Laine Elliott Thomas | Scholars@Duke

Laine Elliott Thomas
Associate Professor of Biostatistics & Bioinformatics

Causal Inference, Heterogeneity of Treatment Effects, Observational Data, Time-varying Treatments, Real World Evidence

Current Appointments & Affiliations

Associate Professor of Biostatistics & Bioinformatics, Biostatistics & Bioinformatics, Basic Science Departments 2021
Associate Director, DCRI Biostatistics, Biostatistics & Bioinformatics, Basic Science Departments 2018
Associate Chair for Diversity and Inclusion in the Department of Biostatistics & Bioinformatics, Biostatistics & Bioinformatics, Basic Science Departments 2020
Member in the Duke Clinical Research Institute, Duke Clinical Research Institute, Institutes and Centers 2009

Contact Information

200 Morris Street, 7812 200 Morris, Durham, NC 27701
Duke Box 3850, Durham, NC 27710
laine.thomas@duke.edu (919) 684-1289

Background
Education, Training, & Certifications
- Ph.D., North Carolina State University 2009
Duke Appointment History
- Associate Professor of Biostatistics and Bioinformatics, Biostatistics & Bioinformatics, Basic Science Departments 2018 - 2020
- Assistant Professor of Biostatistics and Bioinformatics, Biostatistics & Bioinformatics, Basic Science Departments 2009 - 2018
Leadership & Clinical Positions at Duke
- Associate Director, Biostatistics at the DCRI
Expertise
Global Scholarship
- Research
  - Denmark (Country)
Research
Selected Grants
- Innovative Biostatistical Methods for Analysis and Assessment of Clinical Trials Augmented by Real World Data awarded by Burroughs Wellcome Fund 2021 - 2026
- New causal inference methods for cluster randomized trials with post-randomization selection awarded by Patient Centered Outcomes Research Institute 2020 - 2024
- Postdoctoral Training in Cardiovascular Clinical Research awarded by National Institutes of Health 2003 - 2024
- HERO Program, HERO Registry, HERO-HCQ Trial awarded by Patient Centered Outcomes Research Institute 2020 - 2023
- Methods for the Design and Conduct of Subgroup Analysis in Observational Studies awarded by Patient Centered Outcomes Research Institute 2019 - 2022
- CHAMP-HF awarded by Novartis Pharmaceuticals Corporation 2016 - 2022
- Determinants of Incident Stroke Cognitive Outcomes and Vascular Effects on RecoverY awarded by Johns Hopkins University 2019 - 2021
- Hero Ancillary Study: The Nurse HERO Study awarded by Children's Hospital of Philadelphia 2021
- Integrated Biostatistical Training for CVD Research awarded by North Carolina State University 2017 - 2021
- GARFIELD-Atrial Fibrillation Registry Research awarded by Thrombosis Research Institute 2016 - 2020
- Statistical Methods for Complex Data in Cardiovascular Disease awarded by North Carolina State University 2013 - 2018
- Matching Methods for Comparative Effectiveness Studies of Longitudinal Treatments awarded by Agency for Healthcare Research and Quality 2015 - 2017
- NCDR-ACTION awarded by American College of Cardiology Foundation 2008 - 2015
External Relationships
- Amgen, Inc.
- JAMA
- Pfizer Inc.
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Yang S, Li F, Thomas LE. Covariate adjustment in subgroup analyses of randomized clinical trials: A propensity score approach. Clin Trials. 2021 Jul 16;17407745211028588.
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  - Lopes RD, Thomas L, Di Fusco M, Keshishian A, Luo X, Li X, et al. Clinical and Economic Outcomes Among Nonvalvular Atrial Fibrillation Patients With Coronary Artery Disease and/or Peripheral Artery Disease. Am J Cardiol. 2021 Jun 1;148:69–77.
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  - Thomas LE, Turakhia MP, Pencina MJ. Competing Risks, Treatment Switching, and Informative Censoring. Jama Cardiol. 2021 May 19;
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  - Yang S, Lorenzi E, Papadogeorgou G, Wojdyla DM, Li F, Thomas LE. Propensity score weighting for causal subgroup analysis. Stat Med. 2021 May 12;
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  - Albert NM, Tyson RJ, Hill CL, DeVore AD, Spertus JA, Duffy C, et al. Variation in use and dosing escalation of renin angiotensin system, mineralocorticoid receptor antagonist, angiotensin receptor neprilysin inhibitor and beta-blocker therapies in heart failure and reduced ejection fraction: Association of comorbidities. Am Heart J. 2021 May;235:82–96.
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  - Forrest CB, Xu H, Thomas LE, Webb LE, Cohen LW, Carey TS, et al. Impact of the Early Phase of the COVID-19 Pandemic on US Healthcare Workers: Results from the HERO Registry. J Gen Intern Med. 2021 May;36(5):1319–26.
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  - Greene SJ, Butler J, Spertus JA, Hellkamp AS, Vaduganathan M, DeVore AD, et al. Comparison of New York Heart Association Class and Patient-Reported Outcomes for Heart Failure With Reduced Ejection Fraction. Jama Cardiol. 2021 May 1;6(5):522–31.
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  - Jackson LR, Schrader P, Thomas L, Steinberg BA, Blanco R, Allen LA, et al. Dosing of Direct Oral Anticoagulants in Patients with Moderate Chronic Kidney Disease in US Clinical Practice: Results from the Outcomes Registry for Better Informed Treatment of AF (ORBIT-AF II). Am J Cardiovasc Drugs. 2021 Mar 31;
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  - Shen L, Xian Y, Chen AY, Thomas L, Roe MT, Peterson ED, et al. Effect of intervention timing on one-year mortality in elderly non-ST-segment elevation myocardial infarction patients. Coron Artery Dis. 2021 Mar 1;32(2):138–44.
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  - Wegienka G, Stewart EA, Nicholson WK, Zhang S, Li F, Thomas L, et al. Black Women Are More Likely Than White Women to Schedule a Uterine-Sparing Treatment for Leiomyomas. J Womens Health (Larchmt). 2021 Mar;30(3):355–66.
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  - Etherton MR, Shah S, Haolin X, Xian Y, Maisch L, Hannah D, et al. Patterns of antidepressant therapy and clinical outcomes among ischaemic stroke survivors. Stroke Vasc Neurol. 2021 Feb 1;
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  - Khariton Y, Fonarow GC, Hellkamp A, Thomas L, Nassif ME, Butler J, et al. Heterogeneity of health status treatment response with sacubitril/valsartan: insights from the CHAMP-HF registry. Esc Heart Fail. 2021 Feb;8(1):710–3.
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  - Li F, Thomas LE. RE:"ADDRESSING EXTREME PROPENSITY SCORES VIA THE OVERLAP WEIGHTS". Am J Epidemiol. 2021 Jan 4;190(1):189–90.
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  - Srivastava PK, DeVore AD, Hellkamp AS, Thomas L, Albert NM, Butler J, et al. Heart Failure Hospitalization and Guideline-Directed Prescribing Patterns Among Heart Failure With Reduced Ejection Fraction Patients. Jacc Heart Fail. 2021 Jan;9(1):28–38.
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  - Wosik J, Clowse MEB, Overton R, Adagarla B, Economou-Zavlanos N, Cavalier J, et al. Impact of the COVID-19 pandemic on patterns of outpatient cardiovascular care. Am Heart J. 2021 Jan;231:1–5.
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  - Mentz RJ, Xu H, O’Brien EC, Thomas L, Alexy T, Gupta B, et al. PROVIDE-HF primary results: Patient-Reported Outcomes inVestigation following Initiation of Drug therapy with Entresto (sacubitril/valsartan) in heart failure. Am Heart J. 2020 Dec;230:35–43.
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  - Zhou Y, Matsouaka RA, Thomas L. Propensity score weighting under limited overlap and model misspecification. Stat Methods Med Res. 2020 Dec;29(12):3721–56.
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  - Thomas LE, Bonow RO, Pencina MJ. Understanding Observational Treatment Comparisons in the Setting of Coronavirus Disease 2019 (COVID-19). Jama Cardiol. 2020 Sep 1;5(9):988–90.
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  - Jackson LR, Kim S, Blanco R, Thomas L, Ansell J, Fonarow GC, et al. Discontinuation rates of warfarin versus direct acting oral anticoagulants in US clinical practice: Results from Outcomes Registry for Better Informed Treatment of Atrial Fibrillation II (ORBIT-AF II). Am Heart J. 2020 Aug;226:85–93.
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  - Thomas LE, Yang S, Wojdyla D, Schaubel DE. Matching with time-dependent treatments: A review and look forward. Stat Med. 2020 Jul 30;39(17):2350–70.
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  - DeVore AD, Hellkamp AS, Thomas L, Albert NM, Butler J, Patterson JH, et al. Improvement in Left Ventricular Ejection Fraction in Outpatients With Heart Failure With Reduced Ejection Fraction: Data From CHAMP-HF. Circ Heart Fail. 2020 Jul;13(7):e006833.
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  - Thomas LE, Li F, Pencina MJ. Overlap Weighting: A Propensity Score Method That Mimics Attributes of a Randomized Clinical Trial. Jama. 2020 Jun 16;323(23):2417–8.
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  - Vaduganathan M, Fonarow GC, Greene SJ, DeVore AD, Kavati A, Sikirica S, et al. Contemporary Treatment Patterns and Clinical Outcomes of Comorbid Diabetes Mellitus and HFrEF: The CHAMP-HF Registry. Jacc Heart Fail. 2020 Jun;8(6):469–80.
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  - Alexander JH, Wojdyla D, Vora AN, Thomas L, Granger CB, Goodman SG, et al. Risk/Benefit Tradeoff of Antithrombotic Therapy in Patients With Atrial Fibrillation Early and Late After an Acute Coronary Syndrome or Percutaneous Coronary Intervention: Insights From AUGUSTUS. Circulation. 2020 May 19;141(20):1618–27.
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  - Thomas LE, Bonow RO, Pencina MJ. Understanding Observational Treatment Comparisons in the Setting of Coronavirus Disease 2019 (COVID-19). Jama Cardiol. 2020 May 5;
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  - Laughlin-Tommaso SK, Lu D, Thomas L, Diamond M, Wallace K, Wegienka G, et al. Short-term quality of life after myomectomy for uterine fibroids from the compare-uf fibroid registry. Obstetrical and Gynecological Survey. 2020 May 1;75(5):285–7.
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  - Laughlin-Tommaso SK, Lu D, Thomas L, Diamond MP, Wallace K, Wegienka G, et al. Short-term quality of life after myomectomy for uterine fibroids from the COMPARE-UF Fibroid Registry. Am J Obstet Gynecol. 2020 Apr;222(4):345.e1-345.e22.
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  - Pokorney SD, Black-Maier E, Hellkamp AS, Friedman DJ, Vemulapalli S, Granger CB, et al. Oral Anticoagulation and Cardiovascular Outcomes in Patients With Atrial Fibrillation and End-Stage Renal Disease. J Am Coll Cardiol. 2020 Mar 24;75(11):1299–308.
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  - Lopes RD, Leonardi S, Wojdyla DM, Vora AN, Thomas L, Storey RF, et al. Stent Thrombosis in Patients With Atrial Fibrillation Undergoing Coronary Stenting in the AUGUSTUS Trial. Circulation. 2020 Mar 3;141(9):781–3.
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  - Wallace K, Zhang S, Thomas L, Stewart EA, Nicholson WK, Wegienka GR, et al. Comparative effectiveness of hysterectomy versus myomectomy on one-year health-related quality of life in women with uterine fibroids. Fertil Steril. 2020 Mar;113(3):618–26.
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  - Pokorney SD, Holmes DN, Shrader P, Thomas L, Fonarow GC, Mahaffey KW, et al. Patterns of amiodarone use and outcomes in clinical practice for atrial fibrillation. Am Heart J. 2020 Feb;220:145–54.
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  - Loring Z, Shrader P, Allen LA, Blanco R, Chan PS, Ezekowitz MD, et al. Guideline-directed therapies for comorbidities and clinical outcomes among individuals with atrial fibrillation. Am Heart J. 2020 Jan;219:21–30.
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  - Vaduganathan M, Fonarow GC, Greene SJ, DeVore AD, Albert NM, Duffy CI, et al. Health-Related Quality of Life in Comorbid Heart Failure With Reduced Ejection Fraction and Diabetes Mellitus. J Am Coll Cardiol. 2019 Dec 24;74(25):3176–8.
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  - Giblin EM, Adams KF, Hill L, Fonarow GC, Williams FB, Sharma PP, et al. Comparison of Hydralazine/Nitrate and Angiotensin Receptor Neprilysin Inhibitor Use Among Black Versus Nonblack Americans With Heart Failure and Reduced Ejection Fraction (from CHAMP-HF). Am J Cardiol. 2019 Dec 15;124(12):1900–6.
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  - Zullig LL, Jazowski SA, Wang TY, Hellkamp A, Wojdyla D, Thomas L, et al. Novel application of approaches to predicting medication adherence using medical claims data. Health Serv Res. 2019 Dec;54(6):1255–62.
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  - Khariton Y, Fonarow GC, Arnold SV, Hellkamp A, Nassif ME, Sharma PP, et al. Association Between Sacubitril/Valsartan Initiation and Health Status Outcomes in Heart Failure With Reduced Ejection Fraction. Jacc Heart Fail. 2019 Nov;7(11):933–41.
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  - Rymer JA, Chen AY, Thomas L, Fonarow GC, Peterson ED, Wang TY. Readmissions After Acute Myocardial Infarction: How Often Do Patients Return to the Discharging Hospital? J Am Heart Assoc. 2019 Oct;8(19):e012059.
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  - Xian Y, Xu H, O’Brien EC, Shah S, Thomas L, Pencina MJ, et al. Clinical Effectiveness of Direct Oral Anticoagulants vs Warfarin in Older Patients With Atrial Fibrillation and Ischemic Stroke: Findings From the Patient-Centered Research Into Outcomes Stroke Patients Prefer and Effectiveness Research (PROSPER) Study. Jama Neurol. 2019 Oct 1;76(10):1192–202.
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  - Fanaroff AC, Vora AN, Chen AY, Mathews R, Udell JA, Roe MT, et al. Hospital participation in clinical trials for patients with acute myocardial infarction: Results from the National Cardiovascular Data Registry. Am Heart J. 2019 Aug;214:184–93.
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  - Nicholson WK, Wegienka G, Zhang S, Wallace K, Stewart E, Laughlin-Tommaso S, et al. Short-Term Health-Related Quality of Life After Hysterectomy Compared With Myomectomy for Symptomatic Leiomyomas. Obstet Gynecol. 2019 Aug;134(2):261–9.
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  - Pokorney SD, Holmes DN, Thomas L, Fonarow GC, Kowey PR, Reiffel JA, et al. Association Between Warfarin Control Metrics and Atrial Fibrillation Outcomes in the Outcomes Registry for Better Informed Treatment of Atrial Fibrillation. Jama Cardiol. 2019 Aug 1;4(8):756–64.
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  - Guimarães PO, Lopes RD, Alexander JH, Thomas L, Hellkamp AS, Hijazi Z, et al. International normalized ratio control and subsequent clinical outcomes in patients with atrial fibrillation using warfarin. J Thromb Thrombolysis. 2019 Jul;48(1):27–34.
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  - Shavadia JS, Holmes DN, Thomas L, Peterson ED, Granger CB, Roe MT, et al. Comparative Effectiveness of β-Blocker Use Beyond 3 Years After Myocardial Infarction and Long-Term Outcomes Among Elderly Patients. Circ Cardiovasc Qual Outcomes. 2019 Jul;12(7):e005103.
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  - Thomas M, Khariton Y, Fonarow GC, Arnold SV, Hill L, Nassif ME, et al. Association of Changes in Heart Failure Treatment With Patients' Health Status: Real-World Evidence From CHAMP-HF. Jacc Heart Fail. 2019 Jul;7(7):615–25.
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  - Thomas LE, O’Brien EC, Piccini JP, D’Agostino RB, Pencina MJ. Application of net reclassification index to non-nested and point-based risk prediction models: a review. Eur Heart J. 2019 Jun 14;40(23):1880–7.
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  - Greene SJ, Fonarow GC, DeVore AD, Sharma PP, Vaduganathan M, Albert NM, et al. Titration of Medical Therapy for Heart Failure With Reduced Ejection Fraction. J Am Coll Cardiol. 2019 May 21;73(19):2365–83.
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  - Vemulapalli S, Inohara T, Kim S, Thomas L, Piccini JP, Patel MR, et al. Blood Pressure Control and Cardiovascular Outcomes in Patients With Atrial Fibrillation (From the ORBIT-AF Registry). Am J Cardiol. 2019 May 15;123(10):1628–36.
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  - Perino AC, Shrader P, Turakhia MP, Ansell JE, Gersh BJ, Fonarow GC, et al. Comparison of Patient-Reported Care Satisfaction, Quality of Warfarin Therapy, and Outcomes of Atrial Fibrillation: Findings From the ORBIT - AF Registry. J Am Heart Assoc. 2019 May 7;8(9):e011205.
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  - Holmes DN, Piccini JP, Allen LA, Fonarow GC, Gersh BJ, Kowey PR, et al. Defining Clinically Important Difference in the Atrial Fibrillation Effect on Quality-of-Life Score. Circ Cardiovasc Qual Outcomes. 2019 May;12(5):e005358.
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  - Madhavan M, Holmes DN, Piccini JP, Ansell JE, Fonarow GC, Hylek EM, et al. Association of frailty and cognitive impairment with benefits of oral anticoagulation in patients with atrial fibrillation. Am Heart J. 2019 May;211:77–89.
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  - Peri-Okonny PA, Mi X, Khariton Y, Patel KK, Thomas L, Fonarow GC, et al. Target Doses of Heart Failure Medical Therapy and Blood Pressure: Insights From the CHAMP-HF Registry. Jacc Heart Fail. 2019 Apr;7(4):350–8.
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  - Thomas LE, Schulte PJ. Separating variability in healthcare practice patterns from random error. Stat Methods Med Res. 2019 Apr;28(4):1247–60.
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  - Doll JA, Hellkamp AS, Thomas L, Fonarow GC, Peterson E, Wang TY. The association of pre- and posthospital medication adherence in myocardial infarction patients. Am Heart J. 2019 Feb;208:74–80.
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  - Li F, Thomas LE. Addressing Extreme Propensity Scores via the Overlap Weights. Am J Epidemiol. 2019 Jan 1;188(1):250–7.
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  - O’Brien EC, Holmes DN, Thomas L, Singer DE, Fonarow GC, Mahaffey KW, et al. Incremental prognostic value of renal function for stroke prediction in atrial fibrillation. Int J Cardiol. 2019 Jan 1;274:152–7.
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  - Jackson LR, Kim S, Shrader P, Blanco R, Thomas L, Ezekowitz MD, et al. Early therapeutic persistence on dabigatran versus warfarin therapy in patients with atrial fibrillation: results from the Outcomes Registry for Better Informed Treatment of Atrial Fibrillation (ORBIT-AF) registry. J Thromb Thrombolysis. 2018 Nov;46(4):435–9.
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  - Arnold SV, Cohen DJ, Dai D, Jones PG, Li F, Thomas L, et al. Predicting Quality of Life at 1 Year After Transcatheter Aortic Valve Replacement in a Real-World Population. Circ Cardiovasc Qual Outcomes. 2018 Oct;11(10):e004693.
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  - Huffman MD, Thomas LE. Tools for Evaluating and Improving Causal Inference: Introducing JAMA Cardiology Readers to the Risk of Bias in Nonrandomized Studies of Interventions (ROBINS-I) Tool. Jama Cardiol. 2018 Oct 1;3(10):907.
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  - Washam JB, Holmes DN, Thomas LE, Pokorney SD, Hylek EM, Fonarow GC, et al. Pharmacotherapy for Atrial Fibrillation in Patients With Chronic Kidney Disease: Insights From ORBIT-AF. J Am Heart Assoc. 2018 Sep 18;7(18):e008928.
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  - Rymer JA, Chen AY, Thomas L, Stafford J, Enriquez JR, Goyal A, et al. Advanced Practice Provider Versus Physician-Only Outpatient Follow-Up After Acute Myocardial Infarction. J Am Heart Assoc. 2018 Sep 4;7(17):e008481.
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  - DeVore AD, Hill CL, Thomas L, Sharma PP, Albert NM, Butler J, et al. Patient, Provider, and Practice Characteristics Associated With Sacubitril/Valsartan Use in the United States. Circ Heart Fail. 2018 Sep;11(9):e005400.
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  - O’Brien EC, Li S, Thomas L, Wang TY, Roe MT, Peterson ED. The impact of clinical vs administrative claims coding on hospital risk-adjusted outcomes. Clin Cardiol. 2018 Sep;41(9):1225–31.
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  - O’Brien EC, Holmes DN, Thomas LE, Fonarow GC, Allen LA, Gersh BJ, et al. Prognostic Significance of Nuisance Bleeding in Anticoagulated Patients With Atrial Fibrillation. Circulation. 2018 Aug 28;138(9):889–97.
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  - Jackson LR, Kim S, Fonarow GC, Freeman JV, Gersh BJ, Go AS, et al. Stroke Risk and Treatment in Patients with Atrial Fibrillation and Low CHA2DS2-VASc Scores: Findings From the ORBIT-AF I and II Registries. J Am Heart Assoc. 2018 Aug 21;7(16):e008764.
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  - Greene SJ, Butler J, Albert NM, DeVore AD, Sharma PP, Duffy CI, et al. Medical Therapy for Heart Failure With Reduced Ejection Fraction: The CHAMP-HF Registry. J Am Coll Cardiol. 2018 Jul 24;72(4):351–66.
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  - Stewart EA, Lytle BL, Thomas L, Wegienka GR, Jacoby V, Diamond MP, et al. The Comparing Options for Management: PAtient-centered REsults for Uterine Fibroids (COMPARE-UF) registry: rationale and design. Am J Obstet Gynecol. 2018 Jul;219(1):95.e1-95.e10.
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  - DeVore AD, Mi X, Thomas L, Sharma PP, Albert NM, Butler J, et al. Characteristics and Treatments of Patients Enrolled in the CHAMP-HF Registry Compared With Patients Enrolled in the PARADIGM-HF Trial. J Am Heart Assoc. 2018 Jun 12;7(12).
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  - O’Brien EC, Holmes DN, Thomas L, Fonarow GC, Kowey PR, Ansell JE, et al. Therapeutic Strategies Following Major, Clinically Relevant Nonmajor, and Nuisance Bleeding in Atrial Fibrillation: Findings From ORBIT-AF. J Am Heart Assoc. 2018 Jun 9;7(12).
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  - Khariton Y, Nassif ME, Thomas L, Fonarow GC, Mi X, DeVore AD, et al. Health Status Disparities by Sex, Race/Ethnicity, and Socioeconomic Status in Outpatients With Heart Failure. Jacc Heart Fail. 2018 Jun;6(6):465–73.
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  - Udell JA, Desai NR, Li S, Thomas L, de Lemos JA, Wright-Slaughter P, et al. Neighborhood Socioeconomic Disadvantage and Care After Myocardial Infarction in the National Cardiovascular Data Registry. Circ Cardiovasc Qual Outcomes. 2018 Jun;11(6):e004054.
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  - Fanaroff AC, Chen AY, Thomas LE, Pieper KS, Garratt KN, Peterson ED, et al. Risk Score to Predict Need for Intensive Care in Initially Hemodynamically Stable Adults With Non-ST-Segment-Elevation Myocardial Infarction. J Am Heart Assoc. 2018 May 25;7(11).
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  - Mathews R, Wang W, Kaltenbach LA, Thomas L, Shah RU, Ali M, et al. Hospital Variation in Adherence Rates to Secondary Prevention Medications and the Implications on Quality. Circulation. 2018 May 15;137(20):2128–38.
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  - Fudim M, Liu PR, Shrader P, Blanco RG, Allen LA, Fonarow GC, et al. Mineralocorticoid Receptor Antagonism in Patients With Atrial Fibrillation: Findings From the ORBIT-AF (Outcomes Registry for Better Informed Treatment of Atrial Fibrillation) Registry. J Am Heart Assoc. 2018 Apr 13;7(8).
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  - Khariton Y, Hernandez AF, Fonarow GC, Sharma PP, Duffy CI, Thomas L, et al. Health Status Variation Across Practices in Outpatients With Heart Failure: Insights From the CHAMP-HF (Change the Management of Patients With Heart Failure) Registry. Circ Cardiovasc Qual Outcomes. 2018 Apr;11(4):e004668.
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  - Pokorney SD, Yen DC, Campbell KB, Allen LaPointe NM, Sheng S, Thomas L, et al. Dofetilide dose reductions and discontinuations in women compared with men. Heart Rhythm. 2018 Apr;15(4):478–84.
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  - Lopes RD, Rordorf R, De Ferrari GM, Leonardi S, Thomas L, Wojdyla DM, et al. Digoxin and Mortality in Patients With Atrial Fibrillation. J Am Coll Cardiol. 2018 Mar 13;71(10):1063–74.
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  - Shavadia JS, French W, Hellkamp AS, Thomas L, Bates ER, Manoukian SV, et al. Comprehensive electrocardiogram-to-device time for primary percutaneous coronary intervention in ST-segment elevation myocardial infarction: A report from the American Heart Association mission: Lifeline program. Am Heart J. 2018 Mar;197:9–17.
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  - Steinberg BA, Shrader P, Pieper K, Thomas L, Allen LA, Ansell J, et al. Frequency and Outcomes of Reduced Dose Non-Vitamin K Antagonist Anticoagulants: Results From ORBIT-AF II (The Outcomes Registry for Better Informed Treatment of Atrial Fibrillation II). J Am Heart Assoc. 2018 Feb 16;7(4).
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  - Echouffo-Tcheugui JB, Shrader P, Thomas L, Piccini JP, Fonarow GC. Reply: Graphing Ratio Measures on Forest Plot. J Am Coll Cardiol. 2018 Feb 6;71(5):586.
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  - Wang WT, Hellkamp A, Doll JA, Thomas L, Navar AM, Fonarow GC, et al. Lipid Testing and Statin Dosing After Acute Myocardial Infarction. J Am Heart Assoc. 2018 Jan 25;7(3).
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  - Inohara T, Shrader P, Pieper K, Blanco RG, Thomas L, Singer DE, et al. Association of of Atrial Fibrillation Clinical Phenotypes With Treatment Patterns and Outcomes: A Multicenter Registry Study. Jama Cardiol. 2018 Jan 1;3(1):54–63.
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  - Kraus WE, Yates T, Tuomilehto J, Sun J-L, Thomas L, McMurray JJV, et al. Relationship between baseline physical activity assessed by pedometer count and new-onset diabetes in the NAVIGATOR trial. Bmj Open Diabetes Res Care. 2018;6(1):e000523.
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  - Thomas KL, Jackson LR, Shrader P, Ansell J, Fonarow GC, Gersh B, et al. Prevalence, Characteristics, and Outcomes of Valvular Heart Disease in Patients With Atrial Fibrillation: Insights From the ORBIT-AF (Outcomes Registry for Better Informed Treatment for Atrial Fibrillation). J Am Heart Assoc. 2017 Dec 22;6(12).
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  - Steinberg BA, Gao H, Shrader P, Pieper K, Thomas L, Camm AJ, et al. International trends in clinical characteristics and oral anticoagulation treatment for patients with atrial fibrillation: Results from the GARFIELD-AF, ORBIT-AF I, and ORBIT-AF II registries. Am Heart J. 2017 Dec;194:132–40.
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  - Barnett AS, Kim S, Fonarow GC, Thomas LE, Reiffel JA, Allen LA, et al. Treatment of Atrial Fibrillation and Concordance With the American Heart Association/American College of Cardiology/Heart Rhythm Society Guidelines: Findings From ORBIT-AF (Outcomes Registry for Better Informed Treatment of Atrial Fibrillation). Circ Arrhythm Electrophysiol. 2017 Nov;10(11).
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  - Xian Y, Thomas L, Liang L, Federspiel JJ, Webb LE, Bushnell CD, et al. Unexplained Variation for Hospitals' Use of Inpatient Rehabilitation and Skilled Nursing Facilities After an Acute Ischemic Stroke. Stroke. 2017 Oct;48(10):2836–42.
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  - Echouffo-Tcheugui JB, Shrader P, Thomas L, Gersh BJ, Kowey PR, Mahaffey KW, et al. Care Patterns and Outcomes in Atrial Fibrillation Patients With and Without Diabetes: ORBIT-AF Registry. J Am Coll Cardiol. 2017 Sep 12;70(11):1325–35.
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  - Pagidipati NJ, Hellkamp A, Thomas L, Gulati M, Peterson ED, Wang TY. Use of Prescription Smoking Cessation Medications After Myocardial Infarction Among Older Patients in Community Practice. Jama Cardiol. 2017 Sep 1;2(9):1040–2.
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  - Brennan JM, Thomas L, Cohen DJ, Shahian D, Wang A, Mack MJ, et al. Transcatheter Versus Surgical Aortic Valve Replacement: Propensity-Matched Comparison. J Am Coll Cardiol. 2017 Jul 25;70(4):439–50.
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  - DeVore AD, Thomas L, Albert NM, Butler J, Hernandez AF, Patterson JH, et al. Change the management of patients with heart failure: Rationale and design of the CHAMP-HF registry. Am Heart J. 2017 Jul;189:177–83.
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  - Melloni C, Shrader P, Carver J, Piccini JP, Thomas L, Fonarow GC, et al. Management and outcomes of patients with atrial fibrillation and a history of cancer: the ORBIT-AF registry. Eur Heart J Qual Care Clin Outcomes. 2017 Jul 1;3(3):192–7.
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  - Steinberg BA, Shrader P, Thomas L, Ansell J, Fonarow GC, Gersh BJ, et al. Factors associated with non-vitamin K antagonist oral anticoagulants for stroke prevention in patients with new-onset atrial fibrillation: Results from the Outcomes Registry for Better Informed Treatment of Atrial Fibrillation II (ORBIT-AF II). Am Heart J. 2017 Jul;189:40–7.
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  - Huffman KM, Sun J-L, Thomas L, Bales CW, Califf RM, Yates T, et al. Impact of baseline physical activity and diet behavior on metabolic syndrome in a pharmaceutical trial: results from NAVIGATOR. Metabolism. 2014 Apr;63(4):554–61.
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  - Yates T, Haffner SM, Schulte PJ, Thomas L, Huffman KM, Bales CW, et al. Association between change in daily ambulatory activity and cardiovascular events in people with impaired glucose tolerance (NAVIGATOR trial): a cohort analysis. Lancet. 2014 Mar 22;383(9922):1059–66.
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  - Harskamp RE, Wang TY, Bhatt DL, Wiviott SD, Amsterdam EA, Li S, et al. Hospital patterns of medical management strategy use for patients with non-ST-elevation myocardial infarction and 3-vessel or left main coronary artery disease. Am Heart J. 2014 Mar;167(3):355-362.e3.
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  - Xian Y, Chen AY, Thomas L, Roe MT, Subherwal S, Cannon CP, et al. Sources of hospital-level variation in major bleeding among patients with non-st-segment elevation myocardial infarction: a report from the National Cardiovascular Data Registry (NCDR). Circ Cardiovasc Qual Outcomes. 2014 Mar;7(2):236–43.
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  - Wallentin L, Lopes RD, Hanna M, Thomas L, Hellkamp A, Nepal S, et al. Response to letter regarding article, "Efficacy and safety of apixaban compared with warfarin at different levels of predicted international normalized ratio control for stroke prevention in atrial fibrillation". Circulation. 2014 Jan 14;129(2):e21–2.
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  - Alexander JH, Lopes RD, Thomas L, Alings M, Atar D, Aylward P, et al. Apixaban vs. warfarin with concomitant aspirin in patients with atrial fibrillation: insights from the ARISTOTLE trial. Eur Heart J. 2014 Jan;35(4):224–32.
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  - Harskamp RE, Wang TY, Bhatt DL, Wiviott SD, Amsterdam EA, Li S, et al. Hospital patterns of medical management strategy use for patients with non-ST-elevation myocardial infarction and 3-vessel or left main coronary artery disease. American Heart Journal. 2014;167(3):355-362.e3.
  - Shen L, Shah BR, Reyes EM, Thomas L, Wojdyla D, Diem P, et al. Role of diuretics, β blockers, and statins in increasing the risk of diabetes in patients with impaired glucose tolerance: reanalysis of data from the NAVIGATOR study. Bmj. 2013 Dec 9;347:f6745.
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  - Shen L, Peterson ED, Li S, Thomas L, Alexander K, Xian Y, et al. The association between smoking and long-term outcomes after non-ST-segment elevation myocardial infarction in older patients. Am Heart J. 2013 Dec;166(6):1056–62.
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  - Steinberg BA, Holmes DN, Piccini JP, Ansell J, Chang P, Fonarow GC, et al. Early adoption of dabigatran and its dosing in US patients with atrial fibrillation: results from the outcomes registry for better informed treatment of atrial fibrillation. J Am Heart Assoc. 2013 Nov 25;2(6):e000535.
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  - Fosbol EL, Wang TY, Li S, Piccini J, Lopes RD, Mills RM, et al. Warfarin use among older atrial fibrillation patients with non-ST-segment elevation myocardial infarction managed with coronary stenting and dual antiplatelet therapy. Am Heart J. 2013 Nov;166(5):864–70.
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  - Latini R, Staszewsky L, Sun J-L, Bethel MA, Disertori M, Haffner SM, et al. Incidence of atrial fibrillation in a population with impaired glucose tolerance: the contribution of glucose metabolism and other risk factors. A post hoc analysis of the Nateglinide and Valsartan in Impaired Glucose Tolerance Outcomes Research trial. Am Heart J. 2013 Nov;166(5):935-40.e1.
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  - Shah BR, Thomas KL, Elliot-Bynum S, Thomas K, Damon K, Allen LaPointe N, et al. Check it, change it: a community-based intervention to improve blood pressure control. Circ Cardiovasc Qual Outcomes. 2013 Nov;6(6):741–8.
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  - Thomas L, Stefanski LA, Davidian M. Moment Adjusted Imputation for Multivariate Measurement Error Data with Applications to Logistic Regression. Comput Stat Data Anal. 2013 Nov 1;67:15–24.
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  - Hess CN, Shah BR, Peng SA, Thomas L, Roe MT, Peterson ED. Association of early physician follow-up and 30-day readmission after non-ST-segment-elevation myocardial infarction among older patients. Circulation. 2013 Sep 10;128(11):1206–13.
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  - Garcia DA, Wallentin L, Lopes RD, Thomas L, Alexander JH, Hylek EM, et al. Apixaban versus warfarin in patients with atrial fibrillation according to prior warfarin use: results from the Apixaban for Reduction in Stroke and Other Thromboembolic Events in Atrial Fibrillation trial. Am Heart J. 2013 Sep;166(3):549–58.
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  - Preiss D, Giles TD, Thomas LE, Sun J-L, Haffner SM, Holman RR, et al. Predictors of stroke in patients with impaired glucose tolerance: results from the Nateglinide and Valsartan in Impaired Glucose Tolerance Outcomes Research trial. Stroke. 2013 Sep;44(9):2590–3.
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  - Steinberg BA, Kim S, Piccini JP, Fonarow GC, Lopes RD, Thomas L, et al. Use and associated risks of concomitant aspirin therapy with oral anticoagulation in patients with atrial fibrillation: insights from the Outcomes Registry for Better Informed Treatment of Atrial Fibrillation (ORBIT-AF) Registry. Circulation. 2013 Aug 13;128(7):721–8.
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  - Al-Khatib SM, Thomas L, Wallentin L, Lopes RD, Gersh B, Garcia D, et al. Outcomes of apixaban vs. warfarin by type and duration of atrial fibrillation: results from the ARISTOTLE trial. Eur Heart J. 2013 Aug;34(31):2464–71.
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  - Bagai A, Chen AY, Wang TY, Alexander KP, Thomas L, Ohman EM, et al. Long-term outcomes among older patients with non-ST-segment elevation myocardial infarction complicated by cardiogenic shock. Am Heart J. 2013 Aug;166(2):298–305.
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  - Fosbol EL, Holmes DN, Piccini JP, Thomas L, Reiffel JA, Mills RM, et al. Provider specialty and atrial fibrillation treatment strategies in United States community practice: findings from the ORBIT-AF registry. J Am Heart Assoc. 2013 Jul 18;2(4):e000110.
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  - Bethel MA, Chacra AR, Deedwania P, Fulcher GR, Holman RR, Jenssen T, et al. A novel risk classification paradigm for patients with impaired glucose tolerance and high cardiovascular risk. Am J Cardiol. 2013 Jul 15;112(2):231–7.
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  - Cullen MW, Kim S, Piccini JP, Ansell JE, Fonarow GC, Hylek EM, et al. Risks and benefits of anticoagulation in atrial fibrillation: insights from the Outcomes Registry for Better Informed Treatment of Atrial Fibrillation (ORBIT-AF) registry. Circ Cardiovasc Qual Outcomes. 2013 Jul;6(4):461–9.
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  - Hess PL, Kim S, Piccini JP, Allen LA, Ansell JE, Chang P, et al. Use of evidence-based cardiac prevention therapy among outpatients with atrial fibrillation. Am J Med. 2013 Jul;126(7):625-32.e1.
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  - Wallentin L, Lopes RD, Hanna M, Thomas L, Hellkamp A, Nepal S, et al. Efficacy and safety of apixaban compared with warfarin at different levels of predicted international normalized ratio control for stroke prevention in atrial fibrillation. Circulation. 2013 Jun 4;127(22):2166–76.
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  - Chatterjee R, Thomas L, Svetkey L, Brancati FL, Califf RM, Edelman D. Effects of changes in potassium with valsartan use on diabetes risk: Nateglinide and Valsartan in Impaired Glucose Tolerance Outcomes Research (NAVIGATOR) trial. Am J Hypertens. 2013 Jun;26(6):723–6.
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  - Roe MT, Li S, Thomas L, Wang TY, Alexander KP, Ohman EM, et al. Long-term outcomes after invasive management for older patients with non-ST-segment elevation myocardial infarction. Circ Cardiovasc Qual Outcomes. 2013 May 1;6(3):323–32.
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  - Manfredi JA, Al-Khatib SM, Shaw LK, Thomas L, Fogel RI, Padanilam B, et al. Association between left ventricular ejection fraction post-cardiac resynchronization treatment and subsequent implantable cardioverter defibrillator therapy for sustained ventricular tachyarrhythmias. Circ Arrhythm Electrophysiol. 2013 Apr;6(2):257–64.
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  - Fosbøl EL, Peterson ED, Weeke P, Wang TY, Mathews R, Kober L, et al. Spousal depression, anxiety, and suicide after myocardial infarction. Eur Heart J. 2013 Mar;34(9):649–56.
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  - Wong YW, Thomas L, Sun J-L, McMurray JJV, Krum H, Hernandez AF, et al. Predictors of incident heart failure hospitalizations among patients with impaired glucose tolerance: insight from the Nateglinide And Valsartan in Impaired Glucose Tolerance Outcomes Research study. Circ Heart Fail. 2013 Mar;6(2):203–10.
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  - Thomas L, Peterson ED. Statistical analysis plans in observational research--reply. Jama. 2013 Jan 2;309(1):32.
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  - Leonardi S, Thomas L, Neely ML, Tricoci P, Lopes RD, White HD, et al. Comparison of the prognosis of spontaneous and percutaneous coronary intervention-related myocardial infarction. J Am Coll Cardiol. 2012 Dec 4;60(22):2296–304.
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  - Hohnloser SH, Hijazi Z, Thomas L, Alexander JH, Amerena J, Hanna M, et al. Efficacy of apixaban when compared with warfarin in relation to renal function in patients with atrial fibrillation: insights from the ARISTOTLE trial. Eur Heart J. 2012 Nov;33(22):2821–30.
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  - Thomas L, Peterson ED. The value of statistical analysis plans in observational research: defining high-quality research from the start. Jama. 2012 Aug 22;308(8):773–4.
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  - Lopes RD, Subherwal S, Holmes DN, Thomas L, Wang TY, Rao SV, et al. The association of in-hospital major bleeding with short-, intermediate-, and long-term mortality among older patients with non-ST-segment elevation myocardial infarction. Eur Heart J. 2012 Aug;33(16):2044–53.
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  - Subherwal S, Bhatt DL, Li S, Wang TY, Thomas L, Alexander KP, et al. Polyvascular disease and long-term cardiovascular outcomes in older patients with non-ST-segment-elevation myocardial infarction. Circ Cardiovasc Qual Outcomes. 2012 Jul 1;5(4):541–9.
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  - Subherwal S, Peterson ED, Dai D, Thomas L, Messenger JC, Xian Y, et al. Temporal trends in and factors associated with bleeding complications among patients undergoing percutaneous coronary intervention: a report from the National Cardiovascular Data CathPCI Registry. J Am Coll Cardiol. 2012 May 22;59(21):1861–9.
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  - Fosbol EL, Wang TY, Li S, Piccini JP, Lopes RD, Shah B, et al. Safety and effectiveness of antithrombotic strategies in older adult patients with atrial fibrillation and non-ST elevation myocardial infarction. Am Heart J. 2012 Apr;163(4):720–8.
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  - Kociol RD, Lopes RD, Clare R, Thomas L, Mehta RH, Kaul P, et al. International variation in and factors associated with hospital readmission after myocardial infarction. Jama. 2012 Jan 4;307(1):66–74.
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  - Preiss D, Thomas LE, Sun J-L, Haffner SM, Holman RR, Standl E, et al. Predictors of cardiovascular events in a contemporary population with impaired glucose tolerance: an observational analysis of the Nateglinide and Valsartan in impaired glucose tolerance outcomes research (NAVIGATOR) trial. Bmj Open. 2012;2(6).
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  - Samsa GP, Thomas L, Lee LS, Neal EM. An active learning approach to teach advanced multi-predictor modeling concepts to clinicians. Journal of Statistics Education. 2012 Jan 1;20(1):1–34.
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  - Thomas L, Stefanski L, Davidian M. A moment-adjusted imputation method for measurement error models. Biometrics. 2011 Dec;67(4):1461–70.
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  - Roe MT, Chen AY, Thomas L, Wang TY, Alexander KP, Hammill BG, et al. Predicting long-term mortality in older patients after non-ST-segment elevation myocardial infarction: the CRUSADE long-term mortality model and risk score. Am Heart J. 2011 Nov;162(5):875-883.e1.
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  - Piccini JP, Fraulo ES, Ansell JE, Fonarow GC, Gersh BJ, Go AS, et al. Outcomes registry for better informed treatment of atrial fibrillation: rationale and design of ORBIT-AF. Am Heart J. 2011 Oct;162(4):606-612.e1.
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  - Britton KA, Aggarwal V, Chen AY, Alexander KP, Amsterdam E, Fraulo E, et al. No association between hemoglobin A1c and in-hospital mortality in patients with diabetes and acute myocardial infarction. Am Heart J. 2011 Apr;161(4):657-663.e1.
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  - Fiuzat M, Shaw LK, Thomas L, Felker GM, O’Connor CM. United States stock market performance and acute myocardial infarction rates in 2008-2009 (from the Duke Databank for Cardiovascular Disease). Am J Cardiol. 2010 Dec 1;106(11):1545–9.
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  - Berger JS, Elliott L, Gallup D, Roe M, Granger CB, Armstrong PW, et al. Sex differences in mortality following acute coronary syndromes. Jama. 2009 Aug 26;302(8):874–82.
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  - Ashley-Koch AE, Elliott L, Kail ME, De Castro LM, Jonassaint J, Jackson TL, et al. Identification of genetic polymorphisms associated with risk for pulmonary hypertension in sickle cell disease. Blood. 2008 Jun 15;111(12):5721–6.
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  - DREAM Trial Investigators, Dagenais GR, Gerstein HC, Holman R, Budaj A, Escalante A, et al. Effects of ramipril and rosiglitazone on cardiovascular and renal outcomes in people with impaired glucose tolerance or impaired fasting glucose: results of the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) trial. Diabetes Care. 2008 May;31(5):1007–14.
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  - Elliott L, Ashley-Koch AE, De Castro L, Jonassaint J, Price J, Ataga KI, et al. Genetic polymorphisms associated with priapism in sickle cell disease. Br J Haematol. 2007 May;137(3):262–7.
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  - DREAM Trial Investigators, Bosch J, Yusuf S, Gerstein HC, Pogue J, Sheridan P, et al. Effect of ramipril on the incidence of diabetes. N Engl J Med. 2006 Oct 12;355(15):1551–62.
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- Conference Papers
  - Thomas M, Khariton Y, Fonarow GC, Arnold SV, Hill L, Nassif ME, et al. Association between sacubitril/valsartan initiation and real-world health status trajectories over 18 months in heart failure with reduced ejection fraction. In: Esc Heart Failure. 2021.
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  - Melloni C, Dunning A, Granger CB, Thomas L, Khouri MG, Garcia DA, et al. Efficacy and Safety of Apixaban Versus Warfarin in Patients with Atrial Fibrillation and a History of Cancer: Insights from the ARISTOTLE Trial. In: Am J Med. 2017. p. 1440-1448.e1.
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  - Piccini J, Washam JB, Simon DN, Thomas LE, Hylek EM, Fonarow GC, et al. Pharmacotherapy for atrial fibrillation in patients with chronic kidney disease: insights from the outcomes registry for better informed treatment of atrial fibrillation (ORBIT AF). In: European Heart Journal. OXFORD UNIV PRESS; 2016. p. 685–685.
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  - Pokorney SD, Simon DN, Thomas LE, Fonarow GC, Mahaffey KW, Gersh BJ, et al. Patterns of amiodarone use and outcomes in clinical practice for atrial fibrillation: insights from the Outcomes Registry for Better Informed Treatment of Atrial Fibrillation (ORBIT AF). In: European Heart Journal. OXFORD UNIV PRESS; 2016. p. 686–686.
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  - Noheria A, Shrader P, Piccini JP, Fonarow GC, Kowey PR, Mahaffey KW, et al. Rhythm Control Versus Rate Control and Clinical Outcomes in Patients With Atrial Fibrillation: Results From the Outcomes Registry for Better Informed Treatment of Atrial Fibrillation (ORBIT-AF). In: Circulation. LIPPINCOTT WILLIAMS & WILKINS; 2015.
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  - Durheim MT, Cyr DD, Al-Khatib SM, Thomas LE, Lopes RD, Gersh BJ, et al. Chronic Obstructive Pulmonary Disease Is Associated With Increased Risk Of Mortality Among Patients With Atrial Fibrillation: Insights From The Aristotle Trial. In: American Journal of Respiratory and Critical Care Medicine. AMER THORACIC SOC; 2015.
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Teaching & Mentoring
Recent Courses
- BIOSTAT 709: Observational Studies 2021
- BIOSTAT 709: Observational Studies 2020
- BIOSTAT 709: Observational Studies 2019

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Education, Training, & Certifications

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