Overview
Christine Payne is the Donald M. Alstadt Chair of the Thomas Lord Department of Mechanical Engineering and Materials Science at Duke University. Her research focuses on understanding how cells interact with nanomaterials. This includes fundamental questions of nanoparticle-protein interactions, as well as applied research to understand the pulmonary response to the inhalation of nanoparticles in a manufacturing setting. Her team uses an interdisciplinary approach that includes elements of materials science, chemistry, biophysics, and lab automation. She teaches classes on the quantum mechanics and statistical mechanics of materials including a class on the “Materials Science of Science Fiction.” She earned a S.B. in Chemistry from the University of Chicago (1998) and a Ph.D. in Chemistry from the University of California, Berkeley (2003). Prof. Payne spent 2003-2006 as an NIH NRSA Postdoctoral Fellow at Harvard University. Prof. Payne has received many honors including an NIH Director’s New Innovator Award (2009), a DARPA Young Faculty Award (2011), and she is a Fellow of the Royal Society of Chemistry. She served as a Jefferson Science Fellow at the U.S. Department of State working in the Bureau of International Security and Nonproliferation (2024).
Current Appointments & Affiliations
Recent Publications
Predicting the protein corona on nanoparticles using random forest models with nanoparticle, protein, and experimental features.
Journal Article Nanoscale advances · September 2025 Nanoparticles (NPs) present in any biological environment form a "corona" of proteins on the NP surface. This protein corona, rather than the bare NP, determines the biological response to the protein-NP complex. Experiments, especially proteomics, can pro ... Full text CiteDNA coronas resist nuclease degradation.
Journal Article Biophys J · July 15, 2025 The interaction of cell-free DNA with biological particles has been linked to autoimmune diseases such as systemic lupus erythematosus, but mechanistic details are lacking. Our recent work has shown that DNA adsorbed on the surface of synthetic particles, ... Full text Link to item CiteCellular and In Vivo Response to Industrial, Food Grade, and Photocatalytic TiO2 Nanoparticles.
Journal Article J Phys Chem B · September 19, 2024 We encounter titanium dioxide nanoparticles (TiO2 NPs) throughout our daily lives in the form of food coloring, cosmetics, and industrial materials. They are used on a massive industrial scale, with over 1 million metric tons in the global market. For the ... Full text Link to item CiteRecent Grants
Collaborative Research: Machine Learning for the Protein Corona: An Integrated, Feature-Driven Approach to Predict Nano-Bio Interactions
ResearchPrincipal Investigator · Awarded by National Science Foundation · 2024 - 2027Mechanisms of Nanoparticle Modulation of Allergen-Induced Lung Disease
ResearchPrincipal Investigator · Awarded by North Carolina State University · 2021 - 2026Engineering at the interface: Training interdisciplinary engineers at the PhD level
ResearchPrincipal Investigator · Awarded by Burroughs Wellcome Fund · 2024 - 2025View All Grants