Skip to main content

Incidence and Outcomes of Acute Heart Failure With Preserved Versus Reduced Ejection Fraction in SPRINT.

Publication ,  Journal Article
Upadhya, B; Willard, JJ; Lovato, LC; Rocco, MV; Lewis, CE; Oparil, S; Cushman, WC; Bates, JT; Bello, NA; Aurigemma, G; Johnson, KC; Raj, DS ...
Published in: Circ Heart Fail
December 2021

BACKGROUND: In the SPRINT (Systolic Blood Pressure Intervention Trial), intensive BP treatment reduced acute decompensated heart failure (ADHF) events. Here, we report the effect on HF with preserved ejection fraction (HFpEF) and HF with reduced EF (HFrEF) and their subsequent outcomes. METHODS: Incident ADHF was defined as hospitalization or emergency department visit, confirmed, and formally adjudicated by a blinded events committee using standardized protocols. HFpEF was defined as EF ≥45%, and HFrEF was EF <45%. RESULTS: Among the 133 participants with incident ADHF who had EF assessment, 69 (52%) had HFpEF and 64 (48%) had HFrEF (P value: 0.73). During average 3.3 years follow-up in those who developed incident ADHF, rates of subsequent all-cause and HF hospital readmission and mortality were high, but there were no significant differences between those who developed HFpEF versus HFrEF. Randomization to the intensive arm had no effect on subsequent mortality or readmissions after the initial ADHF event, irrespective of EF subtype. During follow-up among participants who developed HFpEF, although relatively modest number of events limited statistical power, age was an independent predictor of all-cause mortality, and Black race independently predicted all-cause and HF hospital readmission. CONCLUSIONS: In SPRINT, intensive BP reduction decreased both acute decompensated HFpEF and HFrEF events. After initial incident ADHF, rates of subsequent hospital admission and mortality were high and were similar for those who developed HFpEF or HFrEF. Randomization to the intensive arm did not alter the risks for subsequent all-cause, or HF events in either HFpEF or HFrEF. Among those who developed HFpEF, age and Black race were independent predictors of clinical outcomes. Registration: URL: https://www.clinicaltrials.gov; Unique identifier: NCT01206062.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Circ Heart Fail

DOI

EISSN

1941-3297

Publication Date

December 2021

Volume

14

Issue

12

Start / End Page

e008322

Location

United States

Related Subject Headings

  • Ventricular Function, Left
  • Ventricular Dysfunction, Left
  • Treatment Outcome
  • Time Factors
  • Stroke Volume
  • Risk Factors
  • Patient Readmission
  • Middle Aged
  • Male
  • Incidence
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Upadhya, B., Willard, J. J., Lovato, L. C., Rocco, M. V., Lewis, C. E., Oparil, S., … SPRINT Research Group. (2021). Incidence and Outcomes of Acute Heart Failure With Preserved Versus Reduced Ejection Fraction in SPRINT. Circ Heart Fail, 14(12), e008322. https://doi.org/10.1161/CIRCHEARTFAILURE.121.008322
Upadhya, Bharathi, James J. Willard, Laura C. Lovato, Michael V. Rocco, Cora E. Lewis, Suzanne Oparil, William C. Cushman, et al. “Incidence and Outcomes of Acute Heart Failure With Preserved Versus Reduced Ejection Fraction in SPRINT.Circ Heart Fail 14, no. 12 (December 2021): e008322. https://doi.org/10.1161/CIRCHEARTFAILURE.121.008322.
Upadhya B, Willard JJ, Lovato LC, Rocco MV, Lewis CE, Oparil S, et al. Incidence and Outcomes of Acute Heart Failure With Preserved Versus Reduced Ejection Fraction in SPRINT. Circ Heart Fail. 2021 Dec;14(12):e008322.
Upadhya, Bharathi, et al. “Incidence and Outcomes of Acute Heart Failure With Preserved Versus Reduced Ejection Fraction in SPRINT.Circ Heart Fail, vol. 14, no. 12, Dec. 2021, p. e008322. Pubmed, doi:10.1161/CIRCHEARTFAILURE.121.008322.
Upadhya B, Willard JJ, Lovato LC, Rocco MV, Lewis CE, Oparil S, Cushman WC, Bates JT, Bello NA, Aurigemma G, Johnson KC, Rodriguez CJ, Raj DS, Rastogi A, Tamariz L, Wiggers A, Kitzman DW, SPRINT Research Group. Incidence and Outcomes of Acute Heart Failure With Preserved Versus Reduced Ejection Fraction in SPRINT. Circ Heart Fail. 2021 Dec;14(12):e008322.

Published In

Circ Heart Fail

DOI

EISSN

1941-3297

Publication Date

December 2021

Volume

14

Issue

12

Start / End Page

e008322

Location

United States

Related Subject Headings

  • Ventricular Function, Left
  • Ventricular Dysfunction, Left
  • Treatment Outcome
  • Time Factors
  • Stroke Volume
  • Risk Factors
  • Patient Readmission
  • Middle Aged
  • Male
  • Incidence