Christine K. Payne | Scholars@Duke

Christine K. Payne
Yoh Family Professor of Mechanical Engineering and Materials Science

Current Research Interests

Molecular mechanisms by which cells interact with materials, specifically nanoparticles and conducting polymers, with applications in nanomedicine and environmental exposure

Current Appointments & Affiliations

Yoh Family Professor of Mechanical Engineering and Materials Science, Thomas Lord Department of Mechanical Engineering and Materials Science, Pratt School of Engineering 2022
Professor in the Thomas Lord Department of Mechanical Engineering and Materials Science, Thomas Lord Department of Mechanical Engineering and Materials Science, Pratt School of Engineering 2022
Director of Graduate Studies in the Thomas Lord Department Mechanical Engineering and Materials Science, Thomas Lord Department of Mechanical Engineering and Materials Science, Pratt School of Engineering 2021
Associate Professor of Chemistry, Chemistry, Trinity College of Arts & Sciences 2018

Contact Information

534 Research Dr. #311, Wilkinson, Durham, NC 27708
534 Research Dr. #311, Wilkinson, Durham, NC 27708
christine.payne@duke.edu
Google Scholar
Payne Lab

Background
Education, Training, & Certifications
- Ph.D., University of California - Berkeley 2003
Previous Appointments & Affiliations
- Associate Chair in the Thomas Lord Department of Mechanical Engineering and Materials Science, Thomas Lord Department of Mechanical Engineering and Materials Science, Pratt School of Engineering 2021 - 2022
- Associate Professor of Mechanical Engineering and Materials Science, Thomas Lord Department of Mechanical Engineering and Materials Science, Pratt School of Engineering 2018 - 2021
- Yoh Family Associate Professor of Mechanical Engineering and Materials Science, Thomas Lord Department of Mechanical Engineering and Materials Science, Pratt School of Engineering 2020 - 2021
- Adjunct Associate Professor in the Department of Mechanical Engineering and Materials Sci, Thomas Lord Department of Mechanical Engineering and Materials Science, Pratt School of Engineering 2017 - 2018
Recognition
In the News
- APR 23, 2020
  
  Five New Bass Professors Named for Excellence in Teaching and Research
- JUN 8, 2018
  
  Mathematics-Bioscience Partnership to Explore Cellular Transport
- SEP 21, 2017 Pratt School of Engineering
  
  Christine Payne: Investigating Interactions between Cells and Engineered Materials
Research
Selected Grants
- Mechanisms of Nanoparticle Modulation of Allergen-Induced Lung Disease awarded by North Carolina State University 2021 - 2026
- Duke University Program in Environmental Health awarded by National Institutes of Health 2019 - 2024
- Engineering at the interface: Training interdisciplinary engineers at the PhD level awarded by Burroughs Wellcome Fund 2022 - 2024
- Pulmonary response to nanomaterial-ozone exposures awarded by National Institutes of Health 2020 - 2023
- Library of protein-nanoparticle interactions: Automated sample handling and low-cost proteomics awarded by National Science Foundation 2019 - 2023
- Conducting Polymer Nanowires for Neural Modulation awarded by National Institutes of Health 2015 - 2019
Fellowships, Supported Research, & Other Grants
- Seed Grant: Fostering an Integrated Faculty-Staff Community through Shared-Purpose Workshops awarded by Duke Office for Faculty Advancement 2022
External Relationships
- IonQ, Inc.
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Poulsen, Karsten M., and Christine K. Payne. “Concentration and composition of the protein corona as a function of incubation time and serum concentration: an automated approach to the protein corona.” Analytical and Bioanalytical Chemistry 414, no. 24 (October 2022): 7265–75. https://doi.org/10.1007/s00216-022-04278-y.
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  - Rayens, Nathan T., Keisha J. Cook, Scott A. McKinley, and Christine K. Payne. “Transport of lysosomes decreases in the perinuclear region: Insights from changepoint analysis.” Biophysical Journal 121, no. 7 (April 2022): 1205–18. https://doi.org/10.1016/j.bpj.2022.02.032.
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  - Han, X., and C. K. Payne. “Effect of Thioflavin T on the Elongation Rate of Bacteria.” Bioelectricity 4, no. 1 (March 1, 2022): 12–17. https://doi.org/10.1089/bioe.2021.0027.
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  - Jayaram, Dhanya T., and Christine K. Payne. “Food-Grade TiO₂ Particles Generate Intracellular Superoxide and Alter Epigenetic Modifiers in Human Lung Cells.” Chemical Research in Toxicology 33, no. 11 (November 2020): 2872–79. https://doi.org/10.1021/acs.chemrestox.0c00331.
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  - Griffith, Darbi M., Dhanya T. Jayaram, Diane M. Spencer, David S. Pisetsky, and Christine K. Payne. “DNA-nanoparticle interactions: Formation of a DNA corona and its effects on a protein corona.” Biointerphases 15, no. 5 (October 1, 2020): 051006. https://doi.org/10.1116/6.0000439.
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  - Poulsen, Karsten M., Thomas Pho, Julie A. Champion, and Christine K. Payne. “Automation and low-cost proteomics for characterization of the protein corona: experimental methods for big data.” Analytical and Bioanalytical Chemistry 412, no. 24 (September 2020): 6543–51. https://doi.org/10.1007/s00216-020-02726-1.
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  - Jayaram, Dhanya T., and Christine K. Payne. “Intracellular Generation of Superoxide by TiO₂ Nanoparticles Decreases Histone Deacetylase 9 (HDAC9), an Epigenetic Modifier.” Bioconjugate Chemistry 31, no. 5 (May 2020): 1354–61. https://doi.org/10.1021/acs.bioconjchem.0c00091.
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  - Payne, Christine K. “A protein corona primer for physical chemists.” The Journal of Chemical Physics 151, no. 13 (October 2019): 130901. https://doi.org/10.1063/1.5120178.
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  - Morris, Joshua D., and Christine K. Payne. “Microscopy and Cell Biology: New Methods and New Questions.” Annual Review of Physical Chemistry 70 (June 2019): 199–218. https://doi.org/10.1146/annurev-physchem-042018-052527.
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  - Jayaram, Dhanya T., Ashwath Kumar, Linda E. Kippner, Po-Yi Ho, Melissa L. Kemp, Yuhong Fan, and Christine K. Payne. “TiO₂ nanoparticles generate superoxide and alter gene expression in human lung cells.” Rsc Advances 9, no. 43 (January 2019): 25039–47. https://doi.org/10.1039/c9ra04037d.
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  - Jayaram, Dhanya T., Samantha M. Pustulka, Robert G. Mannino, Wilbur A. Lam, and Christine K. Payne. “Protein Corona in Response to Flow: Effect on Protein Concentration and Structure.” Biophysical Journal 115, no. 2 (July 2018): 209–16. https://doi.org/10.1016/j.bpj.2018.02.036.
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  - Runa, Sabiha, Michael Hussey, and Christine K. Payne. “Nanoparticle-Cell Interactions: Relevance for Public Health.” The Journal of Physical Chemistry. B 122, no. 3 (January 2018): 1009–16. https://doi.org/10.1021/acs.jpcb.7b08650.
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  - Thourson, Scott B., and Christine K. Payne. “Modulation of action potentials using PEDOT:PSS conducting polymer microwires.” Scientific Reports 7, no. 1 (September 4, 2017). https://doi.org/10.1038/s41598-017-11032-3.
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  - Runa, Sabiha, Melike Lakadamyali, Melissa L. Kemp, and Christine K. Payne. “TiO₂ Nanoparticle-Induced Oxidation of the Plasma Membrane: Importance of the Protein Corona.” The Journal of Physical Chemistry. B 121, no. 37 (September 2017): 8619–25. https://doi.org/10.1021/acs.jpcb.7b04208.
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  - Morris, Joshua D., Scott B. Thourson, Krishna R. Panta, Bret N. Flanders, and Christine K. Payne. “Conducting polymer nanowires for control of local protein concentration in solution.” Journal of Physics D: Applied Physics 50, no. 17 (May 4, 2017): 174003–174003. https://doi.org/10.1088/1361-6463/aa60b0.
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  - Jayaram, D. T., Q. Luo, S. B. Thourson, A. Finlay, and C. K. Payne. “Controlling the resting membrane potential of cells with conducting polymer microwires.” Small, 2017, #1700789.
  - Jayaram, D. T., S. Runa, M. L. Kemp, and C. K. Payne. “Nanoparticle-induced oxidation of corona proteins initiates an oxidative stress response in cells.” Nanoscale 9 (2017): 7595–7601.
  - Flores, J. J., C. K. Payne, and J. D. Morris. “Heme protein-mediated synthesis of PEDOT: PSS: enhancing conductivity by inhibiting heme degradation.” Rsc Advances 7, no. 20 (2017): 12017–21.
  - Morris, J. D., K. M. Wong, C. D. Peñaherrera, and C. K. Payne. “Mechanism of the biomolecular synthesis of PEDOT: PSS: importance of heme degradation by hydrogen peroxide.” Biomaterials Science, 2016.
  - Runa, S., D. Khanal, M. L. Kemp, and C. K. Payne. “TiO2 nanoparticles alter the expression of peroxiredoxin antioxidant genes.” Journal of Physical Chemistry C 120 (2016): 20736–42.
  - Morris, J. D., D. Khanal, J. A. Richey, and C. K. Payne. “Hemoglobin-mediated synthesis of PEDOT: PSS: enhancing conductivity through biological oxidants.” Biomaterials Science 3, no. 3 (2015): 442–45.
  - Warren, E. A. K., T. S. Netterfield, S. Sarkar, M. L. Kemp, and C. K. Payne. “Spatially-resolved intracellular sensing of hydrogen peroxide in living cells.” Scientific Reports 5 (2015): #16929.
  - Warren, E. A. K., and C. K. Payne. “Cellular binding of nanoparticles disrupts the membrane potential.” Rsc Advances 5 (2015): 13660–66.
  - Fleischer, C. C., and C. K. Payne. “Nanoparticle-cell interactions: Molecular structure of the protein corona and cellular outcomes.” Accounts of Chemical Research 47 (2014): 2651–59.
  - Morris, J. D., and C. K. Payne. “Tuning PEDOT:PSS conductivity with iron oxidants.” Organic Electronics 15 (2014): 1701–10.
  - Runa, S., A. Hill, V. L. Cochran, and C. K. Payne. “PEGylated nanoparticles: protein corona and secondary structure.” Proc. Spie, Physical Chemistry of Interfaces and Nanomaterials Xiii 9165 (2014): 1F1-IF8.
  - Fleischer, C. C., and C. K. Payne. “Secondary Structure of Corona Proteins Determines the Cell Surface Receptors Used by Nanoparticles.” Journal of Physical Chemistry B 118 (2014): 14017–26.
  - Hill, A., and C. K. Payne. “Impact of serum proteins on MRI contrast agents: Cellular binding and T2 relaxation.” Rsc Advances 4, no. 60 (2014): 31735–44.
  - Fleischer, C. C., U. Kumar, and C. K. Payne. “Cellular binding of anionic nanoparticles is inhibited by serum proteins independent of nanoparticle composition.” Biomaterials Science 1 (2013): 975–82.
  - Hira, S. M., and C. K. Payne. “Protein-mediated synthesis of the conducting polymer PEDOT:PSS.” Synthetic Metals 176 (2013): 104–7.
  - Sarkar, S., C. K. Payne, and M. L. Kemp. “Conditioned Media Downregulates Nuclear Expression of Nrf2.” Cellular and Molecular Bioengineering 6, no. 2 (2013): 130–37. https://doi.org/10.1007/s12195-013-0272-0.
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  - Shin, E. H., Y. Li, U. Kumar, H. V. Sureka, X. R. Zhang, and C. K. Payne. “Membrane potential mediates the cellular binding of nanoparticles.” Nanoscale 5, no. 13 (2013): 5879–86. https://doi.org/10.1039/c3nr01667f.
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  - Doorley, G. W., and C. K. Payne. “Nanoparticles act as protein carriers during cellular internalization.” Chem. Commun. 48 (2012): 2961–63.
  - Humphries, W. H., and C. K. Payne. “Imaging lysosomal enzyme activity in live cells using self-quenched substrates.” Analytical Biochemistry 424 (2012): 178–83.
  - Fleischer, C. C., and C. K. Payne. “Nanoparticle surface charge mediates the cellular receptors used by protein-nanoparticle complexes.” Journal of Physical Chemistry B 116 (2012): 8901–7.
  - Reddie, K. G., W. H. Humphries, C. P. Bain, C. K. Payne, M. L. Kemp, and N. Murthy. “Fluorescent Coumarin Thiols Measure Biological Redox Couples.” Organic Letters 14, no. 3 (2012): 680–83. https://doi.org/10.1021/ol203105c.
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  - Humphries, W. H., C. J. Szymanski, and C. K. Payne. “Endo-lysosomal vesicles positive for Rab7 and LAMP1 are terminal vesicles for the transport of dextran.” Plos One 6 (2011): e26626.
  - Szymanksi, C. J., W. H. Humphries, and C. K. Payne. “Single particle tracking as a method to resolve differences in highly colocalized proteins.” Analyst 136, no. 17 (2011): 3527–33. https://doi.org/10.1039/C0AN00855A.
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  - Humphries, W. H., N. C. Fay, and C. K. Payne. “Intracellular degradation of low-density lipoprotein probed with two-color fluorescence microscopy.” Integr. Biol. 2 (2010): 536–44. https://doi.org/10.1039/C0IB00035C.
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  - Payne, Christine K., Sara A. Jones, Chen Chen, and Xiaowei Zhuang. “Internalization and Trafficking of Cell Surface Proteoglycans and Proteoglycan-Binding Ligands.” Traffic 8, no. 4 (April 2007): 389–401. https://doi.org/10.1111/j.1600-0854.2007.00540.x.
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  - Payne, C. K. “Imaging gene delivery with fluorescence microscopy.” Nanomedicine 2 (2007): 847–60. https://doi.org/10.2217/17435889.2.6.847|issn.
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  - Hess, G. T., W. H. Humphries, N. C. Fay, and C. K. Payne. “Cellular binding, motion, and internalization of synthetic gene delivery polymers.” Biochimica Et Biophysica Acta Molecular Cell Research 1773, no. 10 (2007): 1583–88.
  - Hayden, O., and C. K. Payne. “Nanophotonic light sources for fluorescence spectroscopy and cellular imaging.” Angewandte Chemie International Edition 44, no. 9 (2005): 1395–98. https://doi.org/10.1002/anie.200462120.
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  - Shanoski, J. E., C. K. Payne, M. F. Kling, E. A. Glascoe, and C. B. Harris. “Ultrafast infrared mechanistic studies of the interaction of 1-Hexyne with group 6 hexacarbonyl complexes.” Organometallics 24, no. 8 (2005): 1852–59. https://doi.org/10.1021/om49101m.
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- Book Sections
  - Szymanski, C. J., H. Yi, J. T. Liu, E. R. Wright, and C. K. Payne. “Imaging intracellular quantum dots: Fluorescence microscopy and transmission electron microscopy.” In Nanobiotechnology Protocols, edited by S. J. Rosenthal and D. X. Wright. New York, NY: Humana Press, 2013.
- Conference Papers
  - Rana, M. A., N. Yao, S. Mukhopadhyay, F. Zhang, E. A. K. Warren, and C. K. Payne. “Modeling the effect of nanoparticles and the bistability of transmembrane potential in nonexcitable cells.” Boston, MA, 2016.
  - Mukhopadhyay, S., F. Zhang, E. Warren, and C. K. Payne. “A model for controlling the resting membrane potential of cells using nanoparticles.” Boston, MA, 2014.
Teaching & Mentoring
Recent Courses

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Education, Training, & Certifications

Previous Appointments & Affiliations

In the News

Selected Grants

Fellowships, Supported Research, & Other Grants

External Relationships

Selected Publications

Academic Articles

Book Sections

Conference Papers

Recent Courses