Christine K. Payne | Scholars@Duke

Christine K. Payne
Associate Professor of Mechanical Engineering and Materials Science

Current Research Interests

Molecular mechanisms by which cells interact with materials, specifically nanoparticles and conducting polymers, with applications in nanomedicine and environmental exposure

Current Appointments & Affiliations

Associate Professor of Mechanical Engineering and Materials Science, Mechanical Engineering and Materials Science, Pratt School of Engineering 2018
Associate Professor of Chemistry, Chemistry, Trinity College of Arts & Sciences 2018

Contact Information

701 W. Main St., Office 4306, Chesterfield Building, Durham, NC 27701
701 W. Main St., Suite 420, Chesterfield Building, Durham, NC 27701
christine.payne@duke.edu (919) 681-2096
Google Scholar
Payne Lab

Background
Education, Training, & Certifications
- Ph.D., University of California at Berkeley 2003
Duke Appointment History
- Adjunct Associate Professor in the Department of Mechanical Engineering and Materials Sci, Mechanical Engineering and Materials Science, Pratt School of Engineering 2017 - 2018
Recognition
In the News
- JUN 8, 2018
  
  Mathematics-Bioscience Partnership to Explore Cellular Transport
- SEP 21, 2017
  
  Christine Payne: Investigating Interactions between Cells and Engineered Materials
Research
Selected Grants
- Conducting Polymer Nanowires for Neural Modulation awarded by National Institutes of Health 2015 - 2019
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Morris, JD, and Payne, CK. "Microscopy and Cell Biology: New Methods and New Questions." Annual Review of Physical Chemistry (March 18, 2019). Full Text
  - Jayaram, DT, Pustulka, SM, Mannino, RG, Lam, WA, and Payne, CK. "Protein Corona in Response to Flow: Effect on Protein Concentration and Structure." Biophysical Journal 115, no. 2 (July 2018): 209-216. Full Text
  - Runa, S, Hussey, M, and Payne, CK. "Nanoparticle-Cell Interactions: Relevance for Public Health." The Journal of Physical Chemistry. B 122, no. 3 (January 2018): 1009-1016. (Review) Full Text
  - Thourson, SB, and Payne, CK. "Modulation of action potentials using PEDOT:PSS conducting polymer microwires." Scientific Reports 7, no. 1 (December 2017). Full Text Open Access Copy
  - Runa, S, Lakadamyali, M, Kemp, ML, and Payne, CK. "TiO2 Nanoparticle-Induced Oxidation of the Plasma Membrane: Importance of the Protein Corona." The journal of physical chemistry. B 121, no. 37 (September 2017): 8619-8625. Full Text
  - Morris, JD, Thourson, SB, Panta, KR, Flanders, BN, and Payne, CK. "Conducting polymer nanowires for control of local protein concentration in solution." Journal of Physics D: Applied Physics 50, no. 17 (May 4, 2017): 174003-174003. Full Text
  - Flores, JJ, Payne, CK, and Morris, JD. "Heme protein-mediated synthesis of PEDOT: PSS: enhancing conductivity by inhibiting heme degradation." RSC Advances 7, no. 20 (2017): 12017-12021.
  - Jayaram, DT, Luo, Q, Thourson, SB, Finlay, A, and Payne, CK. "Controlling the resting membrane potential of cells with conducting polymer microwires." Small (2017): #1700789-.
  - Jayaram, DT, Runa, S, Kemp, ML, and Payne, CK. "Nanoparticle-induced oxidation of corona proteins initiates an oxidative stress response in cells." Nanoscale 9 (2017): 7595-7601.
  - Morris, JD, Wong, KM, Peñaherrera, CD, and Payne, CK. "Mechanism of the biomolecular synthesis of PEDOT: PSS: importance of heme degradation by hydrogen peroxide." Biomaterials science (2016).
  - Runa, S, Khanal, D, Kemp, ML, and Payne, CK. "TiO2 nanoparticles alter the expression of peroxiredoxin antioxidant genes." Journal of Physical Chemistry C 120 (2016): 20736-20742.
  - Morris, JD, Khanal, D, Richey, JA, and Payne, CK. "Hemoglobin-mediated synthesis of PEDOT: PSS: enhancing conductivity through biological oxidants." Biomaterials Science 3, no. 3 (2015): 442-445.
  - Warren, EAK, Netterfield, TS, Sarkar, S, Kemp, ML, and Payne, CK. "Spatially-resolved intracellular sensing of hydrogen peroxide in living cells." Scientific reports 5 (2015): #16929-.
  - Warren, EAK, and Payne, CK. "Cellular binding of nanoparticles disrupts the membrane potential." RSC Advances 5 (2015): 13660-13666.
  - Fleischer, CC, and Payne, CK. "Secondary Structure of Corona Proteins Determines the Cell Surface Receptors Used by Nanoparticles." Journal of Physical Chemistry B 118 (2014): 14017-14026.
  - Fleischer, CC, and Payne, CK. "Nanoparticle-cell interactions: Molecular structure of the protein corona and cellular outcomes." Accounts of Chemical Research 47 (2014): 2651-2659.
  - Hill, A, and Payne, CK. "Impact of serum proteins on MRI contrast agents: Cellular binding and T2 relaxation." RSC Advances 4, no. 60 (2014): 31735-31744.
  - Morris, JD, and Payne, CK. "Tuning PEDOT:PSS conductivity with iron oxidants." Organic Electronics 15 (2014): 1701-1710.
  - Runa, S, Hill, A, Cochran, VL, and Payne, CK. "PEGylated nanoparticles: protein corona and secondary structure." Proc. SPIE, Physical Chemistry of Interfaces and Nanomaterials XIII 9165 (2014): 1F1-IF8.
  - Sarkar, S, Payne, CK, and Kemp, ML. "Conditioned Media Downregulates Nuclear Expression of Nrf2." Cellular and Molecular Bioengineering 6, no. 2 (June 2013): 130-137. Full Text
  - Fleischer, CC, Kumar, U, and Payne, CK. "Cellular binding of anionic nanoparticles is inhibited by serum proteins independent of nanoparticle composition." Biomaterials Science 1 (2013): 975-982.
  - Hira, SM, and Payne, CK. "Protein-mediated synthesis of the conducting polymer PEDOT:PSS." Synthetic Metals 176 (2013): 104-107.
  - Shin, EH, Li, Y, Kumar, U, Sureka, HV, Zhang, X, and Payne, CK. "Membrane potential mediates the cellular binding of nanoparticles." Nanoscale 5, no. 13 (2013): 5879-5879. Full Text
  - Reddie, KG, Humphries, WH, Bain, CP, Payne, CK, Kemp, ML, and Murthy, N. "Fluorescent Coumarin Thiols Measure Biological Redox Couples." Organic Letters 14, no. 3 (February 3, 2012): 680-683. Full Text
  - Doorley, GW, and Payne, CK. "Nanoparticles act as protein carriers during cellular internalization." Chem. Commun. 48 (2012): 2961-2963.
  - Fleischer, CC, and Payne, CK. "Nanoparticle surface charge mediates the cellular receptors used by protein-nanoparticle complexes." Journal of Physical Chemistry B 116 (2012): 8901-8907.
  - Humphries, WH, and Payne, CK. "Imaging lysosomal enzyme activity in live cells using self-quenched substrates." Analytical Biochemistry 424 (2012): 178-183.
  - Humphries, WH, Szymanski, CJ, and Payne, CK. "Endo-lysosomal vesicles positive for Rab7 and LAMP1 are terminal vesicles for the transport of dextran." PLoS One 6 (2011): e26626-.
  - Szymanski, CJ, Humphries, IV, WH, and Payne, CK. "Single particle tracking as a method to resolve differences in highly colocalized proteins." The Analyst 136, no. 17 (2011): 3527-3527. Full Text
  - Humphries IV, WH, Fay, NC, and Payne, CK. "Intracellular degradation of low-density lipoprotein probed with two-color fluorescence microscopy." Integrative Biology 2, no. 10 (2010): 536-536. Full Text
  - Hess, GT, Humphries, WH, Fay, NC, and Payne, CK. "Cellular binding, motion, and internalization of synthetic gene delivery polymers." Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1773, no. 10 (October 2007): 1583-1588. Full Text
  - Payne, CK, Jones, SA, Chen, C, and Zhuang, X. "Internalization and Trafficking of Cell Surface Proteoglycans and Proteoglycan-Binding Ligands." Traffic 8, no. 4 (April 2007): 389-401. Full Text
  - Payne, CK. "Imaging gene delivery with fluorescence microscopy." Nanomedicine 2 (2007): 847-860. Full Text
  - Shanoski, JE, Payne, CK, Kling, MF, Glascoe, EA, and Harris, CB. "Ultrafast Infrared Mechanistic Studies of the Interaction of 1-Hexyne with Group 6 Hexacarbonyl Complexes." Organometallics 24, no. 8 (April 2005): 1852-1859. Full Text
  - Hayden, O, and Payne, CK. "Nanophotonic Light Sources for Fluorescence Spectroscopy and Cellular Imaging." Angewandte Chemie International Edition 44, no. 9 (February 18, 2005): 1395-1398. Full Text
- Book Sections
  - Szymanski, CJ, Yi, H, Liu, JT, Wright, ER, and Payne, CK. "Imaging intracellular quantum dots: Fluorescence microscopy and transmission electron microscopy." In Nanobiotechnology Protocols, edited by SJ Rosenthal and DX Wright. New York, NY: Humana Press, 2013.
- Conference Papers
  - Rana, MA, Yao, N, Mukhopadhyay, S, Zhang, F, Warren, EAK, and Payne, CK. "Modeling the effect of nanoparticles and the bistability of transmembrane potential in nonexcitable cells." American Control Conference. Boston, MA, 2016.
  - Mukhopadhyay, S, Zhang, F, Warren, E, and Payne, CK. "A model for controlling the resting membrane potential of cells using nanoparticles." 53rd IEEE Conference on Decision and Control. Boston, MA, 2014.
Teaching & Mentoring
Recent Courses

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Education, Training, & Certifications

Duke Appointment History

In the News

Selected Grants

Selected Publications

Academic Articles

Book Sections

Conference Papers

Recent Courses