Scholars@Duke
Christopher Robert Longo

Christopher Robert Longo

Clinical Faculty in the Department of Surgery
Surgery, Vascular and Endovascular Surgery

Selected Publications

The C-terminal domain of A1/Bfl-1 regulates its anti-inflammatory function in human endothelial cells.

Journal Article Biochim Biophys Acta · June 2013 A1/Bfl-1 is a NF-κB dependent, anti-apoptotic Bcl-2 family member that contains four Bcl-2 homology domains (BH) and an amphipathic C-terminal domain, and is expressed in endothelial cells (EC). Based on NF-κB reporter assays in bovine aortic EC, we have p ... Full text Link to item Cite

A20 modulates lipid metabolism and energy production to promote liver regeneration.

Journal Article PLoS One · March 17, 2011 BACKGROUND: Liver regeneration is clinically of major importance in the setting of liver injury, resection or transplantation. We have demonstrated that the NF-κB inhibitory protein A20 significantly improves recovery of liver function and mass following e ... Full text Link to item Cite

A20 protects mice from lethal liver ischemia/reperfusion injury by increasing peroxisome proliferator-activated receptor-alpha expression.

Journal Article Liver Transpl · November 2009 The nuclear factor-kappaB inhibitory protein A20 demonstrates hepatoprotective abilities through combined antiapoptotic, anti-inflammatory, and pro-proliferative functions. Accordingly, overexpression of A20 in the liver protects mice from toxic hepatitis ... Full text Link to item Cite

A20, a modulator of smooth muscle cell proliferation and apoptosis, prevents and induces regression of neointimal hyperplasia.

Journal Article FASEB J · July 2006 A20 is a NF-kappaB-dependent gene that has dual anti-inflammatory and antiapoptotic functions in endothelial cells (EC). The function of A20 in smooth muscle cells (SMC) is unknown. We demonstrate that A20 is induced in SMC in response to inflammatory stim ... Full text Link to item Cite

Combined expression of A1 and A20 achieves optimal protection of renal proximal tubular epithelial cells.

Journal Article Kidney Int · October 2005 BACKGROUND: Apoptotic death of renal proximal tubular epithelial cells (RPTECs) is a feature of acute and chronic renal failure. RPTECs are directly damaged by ischemia, inflammatory, and cytotoxic mediators but also contribute to their own demise by up-re ... Full text Link to item Cite

A20 protects mice from lethal radical hepatectomy by promoting hepatocyte proliferation via a p21waf1-dependent mechanism.

Journal Article Hepatology · July 2005 The liver has a remarkable regenerative capacity, allowing recovery following injury. Regeneration after injury is contingent on maintenance of healthy residual liver mass, otherwise fulminant hepatic failure (FHF) may arise. Understanding the protective m ... Full text Link to item Cite

A20 protects endothelial cells from TNF-, Fas-, and NK-mediated cell death by inhibiting caspase 8 activation.

Journal Article Blood · October 15, 2004 A20 is a stress response gene in endothelial cells (ECs). A20 serves a dual cytoprotective function, protecting from tumor necrosis factor (TNF)-mediated apoptosis and inhibiting inflammation via blockade of the transcription factor nuclear factor-kappaB ( ... Full text Link to item Cite

A20 protects from CD40-CD40 ligand-mediated endothelial cell activation and apoptosis.

Journal Article Circulation · September 2, 2003 BACKGROUND: CD40/CD40 ligand (CD40L) signaling is a potent activator of endothelial cells (ECs) and promoter of atherosclerosis. In this study, we investigate whether A20 (a gene we have shown to be antiinflammatory and antiapoptotic in ECs) can protect fr ... Full text Link to item Cite

Genetic engineering of a suboptimal islet graft with A20 preserves beta cell mass and function.

Journal Article J Immunol · June 15, 2003 Transplantation of an excessive number of islets of Langerhans (two to four pancreata per recipient) into patients with type I diabetes is required to restore euglycemia. Hypoxia, nutrient deprivation, local inflammation, and the beta cell inflammatory res ... Full text Link to item Cite

A20 protects mice from D-galactosamine/lipopolysaccharide acute toxic lethal hepatitis.

Journal Article Hepatology · March 2002 Apoptosis of hepatocytes is a seminal feature of fulminant hepatic failure. We show that the anti-apoptotic protein A20 is upregulated in hepatocytes by pro-inflammatory stimuli and functions to protect from apoptosis and limit inflammation by inhibiting N ... Full text Link to item Cite