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The effect of Aliskiren on exercise capacity in older patients with heart failure and preserved ejection fraction: A randomized, placebo-controlled, double-blind trial.

Publication ,  Journal Article
Upadhya, B; Brubaker, PH; Morgan, TM; Eggebeen, JD; Jao, GT; Stewart, KP; Kitzman, DW
Published in: Am Heart J
July 2018

In older patients (70 ± 7 years) with chronic well-compensated heart failure with preserved ejection and controlled blood pressure, 6 months treatment with aliskiren (direct renin inhibitor) showed non-significant trends for modest improvements in peak exercise oxygen consumption (14.9 ± 0.2 mL kg-1 min-1 versus 14.4 ± 0.2 mL kg-1 min-1; P = .10, trend) and ventilatory anaerobic threshold (888 ± 19 mL/min versus 841 ± 18 mL/min; P = .08).

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Published In

Am Heart J

DOI

EISSN

1097-6744

Publication Date

July 2018

Volume

201

Start / End Page

164 / 167

Location

United States

Related Subject Headings

  • Stroke Volume
  • Randomized Controlled Trials as Topic
  • Male
  • Humans
  • Heart Failure
  • Fumarates
  • Female
  • Exercise Tolerance
  • Double-Blind Method
  • Cardiovascular System & Hematology
 

Citation

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Upadhya, B., Brubaker, P. H., Morgan, T. M., Eggebeen, J. D., Jao, G. T., Stewart, K. P., & Kitzman, D. W. (2018). The effect of Aliskiren on exercise capacity in older patients with heart failure and preserved ejection fraction: A randomized, placebo-controlled, double-blind trial. Am Heart J, 201, 164–167. https://doi.org/10.1016/j.ahj.2018.03.019
Upadhya, Bharathi, Peter H. Brubaker, Timothy M. Morgan, Joel D. Eggebeen, Geoffrey T. Jao, Kathryn P. Stewart, and Dalane W. Kitzman. “The effect of Aliskiren on exercise capacity in older patients with heart failure and preserved ejection fraction: A randomized, placebo-controlled, double-blind trial.Am Heart J 201 (July 2018): 164–67. https://doi.org/10.1016/j.ahj.2018.03.019.
Upadhya, Bharathi, et al. “The effect of Aliskiren on exercise capacity in older patients with heart failure and preserved ejection fraction: A randomized, placebo-controlled, double-blind trial.Am Heart J, vol. 201, July 2018, pp. 164–67. Pubmed, doi:10.1016/j.ahj.2018.03.019.
Upadhya B, Brubaker PH, Morgan TM, Eggebeen JD, Jao GT, Stewart KP, Kitzman DW. The effect of Aliskiren on exercise capacity in older patients with heart failure and preserved ejection fraction: A randomized, placebo-controlled, double-blind trial. Am Heart J. 2018 Jul;201:164–167.
Journal cover image

Published In

Am Heart J

DOI

EISSN

1097-6744

Publication Date

July 2018

Volume

201

Start / End Page

164 / 167

Location

United States

Related Subject Headings

  • Stroke Volume
  • Randomized Controlled Trials as Topic
  • Male
  • Humans
  • Heart Failure
  • Fumarates
  • Female
  • Exercise Tolerance
  • Double-Blind Method
  • Cardiovascular System & Hematology