Skip to main content

Eric Mastria

Assistant Professor of Radiology
Radiology, Interventional Radiology
DUMC 3808, Durham, NC 27710

Selected Publications


Data from Tumor Subtype Determines Therapeutic Response to Chimeric Polypeptide Nanoparticle–based Chemotherapy in <i>Pten</i>-deleted Mouse Models of Sarcoma

Other · March 31, 2023 <div>AbstractPurpose:<p>Nanoparticle-encapsulated drug formulations can improve responses to conventional chemotherapy by increasing drug retention within the tumor and by promoting a more effective antitumor immune response than free d ... Full text Cite

Data from Tumor Subtype Determines Therapeutic Response to Chimeric Polypeptide Nanoparticle–based Chemotherapy in <i>Pten</i>-deleted Mouse Models of Sarcoma

Other · March 31, 2023 <div>AbstractPurpose:<p>Nanoparticle-encapsulated drug formulations can improve responses to conventional chemotherapy by increasing drug retention within the tumor and by promoting a more effective antitumor immune response than free d ... Full text Cite

Evaluating Radioactive Analogs of Doxorubicin to Quantify ChemoFilter Binding and Whole-Body Positron Emission Tomography/Magnetic Resonance Imaging for Drug Biodistribution.

Journal Article J Vasc Interv Radiol · June 2022 PURPOSE: To evaluate radiolabeled doxorubicin (Dox) analogs as tracers of baseline Dox biodistribution in vivo during hepatic intra-arterial chemotherapy and to assess the efficacy of ChemoFilter devices to bind Dox in vitro. MATERIALS AND METHODS: In an i ... Full text Link to item Cite

Intratumoral delivery of brachytherapy and immunotherapy by a thermally triggered polypeptide depot.

Journal Article J Control Release · March 2022 Biomaterial-based approaches for a combination of radiotherapy and immunotherapy can improve outcomes in metastatic cancer through local delivery of both therapeutic modalities to the primary tumor to control local tumor growth and distant metastases. This ... Full text Link to item Cite

Tumor Subtype Determines Therapeutic Response to Chimeric Polypeptide Nanoparticle-based Chemotherapy in Pten-deleted Mouse Models of Sarcoma.

Journal Article Clin Cancer Res · September 15, 2020 PURPOSE: Nanoparticle-encapsulated drug formulations can improve responses to conventional chemotherapy by increasing drug retention within the tumor and by promoting a more effective antitumor immune response than free drug. New drug delivery modalities a ... Full text Link to item Cite

Nanoparticle formulation improves doxorubicin efficacy by enhancing host antitumor immunity.

Journal Article J Control Release · January 10, 2018 Strategies that enhance the host antitumor immune response promise to revolutionize cancer therapy. Optimally mobilizing the immune system will likely require a multi-pronged approach to overcome the resistance developed by tumors to therapy. Recently, it ... Full text Link to item Cite

A quantitative study of the intracellular fate of pH-responsive doxorubicin-polypeptide nanoparticles.

Journal Article J Control Release · August 28, 2017 Nanoscale carriers with an acid-labile linker between the carrier and drug are commonly used for drug delivery. However, their efficacy is potentially limited by inefficient linker cleavage, and lysosomal entrapment of drugs. To address these critical issu ... Full text Link to item Cite

One-week glucose control via zero-order release kinetics from an injectable depot of glucagon-like peptide-1 fused to a thermosensitive biopolymer.

Journal Article Nat Biomed Eng · 2017 Stimulation of the glucagon-like peptide-1 (GLP1) receptor is a useful treatment strategy for type 2 diabetes because of pleiotropic effects, including the regulation of islet hormones and the induction of satiety. However, the native ligand for the GLP1 r ... Full text Link to item Cite

Injectable polypeptide micelles that form radiation crosslinked hydrogels in situ for intratumoral radiotherapy.

Journal Article J Control Release · April 28, 2016 Intratumoral radiation therapy - 'brachytherapy' - is a highly effective treatment for solid tumors, particularly prostate cancer. Current titanium seed implants, however, are permanent and are limited in clinical application to indolent malignancies of lo ... Full text Link to item Cite

Abstract 1809: Next-generation brachytherapy: a preclinical study of a thermally stabilized biopolymer gel for delivering intratumoral radionuclide therapy in a pancreatic tumor mouse model

Conference Cancer Research · August 1, 2015 AbstractThe intratumoral delivery of radioactive therapeutics, a clinical technique known as brachytherapy, has proven very successful in treating solid cancers and become a prevalent option for treating pro ... Full text Cite

Doxorubicin-conjugated polypeptide nanoparticles inhibit metastasis in two murine models of carcinoma.

Journal Article J Control Release · June 28, 2015 Drug delivery vehicles are often assessed for their ability to control primary tumor growth, but the outcome of cancer treatment depends on controlling or inhibiting metastasis. Therefore, we studied the efficacy of our genetically encoded polypeptide nano ... Full text Link to item Cite

Genetically encoded smart peptide polymers for biomedicine

Journal Article MRS Bulletin · January 27, 2014 Drug delivery systems are becoming increasingly sophisticated, with the ability to target and penetrate specific tissues and release drugs based upon the local environment. While these advanced systems often offer advantages over their less sophisticated c ... Full text Cite

The margination propensity of ellipsoidal micro/nanoparticles to the endothelium in human blood flow.

Journal Article Biomaterials · July 2013 Particle shape is becoming increasingly recognized as an important parameter for the development of vascular-targeted carriers (VTCs) for disease treatment and diagnosis. However, limited research exists that investigates how particle shape coupled with he ... Full text Link to item Cite

Fabrication of biodegradable spheroidal microparticles for drug delivery applications.

Journal Article J Control Release · September 15, 2009 Particle shape, in addition to size, is becoming increasingly recognized as important in the design of drug carriers for in vivo use. However, few methods exist for fabricating non-spherical particles from biodegradable polymers. This work describes for th ... Full text Link to item Cite