American College of Cardiology 63, no. 5 (February 2014): 457–59. https://doi.org/10.1016/j.jacc.2013.10.007.
       Full Text
    • Iwano, H., M. Pu, B. Upadhya, B. Meyers, P. Vlachos, and W. C. Little. “Delay of left ventricular longitudinal expansion with diastolic dysfunction: Impact on load dependence of e′ and longitudinal strain rate.” Physiological Reports 2, no. 7 (January 1, 2014). https://doi.org/10.14814/phy2.12082.
       Full Text
    • Upadhya, Bharathi, Richard Brandon Stacey, William Ntim, Mary Ann Knovich, and Min Pu. “Echocardiography-derived tricuspid regurgitant jet velocity is an important marker for the progression of sickle-cell disease.” Acta Haematol 132, no. 2 (2014): 152–58. https://doi.org/10.1159/000357393.
       Full Text  Link to Item
    • Upadhya, Bharathi, William Ntim, Richard Brandon Stacey, Rick Henderson, David Leedy, Francis X. O’Brien, and Mary Ann Knovich. “Prolongation of QTc intervals and risk of death among patients with sickle cell disease.” Eur J Haematol 91, no. 2 (August 2013): 170–78. https://doi.org/10.1111/ejh.12127.
       Full Text  Link to Item
    • Wahla, Ali S., Jimmy Ruiz, Nizar Noureddine, Bharathi Upadhya, David C. Sane, and John Owen. “Myocardial infarction in thrombotic thrombocytopenic purpura: a single-center experience and literature review.” Eur J Haematol 81, no. 4 (October 2008): 311–16. https://doi.org/10.1111/j.1600-0609.2008.01112.x.
       Full Text  Link to Item
    • Ntim, William O., Bharathi Upadhya, and Julia Cruz. “Diastolic dysfunction is an independent risk factor for death in patients with sickle cell disease.” J Am Coll Cardiol 50, no. 4 (July 24, 2007): 378. https://doi.org/10.1016/j.jacc.2007.03.043.
       Full Text  Link to Item
    • Deliargyris, Efthymios N., Bharathi Upadhya, Laura G. Melton, Cheryl Thompson, Melrose Fisher, Don A. Gabriel, Gregory J. Dehmer, and David C. Sane. “Unfractionated heparin reduces the anti-platelet effects of abciximab but not eptifibatide during PCI.” Clin Appl Thromb Hemost 12, no. 4 (October 2006): 458–64. https://doi.org/10.1177/1076029606293432.
       Full Text  Link to Item
    • Applegate, Robert J., Bharathi Upadhya, William C. Little, Mark Xenakis, Sanjay K. Gandhi, Talal T. Baki, Frederic R. Kahl, and Michael A. Kutcher. “Late outcomes after intervention of vein grafts in diabetics with abciximab use.” Int J Cardiol 111, no. 1 (July 28, 2006): 136–41. https://doi.org/10.1016/j.ijcard.2005.08.010.
       Full Text  Link to Item
    • Upadhya, Bharathi, Robert J. Applegate, David C. Sane, Efthymios N. Deliargyris, Michael A. Kutcher, Sanjay K. Gandhi, Talal T. Baki, Jason T. Call, and William C. Little. “Preprocedural white blood cell count and major adverse cardiac events late after percutaneous coronary intervention in saphenous vein grafts.” Am J Cardiol 96, no. 4 (August 15, 2005): 515–18. https://doi.org/10.1016/j.amjcard.2005.03.103.
       Full Text  Link to Item
    • Deliargyris, Efthymios N., Bharathi Upadhya, Robert J. Applegate, Jimmy L. Kontos, Michael A. Kutcher, Jeffrey S. Riesmeyer, and David C. Sane. “Safety of abciximab administration during PCI of patients with previous stroke.” J Thromb Thrombolysis 19, no. 3 (June 2005): 147–53. https://doi.org/10.1007/s11239-005-1280-2.
       Full Text  Link to Item
    • Upadhya, Bharathi, David C. Sane, Robert J. Applegate, Michael A. Kutcher, Sanjay K. Gandhi, and Efthymios N. Deliargyris. “Differences in baseline characteristics and in-hospital outcomes in patients with or without prior stroke undergoing percutaneous coronary intervention.” J Invasive Cardiol 17, no. 5 (May 2005): 243–47.
       Link to Item
    • Deliargyris, Efthymios N., Bharathi Upadhya, David C. Sane, Gregory J. Dehmer, Joseph Pye, Sidney C. Smith, William S. Boucher, and Theoharis C. Theoharides. “Mast cell tryptase: a new biomarker in patients with stable coronary artery disease.” Atherosclerosis 178, no. 2 (February 2005): 381–86. https://doi.org/10.1016/j.atherosclerosis.2004.09.008.
       Full Text  Link to Item
    • Deliargyris, Efthymios N., Bharathi Upadhya, Robert J. Applegate, Michael A. Kutcher, Sanjay K. Gandhi, and David C. Sane. “Superior in-hospital and 30-day outcomes with abciximab versus eptifibatide: a contemporary analysis of 495 consecutive percutaneous coronary interventions.” J Invasive Cardiol 16, no. 11 (November 2004): 611–16.
       Link to Item
    • Brucks, Steffen, William C. Little, Tania Chao, Ronald L. Rideman, Bharathi Upadhya, Deborah Wesley-Farrington, and David C. Sane. “Relation of anemia to diastolic heart failure and the effect on outcome.” Am J Cardiol 93, no. 8 (April 15, 2004): 1055–57. https://doi.org/10.1016/j.amjcard.2003.12.062.
       Full Text  Link to Item
    • Upadhya, Bharathi, Jimmy L. Kontos, Farhad Ardeshirpour, Joseph Pye, William S. Boucher, Theoharis C. Theoharides, Gregory J. Dehmer, and Efthymios N. Deliargyris. “Relation of serum levels of mast cell tryptase of left ventricular systolic function, left ventricular volume or congestive heart failure.” J Card Fail 10, no. 1 (February 2004): 31–35. https://doi.org/10.1016/s1071-9164(03)00586-4.
       Full Text  Link to Item

  • Conference Papers

    • Aparna, Fnu, Nicholas Pajewski, Dalane Kitzman, Bharathi Upadhya, Anthony Killeen, Sanjay Rajagopalan, Jackson Wright, Mahboob Rahman, and Mirela Dobre. “MO094: Intensive Blood Pressure Lowering and Myocardial Fibrosis Biomarkers in Individuals With and Without CKD: Results From the Systolic Blood Pressure Intervention Trial (Sprint).” In Nephrology Dialysis Transplantation, Vol. 37. Oxford University Press (OUP), 2022. https://doi.org/10.1093/ndt/gfac133.015.
       Full Text
    • Annabathula, Rahul, Vanya Aggarwal, Bharathi Upadhya, and Thomas Lycan. “IMMUNE CHECKPOINT INHIBITOR-INDUCED AORTITIS TREATED WITH TOCILIZUMAB.” In Journal of the American College of Cardiology, 79:2208–2208. Elsevier BV, 2022. https://doi.org/10.1016/s0735-1097(22)03199-0.
       Full Text
    • Patel, Nikhil, Travis Skipina, Bharathi Upadhya, and Elsayed Soliman. “Abstract 11657: Cannabis Use is Associated With Abnormal P-wave Axis.” In Circulation, Vol. 144. Ovid Technologies (Wolters Kluwer Health), 2021. https://doi.org/10.1161/circ.144.suppl_1.11657.
       Full Text
    • Skipina, T. M. S., N. P. Patel, B. U. Upadhya, and E. Z. S. Soliman. “Cannabis use is associated with prevalent coronary artery disease.” In European Heart Journal, Vol. 42. Oxford University Press (OUP), 2021. https://doi.org/10.1093/eurheartj/ehab724.1258.
       Full Text
    • Brooks, Jeremy, Stephen Smith, Emily Fishman, Rachel Bordelon, Bharathi Upadhya, Min Pu, and Brandon Stacey. “STRESS-RELATED CHEST PAIN AND ASYMPTOMATIC MYOCARDIAL ISCHEMIA IN EXERCISE STRESS ECHOCARDIOGRAM IN DIABETICS AND NON-DIABETICS.” In Journal of the American College of Cardiology, 77:1431–1431. Elsevier BV, 2021. https://doi.org/10.1016/s0735-1097(21)02789-3.
       Full Text
    • Skipina, Travis, Bharathi Upadhya, and Elsayed Soliman. “SECONDHAND SMOKE IS ASSOCIATED WITH PREVALENT HEART FAILURE: THE THIRD NATIONAL HEALTH AND NUTRITION EXAMINATION SURVEY.” In Journal of the American College of Cardiology, 77:1–1. Elsevier BV, 2021. https://doi.org/10.1016/s0735-1097(21)01344-9.
       Full Text
    • Pandey, Ambarish, Amy M. Pastva, Pamela W. Duncan, Michael Nelson, Dalane W. Kitzman, David J. Whellan, Robert J. Mentz, Haiying Chen, Bharathi Upadhya, and Gordon R. Reeves. “Relationship Between Baseline Frailty Status and Benefits of a Novel Multidomain Physical Rehabilitation Intervention Among Older Patients Hospitalized With Acute Decompensated Heart Failure: The REHAB-HF Trial.” In Circulation, Vol. 144, 2021.
       Link to Item
    • Skipina, Travis M., Bharathi Upadhya, and Elsayed Z. Soliman. “Abstract 15034: Exposure to Secondhand Smoke is Associated With Increased Left Ventricular Mass.” In Circulation, Vol. 142. Ovid Technologies (Wolters Kluwer Health), 2020. https://doi.org/10.1161/circ.142.suppl_3.15034.
       Full Text
    • Brooks, Jeremy, Stephen Smith, Bharathi Upadhya, Min Pu, and Brandon Stacey. “PREVALENCE OF ASYMPTOMATIC MYOCARDIAL ISCHEMIA IN EXERCISE STRESS ECHOCARDIOGRAPHY.” In Journal of the American College of Cardiology, 75:1612–1612. Elsevier BV, 2020. https://doi.org/10.1016/s0735-1097(20)32239-7.
       Full Text
    • Stacey, Richard B., Jonathan Brock, Petro Gjini, Jodie Franzil, Ajay Dharod, and Min Pu. “VOLUME OVERLOAD FROM MITRAL OR AORTIC REGURGITATION RESULTS IN FURTHER LV REMODELING IN AORTIC STENOSIS.” In Journal of the American College of Cardiology, 73:2013–2013. Elsevier BV, 2019. https://doi.org/10.1016/s0735-1097(19)32619-1.
       Full Text
    • Warraich, Haider J., Dalane W. Kitzman, David J. Whellan, Pamela W. Duncan, Robert J. Mentz, Amy M. Pastva, M Benjamin Nelson, Bharathi Upadhya, and Gordon R. Reeves. “Physical Function, Frailty, Cognition, Depression, and Quality of Life in Hospitalized Adults ≥60 Years With Acute Decompensated Heart Failure With Preserved Versus Reduced Ejection Fraction.” In Circ Heart Fail, 11:e005254, 2018. https://doi.org/10.1161/CIRCHEARTFAILURE.118.005254.
       Full Text  Link to Item
    • Feldman, Ted, Laura Mauri, Rami Kahwash, Sheldon Litwin, Mark J. Ricciardi, Pim van der Harst, Martin Penicka, et al. “Transcatheter Interatrial Shunt Device for the Treatment of Heart Failure With Preserved Ejection Fraction (REDUCE LAP-HF I [Reduce Elevated Left Atrial Pressure in Patients With Heart Failure]).” In Circulation, 137:364–75. Ovid Technologies (Wolters Kluwer Health), 2018. https://doi.org/10.1161/circulationaha.117.032094.
       Full Text
    • Upadhya, B., J. Williamson, and D. Kitzman. “IMPACT OF INTENSIVE BLOOD PRESSURE CONTROL ON INCIDENCE AND TYPE OF HEART FAILURE IN THE ELDERLY.” In Innovation in Aging, 1:265–265. Oxford University Press (OUP), 2017. https://doi.org/10.1093/geroni/igx004.971.
       Full Text
    • Fan, Yan, Brandon Stacey, David Zhao, Robert Applegate, Sujethra Vasu, Bharathi Upadhya, Peter Flueckiger, Pallavi Gomadam, and Min Pu. “SURGICAL RISK SCORES OUTWEIGH ECHOCARDIOGRAPHIC SEVERITY OF AORTIC STENOSIS FOR DETERMINING PROGNOSIS IN PATIENTS WITH LOW GRADIENT SEVERE AORTIC STENOSIS AND PRESERVED LEFT VENTRICULAR FUNCTION.” In Journal of the American College of Cardiology, 69:1983–1983. Elsevier BV, 2017. https://doi.org/10.1016/s0735-1097(17)35372-x.
       Full Text
    • Kitzman, D. W., S. Oparil, C. E. Lewis, B. Upadhya, L. Lovato, and M. V. Rocco. “Intensive blood pressure treatment consistently reduces heart failure events across all key subgroups in the sprint study.” In Journal of the American Society of Hypertension, 10:e3–4. Elsevier BV, 2016. https://doi.org/10.1016/j.jash.2016.03.009.
       Full Text
    • Shen, Hong, Brandon Stacey, David Zhao, Bharathi Upadhya, Sujethra Vasu, and Min Pu. “IS ATRIAL FIBRILLATION IMPORTANT FOR LOW GRADIENT SEVERE AORTIC STENOSIS WITH PRESERVED EJECTION FRACTION?” In Journal of the American College of Cardiology, 67:2231–2231. Elsevier BV, 2016. https://doi.org/10.1016/s0735-1097(16)32232-x.
       Full Text
    • Shen, Hong, Brandon Stacey, Bob Applegate, David Zhao, Sujethra Vasu, Bharathi Upadhya, Sanjay Gandhi, Rong Liu, Meng Wei, and Min Pu. “Abstract 19826: Utility of Stroke Volume Index for Stratification of Patients With Low Gradient Severe Aortic Stenosis and Normal Left Ventricular Ejection Fraction.” In Circulation, Vol. 132. Ovid Technologies (Wolters Kluwer Health), 2015. https://doi.org/10.1161/circ.132.suppl_3.19826.
       Full Text
    • Byrum, Graham, Augustus Caine, Jodi Franzil, Bharathi Upadhya, W. Hundley, and Richard Stacey. “CARDIAC-CYCLE RELATED CHANGES IN TRABECULATED LEFT VENTRICULAR VOLUME IN CARDIAC MAGNETIC RESONANCE IMAGING.” In Journal of the American College of Cardiology, 65:A1075–A1075. Elsevier BV, 2015. https://doi.org/10.1016/s0735-1097(15)61075-0.
       Full Text
    • Caine, Augustus, Jodi Franzil, Wesley Milks, Bharathi Upadhya, Gregory Hundley, and Brandon Stacey. “RACIAL DIFFERENCES IN LEFT VENTRICULAR TRABECULATIONS BY CARDIAC MAGNETIC RESONANCE IMAGING.” In Journal of the American College of Cardiology, 65:A1094–A1094. Elsevier BV, 2015. https://doi.org/10.1016/s0735-1097(15)61094-4.
       Full Text
    • Gilbert, Olivia N., Natalie Bradford, Sujethra Vasu, Bharathi Upadhya, and Min Pu. “CALCULATION OF LEFT VENTRICULAR STROKE VOLUME BY DOPPLER ECHOCARDIOGRAPHY: IS ONE METHOD BETTER THAN THE OTHER?” In Journal of the American College of Cardiology, 65:A1322–A1322. Elsevier BV, 2015. https://doi.org/10.1016/s0735-1097(15)61322-5.
       Full Text
    • Stacey, Richard B., Bharathi Upadhya, Michael M. Milks, Christian Deutsch, Tiffany Lin, William G. Hundley, and Vinay Thohan. “Abstract 17286: Reconciling Systolic and Diastolic Measures of Left Ventricular Noncompaction Cardiomyopathy in Cardiac Magnetic Resonance.” In Circulation, Vol. 130. Ovid Technologies (Wolters Kluwer Health), 2014. https://doi.org/10.1161/circ.130.suppl_2.17286.
       Full Text
    • Alvarez, Lucia, R. Brandon Stacey, Graham V. Byrum, Gregory Hundley, and Bharathi Upadhya. “Utility of late gadolinium enhancement cardiac MRI (LGE-CMRI) in troponin-positive chest pain with unobstructed coronary arteries.” In Journal of Cardiovascular Magnetic Resonance, Vol. 16. Springer Science and Business Media LLC, 2014. https://doi.org/10.1186/1532-429x-16-s1-p93.
       Full Text
    • Milks, Michael W., Bharathi Upadhya, Gregory Hundley, and R Brandon Stacey. “Right ventricular stress-induced perfusion defects and late gadolinium enhancement in coronary artery disease.” In Journal of Cardiovascular Magnetic Resonance, Vol. 16. Springer Science and Business Media LLC, 2014. https://doi.org/10.1186/1532-429x-16-s1-p210.
       Full Text
    • Upadhya, Bharathi, William Ntim, Joshua Dworkin, David Leedy, Francis X. O’Brien, Rebecca Connor, and Julia M. Cruz. “Prolongation of QTc Intervals and Risk of Sudden Death among Patients with Sickle Cell Diseases.” In Blood, 110:2249–2249. American Society of Hematology, 2007. https://doi.org/10.1182/blood.v110.11.2249.2249.
       Full Text

Some information on this profile has been compiled automatically from Duke databases and external sources. (Our About page explains how this works.) If you see a problem with the information, please write to Scholars@Duke and let us know. We will reply promptly.