Scholars@Duke
David Wendell

David Wendell

Research Scientist, Senior
Medicine, Cardiology
david.wendell@duke.edu
3934, Durham, NC 27710
DUMC, 3934, Durham, NC 27710

Selected Publications

Characterization of Septal Scar After Left Bundle Branch Area Pacemaker Implantation.

Journal Article Pacing Clin Electrophysiol · July 2025 BACKGROUND: Left bundle branch area pacing (LBBAP) is increasingly used in patients with a ventricular pacing indication but necessitates precise septal localization. The resulting effects of intraoperative lead repositioning on septal fibrosis remain unkn ... Full text Link to item Cite

A porcine model of acute rejection for cardiac transplantation

Conference Frontiers in Cardiovascular Medicine · January 1, 2025 Ex vivo machine perfusion has been growing in utility for preserving donor organs prior to transplantation. This modality has tremendous potential for bioengineering and conditioning organs prior to transplantation using small molecule or advanced therapeu ... Full text Cite

Delivery of a Muscle-Targeted Adeno-Associated Vector Via Ex Vivo Normothermic Perfusion Is Efficient, Durable, and Safe in a Preclinical Porcine Heart Transplant Model.

Journal Article Transpl Int · 2025 Normothermic ex-vivo organ perfusion (EVP) systems not only provide a physiological environment that preserves donor organ function outside the body but may also serve as platforms for ex-vivo organ modification via gene therapy. In this study, we demonstr ... Full text Link to item Cite

Sacubitril/valsartan and cardiovascular biomarkers among patients with recent COVID-19 infection: The PARACOR-19 randomized clinical trial.

Journal Article Eur J Heart Fail · June 2024 AIMS: The PARACOR-19 randomized controlled trial (RCT) was designed to examine the effects of sacubitril/valsartan on markers of cardiac injury, inflammation, structure, and function among patients who have recovered from acute coronavirus disease 2019 (CO ... Full text Link to item Cite

Cardiac magnetic resonance imaging characterization of acute rejection in a porcine heterotopic heart transplantation model.

Journal Article PLoS One · 2024 Preclinical disease models are important for the advancement of therapeutics towards human clinical trials. One of the difficult tasks of developing a well-characterized model is having a reliable modality with which to trend the progression of disease. Ac ... Full text Link to item Cite

An enhancer-based gene-therapy strategy for spatiotemporal control of cargoes during tissue repair.

Journal Article Cell Stem Cell · January 5, 2023 The efficacy and safety of gene-therapy strategies for indications like tissue damage hinge on precision; yet, current methods afford little spatial or temporal control of payload delivery. Here, we find that tissue-regeneration enhancer elements (TREEs) i ... Full text Link to item Cite

Video analysis of ex vivo beating hearts during preservation on the TransMedics® organ care system.

Journal Article Front Cardiovasc Med · 2023 BACKGROUND: Reliable biomarkers for assessing the viability of the donor hearts undergoing ex vivo perfusion remain elusive. A unique feature of normothermic ex vivo perfusion on the TransMedics® Organ Care System (OCS™) is that the donor heart is maintain ... Full text Link to item Cite

Native T1 Mapping for the Diagnosis of Myocardial Fibrosis in Patients With Chronic Myocardial Infarction.

Journal Article JACC Cardiovasc Imaging · December 2022 BACKGROUND: Myocardial fibrosis is a fundamental process in cardiac injury. Cardiac magnetic resonance native T1 mapping has been proposed for diagnosing myocardial fibrosis without the need for gadolinium contrast. However, recent studies suggest that T1 ... Full text Link to item Cite

Assessment of Papillary Muscle Infarction with Dark-Blood Delayed Enhancement Cardiac MRI in Canines and Humans.

Journal Article Radiology · November 2022 Background The relationship between papillary muscle infarction (papMI) and the culprit coronary lesion has not been fully investigated. Delayed enhancement cardiac MRI may detect papMI, yet its accuracy is unknown. Flow-independent dark-blood delayed enha ... Full text Link to item Cite

Assessment of myocardial lipomatous metaplasia using an optimized out-of-phase cine steady-state free-precession sequence: Validation and clinical implementation.

Journal Article NMR Biomed · October 2022 Myocardial lipomatous metaplasia, which can serve as substrate for ventricular arrhythmias, is usually composed of regions in which there is an admixture of fat and nonfat tissue. Although dedicated sequences for the detection of fat are available, it woul ... Full text Link to item Cite

Targeted Delivery for Cardiac Regeneration: Comparison of Intra-coronary Infusion and Intra-myocardial Injection in Porcine Hearts.

Journal Article Front Cardiovasc Med · 2022 BACKGROUND: The optimal delivery route to enhance effectiveness of regenerative therapeutics to the human heart is poorly understood. Direct intra-myocardial (IM) injection is the gold standard, however, it is relatively invasive. We thus compared targeted ... Full text Link to item Cite

Patients With Acute Myocarditis Following mRNA COVID-19 Vaccination.

Journal Article JAMA Cardiol · October 1, 2021 IMPORTANCE: Vaccine-associated myocarditis is an unusual entity that has been described for the smallpox vaccine, but only anecdotal case reports have been described for other vaccines. Whether COVID-19 vaccination may be linked to the occurrence of myocar ... Full text Link to item Cite

Double spectral attenuated inversion recovery (DSPAIR)-an efficient fat suppression technique for late gadolinium enhancement at 3 tesla.

Journal Article NMR Biomed · October 2021 Despite clinical use of late gadolinium enhancement (LGE) for two decades, an efficient, robust fat suppression (FS) technique still does not exist for this CMR mainstay. In ischemic and non-ischemic heart disease, differentiating fibrotic tissue from infi ... Full text Link to item Cite

ECG-gated MR angiography provides better reproducibility for standard aortic measurements.

Journal Article Eur Radiol · July 2021 OBJECTIVE: Cardiac motion and aortic pulsatility can affect the image quality of 3D contrast-enhanced MR angiography (CE-MRA). The addition of ECG gating improves image quality; however, no studies have directly linked image quality improvements to clinica ... Full text Link to item Cite

Comparison of magnetization transfer-preparation and T2-preparation for dark-blood delayed-enhancement imaging.

Journal Article NMR Biomed · November 2020 Recently developed dark-blood techniques such as Flow-Independent Dark-blood DeLayed Enhancement (FIDDLE) allow simultaneous visualization of tissue contrast-enhancement and blood-pool suppression. Critical to FIDDLE is the magnetization preparation, which ... Full text Link to item Cite

Dark-Blood Delayed Enhancement Cardiac Magnetic Resonance of Myocardial Infarction.

Journal Article JACC Cardiovasc Imaging · December 2018 OBJECTIVES: This study introduced and validated a novel flow-independent delayed enhancement technique that shows hyperenhanced myocardium while simultaneously suppressing blood-pool signal. BACKGROUND: The diagnosis and assessment of myocardial infarction ... Full text Open Access Link to item Cite

Clinical Cardiovascular Magnetic Resonance Imaging Techniques

Chapter · January 1, 2018 Since the first dedicated cardiovascular magnetic resonance (CMR) clinical services opened in the mid-1990s, CMR imaging has become routine at most medical centers. In recent years, cross-institutional CMR protocols have become more consistent. This chapte ... Full text Cite

Suppression of ghost artifacts arising from long T1 species in segmented inversion-recovery imaging.

Journal Article Magn Reson Med · October 2017 PURPOSE: We demonstrate an improved segmented inversion-recovery sequence that suppresses ghost artifacts arising from tissues with long T1 ( > 1.5 s). THEORY AND METHODS: Long T1 species such as pericardial fluid can create bright ghost artifacts in segme ... Full text Link to item Cite

Introduction to cardiovascular magnetic resonance imaging

Chapter · January 1, 2017 CNR Contrast-to-noise ratio CSI Chemical shift imaging CSPAMM Complementary SPAMM CT Computed tomography DANTE Delays alternating with nutations for tailored excitation DE Delayed enhancement DENSE Displacement encoding with stimulated echoes DWI Diffusion ... Full text Cite

The Impact of Cardiac Motion on Aortic Valve Flow Used in Computational Simulations of the Thoracic Aorta

Journal Article Journal of Biomechanical Engineering · September 1, 2016 Advancements in image-based computational modeling are producing increasingly more realistic representations of vasculature and hemodynamics, but so far have not compensated for cardiac motion when imposing inflow boundary conditions. The effect of ... Full text Cite

Validation of a novel dark-blood delayed enhancement technique for the detection of papillary muscle SCAR

Journal Article Journal of Cardiovascular Magnetic Resonance · January 1, 2016 Full text Cite

Relationship of T2-Weighted MRI Myocardial Hyperintensity and the Ischemic Area-At-Risk.

Journal Article Circ Res · July 17, 2015 RATIONALE: After acute myocardial infarction (MI), delineating the area-at-risk (AAR) is crucial for measuring how much, if any, ischemic myocardium has been salvaged. T2-weighted MRI is promoted as an excellent method to delineate the AAR. However, the ev ... Full text Open Access Link to item Cite

Cardiac cine imaging

Chapter · January 1, 2015 Cine cardiac imaging is the primary technique by which cardiovascular magnetic resonance (CMR) imaging characterizes regional and global contractile function of the heart and resulting blood flow through the great vessels. As such, cine imaging is of funda ... Full text Cite

CMR imaging with rapid visual T1 assessment predicts mortality in patients suspected of cardiac amyloidosis.

Journal Article JACC Cardiovasc Imaging · February 2014 OBJECTIVES: This study tested the diagnostic and prognostic utility of a rapid, visual T1 assessment method for identification of cardiac amyloidosis (CA) in a "real-life" referral population undergoing cardiac magnetic resonance for suspected CA. BACKGROU ... Full text Link to item Cite

Altered hemodynamics, endothelial function, and protein expression occur with aortic coarctation and persist after repair

Journal Article American Journal of Physiology-Heart and Circulatory Physiology · December 1, 2012 Coarctation of the aorta (CoA) is associated with substantial morbidity despite treatment. Mechanically induced structural and functional vascular changes are implicated; however, their relationship with smooth muscle (SM) phenotypic expression is ... Full text Cite

Phase Sensitive Fat Darkening by TI-Minimized Double SPAIR (PHATTI DeSPAIR) for Robust and Highly Effective Fat Suppression in Clinical T1-Weighted Imaging of Ischemic and Non-Ischemic Heart Disease

Conference We present a highly effective and robust fat suppression technique for T1-weighted inversion recovery (IR) imaging such as delayed enhancement, that is compatible with phase sensitive IR (PSIR) imaging. It combines a double-SPAIR (Spectral Selection Attenu ... Cite