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Optimizing The Management of Obese HFpEF Phenotype: Can We Mind Both The Heart and The Kidney?

Publication ,  Journal Article
Upadhya, B; Amjad, A; Stacey, RB
Published in: J Card Fail
February 2020

The adverse prognostic implications of significant renal dysfunction during treatment of acute decompensated heart failure (HF) in patients with obese HF and preserved ejection fraction (HFpEF) provide strong rationale for development of therapeutic strategies that enhance decongestion while preserving renal function in this cohort. The combination of preload sensitivity, intrinsic renal dysfunction related to obesity, glomerular hyperfiltration, reversible renal hypoperfusion (poor renal arterial perfusion and renal venous congestion), and decreased systemic vascular resistance in obesity may predispose patients to renal hemodynamic compromise during diuresis. Thus, serum creatinine increase should not be evaluated in isolation but rather considered in the context of the entire clinical picture in patients with obese HFpEF.

Duke Scholars

Published In

J Card Fail

DOI

EISSN

1532-8414

Publication Date

February 2020

Volume

26

Issue

2

Start / End Page

108 / 111

Location

United States

Related Subject Headings

  • Stroke Volume
  • Phenotype
  • Obesity
  • Kidney
  • Humans
  • Heart Failure
  • Cardiovascular System & Hematology
  • 3202 Clinical sciences
  • 3201 Cardiovascular medicine and haematology
  • 1110 Nursing
 

Citation

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ICMJE
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Upadhya, B., Amjad, A., & Stacey, R. B. (2020). Optimizing The Management of Obese HFpEF Phenotype: Can We Mind Both The Heart and The Kidney? J Card Fail, 26(2), 108–111. https://doi.org/10.1016/j.cardfail.2019.11.018
Upadhya, Bharathi, Aysha Amjad, and Richard Brandon Stacey. “Optimizing The Management of Obese HFpEF Phenotype: Can We Mind Both The Heart and The Kidney?J Card Fail 26, no. 2 (February 2020): 108–11. https://doi.org/10.1016/j.cardfail.2019.11.018.
Upadhya B, Amjad A, Stacey RB. Optimizing The Management of Obese HFpEF Phenotype: Can We Mind Both The Heart and The Kidney? J Card Fail. 2020 Feb;26(2):108–11.
Upadhya, Bharathi, et al. “Optimizing The Management of Obese HFpEF Phenotype: Can We Mind Both The Heart and The Kidney?J Card Fail, vol. 26, no. 2, Feb. 2020, pp. 108–11. Pubmed, doi:10.1016/j.cardfail.2019.11.018.
Upadhya B, Amjad A, Stacey RB. Optimizing The Management of Obese HFpEF Phenotype: Can We Mind Both The Heart and The Kidney? J Card Fail. 2020 Feb;26(2):108–111.
Journal cover image

Published In

J Card Fail

DOI

EISSN

1532-8414

Publication Date

February 2020

Volume

26

Issue

2

Start / End Page

108 / 111

Location

United States

Related Subject Headings

  • Stroke Volume
  • Phenotype
  • Obesity
  • Kidney
  • Humans
  • Heart Failure
  • Cardiovascular System & Hematology
  • 3202 Clinical sciences
  • 3201 Cardiovascular medicine and haematology
  • 1110 Nursing