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Bharathi Upadhya

Bharathi Upadhya

Associate Professor of Medicine
Medicine, Cardiology
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Selected Publications

Long-term Changes in Body Composition and Exercise Capacity Following Calorie Restriction and Exercise Training in Older Patients with Obesity and Heart Failure With Preserved Ejection Fraction.

Journal Article J Card Fail · July 4, 2024 BACKGROUND: Obesity combined with heart failure with preserved ejection fraction (HFpEF) is the dominant form of HF among older persons. In a randomized trial, we previously showed that a 5-month calorie restriction (CR) program, with or without aerobic ex ... Full text Link to item Cite

Preventing new-onset heart failure: Intervening at stage A.

Journal Article Am J Prev Cardiol · December 2023 Heart failure (HF) prevention is an urgent public health need with national and global implications. Stage A HF patients do not show HF symptoms or structural heart disease but are at risk of HF development. There are no unique recommendations on detecting ... Full text Link to item Cite

Relationship of Race With Functional and Clinical Outcomes With the REHAB-HF Multidomain Physical Rehabilitation Intervention for Older Patients With Acute Heart Failure.

Journal Article J Am Heart Assoc · November 7, 2023 Background The REHAB-HF (Rehabilitation Therapy in Older Acute Heart Failure Patients) randomized trial demonstrated that a 3-month transitional, tailored, progressive, multidomain physical rehabilitation intervention improves physical function, frailty, d ... Full text Link to item Cite

Cannabis Use Is Associated with Prevalent Angina in Individuals with Diabetes.

Journal Article Cannabis Cannabinoid Res · August 2023 Introduction: Observational studies have reported associations between cannabis use and coronary heart disease. Since diabetes is a coronary heart disease equivalent, we hypothesized that cannabis use would be associated with prevalent angina among individ ... Full text Link to item Cite

A Randomized, Controlled Trial of Resistance Training Added to Caloric Restriction Plus Aerobic Exercise Training in Obese Heart Failure With Preserved Ejection Fraction.

Journal Article Circulation. Heart failure · February 2023 BackgroundWe have shown that combined caloric restriction (CR) and aerobic exercise training (AT) improve peak exercise O2 consumption (VO2peak), and quality-of-life in older patients with obese heart failure with preserved e ... Full text Cite

Frailty and Effects of a Multidomain Physical Rehabilitation Intervention Among Older Patients Hospitalized for Acute Heart Failure: A Secondary Analysis of a Randomized Clinical Trial.

Journal Article JAMA Cardiol · February 1, 2023 IMPORTANCE: Frailty is common among older patients with acute decompensated heart failure (ADHF) and is associated with worse quality of life (QOL) and a higher risk of clinical events. Frailty can also limit recovery and response to interventions. In the ... Full text Link to item Cite

Skeletal muscle abnormalities in heart failure with preserved ejection fraction.

Journal Article Heart Fail Rev · January 2023 Almost half of all heart failure (HF) disease burden is due to HF with preserved ejection fraction (HFpEF). The primary symptom in patients with HFpEF, even when well compensated, is severe exercise intolerance and is associated with their reduced quality ... Full text Link to item Cite

Prevalence and clinical associations of mitral and aortic regurgitation in patients with aortic stenosis.

Journal Article Echocardiography · January 2023 BACKGROUND: Most guidelines directing clinicians to manage valve disease are directed at single valve lesions. Limited data exists to direct our understanding of how concomitant valve disease impacts the left ventricle (LV). METHODS: We identified 2817 pat ... Full text Link to item Cite

Severity of functional impairments by race and sex in older patients hospitalized with acute decompensated heart failure.

Journal Article J Am Geriatr Soc · December 2022 BACKGROUND: Older patients hospitalized with acute decompensated heart failure (ADHF) have marked functional impairments, which may contribute to their delayed and incomplete recovery and persistently poor outcomes. However, whether impairment severity dif ... Full text Link to item Cite

Obesity Status and Physical Rehabilitation in Older Patients Hospitalized With Acute HF: Insights From REHAB-HF.

Journal Article JACC Heart Fail · December 2022 BACKGROUND: In the REHAB-HF (Rehabilitation Therapy in Older Acute Heart Failure Patients) trial, a novel, early, transitional, multidomain rehabilitation intervention improved physical function, frailty, quality of life (QOL), and depression in older pati ... Full text Link to item Cite

Hypertension Across a Woman's Life Cycle.

Journal Article Curr Hypertens Rep · December 2022 PURPOSE OF REVIEW: We reviewed the effects of hypertension and the means to prevent and treat it across the spectrum of a woman's lifespan and identified gaps in sex-specific mechanisms contributing to hypertension in women that need to be addressed. RECEN ... Full text Link to item Cite

Cannabis use is associated with prevalent coronary artery disease.

Journal Article Am J Med Sci · September 2022 BACKGROUND: Cannabis is associated with risk of acute coronary syndrome in observational studies. However, its association with prevalent coronary artery disease (CAD) remains unclear. We hypothesized that cannabis use is associated with prevalent CAD. MET ... Full text Link to item Cite

Interatrial Stent to Treat Stiff Left Atrium Syndrome.

Journal Article Cardiovasc Revasc Med · July 2022 BACKGROUND: Catheter ablation for atrial fibrillation (CAAF) can result in stiff left atrial syndrome (SLAS) in up to 8% of patients. SLAS can be challenging to diagnose and difficult to distinguish from heart failure with preserved ejection fraction (HFpE ... Full text Link to item Cite

MO094: Intensive Blood Pressure Lowering and Myocardial Fibrosis Biomarkers in Individuals With and Without CKD: Results From the Systolic Blood Pressure Intervention Trial (Sprint)

Conference Nephrology Dialysis Transplantation · May 3, 2022 AbstractBACKGROUND AND AIMSCirculating cardiac biomarkers implicated in the pathogenesis of heart disease may provide a non-invasive, ... Full text Cite

Secondhand smoke exposure is associated with abnormal P-wave axis.

Journal Article Public Health · April 2022 OBJECTIVES: Secondhand smoke exposure (SHSE) is associated with increased risk of cerebrovascular accident (CVA). Abnormal P-wave axis (aPWA) is a marker for atriopathy that is also associated with CVA risk. We hypothesized that SHSE is associated with aPW ... Full text Link to item Cite

Long-term Changes in Body Composition and Exercise Capacity Following Calorie Restriction and Exercise Training in Older Patients with Obesity and Heart Failure With Preserved Ejection Fraction.

Journal Article J Card Fail · July 4, 2024 BACKGROUND: Obesity combined with heart failure with preserved ejection fraction (HFpEF) is the dominant form of HF among older persons. In a randomized trial, we previously showed that a 5-month calorie restriction (CR) program, with or without aerobic ex ... Full text Link to item Cite

Preventing new-onset heart failure: Intervening at stage A.

Journal Article Am J Prev Cardiol · December 2023 Heart failure (HF) prevention is an urgent public health need with national and global implications. Stage A HF patients do not show HF symptoms or structural heart disease but are at risk of HF development. There are no unique recommendations on detecting ... Full text Link to item Cite

Relationship of Race With Functional and Clinical Outcomes With the REHAB-HF Multidomain Physical Rehabilitation Intervention for Older Patients With Acute Heart Failure.

Journal Article J Am Heart Assoc · November 7, 2023 Background The REHAB-HF (Rehabilitation Therapy in Older Acute Heart Failure Patients) randomized trial demonstrated that a 3-month transitional, tailored, progressive, multidomain physical rehabilitation intervention improves physical function, frailty, d ... Full text Link to item Cite

Cannabis Use Is Associated with Prevalent Angina in Individuals with Diabetes.

Journal Article Cannabis Cannabinoid Res · August 2023 Introduction: Observational studies have reported associations between cannabis use and coronary heart disease. Since diabetes is a coronary heart disease equivalent, we hypothesized that cannabis use would be associated with prevalent angina among individ ... Full text Link to item Cite

A Randomized, Controlled Trial of Resistance Training Added to Caloric Restriction Plus Aerobic Exercise Training in Obese Heart Failure With Preserved Ejection Fraction.

Journal Article Circulation. Heart failure · February 2023 BackgroundWe have shown that combined caloric restriction (CR) and aerobic exercise training (AT) improve peak exercise O2 consumption (VO2peak), and quality-of-life in older patients with obese heart failure with preserved e ... Full text Cite

Frailty and Effects of a Multidomain Physical Rehabilitation Intervention Among Older Patients Hospitalized for Acute Heart Failure: A Secondary Analysis of a Randomized Clinical Trial.

Journal Article JAMA Cardiol · February 1, 2023 IMPORTANCE: Frailty is common among older patients with acute decompensated heart failure (ADHF) and is associated with worse quality of life (QOL) and a higher risk of clinical events. Frailty can also limit recovery and response to interventions. In the ... Full text Link to item Cite

Skeletal muscle abnormalities in heart failure with preserved ejection fraction.

Journal Article Heart Fail Rev · January 2023 Almost half of all heart failure (HF) disease burden is due to HF with preserved ejection fraction (HFpEF). The primary symptom in patients with HFpEF, even when well compensated, is severe exercise intolerance and is associated with their reduced quality ... Full text Link to item Cite

Prevalence and clinical associations of mitral and aortic regurgitation in patients with aortic stenosis.

Journal Article Echocardiography · January 2023 BACKGROUND: Most guidelines directing clinicians to manage valve disease are directed at single valve lesions. Limited data exists to direct our understanding of how concomitant valve disease impacts the left ventricle (LV). METHODS: We identified 2817 pat ... Full text Link to item Cite

Severity of functional impairments by race and sex in older patients hospitalized with acute decompensated heart failure.

Journal Article J Am Geriatr Soc · December 2022 BACKGROUND: Older patients hospitalized with acute decompensated heart failure (ADHF) have marked functional impairments, which may contribute to their delayed and incomplete recovery and persistently poor outcomes. However, whether impairment severity dif ... Full text Link to item Cite

Obesity Status and Physical Rehabilitation in Older Patients Hospitalized With Acute HF: Insights From REHAB-HF.

Journal Article JACC Heart Fail · December 2022 BACKGROUND: In the REHAB-HF (Rehabilitation Therapy in Older Acute Heart Failure Patients) trial, a novel, early, transitional, multidomain rehabilitation intervention improved physical function, frailty, quality of life (QOL), and depression in older pati ... Full text Link to item Cite

Hypertension Across a Woman's Life Cycle.

Journal Article Curr Hypertens Rep · December 2022 PURPOSE OF REVIEW: We reviewed the effects of hypertension and the means to prevent and treat it across the spectrum of a woman's lifespan and identified gaps in sex-specific mechanisms contributing to hypertension in women that need to be addressed. RECEN ... Full text Link to item Cite

Cannabis use is associated with prevalent coronary artery disease.

Journal Article Am J Med Sci · September 2022 BACKGROUND: Cannabis is associated with risk of acute coronary syndrome in observational studies. However, its association with prevalent coronary artery disease (CAD) remains unclear. We hypothesized that cannabis use is associated with prevalent CAD. MET ... Full text Link to item Cite

Interatrial Stent to Treat Stiff Left Atrium Syndrome.

Journal Article Cardiovasc Revasc Med · July 2022 BACKGROUND: Catheter ablation for atrial fibrillation (CAAF) can result in stiff left atrial syndrome (SLAS) in up to 8% of patients. SLAS can be challenging to diagnose and difficult to distinguish from heart failure with preserved ejection fraction (HFpE ... Full text Link to item Cite

MO094: Intensive Blood Pressure Lowering and Myocardial Fibrosis Biomarkers in Individuals With and Without CKD: Results From the Systolic Blood Pressure Intervention Trial (Sprint)

Conference Nephrology Dialysis Transplantation · May 3, 2022 AbstractBACKGROUND AND AIMSCirculating cardiac biomarkers implicated in the pathogenesis of heart disease may provide a non-invasive, ... Full text Cite

Secondhand smoke exposure is associated with abnormal P-wave axis.

Journal Article Public Health · April 2022 OBJECTIVES: Secondhand smoke exposure (SHSE) is associated with increased risk of cerebrovascular accident (CVA). Abnormal P-wave axis (aPWA) is a marker for atriopathy that is also associated with CVA risk. We hypothesized that SHSE is associated with aPW ... Full text Link to item Cite

Left Atrial Stiffness Index Independently Predicts Exercise Intolerance and Quality of Life in Older, Obese Patients With Heart Failure With Preserved Ejection Fraction.

Journal Article J Card Fail · April 2022 BACKGROUND: Heart failure with preserved ejection fraction (HFpEF) is the fastest growing form of HF and is associated with high morbidity and mortality. The primary chronic symptom in HFpEF is exercise intolerance, associated with reduced quality of life. ... Full text Link to item Cite

Atrial shunt device for heart failure with preserved and mildly reduced ejection fraction (REDUCE LAP-HF II): a randomised, multicentre, blinded, sham-controlled trial.

Journal Article Lancet · March 19, 2022 BACKGROUND: Placement of an interatrial shunt device reduces pulmonary capillary wedge pressure during exercise in patients with heart failure and preserved or mildly reduced ejection fraction. We aimed to investigate whether an interatrial shunt can reduc ... Full text Link to item Cite

IMMUNE CHECKPOINT INHIBITOR-INDUCED AORTITIS TREATED WITH TOCILIZUMAB

Conference Journal of the American College of Cardiology · March 2022 Full text Cite

Relation of Cannabis Use to Elevated Atherosclerotic Cardiovascular Disease Risk Score.

Journal Article Am J Cardiol · February 15, 2022 We hypothesized that cannabis use is associated with cardiovascular disease (CVD) risk factors. This could explain the reported link between cannabis and cardiovascular events including stroke and myocardial infarction. This analysis included 7,159 partici ... Full text Link to item Cite

Newer Drugs to Reduce High Blood Pressure and Mitigate Hypertensive Target Organ Damage.

Journal Article Curr Hypertens Rep · January 2022 PURPOSE OF REVIEW: This review aims to investigate the blood pressure (BP)-lowering effects of emerging drugs developed to treat diabetic kidney disease and heart failure (HF). We summarize the potential pathophysiological mechanisms responsible for mitiga ... Full text Link to item Cite

A Case Report of Immune Checkpoint Inhibitor-Induced Aortitis Treated with Tocilizumab

Journal Article Case Reports in Immunology · January 1, 2022 Vasculitic immune checkpoint inhibitor-related adverse events (irAEs) are rare, with limited data to guide their management. Here, we present a case of a 67-year-old female with stage IV cutaneous melanoma who received first-line pembrolizumab. She had com ... Full text Cite

Incidence and Outcomes of Acute Heart Failure With Preserved Versus Reduced Ejection Fraction in SPRINT.

Journal Article Circ Heart Fail · December 2021 BACKGROUND: In the SPRINT (Systolic Blood Pressure Intervention Trial), intensive BP treatment reduced acute decompensated heart failure (ADHF) events. Here, we report the effect on HF with preserved ejection fraction (HFpEF) and HF with reduced EF (HFrEF) ... Full text Link to item Cite

Abstract 11657: Cannabis Use is Associated With Abnormal P-wave Axis

Conference Circulation · November 16, 2021 Introduction: Cannabis use has been linked to incident ischemic cerebrovascular disease (CVA) and atrial arrhythmias in various case series and population studies. Full text Cite

Exercise training for prevention and treatment of older adults with heart failure with preserved ejection fraction.

Journal Article Exp Gerontol · November 2021 Heart failure (HF) with preserved ejection fraction (HFpEF) is the most rapidly increasing form of HF, occurs primarily in older women, and is associated with high rates of morbidity, mortality, and health care expenditures. In the highest age decile (≥90  ... Full text Link to item Cite

Cannabis use is associated with prevalent coronary artery disease

Conference European Heart Journal · October 12, 2021 AbstractBackgroundCannabis is the most commonly used illicit drug in the United States and has been associated with an increased risk ... Full text Cite

Rehabilitation Intervention in Older Patients With Acute Heart Failure With Preserved Versus Reduced Ejection Fraction.

Journal Article JACC Heart Fail · October 2021 OBJECTIVES: This study assessed for treatment interactions by ejection fraction (EF) subgroup (≥45% [heart failure with preserved ejection fraction (HFpEF); vs <45% [heart failure with reduced ejection fraction (HFrEF)]). BACKGROUND: The REHAB-HF trial sho ... Full text Open Access Link to item Cite

Secondhand Smoke Exposure is Associated with Prevalent Heart Failure: Longitudinal Examination of the National Health and Nutrition Examination Survey.

Journal Article Nicotine Tob Res · August 18, 2021 INTRODUCTION: Serum cotinine is a sensitive and specific biomarker for tobacco exposure including second-hand smoke exposure (SHS). We sought to examine whether SHS is associated with heart failure (HF) among non-hospitalized adults. METHODS: This analysis ... Full text Link to item Cite

Measured Versus Estimated Resting Metabolic Rate in Heart Failure With Preserved Ejection Fraction.

Journal Article Circ Heart Fail · August 2021 BACKGROUND: Obesity is common in heart failure with preserved ejection fraction (HFpEF), and a hypocaloric diet can improve functional capacity. Malnutrition, sarcopenia, and frailty are also frequently present, and calorie restriction could harm some pati ... Full text Link to item Cite

Physical Rehabilitation for Older Patients Hospitalized for Heart Failure.

Journal Article N Engl J Med · July 15, 2021 BACKGROUND: Older patients who are hospitalized for acute decompensated heart failure have high rates of physical frailty, poor quality of life, delayed recovery, and frequent rehospitalizations. Interventions to address physical frailty in this population ... Full text Link to item Cite

Cannabis Use and Electrocardiographic Myocardial Injury.

Journal Article Am J Cardiol · July 15, 2021 Multiple observational studies have demonstrated an association with cannabis use and acute myocardial infarction, especially among young adults. However, little is known about the connection with subclinical or electrocardiographic myocardial injury. We h ... Full text Link to item Cite

Associations between physical activity, sedentary behaviour and left ventricular structure and function from the Echocardiographic Study of Latinos (ECHO-SOL).

Journal Article Open Heart · July 2021 OBJECTIVE: The cross-sectional association between accelerometer-measured physical activity (PA), sedentary behaviour (SB) and cardiac structure and function is less well described. This study's primary aim was to compare echocardiographic measures of card ... Full text Open Access Link to item Cite

Exposure to secondhand smoke is associated with increased left ventricular mass

Journal Article Tobacco Induced Diseases · June 1, 2021 INTRODUCTION Chronic hypertension is associated with left ventricular hypertrophy. Recent evidence suggests that secondhand smoke (SHS) exposure is associated with chronic hypertension, so we sought to examine the relationship between secondhand smoke expo ... Full text Cite

Heart Failure Primary Prevention: What Does SPRINT Add?: Recent Advances in Hypertension.

Journal Article Hypertension · June 2021 Hypertension is the most prevalent modifiable factor for the development of heart failure. However, the optimal blood pressure (BP) target for preventing heart failure remains uncertain. The SPRINT (Systolic BP Intervention Trial) was a large, randomized o ... Full text Link to item Cite

Exposure to secondhand smoke is associated with increased left ventricular mass

Journal Article Korean Circulation Journal · May 27, 2021 INTRODUCTION Chronic hypertension is associated with left ventricular hypertrophy. Recent evidence suggests that secondhand smoke (SHS) exposure is associated with chronic hypertension, so we sought to examine the relationship between secondhand smoke expo ... Full text Cite

Left ventricular diastolic dysfunction and exercise intolerance in obese heart failure with preserved ejection fraction.

Journal Article Am J Physiol Heart Circ Physiol · April 1, 2021 This study tested the hypothesis that early left ventricular (LV) relaxation is impaired in older obese patients with heart failure with preserved ejection fraction (HFpEF), and related to decreased peak exercise oxygen uptake (peak V̇o2). LV strain and str ... Full text Link to item Cite

Abstract 15034: Exposure to Secondhand Smoke is Associated With Increased Left Ventricular Mass

Conference Circulation · November 17, 2020 Background: Exposure to secondhand smoke (SHS), or passive smoking, has been associated with chronic hypertension. However, little is known about the relationship between SHS and left ventricular (LV) ... Full text Cite

Association between secondhand smoke exposure and hypertension: nearly as large as smoking.

Journal Article J Hypertens · October 2020 : Active smoking is a widely accepted risk factor for cardiovascular disease and is recognized as a major public health problem. Passive smoking, also known as secondhand smoke exposure (SHSE), is thought to have similar cardiovascular consequences and the ... Full text Link to item Cite

Anticoagulation for coexisting bioprosthetic aortic valve thrombosis and anticoagulant-related bleeding: "A double edge sword".

Journal Article Echocardiography · October 2020 The choice of anticoagulant agents for newly implanted bioprosthetic valve varies significantly, particularly in the presence of postoperative atrial fibrillation with increasing use of nonvitamin K oral anticoagulation (NOACs) in recent years. We reported ... Full text Link to item Cite

Association of Alcohol Intake With Hypertension in Type 2 Diabetes Mellitus: The ACCORD Trial.

Journal Article J Am Heart Assoc · September 15, 2020 Background Heavy alcohol consumption has a well-established association with hypertension. However, doubt persists whether moderate alcohol consumption has a similar link. This relationship is not well-studied in patients with diabetes mellitus. We aimed t ... Full text Link to item Cite

Hypertension as a Road to Treatment of Heart Failure with Preserved Ejection Fraction.

Journal Article Curr Hypertens Rep · September 3, 2020 PURPOSE OF REVIEW: Hypertension heralds the diagnosis of heart failure (HF) with preserved ejection fraction (HFpEF) in 75-85% of cases and shares many of its adverse outcomes as well as its acute and chronic symptoms. This review provides important new da ... Full text Link to item Cite

Association of P-Wave Axis With Incident Atrial Fibrillation in Diabetes Mellitus (from the ACCORD Trial).

Journal Article Am J Cardiol · August 1, 2020 Abnormal P-wave axis may reflect preclinical atrial dysfunction and has been associated with an increased risk of incident atrial fibrillation (AF) in the general population. Patients with diabetes mellitus (DM) have a higher prevalence of AF, but the asso ... Full text Link to item Cite

A Biomarker Approach to Understanding HFpEF.

Journal Article J Am Coll Cardiol · March 24, 2020 Full text Link to item Cite

PREVALENCE OF ASYMPTOMATIC MYOCARDIAL ISCHEMIA IN EXERCISE STRESS ECHOCARDIOGRAPHY

Conference Journal of the American College of Cardiology · March 2020 Full text Cite

Heart failure with preserved ejection fraction: New approaches to diagnosis and management.

Journal Article Clin Cardiol · February 2020 The majority of older patients who develop heart failure (HF), particularly older women, have a preserved left ventricular ejection fraction (HFpEF). Patients with HFpEF have severe symptoms of exercise intolerance, poor quality-of-life, frequent hospitali ... Full text Open Access Link to item Cite

Optimizing The Management of Obese HFpEF Phenotype: Can We Mind Both The Heart and The Kidney?

Journal Article J Card Fail · February 2020 The adverse prognostic implications of significant renal dysfunction during treatment of acute decompensated heart failure (HF) in patients with obese HF and preserved ejection fraction (HFpEF) provide strong rationale for development of therapeutic strate ... Full text Link to item Cite

P-wave axis is associated with all-cause mortality in diabetes: The ACCORD trial.

Journal Article J Electrocardiol · 2020 Abnormal P-wave axis (PWA) has emerged as a novel marker of risk for both cardiovascular disease (CVD) and all-cause mortality (ACM) in the general population, though this relationship has not been adequately explored among those with type 2 diabetes (DM2) ... Full text Link to item Cite

Frailty Among Older Decompensated Heart Failure Patients: Prevalence, Association With Patient-Centered Outcomes, and Efficient Detection Methods.

Journal Article JACC Heart Fail · December 2019 OBJECTIVES: This study sought to assess the prevalence of frailty, its associations with physical function, quality of life (QoL), cognition, and depression and to investigate more efficient methods of detection in older patients hospitalized with acute de ... Full text Link to item Cite

Heart Failure Prevention in Older Patients Using Intensive Blood Pressure Reduction: Potential Role of Diuretics.

Journal Article JACC Heart Fail · December 2019 OBJECTIVES: This study assessed the potential role of differential diuretic drugs in preventing incident acute decompensated heart failure (ADHF) in the SPRINT (Systolic Blood Pressure Intervention Trial) study. BACKGROUND: SPRINT showed that intensive blo ... Full text Link to item Cite

Cardiothoracic Morphology Measures in Heart Failure Patients to Inform Device Designs.

Journal Article Cardiovasc Eng Technol · December 2019 PURPOSE: Approximately 5.7 million people in the US are affected by congestive heart failure. This study aimed to quantitatively evaluate cardiothoracic morphology and variability within a cohort of heart failure patients for the purpose of optimally engin ... Full text Link to item Cite

Effect of Intensive Blood Pressure Reduction on Left Ventricular Mass, Structure, Function, and Fibrosis in the SPRINT-HEART.

Journal Article Hypertension · August 2019 In observational studies, left ventricular mass (LVM) and structure are strong predictors of mortality and cardiovascular events. However, the effect of hypertension treatment on LVM reduction and its relation to subsequent outcomes is unclear, particularl ... Full text Link to item Cite

Wake Forest University long-term follow-up of type 2 myocardial infarction: The Wake-Up T2MI Registry.

Journal Article Clin Cardiol · June 2019 BACKGROUND: The Wake-Up T2MI Registry is a retrospective cohort study investigating patients with type 2 myocardial infarction (T2MI), acute myocardial injury, and chronic myocardial injury. We aim to explore risk stratification strategies and investigate ... Full text Link to item Cite

Is Left Ventricular Hypertrophy a Valid Therapeutic Target?

Journal Article Curr Hypertens Rep · May 20, 2019 PURPOSE OF REVIEW: The purpose of this review is to answer the question whether left ventricular hypertrophy (LVH) could be considered a therapeutic target in patients with hypertension. To fulfill this purpose, we briefly outline different methods of meas ... Full text Link to item Cite

Preventing Heart Failure by Treating Systolic Hypertension: What Does the SPRINT Add?

Journal Article Curr Hypertens Rep · January 18, 2019 PURPOSE OF REVIEW: Previous trials definitively established that lowering systolic blood pressure (BP) to 140 mmHg prevented heart failure (HF) exacerbations, but the potential benefits and risks of further BP reduction remain unclear due to a paucity of t ... Full text Link to item Cite

Paint by Numbers.

Journal Article J Am Geriatr Soc · January 2019 Full text Link to item Cite

Physical Function, Frailty, Cognition, Depression, and Quality of Life in Hospitalized Adults ≥60 Years With Acute Decompensated Heart Failure With Preserved Versus Reduced Ejection Fraction.

Conference Circ Heart Fail · November 2018 BACKGROUND: Older hospitalized acute decompensated heart failure (HF) patients have persistently poor outcomes and delayed recovery regardless of ejection fraction (EF). We hypothesized that impairments in physical function, frailty, cognition, mood, and q ... Full text Link to item Cite

Therapy for heart failure with preserved ejection fraction: current status, unique challenges, and future directions.

Journal Article Heart Fail Rev · September 2018 Heart failure (HF) with preserved ejection fraction (HFpEF) is the most common form of HF. Among elderly women, HFpEF comprises more than 80% of incident HF cases. Adverse outcomes-exercise intolerance, poor quality of life, frequent hospitalizations, and ... Full text Link to item Cite

Regional Adipose Distribution and its Relationship to Exercise Intolerance in Older Obese Patients Who Have Heart Failure With Preserved Ejection Fraction.

Journal Article JACC Heart Fail · August 2018 OBJECTIVES: This study sought to test the hypothesis that older obese patients with heart failure with preserved ejection fraction (HFpEF) have significantly greater abdominal, cardiac, and intermuscular fat than healthy, age-matched controls, out of propo ... Full text Link to item Cite

The effect of Aliskiren on exercise capacity in older patients with heart failure and preserved ejection fraction: A randomized, placebo-controlled, double-blind trial.

Journal Article Am Heart J · July 2018 In older patients (70 ± 7 years) with chronic well-compensated heart failure with preserved ejection and controlled blood pressure, 6 months treatment with aliskiren (direct renin inhibitor) showed non-significant trends for modest improvements in peak exe ... Full text Link to item Cite

Transcatheter Interatrial Shunt Device for the Treatment of Heart Failure With Preserved Ejection Fraction (REDUCE LAP-HF I [Reduce Elevated Left Atrial Pressure in Patients With Heart Failure])

Conference Circulation · January 23, 2018 Background:In nonrandomized, open-label studies, a transcatheter interatrial shunt device (IASD, Corvia Medical) was associated with lower pulmonary capillary wedge pressure (PCWP), fewer ... Full text Cite

Evolution of a Geriatric Syndrome: Pathophysiology and Treatment of Heart Failure with Preserved Ejection Fraction.

Journal Article J Am Geriatr Soc · November 2017 The majority of older adults who develop heart failure (HF), particularly older women, have a preserved left ventricular ejection fraction (HFpEF). The prevalence of this syndrome is increasing, and the prognosis is not improving, unlike that of HF with re ... Full text Link to item Cite

Effect of Spironolactone on Exercise Tolerance and Arterial Function in Older Adults with Heart Failure with Preserved Ejection Fraction.

Journal Article J Am Geriatr Soc · November 2017 OBJECTIVES: To evaluate the effects of an aldosterone antagonist on exercise intolerance in older adults with heart failure and preserved ejection fraction (HFpEF). DESIGN: Randomized, placebo-controlled, double-blind trial. SETTING: Academic medical cente ... Full text Link to item Cite

Management of Heart Failure with Preserved Ejection Fraction: Current Challenges and Future Directions.

Journal Article Am J Cardiovasc Drugs · August 2017 Heart failure (HF) with preserved ejection fraction (HFpEF) is the most common form of HF in patients older than 65 years. Among elderly women living in the community, HFpEF comprises nearly 90% of incident HF cases. The health and economic impact of HFpEF ... Full text Link to item Cite

Heart Failure with Preserved Ejection Fraction in Older Adults.

Journal Article Heart Fail Clin · July 2017 Most elderly patients, particularly women, who have heart failure, have a preserved ejection fraction. Patients with this syndrome have severe symptoms of exercise intolerance, frequent hospitalizations, and increased mortality. Despite the importance of h ... Full text Link to item Cite

Effect of Intensive Blood Pressure Treatment on Heart Failure Events in the Systolic Blood Pressure Reduction Intervention Trial.

Journal Article Circ Heart Fail · April 2017 BACKGROUND: Acute decompensated heart failure (ADHF) was a frequent common outcome in SPRINT (Systolic Blood Pressure Intervention Trial). We examined whether there was differential reduction in ADHF events from intensive blood pressure [BP] treatment amon ... Full text Link to item Cite

Clinical Outcomes in Different Types of Aortic Stenosis as Assessed by Doppler Echocardiography.

Journal Article J Heart Valve Dis · November 2016 BACKGROUND AND AIM OF THE STUDY: Cardiologists continue to struggle with the prognosis and significance of low-gradient, severe aortic stenosis (AS) with preserved ejection fraction (EF). Conflicting data makes more substantive decisions challenging. The s ... Link to item Cite

Abstract 19826: Utility of Stroke Volume Index for Stratification of Patients With Low Gradient Severe Aortic Stenosis and Normal Left Ventricular Ejection Fraction

Conference Circulation · November 10, 2015 Background: Decision of intervention for low gradient severe aortic stenosis (AS) with normal left ventricular ejection fraction (LVEF) is clinically challenging. The study was to determine the impact ... Full text Cite

Role of Diastolic Function in Preserved Exercise Capacity in Patients with Reduced Ejection Fractions.

Journal Article J Am Soc Echocardiogr · October 2015 BACKGROUND: Some patients with markedly reduced ejection fractions (EFs) (<35%) have preserved exercise performance greater than predicted for age and gender. Because diastolic function may be a determinant of exercise performance, this study was conducted ... Full text Link to item Cite

Clinical significance of intermediate left ventricular trabeculations in cardiac magnetic resonance.

Journal Article Acta Cardiol · October 2015 OBJECTIVE: Although the clinical importance of left ventricular noncompaction cardiomyopathy (LVNC) is known, few data exist that describe the prognosis associated with intermediate levels of LV trabeculations that do not meet criteria for LVNC. METHODS: T ... Full text Link to item Cite

Sarcopenic obesity and the pathogenesis of exercise intolerance in heart failure with preserved ejection fraction.

Journal Article Curr Heart Fail Rep · June 2015 Heart failure with preserved ejection fraction (HFpEF) is the most common form of heart failure (HF) in older adults. The primary chronic symptom in patients with HFpEF, even when well compensated, is severe exercise intolerance. Cardiac and peripheral fun ... Full text Link to item Cite

Heart failure with preserved ejection fraction in the elderly: scope of the problem.

Journal Article J Mol Cell Cardiol · June 2015 Heart failure with preserved ejection fraction (HFpEF) is the most common form of heart failure (HF) in older adults, particularly women, and is increasing in prevalence as the population ages. With morbidity and mortality on par with HF with reduced eject ... Full text Link to item Cite

RACIAL DIFFERENCES IN LEFT VENTRICULAR TRABECULATIONS BY CARDIAC MAGNETIC RESONANCE IMAGING

Conference Journal of the American College of Cardiology · March 2015 Full text Cite

Right ventricular stress-induced perfusion defects and late gadolinium enhancement in coronary artery disease.

Journal Article J Comput Assist Tomogr · 2015 OBJECTIVE: The assessment of right ventricular (RV) perfusion defects has remained challenging during vasodilator stress perfusion with cardiovascular magnetic resonance (CMR). The significance of RV signal abnormalities during vasodilator stress perfusion ... Full text Link to item Cite

Exercise intolerance in heart failure with preserved ejection fraction: More than a heart problem

Journal Article Journal of Geriatric Cardiology · January 1, 2015 Heart failure (HF) with preserved ejection fraction (HFpEF) is the most common form of HF in older adults, and is increasing in prevalence as the population ages. Furthermore, HFpEF is increasing out of proportion to HF with reduced EF (HFrEF), and its pro ... Full text Cite

Improvement in systolic function in left ventricular non-compaction cardiomyopathy: A case report

Journal Article Journal of Cardiology Cases · December 1, 2014 This is a case of a 48-year-old man who presented with a pulmonary embolism and was found to have left ventricular non-compaction cardiomyopathy. Initial echocardiograms demonstrated prominent apical trabeculations with reduced biventricular function. Thes ... Full text Cite

Abstract 17286: Reconciling Systolic and Diastolic Measures of Left Ventricular Noncompaction Cardiomyopathy in Cardiac Magnetic Resonance

Conference Circulation · November 25, 2014 Background: Previously, it was demonstrated that systolic measures identify higher levels of risk for events related to left ventricular noncompaction cardiomyopathy (LVNC) than diastolic measures. Th ... Full text Cite

Papillary fibroelastoma of the mitral valve chordae with systemic embolization

Journal Article Journal of Cardiology Cases · October 1, 2014 Papillary fibroelastoma (PFE) is a rare benign tumor that most commonly involves heart valves. Cardiac PFE involving the mitral chorda is rarer. Most papillary PFE are asymptomatic; rarely, they are diagnosed because of cardiac symptoms or after an embolic ... Full text Cite

Mitral regurgitation in left ventricular noncompaction cardiomyopathy assessed by cardiac MRI.

Journal Article J Heart Valve Dis · September 2014 BACKGROUND AND AIM OF THE STUDY: Previous case reports have described patients with left ventricular noncompaction cardiomyopathy (LVNC) with significant mitral regurgitation (MR). The study aim was to determine if LVNC is associated with MR, as assessed b ... Link to item Cite

Right ventricular morphology and systolic function in left ventricular noncompaction cardiomyopathy.

Journal Article Am J Cardiol · March 15, 2014 The distinction between normal right ventricular (RV) trabeculations from abnormal has been difficult. We evaluated whether RV volume and function are related to left ventricular (LV) noncompaction (NC) cardiomyopathy and clinical events. Trabeculations or ... Full text Link to item Cite

Heart Failure With Preserved Ejection Fraction

Journal Article Journal of the American College of Cardiology · February 2014 Full text Cite

Echocardiography-derived tricuspid regurgitant jet velocity is an important marker for the progression of sickle-cell disease.

Journal Article Acta Haematol · 2014 BACKGROUND: Although echocardiography-derived tricuspid regurgitant jet velocity (TRV) is associated with increased mortality in sickle-cell disease (SCD), it is unclear whether increased TRV is a marker of multiorgan disease due to systemic vasculopathy o ... Full text Link to item Cite

Delay of left ventricular longitudinal expansion with diastolic dysfunction: Impact on load dependence of e′ and longitudinal strain rate

Journal Article Physiological Reports · January 1, 2014 The effect of diastolic dysfunction (DD) on the timing of left ventricular (LV) diastolic longitudinal and circumferential expansion and their load dependence is not known. This study evaluated the timing of the peak early diastolic LV inflow velocity (E), ... Full text Cite

Prolongation of QTc intervals and risk of death among patients with sickle cell disease.

Journal Article Eur J Haematol · August 2013 BACKGROUND: Unexplained sudden death is common among patients with sickle cell diseases (SCD). QTc prolongation is a risk factor for fatal arrhythmias among adults. This study sought to identify the predictors for QTc prolongation and determine whether QTc ... Full text Link to item Cite

Myocardial infarction in thrombotic thrombocytopenic purpura: a single-center experience and literature review.

Journal Article Eur J Haematol · October 2008 BACKGROUND: Several case reports and series have described myocardial infarctions (MIs) in patients hospitalized for thrombotic thrombocytopenic purpura (TTP). The exact magnitude and outcome of this complication are unknown. METHODS: Electronic medical re ... Full text Link to item Cite

Prolongation of QTc Intervals and Risk of Sudden Death among Patients with Sickle Cell Diseases.

Conference Blood · November 16, 2007 AbstractUnexplained sudden death is common among patients (pts) with sickle cell diseases (SCD). QTc prolongation is a risk factor for fatal arrhythmias among adults. Cardiovascular autonomic dysfunction has ... Full text Cite

Unfractionated heparin reduces the anti-platelet effects of abciximab but not eptifibatide during PCI.

Journal Article Clin Appl Thromb Hemost · October 2006 In 29 patients undergoing percutaneous coronary intervention (PCI), we obtained blood samples at baseline, 10 minutes after standard weight-based abciximab (n=15) or double-bolus eptifibatide (n=14) and 5 minutes after unfractionated heparin (UFH; 70 U/kg ... Full text Link to item Cite

Late outcomes after intervention of vein grafts in diabetics with abciximab use.

Journal Article Int J Cardiol · July 28, 2006 OBJECTIVES: We sought to evaluate late clinical outcomes following elective percutaneous coronary interventions for saphenous vein graft with planned abciximab use in diabetics. BACKGROUND: Diabetes adversely affects long-term outcomes after percutaneous c ... Full text Link to item Cite

Preprocedural white blood cell count and major adverse cardiac events late after percutaneous coronary intervention in saphenous vein grafts.

Journal Article Am J Cardiol · August 15, 2005 Elevation of white blood cells (WBCs) is associated with worse outcomes in patients with coronary artery disease (CAD), including patients undergoing percutaneous coronary intervention (PCI) of native coronary arteries, but this relation has not been studi ... Full text Link to item Cite

Safety of abciximab administration during PCI of patients with previous stroke.

Journal Article J Thromb Thrombolysis · June 2005 OBJECTIVES: To examine the frequency of cerebrovascular complications among patients receiving abciximab (AB) undergoing PCI with prior intracranial hemorrhage (ICH) or recent (< 2 years) ischemic strokes. BACKGROUND: AB improves clinical outcomes in high- ... Full text Link to item Cite

Differences in baseline characteristics and in-hospital outcomes in patients with or without prior stroke undergoing percutaneous coronary intervention.

Journal Article J Invasive Cardiol · May 2005 BACKGROUND: Percutaneous coronary intervention (PCI) is increasingly used in patients with high-risk baseline characteristics. A prior stroke may identify patients who have a higher risk for post-PCI complications. However, no comparative data exist on pos ... Link to item Cite

Mast cell tryptase: a new biomarker in patients with stable coronary artery disease.

Journal Article Atherosclerosis · February 2005 Mast cells may participate actively in the inflammatory process of atherosclerotic plaques by releasing proteolytic enzymes and various other pro-inflammatory substances. We hypothesized that increased levels of mast cell tryptase, could be an important bi ... Full text Link to item Cite

Superior in-hospital and 30-day outcomes with abciximab versus eptifibatide: a contemporary analysis of 495 consecutive percutaneous coronary interventions.

Journal Article J Invasive Cardiol · November 2004 BACKGROUND: Both abciximab (AB) and eptifibatide (EP) are approved for use during percutaneous coronary intervention (PCI) but comparative data between the 2 agents are limited. METHODS: We compared in-hospital and 30-day outcomes of contemporary 495 conse ... Link to item Cite

Relation of anemia to diastolic heart failure and the effect on outcome.

Journal Article Am J Cardiol · April 15, 2004 We evaluated the frequency and importance of anemia in 137 patients with heart failure and a normal ejection fraction (diastolic heart failure). We found that anemia is common in these patients and is associated with greater elevations in serum B-type natr ... Full text Link to item Cite

Relation of serum levels of mast cell tryptase of left ventricular systolic function, left ventricular volume or congestive heart failure.

Journal Article J Card Fail · February 2004 BACKGROUND: Activated mast cells (MC) present in the myocardium of patients with cardiomyopathy may contribute to left ventricular dilatation and systolic dysfunction. We sought to determine whether peripheral levels of tryptase, an MC-specific protease, a ... Full text Link to item Cite