Christine K. Payne | Scholars@Duke

Christine K. Payne
Yoh Family Associate Professor of Mechanical Engineering and Materials Science

Current Research Interests

Molecular mechanisms by which cells interact with materials, specifically nanoparticles and conducting polymers, with applications in nanomedicine and environmental exposure

Current Appointments & Affiliations

Yoh Family Associate Professor of Mechanical Engineering and Materials Science, Thomas Lord Department of Mechanical Engineering and Materials Science, Pratt School of Engineering 2020 - 2025
Associate Professor of Mechanical Engineering and Materials Science, Thomas Lord Department of Mechanical Engineering and Materials Science, Pratt School of Engineering 2018
Director of Graduate Studies in the Thomas Lord Department Mechanical Engineering and Materials Science, Thomas Lord Department of Mechanical Engineering and Materials Science, Pratt School of Engineering 2021

Contact Information

701 W. Main St., Office 4306, Chesterfield Building, Durham, NC 27701
701 W. Main St., Suite 420, Chesterfield Building, Durham, NC 27701
christine.payne@duke.edu (919) 681-2096
Google Scholar
Payne Lab

Background
Education, Training, & Certifications
- Ph.D., University of California - Berkeley 2003
Duke Appointment History
- Associate Professor of Chemistry, Chemistry, Trinity College of Arts & Sciences 2018 - 2021
- Adjunct Associate Professor in the Department of Mechanical Engineering and Materials Sci, Thomas Lord Department of Mechanical Engineering and Materials Science, Pratt School of Engineering 2017 - 2018
Recognition
In the News
- APR 23, 2020
  
  Five New Bass Professors Named for Excellence in Teaching and Research
- JUN 8, 2018
  
  Mathematics-Bioscience Partnership to Explore Cellular Transport
- SEP 21, 2017 Pratt School of Engineering
  
  Christine Payne: Investigating Interactions between Cells and Engineered Materials
Research
Selected Grants
- Duke University Program in Environmental Health awarded by National Institutes of Health 2013 - 2024
- Pulmonary response to nanomaterial-ozone exposures awarded by National Institutes of Health 2020 - 2022
- Library of protein-nanoparticle interactions: Automated sample handling and low-cost proteomics awarded by National Science Foundation 2019 - 2022
- Conducting Polymer Nanowires for Neural Modulation awarded by National Institutes of Health 2015 - 2019
External Relationships
- ionQ, Inc.
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Jayaram, Dhanya T., and Christine K. Payne. “Food-Grade TiO₂ Particles Generate Intracellular Superoxide and Alter Epigenetic Modifiers in Human Lung Cells.” Chemical Research in Toxicology 33, no. 11 (November 2020): 2872–79. https://doi.org/10.1021/acs.chemrestox.0c00331.
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  - Griffith, Darbi M., Dhanya T. Jayaram, Diane M. Spencer, David S. Pisetsky, and Christine K. Payne. “DNA-nanoparticle interactions: Formation of a DNA corona and its effects on a protein corona.” Biointerphases 15, no. 5 (October 1, 2020): 051006. https://doi.org/10.1116/6.0000439.
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  - Poulsen, Karsten M., Thomas Pho, Julie A. Champion, and Christine K. Payne. “Automation and low-cost proteomics for characterization of the protein corona: experimental methods for big data.” Analytical and Bioanalytical Chemistry 412, no. 24 (September 2020): 6543–51. https://doi.org/10.1007/s00216-020-02726-1.
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  - Jayaram, Dhanya T., and Christine K. Payne. “Intracellular Generation of Superoxide by TiO₂ Nanoparticles Decreases Histone Deacetylase 9 (HDAC9), an Epigenetic Modifier.” Bioconjugate Chemistry 31, no. 5 (May 2020): 1354–61. https://doi.org/10.1021/acs.bioconjchem.0c00091.
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  - Payne, Christine K. “A protein corona primer for physical chemists.” The Journal of Chemical Physics 151, no. 13 (October 2019): 130901. https://doi.org/10.1063/1.5120178.
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  - Morris, Joshua D., and Christine K. Payne. “Microscopy and Cell Biology: New Methods and New Questions.” Annual Review of Physical Chemistry 70 (June 2019): 199–218. https://doi.org/10.1146/annurev-physchem-042018-052527.
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  - Jayaram, D. T., A. Kumar, L. E. Kippner, P. Y. Ho, M. L. Kemp, Y. Fan, and C. K. Payne. “TiO2 nanoparticles generate superoxide and alter gene expression in human lung cells.” Rsc Advances 9, no. 43 (January 1, 2019): 25039–47. https://doi.org/10.1039/c9ra04037d.
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  - Jayaram, Dhanya T., Samantha M. Pustulka, Robert G. Mannino, Wilbur A. Lam, and Christine K. Payne. “Protein Corona in Response to Flow: Effect on Protein Concentration and Structure.” Biophysical Journal 115, no. 2 (July 2018): 209–16. https://doi.org/10.1016/j.bpj.2018.02.036.
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  - Runa, Sabiha, Michael Hussey, and Christine K. Payne. “Nanoparticle-Cell Interactions: Relevance for Public Health.” The Journal of Physical Chemistry. B 122, no. 3 (January 2018): 1009–16. https://doi.org/10.1021/acs.jpcb.7b08650.
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  - Thourson, Scott B., and Christine K. Payne. “Modulation of action potentials using PEDOT:PSS conducting polymer microwires.” Scientific Reports 7, no. 1 (December 2017). https://doi.org/10.1038/s41598-017-11032-3.
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  - Runa, Sabiha, Melike Lakadamyali, Melissa L. Kemp, and Christine K. Payne. “TiO₂ Nanoparticle-Induced Oxidation of the Plasma Membrane: Importance of the Protein Corona.” The Journal of Physical Chemistry. B 121, no. 37 (September 11, 2017): 8619–25. https://doi.org/10.1021/acs.jpcb.7b04208.
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  - Morris, Joshua D., Scott B. Thourson, Krishna R. Panta, Bret N. Flanders, and Christine K. Payne. “Conducting polymer nanowires for control of local protein concentration in solution.” Journal of Physics D: Applied Physics 50, no. 17 (May 4, 2017): 174003–174003. https://doi.org/10.1088/1361-6463/aa60b0.
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  - Flores, J. J., C. K. Payne, and J. D. Morris. “Heme protein-mediated synthesis of PEDOT: PSS: enhancing conductivity by inhibiting heme degradation.” Rsc Advances 7, no. 20 (2017): 12017–21.
  - Jayaram, D. T., Q. Luo, S. B. Thourson, A. Finlay, and C. K. Payne. “Controlling the resting membrane potential of cells with conducting polymer microwires.” Small, 2017, #1700789.
  - Jayaram, D. T., S. Runa, M. L. Kemp, and C. K. Payne. “Nanoparticle-induced oxidation of corona proteins initiates an oxidative stress response in cells.” Nanoscale 9 (2017): 7595–7601.
  - Morris, J. D., K. M. Wong, C. D. Peñaherrera, and C. K. Payne. “Mechanism of the biomolecular synthesis of PEDOT: PSS: importance of heme degradation by hydrogen peroxide.” Biomaterials Science, 2016.
  - Runa, S., D. Khanal, M. L. Kemp, and C. K. Payne. “TiO2 nanoparticles alter the expression of peroxiredoxin antioxidant genes.” Journal of Physical Chemistry C 120 (2016): 20736–42.
  - Morris, J. D., D. Khanal, J. A. Richey, and C. K. Payne. “Hemoglobin-mediated synthesis of PEDOT: PSS: enhancing conductivity through biological oxidants.” Biomaterials Science 3, no. 3 (2015): 442–45.
  - Warren, E. A. K., T. S. Netterfield, S. Sarkar, M. L. Kemp, and C. K. Payne. “Spatially-resolved intracellular sensing of hydrogen peroxide in living cells.” Scientific Reports 5 (2015): #16929.
  - Warren, E. A. K., and C. K. Payne. “Cellular binding of nanoparticles disrupts the membrane potential.” Rsc Advances 5 (2015): 13660–66.
  - Fleischer, C. C., and C. K. Payne. “Secondary Structure of Corona Proteins Determines the Cell Surface Receptors Used by Nanoparticles.” Journal of Physical Chemistry B 118 (2014): 14017–26.
  - Fleischer, C. C., and C. K. Payne. “Nanoparticle-cell interactions: Molecular structure of the protein corona and cellular outcomes.” Accounts of Chemical Research 47 (2014): 2651–59.
  - Hill, A., and C. K. Payne. “Impact of serum proteins on MRI contrast agents: Cellular binding and T2 relaxation.” Rsc Advances 4, no. 60 (2014): 31735–44.
  - Morris, J. D., and C. K. Payne. “Tuning PEDOT:PSS conductivity with iron oxidants.” Organic Electronics 15 (2014): 1701–10.
  - Runa, S., A. Hill, V. L. Cochran, and C. K. Payne. “PEGylated nanoparticles: protein corona and secondary structure.” Proc. Spie, Physical Chemistry of Interfaces and Nanomaterials Xiii 9165 (2014): 1F1-IF8.
  - Sarkar, Saheli, Christine K. Payne, and Melissa L. Kemp. “Conditioned Media Downregulates Nuclear Expression of Nrf2.” Cellular and Molecular Bioengineering 6, no. 2 (June 2013): 130–37. https://doi.org/10.1007/s12195-013-0272-0.
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  - Fleischer, C. C., U. Kumar, and C. K. Payne. “Cellular binding of anionic nanoparticles is inhibited by serum proteins independent of nanoparticle composition.” Biomaterials Science 1 (2013): 975–82.
  - Hira, S. M., and C. K. Payne. “Protein-mediated synthesis of the conducting polymer PEDOT:PSS.” Synthetic Metals 176 (2013): 104–7.
  - Shin, Edwin H., Ye Li, Umesh Kumar, Hursh V. Sureka, Xianren Zhang, and Christine K. Payne. “Membrane potential mediates the cellular binding of nanoparticles.” Nanoscale 5, no. 13 (2013): 5879–5879. https://doi.org/10.1039/c3nr01667f.
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  - Reddie, Khalilah G., William H. Humphries, Charlo P. Bain, Christine K. Payne, Melissa L. Kemp, and Niren Murthy. “Fluorescent Coumarin Thiols Measure Biological Redox Couples.” Organic Letters 14, no. 3 (February 3, 2012): 680–83. https://doi.org/10.1021/ol203105c.
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  - Doorley, G. W., and C. K. Payne. “Nanoparticles act as protein carriers during cellular internalization.” Chem. Commun. 48 (2012): 2961–63.
  - Fleischer, C. C., and C. K. Payne. “Nanoparticle surface charge mediates the cellular receptors used by protein-nanoparticle complexes.” Journal of Physical Chemistry B 116 (2012): 8901–7.
  - Humphries, W. H., and C. K. Payne. “Imaging lysosomal enzyme activity in live cells using self-quenched substrates.” Analytical Biochemistry 424 (2012): 178–83.
  - Humphries, W. H., C. J. Szymanski, and C. K. Payne. “Endo-lysosomal vesicles positive for Rab7 and LAMP1 are terminal vesicles for the transport of dextran.” Plos One 6 (2011): e26626.
  - Szymanski, Craig J., William H. Humphries, IV, and Christine K. Payne. “Single particle tracking as a method to resolve differences in highly colocalized proteins.” The Analyst 136, no. 17 (2011): 3527–3527. https://doi.org/10.1039/c0an00855a.
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  - Humphries IV, William H., Nicole C. Fay, and Christine K. Payne. “Intracellular degradation of low-density lipoprotein probed with two-color fluorescence microscopy.” Integrative Biology 2, no. 10 (2010): 536–536. https://doi.org/10.1039/c0ib00035c.
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  - Hess, Gaelen T., William H. Humphries, Nicole C. Fay, and Christine K. Payne. “Cellular binding, motion, and internalization of synthetic gene delivery polymers.” Biochimica Et Biophysica Acta (Bba) Molecular Cell Research 1773, no. 10 (October 2007): 1583–88. https://doi.org/10.1016/j.bbamcr.2007.07.009.
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  - Payne, Christine K., Sara A. Jones, Chen Chen, and Xiaowei Zhuang. “Internalization and Trafficking of Cell Surface Proteoglycans and Proteoglycan-Binding Ligands.” Traffic 8, no. 4 (April 2007): 389–401. https://doi.org/10.1111/j.1600-0854.2007.00540.x.
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  - Payne, C. K. “Imaging gene delivery with fluorescence microscopy.” Nanomedicine 2 (2007): 847–60. https://doi.org/10.2217/17435889.2.6.847|issn.
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  - Shanoski, Jennifer E., Christine K. Payne, Matthias F. Kling, Elizabeth A. Glascoe, and Charles B. Harris. “Ultrafast Infrared Mechanistic Studies of the Interaction of 1-Hexyne with Group 6 Hexacarbonyl Complexes.” Organometallics 24, no. 8 (April 2005): 1852–59. https://doi.org/10.1021/om049101m.
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  - Hayden, Oliver, and Christine K. Payne. “Nanophotonic Light Sources for Fluorescence Spectroscopy and Cellular Imaging.” Angewandte Chemie International Edition 44, no. 9 (February 18, 2005): 1395–98. https://doi.org/10.1002/anie.200462120.
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- Book Sections
  - Szymanski, C. J., H. Yi, J. T. Liu, E. R. Wright, and C. K. Payne. “Imaging intracellular quantum dots: Fluorescence microscopy and transmission electron microscopy.” In Nanobiotechnology Protocols, edited by S. J. Rosenthal and D. X. Wright. New York, NY: Humana Press, 2013.
- Conference Papers
  - Rana, M. A., N. Yao, S. Mukhopadhyay, F. Zhang, E. A. K. Warren, and C. K. Payne. “Modeling the effect of nanoparticles and the bistability of transmembrane potential in nonexcitable cells.” Boston, MA, 2016.
  - Mukhopadhyay, S., F. Zhang, E. Warren, and C. K. Payne. “A model for controlling the resting membrane potential of cells using nanoparticles.” Boston, MA, 2014.
Teaching & Mentoring
Recent Courses

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Education, Training, & Certifications

Duke Appointment History

In the News

Selected Grants

External Relationships

Selected Publications

Academic Articles

Book Sections

Conference Papers

Recent Courses