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Laine Elliott Thomas

Professor of Biostatistics & Bioinformatics
Biostatistics & Bioinformatics, Division of Biostatistics
Duke Box 3850, Durham, NC 27710
200 Morris Street, 7812 200 Morris, Durham, NC 27701

Research Interests


Causal Inference, Heterogeneity of Treatment Effects, Observational Data, Time-varying Treatments, Real World Evidence, Estimands, External controls

Selected Grants


Principal stratification methods and software for intercurrent events in clinical trials

ResearchCo Investigator · Awarded by University of North Carolina - Chapel Hill · 2023 - 2028

Integrated Biostatistical Training for CVD Research

Inst. Training Prgm or CMEMentor · Awarded by North Carolina State University · 2022 - 2027

Innovative Biostatistical Methods for Analysis and Assessment of Clinical Trials Augmented by Real World Data

ResearchPrincipal Investigator · Awarded by Burroughs Wellcome Fund · 2021 - 2026

HERO Program, HERO Registry, HERO-HCQ Trial

Clinical TrialStatistical Investigator · Awarded by Patient-Centered Outcomes Research Institute · 2020 - 2025

PCORNet Statment 9: Representativeness

ResearchPrincipal Investigator · Awarded by Patient-Centered Outcomes Research Institute · 2024 - 2025

Postdoctoral Training in Cardiovascular Clinical Research

Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 2003 - 2025

New causal inference methods for cluster randomized trials with post-randomization selection

ResearchCo Investigator · Awarded by Patient-Centered Outcomes Research Institute · 2020 - 2024

Methods for the Design and Conduct of Subgroup Analysis in Observational Studies

ResearchPrincipal Investigator · Awarded by Patient-Centered Outcomes Research Institute · 2019 - 2022

CHAMP-HF

ResearchPrincipal Investigator · Awarded by Novartis Pharmaceuticals Corporation · 2016 - 2022

Hero Ancillary Study: The Nurse HERO Study

ResearchStatistical Investigator · Awarded by Children's Hospital of Philadelphia · 2021 - 2021

GARFIELD-Atrial Fibrillation Registry Research

ResearchPrincipal Investigator · Awarded by Thrombosis Research Institute · 2016 - 2020

Statistical Methods for Complex Data in Cardiovascular Disease

ResearchCo Investigator · Awarded by North Carolina State University · 2013 - 2018

Matching Methods for Comparative Effectiveness Studies of Longitudinal Treatments

ResearchPrincipal Investigator · Awarded by Agency for Healthcare Research and Quality · 2015 - 2017

NCDR-ACTION

ResearchStatistical Investigator · Awarded by American College of Cardiology Foundation · 2008 - 2015

External Relationships


  • Bristol-Myers Squibb (BMS)
  • GlaxoSmithKline
  • InQuera
  • JAMA Cardiology
  • Merck

This faculty member (or a member of their immediate family) has reported outside activities with the companies, institutions, or organizations listed above. This information is available to institutional leadership and, when appropriate, management plans are in place to address potential conflicts of interest.