Christine K. Payne
Yoh Family Professor of Mechanical Engineering and Materials Science
Current Research Interests
Molecular mechanisms by which cells interact with materials, specifically nanoparticles and conducting polymers, with applications in nanomedicine and environmental exposure
Current Appointments & Affiliations
- Yoh Family Professor of Mechanical Engineering and Materials Science, Thomas Lord Department of Mechanical Engineering and Materials Science, Pratt School of Engineering 2022
- Professor in the Thomas Lord Department of Mechanical Engineering and Materials Science, Thomas Lord Department of Mechanical Engineering and Materials Science, Pratt School of Engineering 2022
- Director of Graduate Studies in the Thomas Lord Department Mechanical Engineering and Materials Science, Thomas Lord Department of Mechanical Engineering and Materials Science, Pratt School of Engineering 2021
- Associate Professor of Chemistry, Chemistry, Trinity College of Arts & Sciences 2018
Contact Information
- 534 Research Dr. #311, Wilkinson, Durham, NC 27708
- 534 Research Dr. #311, Wilkinson, Durham, NC 27708
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christine.payne@duke.edu
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Google Scholar
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Payne Lab
- Background
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Education, Training, & Certifications
- Ph.D., University of California - Berkeley 2003
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Previous Appointments & Affiliations
- Associate Chair in the Thomas Lord Department of Mechanical Engineering and Materials Science, Thomas Lord Department of Mechanical Engineering and Materials Science, Pratt School of Engineering 2021 - 2022
- Associate Professor of Mechanical Engineering and Materials Science, Thomas Lord Department of Mechanical Engineering and Materials Science, Pratt School of Engineering 2018 - 2021
- Yoh Family Associate Professor of Mechanical Engineering and Materials Science, Thomas Lord Department of Mechanical Engineering and Materials Science, Pratt School of Engineering 2020 - 2021
- Adjunct Associate Professor in the Department of Mechanical Engineering and Materials Sci, Thomas Lord Department of Mechanical Engineering and Materials Science, Pratt School of Engineering 2017 - 2018
- Recognition
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In the News
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APR 23, 2020 -
JUN 8, 2018 -
SEP 21, 2017 Pratt School of Engineering
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- Research
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Selected Grants
- Mechanisms of Nanoparticle Modulation of Allergen-Induced Lung Disease awarded by North Carolina State University 2021 - 2026
- Duke University Program in Environmental Health awarded by National Institutes of Health 2019 - 2024
- Engineering at the interface: Training interdisciplinary engineers at the PhD level awarded by Burroughs Wellcome Fund 2022 - 2024
- Pulmonary response to nanomaterial-ozone exposures awarded by National Institutes of Health 2020 - 2023
- Library of protein-nanoparticle interactions: Automated sample handling and low-cost proteomics awarded by National Science Foundation 2019 - 2023
- Conducting Polymer Nanowires for Neural Modulation awarded by National Institutes of Health 2015 - 2019
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Fellowships, Supported Research, & Other Grants
- Seed Grant: Fostering an Integrated Faculty-Staff Community through Shared-Purpose Workshops awarded by Duke Office for Faculty Advancement 2022
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External Relationships
- IonQ, Inc.
- Publications & Artistic Works
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Selected Publications
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Academic Articles
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Poulsen, Karsten M., and Christine K. Payne. “Concentration and composition of the protein corona as a function of incubation time and serum concentration: an automated approach to the protein corona.” Analytical and Bioanalytical Chemistry 414, no. 24 (October 2022): 7265–75. https://doi.org/10.1007/s00216-022-04278-y.Full Text
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Rayens, Nathan T., Keisha J. Cook, Scott A. McKinley, and Christine K. Payne. “Transport of lysosomes decreases in the perinuclear region: Insights from changepoint analysis.” Biophysical Journal 121, no. 7 (April 2022): 1205–18. https://doi.org/10.1016/j.bpj.2022.02.032.Full Text
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Han, X., and C. K. Payne. “Effect of Thioflavin T on the Elongation Rate of Bacteria.” Bioelectricity 4, no. 1 (March 1, 2022): 12–17. https://doi.org/10.1089/bioe.2021.0027.Full Text
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Jayaram, Dhanya T., and Christine K. Payne. “Food-Grade TiO2 Particles Generate Intracellular Superoxide and Alter Epigenetic Modifiers in Human Lung Cells.” Chemical Research in Toxicology 33, no. 11 (November 2020): 2872–79. https://doi.org/10.1021/acs.chemrestox.0c00331.Full Text
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Griffith, Darbi M., Dhanya T. Jayaram, Diane M. Spencer, David S. Pisetsky, and Christine K. Payne. “DNA-nanoparticle interactions: Formation of a DNA corona and its effects on a protein corona.” Biointerphases 15, no. 5 (October 1, 2020): 051006. https://doi.org/10.1116/6.0000439.Full Text Link to Item
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Poulsen, Karsten M., Thomas Pho, Julie A. Champion, and Christine K. Payne. “Automation and low-cost proteomics for characterization of the protein corona: experimental methods for big data.” Analytical and Bioanalytical Chemistry 412, no. 24 (September 2020): 6543–51. https://doi.org/10.1007/s00216-020-02726-1.Full Text
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Jayaram, Dhanya T., and Christine K. Payne. “Intracellular Generation of Superoxide by TiO2 Nanoparticles Decreases Histone Deacetylase 9 (HDAC9), an Epigenetic Modifier.” Bioconjugate Chemistry 31, no. 5 (May 2020): 1354–61. https://doi.org/10.1021/acs.bioconjchem.0c00091.Full Text
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Payne, Christine K. “A protein corona primer for physical chemists.” The Journal of Chemical Physics 151, no. 13 (October 2019): 130901. https://doi.org/10.1063/1.5120178.Full Text
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Morris, Joshua D., and Christine K. Payne. “Microscopy and Cell Biology: New Methods and New Questions.” Annual Review of Physical Chemistry 70 (June 2019): 199–218. https://doi.org/10.1146/annurev-physchem-042018-052527.Full Text
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Jayaram, Dhanya T., Ashwath Kumar, Linda E. Kippner, Po-Yi Ho, Melissa L. Kemp, Yuhong Fan, and Christine K. Payne. “TiO2 nanoparticles generate superoxide and alter gene expression in human lung cells.” Rsc Advances 9, no. 43 (January 2019): 25039–47. https://doi.org/10.1039/c9ra04037d.Full Text
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Jayaram, Dhanya T., Samantha M. Pustulka, Robert G. Mannino, Wilbur A. Lam, and Christine K. Payne. “Protein Corona in Response to Flow: Effect on Protein Concentration and Structure.” Biophysical Journal 115, no. 2 (July 2018): 209–16. https://doi.org/10.1016/j.bpj.2018.02.036.Full Text
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Runa, Sabiha, Michael Hussey, and Christine K. Payne. “Nanoparticle-Cell Interactions: Relevance for Public Health.” The Journal of Physical Chemistry. B 122, no. 3 (January 2018): 1009–16. https://doi.org/10.1021/acs.jpcb.7b08650.Full Text
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Thourson, Scott B., and Christine K. Payne. “Modulation of action potentials using PEDOT:PSS conducting polymer microwires.” Scientific Reports 7, no. 1 (September 4, 2017). https://doi.org/10.1038/s41598-017-11032-3.Full Text Open Access Copy
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Runa, Sabiha, Melike Lakadamyali, Melissa L. Kemp, and Christine K. Payne. “TiO2 Nanoparticle-Induced Oxidation of the Plasma Membrane: Importance of the Protein Corona.” The Journal of Physical Chemistry. B 121, no. 37 (September 2017): 8619–25. https://doi.org/10.1021/acs.jpcb.7b04208.Full Text
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Morris, Joshua D., Scott B. Thourson, Krishna R. Panta, Bret N. Flanders, and Christine K. Payne. “Conducting polymer nanowires for control of local protein concentration in solution.” Journal of Physics D: Applied Physics 50, no. 17 (May 4, 2017): 174003–174003. https://doi.org/10.1088/1361-6463/aa60b0.Full Text
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Jayaram, D. T., Q. Luo, S. B. Thourson, A. Finlay, and C. K. Payne. “Controlling the resting membrane potential of cells with conducting polymer microwires.” Small, 2017, #1700789.
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Jayaram, D. T., S. Runa, M. L. Kemp, and C. K. Payne. “Nanoparticle-induced oxidation of corona proteins initiates an oxidative stress response in cells.” Nanoscale 9 (2017): 7595–7601.
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Flores, J. J., C. K. Payne, and J. D. Morris. “Heme protein-mediated synthesis of PEDOT: PSS: enhancing conductivity by inhibiting heme degradation.” Rsc Advances 7, no. 20 (2017): 12017–21.
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Morris, J. D., K. M. Wong, C. D. Peñaherrera, and C. K. Payne. “Mechanism of the biomolecular synthesis of PEDOT: PSS: importance of heme degradation by hydrogen peroxide.” Biomaterials Science, 2016.
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Runa, S., D. Khanal, M. L. Kemp, and C. K. Payne. “TiO2 nanoparticles alter the expression of peroxiredoxin antioxidant genes.” Journal of Physical Chemistry C 120 (2016): 20736–42.
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Morris, J. D., D. Khanal, J. A. Richey, and C. K. Payne. “Hemoglobin-mediated synthesis of PEDOT: PSS: enhancing conductivity through biological oxidants.” Biomaterials Science 3, no. 3 (2015): 442–45.
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Warren, E. A. K., T. S. Netterfield, S. Sarkar, M. L. Kemp, and C. K. Payne. “Spatially-resolved intracellular sensing of hydrogen peroxide in living cells.” Scientific Reports 5 (2015): #16929.
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Warren, E. A. K., and C. K. Payne. “Cellular binding of nanoparticles disrupts the membrane potential.” Rsc Advances 5 (2015): 13660–66.
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Fleischer, C. C., and C. K. Payne. “Nanoparticle-cell interactions: Molecular structure of the protein corona and cellular outcomes.” Accounts of Chemical Research 47 (2014): 2651–59.
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Morris, J. D., and C. K. Payne. “Tuning PEDOT:PSS conductivity with iron oxidants.” Organic Electronics 15 (2014): 1701–10.
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Runa, S., A. Hill, V. L. Cochran, and C. K. Payne. “PEGylated nanoparticles: protein corona and secondary structure.” Proc. Spie, Physical Chemistry of Interfaces and Nanomaterials Xiii 9165 (2014): 1F1-IF8.
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Fleischer, C. C., and C. K. Payne. “Secondary Structure of Corona Proteins Determines the Cell Surface Receptors Used by Nanoparticles.” Journal of Physical Chemistry B 118 (2014): 14017–26.
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Hill, A., and C. K. Payne. “Impact of serum proteins on MRI contrast agents: Cellular binding and T2 relaxation.” Rsc Advances 4, no. 60 (2014): 31735–44.
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Fleischer, C. C., U. Kumar, and C. K. Payne. “Cellular binding of anionic nanoparticles is inhibited by serum proteins independent of nanoparticle composition.” Biomaterials Science 1 (2013): 975–82.
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Hira, S. M., and C. K. Payne. “Protein-mediated synthesis of the conducting polymer PEDOT:PSS.” Synthetic Metals 176 (2013): 104–7.
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Sarkar, S., C. K. Payne, and M. L. Kemp. “Conditioned Media Downregulates Nuclear Expression of Nrf2.” Cellular and Molecular Bioengineering 6, no. 2 (2013): 130–37. https://doi.org/10.1007/s12195-013-0272-0.Full Text
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Shin, E. H., Y. Li, U. Kumar, H. V. Sureka, X. R. Zhang, and C. K. Payne. “Membrane potential mediates the cellular binding of nanoparticles.” Nanoscale 5, no. 13 (2013): 5879–86. https://doi.org/10.1039/c3nr01667f.Full Text
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Doorley, G. W., and C. K. Payne. “Nanoparticles act as protein carriers during cellular internalization.” Chem. Commun. 48 (2012): 2961–63.
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Humphries, W. H., and C. K. Payne. “Imaging lysosomal enzyme activity in live cells using self-quenched substrates.” Analytical Biochemistry 424 (2012): 178–83.
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Fleischer, C. C., and C. K. Payne. “Nanoparticle surface charge mediates the cellular receptors used by protein-nanoparticle complexes.” Journal of Physical Chemistry B 116 (2012): 8901–7.
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Reddie, K. G., W. H. Humphries, C. P. Bain, C. K. Payne, M. L. Kemp, and N. Murthy. “Fluorescent Coumarin Thiols Measure Biological Redox Couples.” Organic Letters 14, no. 3 (2012): 680–83. https://doi.org/10.1021/ol203105c.Full Text
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Humphries, W. H., C. J. Szymanski, and C. K. Payne. “Endo-lysosomal vesicles positive for Rab7 and LAMP1 are terminal vesicles for the transport of dextran.” Plos One 6 (2011): e26626.
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Szymanksi, C. J., W. H. Humphries, and C. K. Payne. “Single particle tracking as a method to resolve differences in highly colocalized proteins.” Analyst 136, no. 17 (2011): 3527–33. https://doi.org/10.1039/C0AN00855A.Full Text
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Humphries, W. H., N. C. Fay, and C. K. Payne. “Intracellular degradation of low-density lipoprotein probed with two-color fluorescence microscopy.” Integr. Biol. 2 (2010): 536–44. https://doi.org/10.1039/C0IB00035C.Full Text
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Payne, Christine K., Sara A. Jones, Chen Chen, and Xiaowei Zhuang. “Internalization and Trafficking of Cell Surface Proteoglycans and Proteoglycan-Binding Ligands.” Traffic 8, no. 4 (April 2007): 389–401. https://doi.org/10.1111/j.1600-0854.2007.00540.x.Full Text
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Payne, C. K. “Imaging gene delivery with fluorescence microscopy.” Nanomedicine 2 (2007): 847–60. https://doi.org/10.2217/17435889.2.6.847|issn.Full Text
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Hess, G. T., W. H. Humphries, N. C. Fay, and C. K. Payne. “Cellular binding, motion, and internalization of synthetic gene delivery polymers.” Biochimica Et Biophysica Acta Molecular Cell Research 1773, no. 10 (2007): 1583–88.
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Hayden, O., and C. K. Payne. “Nanophotonic light sources for fluorescence spectroscopy and cellular imaging.” Angewandte Chemie International Edition 44, no. 9 (2005): 1395–98. https://doi.org/10.1002/anie.200462120.Full Text
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Shanoski, J. E., C. K. Payne, M. F. Kling, E. A. Glascoe, and C. B. Harris. “Ultrafast infrared mechanistic studies of the interaction of 1-Hexyne with group 6 hexacarbonyl complexes.” Organometallics 24, no. 8 (2005): 1852–59. https://doi.org/10.1021/om49101m.Full Text
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Book Sections
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Szymanski, C. J., H. Yi, J. T. Liu, E. R. Wright, and C. K. Payne. “Imaging intracellular quantum dots: Fluorescence microscopy and transmission electron microscopy.” In Nanobiotechnology Protocols, edited by S. J. Rosenthal and D. X. Wright. New York, NY: Humana Press, 2013.
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Conference Papers
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Rana, M. A., N. Yao, S. Mukhopadhyay, F. Zhang, E. A. K. Warren, and C. K. Payne. “Modeling the effect of nanoparticles and the bistability of transmembrane potential in nonexcitable cells.” Boston, MA, 2016.
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Mukhopadhyay, S., F. Zhang, E. Warren, and C. K. Payne. “A model for controlling the resting membrane potential of cells using nanoparticles.” Boston, MA, 2014.
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- Teaching & Mentoring
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Recent Courses
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