Laine Elliott Thomas | Scholars@Duke

Laine Elliott Thomas
Associate Professor of Biostatistics and Bioinformatics

Measurement error, longitudinal data, joint modeling

Current Appointments & Affiliations

Associate Professor of Biostatistics and Bioinformatics, Biostatistics & Bioinformatics, Basic Science Departments 2021
Associate Director, DCRI Biostatistics, Biostatistics & Bioinformatics, Basic Science Departments 2018
Associate Chair for Diversity and Inclusion in the Department of Biostatistics & Bioinformatics, Biostatistics & Bioinformatics, Basic Science Departments 2020
Member in the Duke Clinical Research Institute, Duke Clinical Research Institute, Institutes and Centers 2009

Contact Information

200 Morris Street, 7812 200 Morris, Durham, NC 27701
Duke Box 3850, Durham, NC 27710
laine.thomas@duke.edu (919) 684-1289

Background
Education, Training, & Certifications
- Ph.D., North Carolina State University 2009
Duke Appointment History
- Associate Professor of Biostatistics and Bioinformatics, Biostatistics & Bioinformatics, Basic Science Departments 2018 - 2020
- Assistant Professor of Biostatistics and Bioinformatics, Biostatistics & Bioinformatics, Basic Science Departments 2009 - 2018
Leadership & Clinical Positions at Duke
- Associate Director, Biostatistics at the DCRI
Expertise
Global Scholarship
- Research
  - Denmark (Country)
Research
Selected Grants
- New causal inference methods for cluster randomized trials with post-randomization selection awarded by Patient Centered Outcomes Research Institute 2020 - 2024
- Postdoctoral Training in Cardiovascular Clinical Research awarded by National Institutes of Health 2003 - 2024
- HERO Program, HERO Registry, HERO-HCQ Trial awarded by Patient Centered Outcomes Research Institute 2020 - 2023
- Methods for the Design and Conduct of Subgroup Analysis in Observational Studies awarded by Patient Centered Outcomes Research Institute 2019 - 2022
- CHAMP-HF awarded by Novartis Pharmaceuticals Corporation 2016 - 2022
- Integrated Biostatistical Training for CVD Research awarded by North Carolina State University 2017 - 2021
- Determinants of Incident Stroke Cognitive Outcomes and Vascular Effects on RecoverY awarded by Johns Hopkins University 2019 - 2020
- GARFIELD-Atrial Fibrillation Registry Research awarded by Thrombosis Research Institute 2016 - 2020
- Statistical Methods for Complex Data in Cardiovascular Disease awarded by North Carolina State University 2013 - 2018
- Matching Methods for Comparative Effectiveness Studies of Longitudinal Treatments awarded by Agency for Healthcare Research and Quality 2015 - 2017
- NCDR-ACTION awarded by American College of Cardiology Foundation 2008 - 2015
External Relationships
- Amgen, Inc.
- JAMA
- Pfizer Inc.
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Shen, Lan, Ying Xian, Anita Y. Chen, Laine Thomas, Matthew T. Roe, Eric D. Peterson, and Ben He. “Effect of intervention timing on one-year mortality in elderly non-ST-segment elevation myocardial infarction patients.” Coron Artery Dis 32, no. 2 (March 1, 2021): 138–44. https://doi.org/10.1097/MCA.0000000000000916.
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  - Zhou, Yunji, Roland A. Matsouaka, and Laine Thomas. “Propensity score weighting under limited overlap and model misspecification.” Stat Methods Med Res 29, no. 12 (December 2020): 3721–56. https://doi.org/10.1177/0962280220940334.
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  - Jackson, Larry R., Sunghee Kim, Rosalia Blanco, Laine Thomas, Jack Ansell, Gregg C. Fonarow, Bernard J. Gersh, et al. “Discontinuation rates of warfarin versus direct acting oral anticoagulants in US clinical practice: Results from Outcomes Registry for Better Informed Treatment of Atrial Fibrillation II (ORBIT-AF II).” Am Heart J 226 (August 2020): 85–93. https://doi.org/10.1016/j.ahj.2020.04.016.
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  - Thomas, Laine E., Siyun Yang, Daniel Wojdyla, and Douglas E. Schaubel. “Matching with time-dependent treatments: A review and look forward.” Stat Med 39, no. 17 (July 30, 2020): 2350–70. https://doi.org/10.1002/sim.8533.
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  - Thomas, Laine E., Fan Li, and Michael J. Pencina. “Overlap Weighting: A Propensity Score Method That Mimics Attributes of a Randomized Clinical Trial.” Jama 323, no. 23 (June 16, 2020): 2417–18. https://doi.org/10.1001/jama.2020.7819.
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  - Vaduganathan, Muthiah, Gregg C. Fonarow, Stephen J. Greene, Adam D. DeVore, Abhishek Kavati, Slaven Sikirica, Nancy M. Albert, et al. “Contemporary Treatment Patterns and Clinical Outcomes of Comorbid Diabetes Mellitus and HFrEF: The CHAMP-HF Registry.” Jacc Heart Fail 8, no. 6 (June 2020): 469–80. https://doi.org/10.1016/j.jchf.2019.12.015.
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  - Alexander, John H., Daniel Wojdyla, Amit N. Vora, Laine Thomas, Christopher B. Granger, Shaun G. Goodman, Ronald Aronson, Stephan Windecker, Roxana Mehran, and Renato D. Lopes. “Risk/Benefit Tradeoff of Antithrombotic Therapy in Patients With Atrial Fibrillation Early and Late After an Acute Coronary Syndrome or Percutaneous Coronary Intervention: Insights From AUGUSTUS.” Circulation 141, no. 20 (May 19, 2020): 1618–27. https://doi.org/10.1161/CIRCULATIONAHA.120.046534.
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  - Thomas, Laine E., Robert O. Bonow, and Michael J. Pencina. “Understanding Observational Treatment Comparisons in the Setting of Coronavirus Disease 2019 (COVID-19).” Jama Cardiol, May 5, 2020. https://doi.org/10.1001/jamacardio.2020.1874.
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  - Laughlin-Tommaso, Shannon K., Di Lu, Laine Thomas, Michael P. Diamond, Kedra Wallace, Ganesa Wegienka, Anissa I. Vines, et al. “Short-term quality of life after myomectomy for uterine fibroids from the COMPARE-UF Fibroid Registry.” Am J Obstet Gynecol 222, no. 4 (April 2020): 345.e1-345.e22. https://doi.org/10.1016/j.ajog.2019.09.052.
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  - Pokorney, Sean D., Eric Black-Maier, Anne S. Hellkamp, Daniel J. Friedman, Sreekanth Vemulapalli, Christopher B. Granger, Laine Thomas, Eric D. Peterson, and Jonathan P. Piccini. “Oral Anticoagulation and Cardiovascular Outcomes in Patients With Atrial Fibrillation and End-Stage Renal Disease.” J Am Coll Cardiol 75, no. 11 (March 24, 2020): 1299–1308. https://doi.org/10.1016/j.jacc.2020.01.019.
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  - Lopes, Renato D., Sergio Leonardi, Daniel M. Wojdyla, Amit N. Vora, Laine Thomas, Robert F. Storey, Dragos Vinereanu, et al. “Stent Thrombosis in Patients With Atrial Fibrillation Undergoing Coronary Stenting in the AUGUSTUS Trial.” Circulation 141, no. 9 (March 3, 2020): 781–83. https://doi.org/10.1161/CIRCULATIONAHA.119.044584.
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  - Wallace, Kedra, Shuaiqi Zhang, Laine Thomas, Elizabeth A. Stewart, Wanda Kay Nicholson, Ganesa R. Wegienka, Lauren A. Wise, et al. “Comparative effectiveness of hysterectomy versus myomectomy on one-year health-related quality of life in women with uterine fibroids.” Fertil Steril 113, no. 3 (March 2020): 618–26. https://doi.org/10.1016/j.fertnstert.2019.10.028.
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  - Vaduganathan, Muthiah, Gregg C. Fonarow, Stephen J. Greene, Adam D. DeVore, Nancy M. Albert, Carol I. Duffy, C Larry Hill, John A. Spertus, Laine E. Thomas, and Javed Butler. “Health-Related Quality of Life in Comorbid Heart Failure With Reduced Ejection Fraction and Diabetes Mellitus.” J Am Coll Cardiol 74, no. 25 (December 24, 2019): 3176–78. https://doi.org/10.1016/j.jacc.2019.10.020.
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  - Giblin, Erika M., Kirkwood F. Adams, Larry Hill, Gregg C. Fonarow, Fredonia B. Williams, Puza P. Sharma, Nancy M. Albert, et al. “Comparison of Hydralazine/Nitrate and Angiotensin Receptor Neprilysin Inhibitor Use Among Black Versus Nonblack Americans With Heart Failure and Reduced Ejection Fraction (from CHAMP-HF).” Am J Cardiol 124, no. 12 (December 15, 2019): 1900–1906. https://doi.org/10.1016/j.amjcard.2019.09.020.
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  - Zullig, Leah L., Shelley A. Jazowski, Tracy Y. Wang, Anne Hellkamp, Daniel Wojdyla, Laine Thomas, Lisa Egbuonu-Davis, Anne Beal, and Hayden B. Bosworth. “Novel application of approaches to predicting medication adherence using medical claims data.” Health Serv Res 54, no. 6 (December 2019): 1255–62. https://doi.org/10.1111/1475-6773.13200.
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  - Khariton, Yevgeniy, Gregg C. Fonarow, Suzanne V. Arnold, Ann Hellkamp, Michael E. Nassif, Puza P. Sharma, Javed Butler, et al. “Association Between Sacubitril/Valsartan Initiation and Health Status Outcomes in Heart Failure With Reduced Ejection Fraction.” Jacc Heart Fail 7, no. 11 (November 2019): 933–41. https://doi.org/10.1016/j.jchf.2019.05.016.
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  - Rymer, Jennifer A., Anita Y. Chen, Laine Thomas, Gregg C. Fonarow, Eric D. Peterson, and Tracy Y. Wang. “Readmissions After Acute Myocardial Infarction: How Often Do Patients Return to the Discharging Hospital?” J Am Heart Assoc 8, no. 19 (October 2019): e012059. https://doi.org/10.1161/JAHA.119.012059.
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  - Fanaroff, Alexander C., Amit N. Vora, Anita Y. Chen, Robin Mathews, Jacob A. Udell, Matthew T. Roe, Laine E. Thomas, and Tracy Y. Wang. “Hospital participation in clinical trials for patients with acute myocardial infarction: Results from the National Cardiovascular Data Registry.” Am Heart J 214 (August 2019): 184–93. https://doi.org/10.1016/j.ahj.2019.05.011.
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  - Nicholson, Wanda K., Ganesa Wegienka, Shuaiqi Zhang, Kedra Wallace, Elizabeth Stewart, Shannon Laughlin-Tommaso, Laine Thomas, et al. “Short-Term Health-Related Quality of Life After Hysterectomy Compared With Myomectomy for Symptomatic Leiomyomas.” Obstet Gynecol 134, no. 2 (August 2019): 261–69. https://doi.org/10.1097/AOG.0000000000003354.
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  - Pokorney, Sean D., DaJuanicia N. Holmes, Laine Thomas, Gregg C. Fonarow, Peter R. Kowey, James A. Reiffel, Daniel E. Singer, et al. “Association Between Warfarin Control Metrics and Atrial Fibrillation Outcomes in the Outcomes Registry for Better Informed Treatment of Atrial Fibrillation.” Jama Cardiol 4, no. 8 (August 1, 2019): 756–64. https://doi.org/10.1001/jamacardio.2019.1960.
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  - Xian, Ying, Haolin Xu, Emily C. O’Brien, Shreyansh Shah, Laine Thomas, Michael J. Pencina, Gregg C. Fonarow, et al. “Clinical Effectiveness of Direct Oral Anticoagulants vs Warfarin in Older Patients With Atrial Fibrillation and Ischemic Stroke: Findings From the Patient-Centered Research Into Outcomes Stroke Patients Prefer and Effectiveness Research (PROSPER) Study.” Jama Neurol, July 22, 2019. https://doi.org/10.1001/jamaneurol.2019.2099.
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  - Guimarães, Patricia O., Renato D. Lopes, John H. Alexander, Laine Thomas, Anne S. Hellkamp, Ziad Hijazi, Elaine M. Hylek, et al. “International normalized ratio control and subsequent clinical outcomes in patients with atrial fibrillation using warfarin.” J Thromb Thrombolysis 48, no. 1 (July 2019): 27–34. https://doi.org/10.1007/s11239-019-01858-1.
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  - Shavadia, Jay S., DaJuanicia N. Holmes, Laine Thomas, Eric D. Peterson, Christopher B. Granger, Matthew T. Roe, and Tracy Y. Wang. “Comparative Effectiveness of β-Blocker Use Beyond 3 Years After Myocardial Infarction and Long-Term Outcomes Among Elderly Patients.” Circ Cardiovasc Qual Outcomes 12, no. 7 (July 2019): e005103. https://doi.org/10.1161/CIRCOUTCOMES.118.005103.
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  - Thomas, Merrill, Yevgeniy Khariton, Gregg C. Fonarow, Suzanne V. Arnold, Larry Hill, Michael E. Nassif, Puza P. Sharma, et al. “Association of Changes in Heart Failure Treatment With Patients' Health Status: Real-World Evidence From CHAMP-HF.” Jacc Heart Fail 7, no. 7 (July 2019): 615–25. https://doi.org/10.1016/j.jchf.2019.03.020.
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  - Thomas, Laine E., Emily C. O’Brien, Jonathan P. Piccini, Ralph B. D’Agostino, and Michael J. Pencina. “Application of net reclassification index to non-nested and point-based risk prediction models: a review.” Eur Heart J 40, no. 23 (June 14, 2019): 1880–87. https://doi.org/10.1093/eurheartj/ehy345.
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  - Greene, Stephen J., Gregg C. Fonarow, Adam D. DeVore, Puza P. Sharma, Muthiah Vaduganathan, Nancy M. Albert, Carol I. Duffy, et al. “Titration of Medical Therapy for Heart Failure With Reduced Ejection Fraction.” J Am Coll Cardiol 73, no. 19 (May 21, 2019): 2365–83. https://doi.org/10.1016/j.jacc.2019.02.015.
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  - Perino, Alexander C., Peter Shrader, Mintu P. Turakhia, Jack E. Ansell, Bernard J. Gersh, Gregg C. Fonarow, Alan S. Go, et al. “Comparison of Patient-Reported Care Satisfaction, Quality of Warfarin Therapy, and Outcomes of Atrial Fibrillation: Findings From the ORBIT - AF Registry.” J Am Heart Assoc 8, no. 9 (May 7, 2019): e011205. https://doi.org/10.1161/JAHA.118.011205.
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  - Holmes, DaJuanicia N., Jonathan P. Piccini, Larry A. Allen, Gregg C. Fonarow, Bernard J. Gersh, Peter R. Kowey, Emily C. O’Brien, et al. “Defining Clinically Important Difference in the Atrial Fibrillation Effect on Quality-of-Life Score.” Circ Cardiovasc Qual Outcomes 12, no. 5 (May 2019): e005358. https://doi.org/10.1161/CIRCOUTCOMES.118.005358.
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  - Madhavan, Malini, DaJuanicia N. Holmes, Jonathan P. Piccini, Jack E. Ansell, Gregg C. Fonarow, Elaine M. Hylek, Peter R. Kowey, et al. “Association of frailty and cognitive impairment with benefits of oral anticoagulation in patients with atrial fibrillation.” Am Heart J 211 (May 2019): 77–89. https://doi.org/10.1016/j.ahj.2019.01.005.
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  - Peri-Okonny, Poghni A., Xiaojuan Mi, Yevgeniy Khariton, Krishna K. Patel, Laine Thomas, Gregg C. Fonarow, Puza P. Sharma, et al. “Target Doses of Heart Failure Medical Therapy and Blood Pressure: Insights From the CHAMP-HF Registry.” Jacc Heart Fail 7, no. 4 (April 2019): 350–58. https://doi.org/10.1016/j.jchf.2018.11.011.
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  - Thomas, Laine E., and Phillip J. Schulte. “Separating variability in healthcare practice patterns from random error.” Stat Methods Med Res 28, no. 4 (April 2019): 1247–60. https://doi.org/10.1177/0962280217754230.
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  - Doll, Jacob A., Anne S. Hellkamp, Laine Thomas, Gregg C. Fonarow, Eric Peterson, and Tracy Y. Wang. “The association of pre- and posthospital medication adherence in myocardial infarction patients.” Am Heart J 208 (February 2019): 74–80. https://doi.org/10.1016/j.ahj.2018.11.004.
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  - Li, Fan, and Laine E. Thomas. “Addressing Extreme Propensity Scores via the Overlap Weights.” Am J Epidemiol 188, no. 1 (January 1, 2019): 250–57. https://doi.org/10.1093/aje/kwy201.
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  - O’Brien, Emily C., DaJuanicia N. Holmes, Laine Thomas, Daniel E. Singer, Gregg C. Fonarow, Kenneth W. Mahaffey, Peter R. Kowey, et al. “Incremental prognostic value of renal function for stroke prediction in atrial fibrillation.” Int J Cardiol 274 (January 1, 2019): 152–57. https://doi.org/10.1016/j.ijcard.2018.07.113.
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  - Jackson, Larry R., Sunghee Kim, Peter Shrader, Rosalia Blanco, Laine Thomas, Michael D. Ezekowitz, Jack Ansell, et al. “Early therapeutic persistence on dabigatran versus warfarin therapy in patients with atrial fibrillation: results from the Outcomes Registry for Better Informed Treatment of Atrial Fibrillation (ORBIT-AF) registry.” J Thromb Thrombolysis 46, no. 4 (November 2018): 435–39. https://doi.org/10.1007/s11239-018-1715-1.
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  - Arnold, Suzanne V., David J. Cohen, David Dai, Philip G. Jones, Fan Li, Laine Thomas, Suzanne J. Baron, et al. “Predicting Quality of Life at 1 Year After Transcatheter Aortic Valve Replacement in a Real-World Population.” Circ Cardiovasc Qual Outcomes 11, no. 10 (October 2018): e004693. https://doi.org/10.1161/CIRCOUTCOMES.118.004693.
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  - Huffman, Mark D., and Laine E. Thomas. “Tools for Evaluating and Improving Causal Inference: Introducing JAMA Cardiology Readers to the Risk of Bias in Nonrandomized Studies of Interventions (ROBINS-I) Tool.” Jama Cardiol 3, no. 10 (October 1, 2018): 907. https://doi.org/10.1001/jamacardio.2018.2270.
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  - Washam, Jeffrey B., DaJuanicia N. Holmes, Laine E. Thomas, Sean D. Pokorney, Elaine M. Hylek, Gregg C. Fonarow, Kenneth W. Mahaffey, et al. “Pharmacotherapy for Atrial Fibrillation in Patients With Chronic Kidney Disease: Insights From ORBIT-AF.” J Am Heart Assoc 7, no. 18 (September 18, 2018): e008928. https://doi.org/10.1161/JAHA.118.008928.
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  - Rymer, Jennifer A., Anita Y. Chen, Laine Thomas, Judith Stafford, Jonathan R. Enriquez, Abhinav Goyal, Eric D. Peterson, and Tracy Y. Wang. “Advanced Practice Provider Versus Physician-Only Outpatient Follow-Up After Acute Myocardial Infarction.” J Am Heart Assoc 7, no. 17 (September 4, 2018): e008481. https://doi.org/10.1161/JAHA.117.008481.
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  - DeVore, Adam D., C Larry Hill, Laine Thomas, Puza P. Sharma, Nancy M. Albert, Javed Butler, J Herbert Patterson, et al. “Patient, Provider, and Practice Characteristics Associated With Sacubitril/Valsartan Use in the United States.” Circulation. Heart Failure 11, no. 9 (September 2018): e005400. https://doi.org/10.1161/circheartfailure.118.005400.
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  - O’Brien, Emily C., Shuang Li, Laine Thomas, Tracy Y. Wang, Matthew T. Roe, and Eric D. Peterson. “The impact of clinical vs administrative claims coding on hospital risk-adjusted outcomes.” Clin Cardiol 41, no. 9 (September 2018): 1225–31. https://doi.org/10.1002/clc.23059.
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  - O’Brien, Emily C., DaJuanicia N. Holmes, Laine E. Thomas, Gregg C. Fonarow, Larry A. Allen, Bernard J. Gersh, Peter R. Kowey, et al. “Prognostic Significance of Nuisance Bleeding in Anticoagulated Patients With Atrial Fibrillation.” Circulation 138, no. 9 (August 28, 2018): 889–97. https://doi.org/10.1161/CIRCULATIONAHA.117.031354.
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  - Jackson, Larry R., Sunghee Kim, Gregg C. Fonarow, James V. Freeman, Bernard J. Gersh, Alan S. Go, Elaine M. Hylek, et al. “Stroke Risk and Treatment in Patients with Atrial Fibrillation and Low CHA2DS2-VASc Scores: Findings From the ORBIT-AF I and II Registries.” J Am Heart Assoc 7, no. 16 (August 21, 2018): e008764. https://doi.org/10.1161/JAHA.118.008764.
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  - Greene, Stephen J., Javed Butler, Nancy M. Albert, Adam D. DeVore, Puza P. Sharma, Carol I. Duffy, C Larry Hill, et al. “Medical Therapy for Heart Failure With Reduced Ejection Fraction: The CHAMP-HF Registry.” J Am Coll Cardiol 72, no. 4 (July 24, 2018): 351–66. https://doi.org/10.1016/j.jacc.2018.04.070.
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  - Stewart, Elizabeth A., Barbara L. Lytle, Laine Thomas, Ganesa R. Wegienka, Vanessa Jacoby, Michael P. Diamond, Wanda K. Nicholson, et al. “The Comparing Options for Management: PAtient-centered REsults for Uterine Fibroids (COMPARE-UF) registry: rationale and design.” Am J Obstet Gynecol 219, no. 1 (July 2018): 95.e1-95.e10. https://doi.org/10.1016/j.ajog.2018.05.004.
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  - DeVore, Adam D., Xiaojuan Mi, Laine Thomas, Puza P. Sharma, Nancy M. Albert, Javed Butler, Adrian F. Hernandez, et al. “Characteristics and Treatments of Patients Enrolled in the CHAMP-HF Registry Compared With Patients Enrolled in the PARADIGM-HF Trial.” J Am Heart Assoc 7, no. 12 (June 12, 2018). https://doi.org/10.1161/JAHA.118.009237.
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  - O’Brien, Emily C., DaJuanicia N. Holmes, Laine Thomas, Gregg C. Fonarow, Peter R. Kowey, Jack E. Ansell, Kenneth W. Mahaffey, et al. “Therapeutic Strategies Following Major, Clinically Relevant Nonmajor, and Nuisance Bleeding in Atrial Fibrillation: Findings From ORBIT-AF.” J Am Heart Assoc 7, no. 12 (June 9, 2018). https://doi.org/10.1161/JAHA.117.006391.
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  - Khariton, Yevgeniy, Michael E. Nassif, Laine Thomas, Gregg C. Fonarow, Xiaojuan Mi, Adam D. DeVore, Carol Duffy, et al. “Health Status Disparities by Sex, Race/Ethnicity, and Socioeconomic Status in Outpatients With Heart Failure.” Jacc Heart Fail 6, no. 6 (June 2018): 465–73. https://doi.org/10.1016/j.jchf.2018.02.002.
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  - Udell, Jacob A., Nihar R. Desai, Shuang Li, Laine Thomas, James A. de Lemos, Phyllis Wright-Slaughter, Wenying Zhang, Matthew T. Roe, and Deepak L. Bhatt. “Neighborhood Socioeconomic Disadvantage and Care After Myocardial Infarction in the National Cardiovascular Data Registry.” Circ Cardiovasc Qual Outcomes 11, no. 6 (June 2018): e004054. https://doi.org/10.1161/CIRCOUTCOMES.117.004054.
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  - Fanaroff, Alexander C., Anita Y. Chen, Laine E. Thomas, Karen S. Pieper, Kirk N. Garratt, Eric D. Peterson, L Kristin Newby, et al. “Risk Score to Predict Need for Intensive Care in Initially Hemodynamically Stable Adults With Non-ST-Segment-Elevation Myocardial Infarction.” J Am Heart Assoc 7, no. 11 (May 25, 2018). https://doi.org/10.1161/JAHA.118.008894.
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  - Fudim, Marat, Peter R. Liu, Peter Shrader, Rosalia G. Blanco, Larry A. Allen, Gregg C. Fonarow, Bernard J. Gersh, et al. “Mineralocorticoid Receptor Antagonism in Patients With Atrial Fibrillation: Findings From the ORBIT-AF (Outcomes Registry for Better Informed Treatment of Atrial Fibrillation) Registry.” J Am Heart Assoc 7, no. 8 (April 13, 2018). https://doi.org/10.1161/JAHA.117.007987.
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  - Khariton, Yevgeniy, Adrian F. Hernandez, Gregg C. Fonarow, Puza P. Sharma, Carol I. Duffy, Laine Thomas, Xiaojuan Mi, et al. “Health Status Variation Across Practices in Outpatients With Heart Failure: Insights From the CHAMP-HF (Change the Management of Patients With Heart Failure) Registry.” Circ Cardiovasc Qual Outcomes 11, no. 4 (April 2018): e004668. https://doi.org/10.1161/CIRCOUTCOMES.118.004668.
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  - Pokorney, Sean D., Debbie C. Yen, Kristen B. Campbell, Nancy M. Allen LaPointe, Shubin Sheng, Laine Thomas, Tristram D. Bahnson, et al. “Dofetilide dose reductions and discontinuations in women compared with men.” Heart Rhythm 15, no. 4 (April 2018): 478–84. https://doi.org/10.1016/j.hrthm.2018.01.027.
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  - Lopes, Renato D., Roberto Rordorf, Gaetano M. De Ferrari, Sergio Leonardi, Laine Thomas, Daniel M. Wojdyla, Peter Ridefelt, et al. “Digoxin and Mortality in Patients With Atrial Fibrillation.” J Am Coll Cardiol 71, no. 10 (March 13, 2018): 1063–74. https://doi.org/10.1016/j.jacc.2017.12.060.
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  - Shavadia, Jay S., William French, Anne S. Hellkamp, Laine Thomas, Eric R. Bates, Steven V. Manoukian, Michael C. Kontos, et al. “Comprehensive electrocardiogram-to-device time for primary percutaneous coronary intervention in ST-segment elevation myocardial infarction: A report from the American Heart Association mission: Lifeline program.” Am Heart J 197 (March 2018): 9–17. https://doi.org/10.1016/j.ahj.2017.10.017.
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  - Steinberg, Benjamin A., Peter Shrader, Karen Pieper, Laine Thomas, Larry A. Allen, Jack Ansell, Paul S. Chan, et al. “Frequency and Outcomes of Reduced Dose Non-Vitamin K Antagonist Anticoagulants: Results From ORBIT-AF II (The Outcomes Registry for Better Informed Treatment of Atrial Fibrillation II).” J Am Heart Assoc 7, no. 4 (February 16, 2018). https://doi.org/10.1161/JAHA.117.007633.
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  - Echouffo-Tcheugui, Justin B., Peter Shrader, Laine Thomas, Jonathan P. Piccini, and Gregg C. Fonarow. “Reply: Graphing Ratio Measures on Forest Plot.” J Am Coll Cardiol 71, no. 5 (February 6, 2018): 586. https://doi.org/10.1016/j.jacc.2017.11.060.
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  - Wang, William T., Anne Hellkamp, Jacob A. Doll, Laine Thomas, Ann Marie Navar, Gregg C. Fonarow, Howard M. Julien, Eric D. Peterson, and Tracy Y. Wang. “Lipid Testing and Statin Dosing After Acute Myocardial Infarction.” J Am Heart Assoc 7, no. 3 (January 25, 2018). https://doi.org/10.1161/JAHA.117.006460.
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  - Inohara, Taku, Peter Shrader, Karen Pieper, Rosalia G. Blanco, Laine Thomas, Daniel E. Singer, James V. Freeman, et al. “Association of of Atrial Fibrillation Clinical Phenotypes With Treatment Patterns and Outcomes: A Multicenter Registry Study.” Jama Cardiol 3, no. 1 (January 1, 2018): 54–63. https://doi.org/10.1001/jamacardio.2017.4665.
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  - Kraus, William E., Thomas Yates, Jaakko Tuomilehto, Jie-Lena Sun, Laine Thomas, John J. V. McMurray, M Angelyn Bethel, and Rury R. Holman. “Relationship between baseline physical activity assessed by pedometer count and new-onset diabetes in the NAVIGATOR trial.” Bmj Open Diabetes Res Care 6, no. 1 (2018): e000523. https://doi.org/10.1136/bmjdrc-2018-000523.
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  - Thomas, Kevin L., Larry R. Jackson, Peter Shrader, Jack Ansell, Gregg C. Fonarow, Bernard Gersh, Peter R. Kowey, et al. “Prevalence, Characteristics, and Outcomes of Valvular Heart Disease in Patients With Atrial Fibrillation: Insights From the ORBIT-AF (Outcomes Registry for Better Informed Treatment for Atrial Fibrillation).” J Am Heart Assoc 6, no. 12 (December 22, 2017). https://doi.org/10.1161/JAHA.117.006475.
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  - Steinberg, Benjamin A., Haiyan Gao, Peter Shrader, Karen Pieper, Laine Thomas, A John Camm, Michael D. Ezekowitz, et al. “International trends in clinical characteristics and oral anticoagulation treatment for patients with atrial fibrillation: Results from the GARFIELD-AF, ORBIT-AF I, and ORBIT-AF II registries.” Am Heart J 194 (December 2017): 132–40. https://doi.org/10.1016/j.ahj.2017.08.011.
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  - Barnett, Adam S., Sunghee Kim, Gregg C. Fonarow, Laine E. Thomas, James A. Reiffel, Larry A. Allen, James V. Freeman, et al. “Treatment of Atrial Fibrillation and Concordance With the American Heart Association/American College of Cardiology/Heart Rhythm Society Guidelines: Findings From ORBIT-AF (Outcomes Registry for Better Informed Treatment of Atrial Fibrillation).” Circ Arrhythm Electrophysiol 10, no. 11 (November 2017). https://doi.org/10.1161/CIRCEP.117.005051.
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  - Xian, Ying, Laine Thomas, Li Liang, Jerome J. Federspiel, Laura E. Webb, Cheryl D. Bushnell, Pamela W. Duncan, et al. “Unexplained Variation for Hospitals' Use of Inpatient Rehabilitation and Skilled Nursing Facilities After an Acute Ischemic Stroke.” Stroke 48, no. 10 (October 2017): 2836–42. https://doi.org/10.1161/STROKEAHA.117.016904.
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  - Echouffo-Tcheugui, Justin B., Peter Shrader, Laine Thomas, Bernard J. Gersh, Peter R. Kowey, Kenneth W. Mahaffey, Daniel E. Singer, et al. “Care Patterns and Outcomes in Atrial Fibrillation Patients With and Without Diabetes: ORBIT-AF Registry.” J Am Coll Cardiol 70, no. 11 (September 12, 2017): 1325–35. https://doi.org/10.1016/j.jacc.2017.07.755.
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  - Pagidipati, Neha J., Anne Hellkamp, Laine Thomas, Martha Gulati, Eric D. Peterson, and Tracy Y. Wang. “Use of Prescription Smoking Cessation Medications After Myocardial Infarction Among Older Patients in Community Practice.” Jama Cardiol 2, no. 9 (September 1, 2017): 1040–42. https://doi.org/10.1001/jamacardio.2017.2369.
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  - Brennan, J Matthew, Laine Thomas, David J. Cohen, David Shahian, Alice Wang, Michael J. Mack, David R. Holmes, et al. “Transcatheter Versus Surgical Aortic Valve Replacement: Propensity-Matched Comparison.” J Am Coll Cardiol 70, no. 4 (July 25, 2017): 439–50. https://doi.org/10.1016/j.jacc.2017.05.060.
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  - DeVore, Adam D., Laine Thomas, Nancy M. Albert, Javed Butler, Adrian F. Hernandez, J Herbert Patterson, John A. Spertus, et al. “Change the management of patients with heart failure: Rationale and design of the CHAMP-HF registry.” Am Heart J 189 (July 2017): 177–83. https://doi.org/10.1016/j.ahj.2017.04.010.
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  - Melloni, Chiara, Peter Shrader, Joseph Carver, Jonathan P. Piccini, Laine Thomas, Gregg C. Fonarow, Jack Ansell, et al. “Management and outcomes of patients with atrial fibrillation and a history of cancer: the ORBIT-AF registry.” Eur Heart J Qual Care Clin Outcomes 3, no. 3 (July 1, 2017): 192–97. https://doi.org/10.1093/ehjqcco/qcx004.
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  - Steinberg, Benjamin A., Peter Shrader, Laine Thomas, Jack Ansell, Gregg C. Fonarow, Bernard J. Gersh, Elaine Hylek, et al. “Factors associated with non-vitamin K antagonist oral anticoagulants for stroke prevention in patients with new-onset atrial fibrillation: Results from the Outcomes Registry for Better Informed Treatment of Atrial Fibrillation II (ORBIT-AF II).” Am Heart J 189 (July 2017): 40–47. https://doi.org/10.1016/j.ahj.2017.03.024.
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  - Cherian, Tharian S., Peter Shrader, Gregg C. Fonarow, Larry A. Allen, Jonathan P. Piccini, Eric D. Peterson, Laine Thomas, Peter R. Kowey, Bernard J. Gersh, and Kenneth W. Mahaffey. “Effect of Atrial Fibrillation on Mortality, Stroke Risk, and Quality-of-Life Scores in Patients With Heart Failure (from the Outcomes Registry for Better Informed Treatment of Atrial Fibrillation [ORBIT-AF]).” Am J Cardiol 119, no. 11 (June 1, 2017): 1763–69. https://doi.org/10.1016/j.amjcard.2017.02.050.
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  - Lopes, Renato D., Patrícia O. Guimarães, Bradley J. Kolls, Daniel M. Wojdyla, Cheryl D. Bushnell, Michael Hanna, J Donald Easton, et al. “Intracranial hemorrhage in patients with atrial fibrillation receiving anticoagulation therapy.” Blood 129, no. 22 (June 1, 2017): 2980–87. https://doi.org/10.1182/blood-2016-08-731638.
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  - Steinberg, Benjamin A., DaJuanicia N. Simon, Laine Thomas, Jack Ansell, Gregg C. Fonarow, Bernard J. Gersh, Peter R. Kowey, et al. “Management of Major Bleeding in Patients With Atrial Fibrillation Treated With Non-Vitamin K Antagonist Oral Anticoagulants Compared With Warfarin in Clinical Practice (from Phase II of the Outcomes Registry for Better Informed Treatment of Atrial Fibrillation [ORBIT-AF II]).” Am J Cardiol 119, no. 10 (May 15, 2017): 1590–95. https://doi.org/10.1016/j.amjcard.2017.02.015.
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  - Bethel, Mary Angelyn, Kristen A. Hyland, Antonio R. Chacra, Prakash Deedwania, Gregory R. Fulcher, Rury R. Holman, Trond Jenssen, et al. “Updated risk factors should be used to predict development of diabetes.” J Diabetes Complications 31, no. 5 (May 2017): 859–63. https://doi.org/10.1016/j.jdiacomp.2017.02.012.
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  - Hess, Paul L., Sunghee Kim, Gregg C. Fonarow, Laine Thomas, Daniel E. Singer, James V. Freeman, Bernard J. Gersh, et al. “Absence of Oral Anticoagulation and Subsequent Outcomes Among Outpatients with Atrial Fibrillation.” Am J Med 130, no. 4 (April 2017): 449–56. https://doi.org/10.1016/j.amjmed.2016.11.001.
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  - Sharma, Abhinav, Flávio de Souza Brito, Jie-Lena Sun, Laine Thomas, Steven Haffner, Rury R. Holman, and Renato D. Lopes. “Noncardiovascular deaths are more common than cardiovascular deaths in patients with cardiovascular disease or cardiovascular risk factors and impaired glucose tolerance: Insights from the Nateglinide and Valsartan in Impaired Glucose Tolerance Outcomes Research (NAVIGATOR) trial.” Am Heart J 186 (April 2017): 73–82. https://doi.org/10.1016/j.ahj.2016.12.011.
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  - Pokorney, Sean D., Sunghee Kim, Laine Thomas, Gregg C. Fonarow, Peter R. Kowey, Bernard J. Gersh, Kenneth W. Mahaffey, Eric D. Peterson, Jonathan P. Piccini, and Jonathan P. Outcomes Registry for Better Informed Treatment of Atrial Fibrillation (ORBIT-AF) Investigators. “Cardioversion and subsequent quality of life and natural history of atrial fibrillation.” Am Heart J 185 (March 2017): 59–66. https://doi.org/10.1016/j.ahj.2016.10.018.
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  - Westenbrink, B Daan, Marco Alings, Christopher B. Granger, John H. Alexander, Renato D. Lopes, Elaine M. Hylek, Laine Thomas, et al. “Anemia is associated with bleeding and mortality, but not stroke, in patients with atrial fibrillation: Insights from the Apixaban for Reduction in Stroke and Other Thromboembolic Events in Atrial Fibrillation (ARISTOTLE) trial.” Am Heart J 185 (March 2017): 140–49. https://doi.org/10.1016/j.ahj.2016.12.008.
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  - Hu, Peter T., Renato D. Lopes, Susanna R. Stevens, Lars Wallentin, Laine Thomas, John H. Alexander, Michael Hanna, et al. “Efficacy and Safety of Apixaban Compared With Warfarin in Patients With Atrial Fibrillation and Peripheral Artery Disease: Insights From the ARISTOTLE Trial.” J Am Heart Assoc 6, no. 1 (January 17, 2017). https://doi.org/10.1161/JAHA.116.004699.
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  - Guimarães, Patrícia O., Daniel M. Wojdyla, John H. Alexander, Laine Thomas, Marco Alings, Greg C. Flaker, Sana M. Al-Khatib, et al. “Anticoagulation therapy and clinical outcomes in patients with recently diagnosed atrial fibrillation: Insights from the ARISTOTLE trial.” Int J Cardiol 227 (January 15, 2017): 443–49. https://doi.org/10.1016/j.ijcard.2016.11.014.
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  - Pokorney, Sean D., Amy L. Miller, Anita Y. Chen, Laine Thomas, Gregg C. Fonarow, James A. de Lemos, Sana M. Al-Khatib, Eric J. Velazquez, Eric D. Peterson, and Tracy Y. Wang. “Reassessment of Cardiac Function and Implantable Cardioverter-Defibrillator Use Among Medicare Patients With Low Ejection Fraction After Myocardial Infarction.” Circulation 135, no. 1 (January 3, 2017): 38–47. https://doi.org/10.1161/CIRCULATIONAHA.116.022359.
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  - Bettger, Janet Prvu, Laine Thomas, Li Liang, Ying Xian, Cheryl D. Bushnell, Jeffrey L. Saver, Gregg C. Fonarow, and Eric D. Peterson. “Hospital Variation in Functional Recovery After Stroke.” Circ Cardiovasc Qual Outcomes 10, no. 1 (January 2017). https://doi.org/10.1161/CIRCOUTCOMES.115.002391.
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  - Fanaroff, Alexander C., Eric D. Peterson, Anita Y. Chen, Laine Thomas, Jacob A. Doll, Christopher B. Fordyce, L Kristin Newby, et al. “Intensive Care Unit Utilization and Mortality Among Medicare Patients Hospitalized With Non-ST-Segment Elevation Myocardial Infarction.” Jama Cardiol 2, no. 1 (January 1, 2017): 36–44. https://doi.org/10.1001/jamacardio.2016.3855.
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  - Pandey, Ambarish, Sunghee Kim, Curtiss Moore, Laine Thomas, Bernard Gersh, Larry A. Allen, Peter R. Kowey, et al. “Predictors and Prognostic Implications of Incident Heart Failure in Patients With Prevalent Atrial Fibrillation.” Jacc Heart Fail 5, no. 1 (January 2017): 44–52. https://doi.org/10.1016/j.jchf.2016.09.016.
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  - Steinberg, Benjamin A., Peter Shrader, Laine Thomas, Jack Ansell, Gregg C. Fonarow, Bernard J. Gersh, Peter R. Kowey, et al. “Off-Label Dosing of Non-Vitamin K Antagonist Oral Anticoagulants and Adverse Outcomes: The ORBIT-AF II Registry.” J Am Coll Cardiol 68, no. 24 (December 20, 2016): 2597–2604. https://doi.org/10.1016/j.jacc.2016.09.966.
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  - Randolph, Tiffany C., DaJuanicia N. Simon, Laine Thomas, Larry A. Allen, Gregg C. Fonarow, Bernard J. Gersh, Peter R. Kowey, et al. “Patient factors associated with quality of life in atrial fibrillation.” Am Heart J 182 (December 2016): 135–43. https://doi.org/10.1016/j.ahj.2016.08.003.
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  - Thomas, Laine E., and Michael J. Pencina. “Do Not Over (P) Value Your Research Article.” Jama Cardiol 1, no. 9 (December 1, 2016): 1055. https://doi.org/10.1001/jamacardio.2016.3827.
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  - Steinberg, Benjamin A., Peter Shrader, Sunghee Kim, Laine Thomas, Gregg C. Fonarow, Jack Ansell, Peter R. Kowey, et al. “How well does physician risk assessment predict stroke and bleeding in atrial fibrillation? Results from the Outcomes Registry for Better Informed Treatment of Atrial Fibrillation (ORBIT-AF).” Am Heart J 181 (November 2016): 145–52. https://doi.org/10.1016/j.ahj.2016.07.026.
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  - Pokorney, Sean D., Peter Shrader, Laine Thomas, Gregg C. Fonarow, Peter R. Kowey, Daniel E. Singer, Jack Ansell, et al. “Influence of Kidney Function Estimation Methods on Eligibility for Edoxaban Population Impact of the US Food and Drug Administration's Approach for Its Product Labeling.” Circulation 134, no. 15 (October 11, 2016): 1122–24. https://doi.org/10.1161/CIRCULATIONAHA.116.024333.
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  - Edmund Anstey, D., Shuang Li, Laine Thomas, Tracy Y. Wang, and Stephen D. Wiviott. “Race and Sex Differences in Management and Outcomes of Patients After ST-Elevation and Non-ST-Elevation Myocardial Infarct: Results From the NCDR.” Clin Cardiol 39, no. 10 (October 2016): 585–95. https://doi.org/10.1002/clc.22570.
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  - Kontos, Michael C., Tracy Y. Wang, Anita Y. Chen, Eric R. Bates, Harold L. Dauerman, Timothy D. Henry, Steven V. Manoukian, et al. “The effect of high-risk ST elevation myocardial infarction transfer patients on risk-adjusted in-hospital mortality: A report from the American Heart Association Mission: Lifeline program.” Am Heart J 180 (October 2016): 74–81. https://doi.org/10.1016/j.ahj.2016.07.010.
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  - Vora, Amit N., Tracy Y. Wang, Anne S. Hellkamp, Laine Thomas, Timothy D. Henry, Abhinav Goyal, and Matthew T. Roe. “Differences in Short- and Long-Term Outcomes Among Older Patients With ST-Elevation Versus Non-ST-Elevation Myocardial Infarction With Angiographically Proven Coronary Artery Disease.” Circ Cardiovasc Qual Outcomes 9, no. 5 (September 2016): 513–22. https://doi.org/10.1161/CIRCOUTCOMES.115.002312.
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  - Pokorney, Sean D., DaJuanicia N. Simon, Laine Thomas, Bernard J. Gersh, Elaine M. Hylek, Jonathan P. Piccini, and Eric D. Peterson. “Stability of International Normalized Ratios in Patients Taking Long-term Warfarin Therapy.” Jama 316, no. 6 (August 9, 2016): 661–63. https://doi.org/10.1001/jama.2016.9356.
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  - Sutton, Nadia R., Shuang Li, Laine Thomas, Tracy Y. Wang, James A. de Lemos, Jonathan R. Enriquez, Rashmee U. Shah, and Gregg C. Fonarow. “The association of left ventricular ejection fraction with clinical outcomes after myocardial infarction: Findings from the Acute Coronary Treatment and Intervention Outcomes Network (ACTION) Registry-Get With the Guidelines (GWTG) Medicare-linked database.” Am Heart J 178 (August 2016): 65–73. https://doi.org/10.1016/j.ahj.2016.05.003.
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  - Goldstein, Benjamin A., Laine Thomas, Jonathan G. Zaroff, John Nguyen, Rebecca Menza, and Kiran K. Khush. “Assessment of Heart Transplant Waitlist Time and Pre- and Post-transplant Failure: A Mixed Methods Approach.” Epidemiology 27, no. 4 (July 2016): 469–76. https://doi.org/10.1097/EDE.0000000000000472.
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  - Jaspers Focks, Jeroen, Marc A. Brouwer, Daniel M. Wojdyla, Laine Thomas, Renato D. Lopes, Jeffrey B. Washam, Fernando Lanas, et al. “Polypharmacy and effects of apixaban versus warfarin in patients with atrial fibrillation: post hoc analysis of the ARISTOTLE trial.” Bmj 353 (June 15, 2016): i2868. https://doi.org/10.1136/bmj.i2868.
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  - Lopes, Renato D., Meena Rao, DaJuanicia N. Simon, Laine Thomas, Jack Ansell, Gregg C. Fonarow, Bernard J. Gersh, et al. “Triple vs Dual Antithrombotic Therapy in Patients with Atrial Fibrillation and Coronary Artery Disease.” Am J Med 129, no. 6 (June 2016): 592-599.e1. https://doi.org/10.1016/j.amjmed.2015.12.026.
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  - Pandey, Ambarish, Bernard J. Gersh, Darren K. McGuire, Peter Shrader, Laine Thomas, Peter R. Kowey, Kenneth W. Mahaffey, et al. “Association of Body Mass Index With Care and Outcomes in Patients With Atrial Fibrillation: Results From the ORBIT-AF Registry.” Jacc Clin Electrophysiol 2, no. 3 (June 2016): 355–63. https://doi.org/10.1016/j.jacep.2015.12.001.
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  - Piccini, Jonathan P., DaJuanicia N. Simon, Benjamin A. Steinberg, Laine Thomas, Larry A. Allen, Gregg C. Fonarow, Bernard Gersh, et al. “Differences in Clinical and Functional Outcomes of Atrial Fibrillation in Women and Men: Two-Year Results From the ORBIT-AF Registry.” Jama Cardiol 1, no. 3 (June 1, 2016): 282–91. https://doi.org/10.1001/jamacardio.2016.0529.
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  - O’Brien, Emily C., Sunghee Kim, Laine Thomas, Gregg C. Fonarow, Peter R. Kowey, Kenneth W. Mahaffey, Bernard J. Gersh, Jonathan P. Piccini, and Eric D. Peterson. “Clinical Characteristics, Oral Anticoagulation Patterns, and Outcomes of Medicaid Patients With Atrial Fibrillation: Insights From the Outcomes Registry for Better Informed Treatment of Atrial Fibrillation (ORBIT-AF I) Registry.” J Am Heart Assoc 5, no. 5 (May 4, 2016). https://doi.org/10.1161/JAHA.115.002721.
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  - Fordyce, Christopher B., Tracy Y. Wang, Anita Y. Chen, Laine Thomas, Christopher B. Granger, Benjamin M. Scirica, Timothy D. Henry, et al. “Long-Term Post-Discharge Risks in Older Survivors of Myocardial Infarction With and Without Out-of-Hospital Cardiac Arrest.” J Am Coll Cardiol 67, no. 17 (May 3, 2016): 1981–90. https://doi.org/10.1016/j.jacc.2016.02.044.
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  - Alexander, John H., and Laine E. Thomas. “Using Data to Guide Anticoagulation in Patients With Atrial Fibrillation: Does the Analysis Fit the Question?” Jama Cardiol 1, no. 2 (May 1, 2016): 121–22. https://doi.org/10.1001/jamacardio.2016.0198.
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  - Faridi, Kamil F., Eric D. Peterson, Lisa A. McCoy, Laine Thomas, Jonathan Enriquez, and Tracy Y. Wang. “Timing of First Postdischarge Follow-up and Medication Adherence After Acute Myocardial Infarction.” Jama Cardiol 1, no. 2 (May 1, 2016): 147–55. https://doi.org/10.1001/jamacardio.2016.0001.
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  - Gundlund, Anna, Emil Loldrup Fosbøl, Sunghee Kim, Gregg C. Fonarow, Bernard J. Gersh, Peter R. Kowey, Elaine Hylek, et al. “Family history of atrial fibrillation is associated with earlier-onset and more symptomatic atrial fibrillation: Results from the Outcomes Registry for Better Informed Treatment of Atrial Fibrillation (ORBIT-AF) registry.” Am Heart J 175 (May 2016): 28–35. https://doi.org/10.1016/j.ahj.2016.01.020.
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  - Anderson, Monique L., Graham Nichol, David Dai, Paul S. Chan, Laine Thomas, Sana M. Al-Khatib, Robert A. Berg, Steven M. Bradley, Eric D. Peterson, and Eric D. American Heart Association’s Get With the Guidelines–Resuscitation Investigators. “Association Between Hospital Process Composite Performance and Patient Outcomes After In-Hospital Cardiac Arrest Care.” Jama Cardiol 1, no. 1 (April 1, 2016): 37–45. https://doi.org/10.1001/jamacardio.2015.0275.
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  - Golwala, Harsh, Larry R. Jackson, DaJuanicia N. Simon, Jonathan P. Piccini, Bernard Gersh, Alan S. Go, Elaine M. Hylek, et al. “Racial/ethnic differences in atrial fibrillation symptoms, treatment patterns, and outcomes: Insights from Outcomes Registry for Better Informed Treatment for Atrial Fibrillation Registry.” Am Heart J 174 (April 2016): 29–36. https://doi.org/10.1016/j.ahj.2015.10.028.
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  - Noheria, Amit, Peter Shrader, Jonathan P. Piccini, Gregg C. Fonarow, Peter R. Kowey, Kenneth W. Mahaffey, Gerald Naccarelli, et al. “Rhythm Control Versus Rate Control and Clinical Outcomes in Patients With Atrial Fibrillation: Results From the ORBIT-AF Registry.” Jacc Clin Electrophysiol 2, no. 2 (April 2016): 221–29. https://doi.org/10.1016/j.jacep.2015.11.001.
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  - Prates, Paulo Roberto L., Judson B. Williams, Rajendra H. Mehta, Susanna R. Stevens, Laine Thomas, Peter K. Smith, L Kristin Newby, Renato A. K. Kalil, John H. Alexander, and Renato D. Lopes. “Clopidogrel use After Myocardial Revascularization: Prevalence, Predictors, and One-Year Survival Rate.” Braz J Cardiovasc Surg 31, no. 2 (April 2016): 106–14. https://doi.org/10.5935/1678-9741.20160019.
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  - Hess, Connie N., Anne S. Hellkamp, Matthew T. Roe, Laine Thomas, Benjamin M. Scirica, S Andrew Peng, Eric D. Peterson, and Tracy Y. Wang. “Outcomes According to Cardiac Catheterization Referral and Clopidogrel Use Among Medicare Patients With Non-ST-Segment Elevation Myocardial Infarction Discharged Without In-hospital Revascularization.” J Am Heart Assoc 5, no. 3 (March 14, 2016): e002784. https://doi.org/10.1161/JAHA.115.002784.
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  - Fonarow, Gregg C., Li Liang, Laine Thomas, Ying Xian, Jeffrey L. Saver, Eric E. Smith, Lee H. Schwamm, et al. “Assessment of Home-Time After Acute Ischemic Stroke in Medicare Beneficiaries.” Stroke 47, no. 3 (March 2016): 836–42. https://doi.org/10.1161/STROKEAHA.115.011599.
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  - Vora, Amit N., Eric D. Peterson, Anne S. Hellkamp, Nadia R. Sutton, Edward Panacek, Laine Thomas, James A. de Lemos, and Tracy Y. Wang. “Care Transitions After Acute Myocardial Infarction for Transferred-In Versus Direct-Arrival Patients.” Circ Cardiovasc Qual Outcomes 9, no. 2 (March 2016): 109–16. https://doi.org/10.1161/CIRCOUTCOMES.115.002108.
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  - Shah, Rashmee U., James A. de Lemos, Tracy Y. Wang, Anita Y. Chen, Laine Thomas, Nadia R. Sutton, James C. Fang, Benjamin M. Scirica, Timothy D. Henry, and Christopher B. Granger. “Post-Hospital Outcomes of Patients With Acute Myocardial Infarction With Cardiogenic Shock: Findings From the NCDR.” J Am Coll Cardiol 67, no. 7 (February 23, 2016): 739–47. https://doi.org/10.1016/j.jacc.2015.11.048.
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  - Jackson, Larry R., Sung Hee Kim, Jonathan P. Piccini, Bernard J. Gersh, Gerald V. Naccarelli, James A. Reiffel, James Freeman, et al. “Sinus Node Dysfunction Is Associated With Higher Symptom Burden and Increased Comorbid Illness: Results From the ORBIT-AF Registry.” Clin Cardiol 39, no. 2 (February 2016): 119–25. https://doi.org/10.1002/clc.22504.
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  - O’Brien, Emily C., and Laine E. Thomas. “Untangling the paradox: Obesity as prognostic marker in prevalent cardiovascular disease.” Am Heart J 172 (February 2016): 170–72. https://doi.org/10.1016/j.ahj.2015.11.005.
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  - Durheim, Michael T., Derek D. Cyr, Renato D. Lopes, Laine E. Thomas, Wayne M. Tsuang, Bernard J. Gersh, Claes Held, et al. “Chronic obstructive pulmonary disease in patients with atrial fibrillation: Insights from the ARISTOTLE trial.” Int J Cardiol 202 (January 1, 2016): 589–94. https://doi.org/10.1016/j.ijcard.2015.09.062.
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  - Xian, Ying, Jerome J. Federspiel, Maria Grau-Sepulveda, Adrian F. Hernandez, Lee H. Schwamm, Deepak L. Bhatt, Eric E. Smith, et al. “Risks and Benefits Associated With Prestroke Antiplatelet Therapy Among Patients With Acute Ischemic Stroke Treated With Intravenous Tissue Plasminogen Activator.” Jama Neurol 73, no. 1 (January 2016): 50–59. https://doi.org/10.1001/jamaneurol.2015.3106.
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  - Gruberg, Luis, Anne S. Hellkamp, Laine E. Thomas, James A. de Lemos, Benjamin M. Scirica, Anthony Hilliard, Jonathan R. Enriquez, Amr Mohsen, and Tracy Y. Wang. “The Association of Previous Revascularization With In-Hospital Outcomes in Acute Myocardial Infarction Patients: Results From the National Cardiovascular Data Registry.” Jacc Cardiovasc Interv 8, no. 15 (December 28, 2015): 1954–62. https://doi.org/10.1016/j.jcin.2015.08.030.
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  - O’Brien, Emily C., DaJuanicia N. Simon, Laine E. Thomas, Elaine M. Hylek, Bernard J. Gersh, Jack E. Ansell, Peter R. Kowey, et al. “The ORBIT bleeding score: a simple bedside score to assess bleeding risk in atrial fibrillation.” Eur Heart J 36, no. 46 (December 7, 2015): 3258–64. https://doi.org/10.1093/eurheartj/ehv476.
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  - Shen, Lan, Bimal R. Shah, Shuang Li, Laine Thomas, Tracy Y. Wang, Karen P. Alexander, Eric D. Peterson, Ben He, and Matthew T. Roe. “The Association of Transfer Rate From Hospitals Without Revascularization Capabilities and Mortality Risk for Older Non-ST-Segment Elevation Myocardial Infarction Patients.” Clin Cardiol 38, no. 12 (December 2015): 733–39. https://doi.org/10.1002/clc.22480.
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  - Doll, Jacob A., Anne Hellkamp, Laine Thomas, P Michael Ho, Michael C. Kontos, Mary A. Whooley, Thomas F. Boyden, Eric D. Peterson, and Tracy Y. Wang. “Effectiveness of cardiac rehabilitation among older patients after acute myocardial infarction.” Am Heart J 170, no. 5 (November 2015): 855–64. https://doi.org/10.1016/j.ahj.2015.08.001.
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  - Enriquez, Jonathan R., James A. de Lemos, Shailja V. Parikh, DaJuanicia N. Simon, Laine E. Thomas, Tracy Y. Wang, Paul S. Chan, John A. Spertus, and Sandeep R. Das. “Modest Associations Between Electronic Health Record Use and Acute Myocardial Infarction Quality of Care and Outcomes: Results From the National Cardiovascular Data Registry.” Circ Cardiovasc Qual Outcomes 8, no. 6 (November 2015): 576–85. https://doi.org/10.1161/CIRCOUTCOMES.115.001837.
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  - Goyal, Abhinav, James A. de Lemos, S Andrew Peng, Laine Thomas, Ezra A. Amsterdam, Jason M. Hockenberry, Eric D. Peterson, and Tracy Y. Wang. “Association of Patient Enrollment in Medicare Part D With Outcomes After Acute Myocardial Infarction.” Circ Cardiovasc Qual Outcomes 8, no. 6 (November 2015): 567–75. https://doi.org/10.1161/CIRCOUTCOMES.115.001650.
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  - Steinberg, Benjamin A., Sunghee Kim, Laine Thomas, Gregg C. Fonarow, Bernard J. Gersh, Fredrik Holmqvist, Elaine Hylek, et al. “Increased Heart Rate Is Associated With Higher Mortality in Patients With Atrial Fibrillation (AF): Results From the Outcomes Registry for Better Informed Treatment of AF (ORBIT-AF).” J Am Heart Assoc 4, no. 9 (September 14, 2015): e002031. https://doi.org/10.1161/JAHA.115.002031.
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  - Pokorney, Sean D., Amy L. Miller, Anita Y. Chen, Laine Thomas, Gregg C. Fonarow, James A. de Lemos, Sana M. Al-Khatib, Eric D. Peterson, and Tracy Y. Wang. “Implantable Cardioverter-Defibrillator Use Among Medicare Patients With Low Ejection Fraction After Acute Myocardial Infarction.” Jama 313, no. 24 (June 23, 2015): 2433–40. https://doi.org/10.1001/jama.2015.6409.
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  - Allen LaPointe, Nancy M., David Dai, Laine Thomas, Jonathan P. Piccini, Eric D. Peterson, and Sana M. Al-Khatib. “Comparisons of hospitalization rates among younger atrial fibrillation patients receiving different antiarrhythmic drugs.” Circ Cardiovasc Qual Outcomes 8, no. 3 (May 2015): 292–300. https://doi.org/10.1161/CIRCOUTCOMES.114.001499.
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  - Katz, Marcelo, Robert M. Califf, Jie-Lena Sun, John J. V. McMurray, Laine Thomas, and Renato D. Lopes. “Venous thromboembolism and cardiovascular risk: results from the NAVIGATOR trial.” Am J Med 128, no. 3 (March 2015): 297–302. https://doi.org/10.1016/j.amjmed.2014.08.022.
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  - Allen LaPointe, Nancy M., Dadi Dai, Laine Thomas, Jonathan P. Piccini, Eric D. Peterson, and Sana M. Al-Khatib. “Antiarrhythmic drug use in patients <65 years with atrial fibrillation and without structural heart disease.” Am J Cardiol 115, no. 3 (February 1, 2015): 316–22. https://doi.org/10.1016/j.amjcard.2014.11.005.
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  - Allen, Larry A., Gregg C. Fonarow, DaJuanicia N. Holmes, Laine E. Thomas, Lucas N. Marzec, Sean D. Pokorney, Bernard Gersh, et al. “Digoxin Use and Subsequent Outcomes Among Patients with and without Heart Failure in a Contemporary Atrial Fibrillation Cohort: Outcomes Registry for Better Informed Treatment of Atrial Fibrillation (ORBIT-AF).” Circulation 130 (November 25, 2014).
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  - Wallentin, Lars, Renato D. Lopes, Michael Hanna, Laine Thomas, Anne Hellkamp, Sunil Nepal, Elaine M. Hylek, et al. “Efficacy and safety of apixaban compared with warfarin at different levels of predicted international normalized ratio control for stroke prevention in atrial fibrillation.” Circulation 127, no. 22 (June 4, 2013): 2166–76. https://doi.org/10.1161/CIRCULATIONAHA.112.142158.
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  - Chatterjee, Ranee, Laine Thomas, Laura Svetkey, Frederick L. Brancati, Robert M. Califf, and David Edelman. “Effects of changes in potassium with valsartan use on diabetes risk: Nateglinide and Valsartan in Impaired Glucose Tolerance Outcomes Research (NAVIGATOR) trial.” Am J Hypertens 26, no. 6 (June 2013): 723–26. https://doi.org/10.1093/ajh/hpt016.
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  - Roe, Matthew T., Shuang Li, Laine Thomas, Tracy Y. Wang, Karen P. Alexander, E Magnus Ohman, and Eric D. Peterson. “Long-term outcomes after invasive management for older patients with non-ST-segment elevation myocardial infarction.” Circ Cardiovasc Qual Outcomes 6, no. 3 (May 1, 2013): 323–32. https://doi.org/10.1161/CIRCOUTCOMES.113.000120.
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  - Manfredi, Joseph A., Sana M. Al-Khatib, Linda K. Shaw, Laine Thomas, Richard I. Fogel, Benzy Padanilam, David Rardon, et al. “Association between left ventricular ejection fraction post-cardiac resynchronization treatment and subsequent implantable cardioverter defibrillator therapy for sustained ventricular tachyarrhythmias.” Circ Arrhythm Electrophysiol 6, no. 2 (April 2013): 257–64. https://doi.org/10.1161/CIRCEP.112.000214.
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  - Fosbøl, Emil L., Eric D. Peterson, Peter Weeke, Tracy Y. Wang, Robin Mathews, Lars Kober, Laine Thomas, Gunnar H. Gislason, and Christian Torp-Pedersen. “Spousal depression, anxiety, and suicide after myocardial infarction.” Eur Heart J 34, no. 9 (March 2013): 649–56. https://doi.org/10.1093/eurheartj/ehs242.
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  - Wong, Yee Weng, Laine Thomas, Jie-Lena Sun, John J. V. McMurray, Henry Krum, Adrian F. Hernandez, Guy E. H. M. Rutten, et al. “Predictors of incident heart failure hospitalizations among patients with impaired glucose tolerance: insight from the Nateglinide And Valsartan in Impaired Glucose Tolerance Outcomes Research study.” Circ Heart Fail 6, no. 2 (March 2013): 203–10. https://doi.org/10.1161/CIRCHEARTFAILURE.112.000086.
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  - Thomas, Laine, and Eric D. Peterson. “Statistical analysis plans in observational research--reply.” Jama 309, no. 1 (January 2, 2013): 32. https://doi.org/10.1001/jama.2012.56917.
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  - Leonardi, Sergio, Laine Thomas, Megan L. Neely, Pierluigi Tricoci, Renato D. Lopes, Harvey D. White, Paul W. Armstrong, et al. “Comparison of the prognosis of spontaneous and percutaneous coronary intervention-related myocardial infarction.” J Am Coll Cardiol 60, no. 22 (December 4, 2012): 2296–2304. https://doi.org/10.1016/j.jacc.2012.09.005.
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  - Hohnloser, Stefan H., Ziad Hijazi, Laine Thomas, John H. Alexander, John Amerena, Michael Hanna, Matyas Keltai, et al. “Efficacy of apixaban when compared with warfarin in relation to renal function in patients with atrial fibrillation: insights from the ARISTOTLE trial.” Eur Heart J 33, no. 22 (November 2012): 2821–30. https://doi.org/10.1093/eurheartj/ehs274.
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  - Thomas, Laine, and Eric D. Peterson. “The value of statistical analysis plans in observational research: defining high-quality research from the start.” Jama 308, no. 8 (August 22, 2012): 773–74. https://doi.org/10.1001/jama.2012.9502.
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  - Lopes, Renato D., Sumeet Subherwal, Dajuanicia N. Holmes, Laine Thomas, Tracy Y. Wang, Sunil V. Rao, Erik Magnus Ohman, Matthew T. Roe, Eric D. Peterson, and Karen P. Alexander. “The association of in-hospital major bleeding with short-, intermediate-, and long-term mortality among older patients with non-ST-segment elevation myocardial infarction.” Eur Heart J 33, no. 16 (August 2012): 2044–53. https://doi.org/10.1093/eurheartj/ehs012.
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  - Subherwal, Sumeet, Deepak L. Bhatt, Shuang Li, Tracy Y. Wang, Laine Thomas, Karen P. Alexander, Manesh R. Patel, et al. “Polyvascular disease and long-term cardiovascular outcomes in older patients with non-ST-segment-elevation myocardial infarction.” Circ Cardiovasc Qual Outcomes 5, no. 4 (July 1, 2012): 541–49. https://doi.org/10.1161/CIRCOUTCOMES.111.964379.
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  - Subherwal, Sumeet, Eric D. Peterson, David Dai, Laine Thomas, John C. Messenger, Ying Xian, Ralph G. Brindis, et al. “Temporal trends in and factors associated with bleeding complications among patients undergoing percutaneous coronary intervention: a report from the National Cardiovascular Data CathPCI Registry.” J Am Coll Cardiol 59, no. 21 (May 22, 2012): 1861–69. https://doi.org/10.1016/j.jacc.2011.12.045.
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  - Fosbol, Emil L., Tracy Y. Wang, Shuang Li, Jonathan P. Piccini, Renato D. Lopes, Bimal Shah, Roger M. Mills, et al. “Safety and effectiveness of antithrombotic strategies in older adult patients with atrial fibrillation and non-ST elevation myocardial infarction.” Am Heart J 163, no. 4 (April 2012): 720–28. https://doi.org/10.1016/j.ahj.2012.01.017.
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  - Kociol, Robb D., Renato D. Lopes, Robert Clare, Laine Thomas, Rajendra H. Mehta, Padma Kaul, Karen S. Pieper, et al. “International variation in and factors associated with hospital readmission after myocardial infarction.” Jama 307, no. 1 (January 4, 2012): 66–74. https://doi.org/10.1001/jama.2011.1926.
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  - Preiss, David, Laine E. Thomas, Jie-Lena Sun, Steven M. Haffner, Rury R. Holman, Eberhard Standl, Lawrence A. Leiter, et al. “Predictors of cardiovascular events in a contemporary population with impaired glucose tolerance: an observational analysis of the Nateglinide and Valsartan in impaired glucose tolerance outcomes research (NAVIGATOR) trial.” Bmj Open 2, no. 6 (2012). https://doi.org/10.1136/bmjopen-2012-001925.
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  - Samsa, G. P., L. Thomas, L. S. Lee, and E. M. Neal. “An active learning approach to teach advanced multi-predictor modeling concepts to clinicians.” Journal of Statistics Education 20, no. 1 (January 1, 2012): 1–34. https://doi.org/10.1080/10691898.2012.11889631.
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  - Thomas, Laine, Leonard Stefanski, and Marie Davidian. “A moment-adjusted imputation method for measurement error models.” Biometrics 67, no. 4 (December 2011): 1461–70. https://doi.org/10.1111/j.1541-0420.2011.01569.x.
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  - Roe, Matthew T., Anita Y. Chen, Laine Thomas, Tracy Y. Wang, Karen P. Alexander, Bradley G. Hammill, W Brian Gibler, E Magnus Ohman, and Eric D. Peterson. “Predicting long-term mortality in older patients after non-ST-segment elevation myocardial infarction: the CRUSADE long-term mortality model and risk score.” Am Heart J 162, no. 5 (November 2011): 875-883.e1. https://doi.org/10.1016/j.ahj.2011.08.010.
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  - Piccini, Jonathan P., Elizabeth S. Fraulo, Jack E. Ansell, Gregg C. Fonarow, Bernard J. Gersh, Alan S. Go, Elaine M. Hylek, et al. “Outcomes registry for better informed treatment of atrial fibrillation: rationale and design of ORBIT-AF.” Am Heart J 162, no. 4 (October 2011): 606-612.e1. https://doi.org/10.1016/j.ahj.2011.07.001.
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  - Britton, Kathryn A., Vikas Aggarwal, Anita Y. Chen, Karen P. Alexander, Ezra Amsterdam, Elizabeth Fraulo, Paul Muntner, et al. “No association between hemoglobin A1c and in-hospital mortality in patients with diabetes and acute myocardial infarction.” Am Heart J 161, no. 4 (April 2011): 657-663.e1. https://doi.org/10.1016/j.ahj.2010.12.004.
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  - Fiuzat, Mona, Linda K. Shaw, Laine Thomas, G Michael Felker, and Christopher M. O’Connor. “United States stock market performance and acute myocardial infarction rates in 2008-2009 (from the Duke Databank for Cardiovascular Disease).” Am J Cardiol 106, no. 11 (December 1, 2010): 1545–49. https://doi.org/10.1016/j.amjcard.2010.07.027.
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  - Berger, Jeffrey S., Laine Elliott, Dianne Gallup, Matthew Roe, Christopher B. Granger, Paul W. Armstrong, R John Simes, et al. “Sex differences in mortality following acute coronary syndromes.” Jama 302, no. 8 (August 26, 2009): 874–82. https://doi.org/10.1001/jama.2009.1227.
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  - Ashley-Koch, Allison E., Laine Elliott, Melanie E. Kail, Laura M. De Castro, Jude Jonassaint, Terry L. Jackson, Jennifer Price, et al. “Identification of genetic polymorphisms associated with risk for pulmonary hypertension in sickle cell disease.” Blood 111, no. 12 (June 15, 2008): 5721–26. https://doi.org/10.1182/blood-2007-02-074849.
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  - DREAM Trial Investigators, S., G. R. Dagenais, H. C. Gerstein, R. Holman, A. Budaj, A. Escalante, T. Hedner, et al. “Effects of ramipril and rosiglitazone on cardiovascular and renal outcomes in people with impaired glucose tolerance or impaired fasting glucose: results of the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) trial.” Diabetes Care 31, no. 5 (May 2008): 1007–14. https://doi.org/10.2337/dc07-1868.
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  - Elliott, Laine, Allison E. Ashley-Koch, Laura De Castro, Jude Jonassaint, Jennifer Price, Kenneth I. Ataga, Marc C. Levesque, et al. “Genetic polymorphisms associated with priapism in sickle cell disease.” Br J Haematol 137, no. 3 (May 2007): 262–67. https://doi.org/10.1111/j.1365-2141.2007.06560.x.
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  - DREAM Trial Investigators, Rury R., Jackie Bosch, Salim Yusuf, Hertzel C. Gerstein, Janice Pogue, Patrick Sheridan, Gilles Dagenais, et al. “Effect of ramipril on the incidence of diabetes.” N Engl J Med 355, no. 15 (October 12, 2006): 1551–62. https://doi.org/10.1056/NEJMoa065061.
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- Conference Papers
  - Melloni, Chiara, Allison Dunning, Christopher B. Granger, Laine Thomas, Michel G. Khouri, David A. Garcia, Elaine M. Hylek, et al. “Efficacy and Safety of Apixaban Versus Warfarin in Patients with Atrial Fibrillation and a History of Cancer: Insights from the ARISTOTLE Trial.” In Am J Med, 130:1440-1448.e1, 2017. https://doi.org/10.1016/j.amjmed.2017.06.026.
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  - Piccini, J., J. B. Washam, D. N. Simon, L. E. Thomas, E. M. Hylek, G. C. Fonarow, K. W. Mahaffey, et al. “Pharmacotherapy for atrial fibrillation in patients with chronic kidney disease: insights from the outcomes registry for better informed treatment of atrial fibrillation (ORBIT AF).” In European Heart Journal, 37:685–685. OXFORD UNIV PRESS, 2016.
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  - Pokorney, S. D., D. N. Simon, L. E. Thomas, G. C. Fonarow, K. W. Mahaffey, B. J. Gersh, P. R. Kowey, et al. “Patterns of amiodarone use and outcomes in clinical practice for atrial fibrillation: insights from the Outcomes Registry for Better Informed Treatment of Atrial Fibrillation (ORBIT AF).” In European Heart Journal, 37:686–686. OXFORD UNIV PRESS, 2016.
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  - Noheria, Amit, Peter Shrader, Jonathan P. Piccini, Gregg C. Fonarow, Peter R. Kowey, Kenneth W. Mahaffey, Gerald Naccarelli, et al. “Rhythm Control Versus Rate Control and Clinical Outcomes in Patients With Atrial Fibrillation: Results From the Outcomes Registry for Better Informed Treatment of Atrial Fibrillation (ORBIT-AF).” In Circulation, Vol. 132. LIPPINCOTT WILLIAMS & WILKINS, 2015.
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  - Durheim, M. T., D. D. Cyr, S. M. Al-Khatib, L. E. Thomas, R. D. Lopes, B. J. Gersh, S. M. Palmer, and C. B. Granger. “Chronic Obstructive Pulmonary Disease Is Associated With Increased Risk Of Mortality Among Patients With Atrial Fibrillation: Insights From The Aristotle Trial.” In American Journal of Respiratory and Critical Care Medicine, Vol. 191. AMER THORACIC SOC, 2015.
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Teaching & Mentoring
Recent Courses
- BIOSTAT 709: Observational Studies 2021
- BIOSTAT 709: Observational Studies 2020
- BIOSTAT 709: Observational Studies 2019

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