Scholars@Duke
Huansheng Cao

Huansheng Cao

Assistant Professor of Environmental Science at Duke Kunshan University
DKU Faculty

Selected Publications

β-cyclocitral induced rapid cell death of Microcystis aeruginosa.

Journal Article Environmental pollution (Barking, Essex : 1987) · May 2024 β-cyclocitral (BCC) is an odorous compound that can be produced by bloom-forming cyanobacteria, for example, Microcystis aeruginosa. BCC has been proposed to explain the rapid decline of cyanobacterial blooms in natural water bodies due to its lytic effect ... Full text Cite

Local flux coordination and global gene expression regulation in metabolic modeling.

Journal Article Nature communications · September 2023 Genome-scale metabolic networks (GSMs) are fundamental systems biology representations of a cell's entire set of stoichiometrically balanced reactions. However, such static GSMs do not incorporate the functional organization of metabolic genes and their dy ... Full text Cite

Draft Genome Sequence of an Epibiotic Bacterium, Bacillus cereus, Isolated from Cyanobacterial Blooms in Lake Taihu, China.

Journal Article Microbiology resource announcements · March 2023 Here, we report the draft genome sequence of Bacillus cereus strain THSB-6-2, which was isolated from cyanobacterial blooms in Lake Taihu, China. The 5,496,658-bp genome assembly of Bacillus cereus consists of 28 contigs, with a GC content of 35% and with ... Full text Cite

Cyanobacterial Blooms Are Not a Result of Positive Selection by Freshwater Eutrophication.

Journal Article Microbiology spectrum · December 2022 Long-standing cyanobacterial harmful algal blooms (CyanoHABs) are known to result from synergistic interaction between elevated nutrients and superior ecophysiology of cyanobacteria. However, it remains to be determined whether CyanoHABs are a result of po ... Full text Cite

CyanoPATH: a knowledgebase of genome-scale functional repertoire for toxic cyanobacterial blooms.

Journal Article Briefings in bioinformatics · July 2021 CyanoPATH is a database that curates and analyzes the common genomic functional repertoire for cyanobacteria harmful algal blooms (CyanoHABs) in eutrophic waters. Based on the literature of empirical studies and genome/protein databases, it summarizes four ... Full text Cite

Suppression of water-bloom cyanobacterium Microcystis aeruginosa by algaecide hydrogen peroxide maximized through programmed cell death.

Journal Article Journal of hazardous materials · July 2020 The global expansion and intensification of toxic cyanobacterial blooms require effective algaecides. Algaecides should be selective, effective, fast-acting, and ideally suppress cyanotoxin production. In this study, whether both maximum growth suppression ... Full text Cite

The Trait Repertoire Enabling Cyanobacteria to Bloom Assessed through Comparative Genomic Complexity and Metatranscriptomics.

Journal Article mBio · June 2020 Water bloom development due to eutrophication constitutes a case of niche specialization among planktonic cyanobacteria, but the genomic repertoire allowing bloom formation in only some species has not been fully characterized. We posited that the habitat ... Full text Cite

DeepUEP: Prediction of Urine Excretory Proteins Using Deep Learning

Journal Article IEEE Access · January 1, 2020 Urine excretory proteins are among the most commonly used biomarkers in body fluids. Computational identification of urine excretory proteins can provide very useful information for identifying targeted disease biomarkers in urine by linking transcriptome ... Full text Cite

Essentiality of local topology and regulation in kinetic metabolic modeling

Journal Article · October 16, 2019 AbstractGenome-scale metabolic networks (GSMs) are mathematic representation of a set of stoichiometrically balanced reactions. However, such static GSMs do not reflect or incorporate functional organization of genes and th ... Full text Cite

DOOR: a prokaryotic operon database for genome analyses and functional inference

Journal Article Briefings in Bioinformatics · July 19, 2019 AbstractThe rapid accumulation of fully sequenced prokaryotic genomes provides unprecedented information for biological studies of bacterial and archaeal organisms in a systematic manner. Operons are the basic functional un ... Full text Cite

Structural and functional analyses of microbial metabolic networks reveal novel insights into genome-scale metabolic fluxes.

Journal Article Briefings in bioinformatics · July 2019 We present here an integrated analysis of structures and functions of genome-scale metabolic networks of 17 microorganisms. Our structural analyses of these networks revealed that the node degree of each network, represented as a (simplified) reaction netw ... Full text Cite

Growth suppression and apoptosis-like cell death in Microcystis aeruginosa by H2O2: A new insight into extracellular and intracellular damage pathways.

Journal Article Chemosphere · November 2018 H2O2 has been suggested and applied as effective algaecide for harmful cyanobacterial bloom control, however, the transport of exogenous H2O2 into microalgal cells, the subsequent intracellular damage pathway and ... Full text Cite

A closely-related clade of globally distributed bloom-forming cyanobacteria within the Nostocales.

Journal Article Harmful algae · July 2018 In order to better understand the relationships among current Nostocales cyanobacterial blooms, eight genomes were sequenced from cultured isolates or from environmental metagenomes of recent planktonic Nostocales blooms. Phylogenomic analysis of publicly ... Full text Cite

Systems-level understanding of ethanol-induced stresses and adaptation in E. coli

Journal Article Scientific Reports · March 16, 2017 AbstractUnderstanding ethanol-induced stresses and responses in biofuel-producing bacteria at systems level has significant implications in engineering more efficient biofuel producers. We present a computational study of t ... Full text Cite

Life history responses of Daphnia similoides simultaneously exposed to microcystin-LR and ammonia and their postexposure recovery.

Journal Article Environmental toxicology and chemistry · November 2014 Aquatic organisms often suffer episodic stress from cyanobacterial bloom-derived concomitants and sometimes interactive stressors, and they may recover when stressors terminate. To assess whether exposed Daphnia can quickly recover from combined toxicity o ... Full text Cite

A survey of plant and algal genomes and transcriptomes reveals new insights into the evolution and function of the cellulose synthase superfamily.

Journal Article BMC genomics · April 2014 BackgroundEnzymes of the cellulose synthase (CesA) family and CesA-like (Csl) families are responsible for the synthesis of celluloses and hemicelluloses, and thus are of great interest to bioenergy research. We studied the occurrences and phyloge ... Full text Cite

Variation in the fitness effects of mutations with population density and size in Escherichia coli.

Journal Article PloS one · January 2014 The fitness effects of mutations are context specific and depend on both external (e.g., environment) and internal (e.g., cellular stress, genetic background) factors. The influence of population size and density on fitness effects are unknown, despite the ... Full text Cite

Combined effects of hypoxia and ammonia to Daphnia similis estimated with life-history traits.

Journal Article Environmental science and pollution research international · August 2013 The degradation of cyanobacterial blooms often causes hypoxia and elevated concentrations of ammonia, which can aggravate the adverse effects of blooms on aquatic organisms. However, it is not clear how one stressor would work in the presence of other coex ... Full text Cite

Relaxed natural selection alone does not permit transposable element expansion within 4,000 generations in Escherichia coli.

Journal Article Genetica · July 2011 Insertion sequences (ISs) are transposable genetic elements in bacterial genomes. IS elements are common among bacteria but are generally rare within free-living species, probably because of the negative fitness effects they have on their hosts. Conversely ... Full text Cite

Seasonal variation of Microcystis in Lake Taihu and its relationships with environmental factors.

Journal Article Journal of environmental sciences (China) · January 2009 In order to monitor the changes of Microcystis along with temporal and spatial variations, seasonal variation of Microcystis in Lake Taihu was investigated by 16S-23S rRNA internal transcribed spacer denaturing gradient gel electrophoresis (16S-23S rRNA-IT ... Full text Cite

CHANGES IN THE MORPHOLOGY AND POLYSACCHARIDE CONTENT OF MICROCYSTIS AERUGINOSA (CYANOBACTERIA) DURING FLAGELLATE GRAZING(1).

Journal Article Journal of phycology · June 2008 To investigate the changes in the morphology and polysaccharide content of Microcystis aeruginosa (Kütz.) Kütz. during flagellate grazing, cultures of M. aeruginosa were exposed to grazing Ochromonas sp. for a period of 9 d under controlled laboratory cond ... Full text Cite

Recruitment of bloom-forming cyanobacteria and its driving factors

Journal Article AFRICAN JOURNAL OF BIOTECHNOLOGY · 2008 Cite

Observation on colony formation of Microcystis aeruginosa induced by filtered lake water under laboratory conditions

Journal Article Annales de Limnologie - International Journal of Limnology · September 2005 Full text Cite

Recruitment of Total Phytoplankton, Chlorophytes and Cyanobacteria from Lake Sediments Recorded by Photosynthetic Pigments in a Large, Shallow Lake (Lake Taihu, China)

Journal Article International Review of Hydrobiology · August 2005 AbstractRecruitment of total phytoplankton, chlorophytes and cyanobacteria from lake sediments to the water column was studied using photosynthetic pigments at one site (1.5 m) in Lake Taihu, a large shallow lake in China. ... Full text Cite

Effects of acid precipitation and aluminum on carbohydrate metabolism in mycorrhizae of Pinus massioniana.

Journal Article Bulletin of environmental contamination and toxicology · March 2005 Full text Cite