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Christopher Lindsell

Professor of Biostatistics & Bioinformatics
Biostatistics & Bioinformatics, Division of Biostatistics

Overview


As Director, Chris Lindsell, PhD leads the visionary strategic planning, development, and execution of state-of-the-art research for DCRI to achieve its scientific goals. He also serves as a member of the Senior Management Team and, along with Dr. Laine Thomas, will partner with Jack Shostak, Director of Statistical Operations, to execute research.

Lindsell has served as the Institute for Clinical and Translational Research Methods program Director, co-Director of the Center for Health Data Science, and professor of biostatistics and biomedical informatics at Vanderbilt University. He is a leader in the application of rigorous methods in the acute care environment, and to the intersection between emergency care and public health. He has led data coordinating centers for numerous multi-center clinical trials, including FDA-regulated trials, and epidemiological studies. His experience spans mechanistic studies, network trials, pragmatic trials, embedded trials, and more.

Lindsell holds patents for using clinical information, biomarkers and transcriptomics for prognosis and prediction in sepsis and septic shock with a goal of precision therapy in critical illness. He has contributed to data standards for CONNECTS, NHLBI’s network of networks for COVID-19 research, and to the DAQCORD guidelines for data collection and curation in observational studies. He has published over 350 peer-reviewed papers, and most recently, he has been leading multiple major data center efforts during the Covid-19 pandemic including TREAT NOW, ACTIV6 and the IVY Network.

Current Appointments & Affiliations


Professor of Biostatistics & Bioinformatics · 2023 - Present Biostatistics & Bioinformatics, Division of Biostatistics, Biostatistics & Bioinformatics
Co-Chief, Division of Biostatistics & Bioinformatics · 2023 - Present Biostatistics & Bioinformatics, Basic Science Departments
Director, DCRI Biostatistics · 2023 - Present Biostatistics & Bioinformatics, Basic Science Departments
Member in the Duke Clinical Research Institute · 2023 - Present Duke Clinical Research Institute, Institutes and Centers

In the News


Published October 24, 2024
The Need for Other Options to Treat Covid
Published October 12, 2022
DCRI names Lindsell, Thomas new Data Science and Biostatistics Leadership

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Recent Publications


Embracing Generative Artificial Intelligence in Clinical Research and Beyond: Opportunities, Challenges, and Solutions.

Journal Article JACC Adv · March 2025 To explore threats and opportunities and to chart a path for safely navigating the rapid changes that generative artificial intelligence (AI) will bring to clinical research, the Duke Clinical Research Institute convened a multidisciplinary think tank in J ... Full text Link to item Cite
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Recent Grants


Liposomal Amphotericin B and Flucytosine Antifungal Strategies for Talaromycosis (LAmB-FAST) - R01

ResearchAdvisor · Awarded by National Institutes of Health · 2024 - 2031

Engaging Cooperative Sites for Trial Acceleration, Trust, Innovation, and Capability (ECSTATIC)

ResearchPrincipal Investigator · Awarded by Vanderbilt University Medical Center · 2023 - 2028

2/2 Kids MoD PAH Trial: Mono- vs. Duo-Therapy for Pediatric Pulmonary Arterial Hypertension-DCC

ResearchCo Investigator · Awarded by National Institutes of Health · 2021 - 2026

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Education, Training & Certifications


University of Southampton (United Kingdom) · 2000 Ph.D.
University of Southampton (United Kingdom) · 1994 B.S.M.E.