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Genetically encoded smart peptide polymers for biomedicine

Publication ,  Journal Article
Mastria, E; Chilkoti, A
Published in: MRS Bulletin
January 27, 2014

Drug delivery systems are becoming increasingly sophisticated, with the ability to target and penetrate specific tissues and release drugs based upon the local environment. While these advanced systems often offer advantages over their less sophisticated counterparts, the final product may be more complex and require additional manufacturing steps. In this article, we review a body of work based on genetically encoded elastin-like polypeptides (ELPs) that offer a route to modular, multifunctional delivery systems that are simple to manufacture. ELPs are temperature-sensitive biopolymers that can be designed on the genetic level and expressed in cell-based protein production systems. The tools of molecular biology and versatility of proteins are used to engineer polymers with precise composition and molecular weight that self-assemble to form drug delivery systems with an impressive variety of features and functions. Due to their versatility and ease of production, ELPs are likely to contribute to the goal of designing simple and effective smart delivery systems. © 2014 Materials Research Society.

Duke Scholars

Published In

MRS Bulletin

DOI

ISSN

0883-7694

Publication Date

January 27, 2014

Volume

39

Issue

1

Start / End Page

35 / 43

Related Subject Headings

  • Applied Physics
  • 4018 Nanotechnology
  • 4016 Materials engineering
  • 0913 Mechanical Engineering
  • 0912 Materials Engineering
  • 0303 Macromolecular and Materials Chemistry
 

Citation

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Mastria, E., & Chilkoti, A. (2014). Genetically encoded smart peptide polymers for biomedicine. MRS Bulletin, 39(1), 35–43. https://doi.org/10.1557/mrs.2013.313
Mastria, E., and A. Chilkoti. “Genetically encoded smart peptide polymers for biomedicine.” MRS Bulletin 39, no. 1 (January 27, 2014): 35–43. https://doi.org/10.1557/mrs.2013.313.
Mastria E, Chilkoti A. Genetically encoded smart peptide polymers for biomedicine. MRS Bulletin. 2014 Jan 27;39(1):35–43.
Mastria, E., and A. Chilkoti. “Genetically encoded smart peptide polymers for biomedicine.” MRS Bulletin, vol. 39, no. 1, Jan. 2014, pp. 35–43. Scopus, doi:10.1557/mrs.2013.313.
Mastria E, Chilkoti A. Genetically encoded smart peptide polymers for biomedicine. MRS Bulletin. 2014 Jan 27;39(1):35–43.
Journal cover image

Published In

MRS Bulletin

DOI

ISSN

0883-7694

Publication Date

January 27, 2014

Volume

39

Issue

1

Start / End Page

35 / 43

Related Subject Headings

  • Applied Physics
  • 4018 Nanotechnology
  • 4016 Materials engineering
  • 0913 Mechanical Engineering
  • 0912 Materials Engineering
  • 0303 Macromolecular and Materials Chemistry