Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • M.P.H., University of Florida 2012
  • Research Fellow, School Of Public Health, Harvard University 2004 - 2006
  • Clinical Fellow, Boston Children's Hospital, Harvard Medical School 2003 - 2006
  • Internship and Residency, Pediatrics, University of Vermont, College of Medicine 1998 - 2001
  • M.D., University of Vermont, College of Medicine 1998
• 

  Previous Appointments & Affiliations

  • Instructor in the Department of Pediatrics, Pediatrics, Pulmonary and Sleep Medicine, Pediatrics 2016 - 2017
• 

  Leadership & Clinical Positions at Duke

  • Director, Duke Children's Health Center Pulmonary Function Lab
    Medical Director, Safety Surveillance program, Duke Clinical Research Institute
    Associate Director, Pediatric Pulmonology Fellowship Program
• Recognition
• 

  In the News

  • NOV 26, 2018

    Duke Health News

    Weight Likely Cause for One-Fourth of Asthma Cases in Kids With Obesity

  • DEC 19, 2017

    Duke Health News

    Obesity Can Add Five Weeks of Asthma Symptoms Per Year in Preschoolers
• Research
• 

  Selected Grants

  • Lung Transplant Clinical Trial Network (LT-CTN) awarded by National Institutes of Health 2021 - 2028
  • Neonatal IL-6 awarded by Roche Diagnostics 2023 - 2028
  • Duke Program of Training in Pulmonary ReSearch to Promote, Engage and Retain Academic Researchers (PROSPER) awarded by National Institutes of Health 2022 - 2026
  • PTN 2.0 TO #TBD: SIL02 Sildenafil awarded by National Institutes of Health 2022 - 2025
  • iPRO (Inspiratory Pulmonary Rehabilitation for Children with Obesity and Asthma) awarded by American Lung Association 2022 - 2024
  • Research Training in Allergy and Clinical Immunology awarded by University of North Carolina - Chapel Hill 2000 - 2023
  • American Lung Association (ALA) Novel Digital Diary (ANDDI) Trial awarded by American Lung Association 2019 - 2023
  • American Lung Association Airways Clinical Research Centers Network awarded by American Lung Association 2016 - 2023
  • Data Coordinating and Operations Center for the ECHO IDeA States Pediatric Clinical Trials Network - VDORA 1 awarded by University of Arkansas for Medical Sciences 2020 - 2023
  • Safety of Sildenafil in Premature Infants at Risk of Bronchopulmonary Dysplasia awarded by University of North Carolina - Chapel Hill 2018 - 2023
  • Genotype-tailored treatment of symptomatic acid-reflux in children with uncontrolled asthma awarded by Thrasher Research Fund 2017 - 2022
  • Data Coordinating and Operations Center for the ECHO IDeA States Pediatric Clinical Trials Network - VDORA 1 awarded by University of Arkansas for Medical Sciences 2020 - 2022
  • Pilot: Zinc Acetate to Treat Chronic Refractory Cough (ZICO) awarded by American Lung Association 2017 - 2022
  • Targeting virally induced inflammation to prevent the development of asthma awarded by Hartwell Foundation 2018 - 2022
  • A County-level spatiotemporal multi-dimensional database to define risk modifiers of environmentally triggered severe asthma exacerbations in children awarded by National Institutes of Health 2019 - 2021
  • Vitamin D Supplementation in Children with Obesity-Related Asthma (VDORA1) awarded by University of Arkansas for Medical Sciences 2018 - 2020
  • Safety of Furosemide in Premature Infants at Risk of Bronchopulmonary Dysplasia awarded by University of North Carolina - Chapel Hill 2016 - 2020
  • A randomized, double-blind, placebo-controlled, parallel group study to evaluate the efficacy and safety of dupilumab in children 6 to <12 years of age with uncontrolled persistent asthma STUDY NUMBER: EFC14153 awarded by Sanofi US 2017 - 2019
• 

  External Relationships

  • AbbVie, Inc.
• Publications & Artistic Works
• 

  Selected Publications

  • Academic Articles

    • Josephson, Gary D., Joshua B. Bradshaw, Cheyenne Roohani, Jobayer Hossain, Steven M. Andreoli, and Jason E. Lang. “Asthma control in normal weight and overweight/obese asthmatic children following adenotonsillectomy.” Ear Nose Throat J, December 1, 2022, 1455613221101085. https://doi.org/10.1177/01455613221101085.
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    • Lang, Jason E., Chi D. Hornik, Karen Martz, Juliana Jacangelo, Ravinder Anand, Rachel Greenberg, Christoph Hornik, et al. “Safety of sildenafil in premature infants at risk of bronchopulmonary dysplasia: Rationale and methods of a phase II randomized trial.” Contemp Clin Trials Commun 30 (December 2022): 101025. https://doi.org/10.1016/j.conctc.2022.101025.
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    • James, Laura, Brian P. O’Sullivan, Mark Majure, Jason Lang, Song Ounpraseuth, Christoph Hornik, Jamie Baldner, et al. “Protocol for the Vitamin D Oral Replacement in Asthma (VDORA) study.” Contemp Clin Trials 120 (September 2022): 106861. https://doi.org/10.1016/j.cct.2022.106861.
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    • Lang, Jason E., Christoph P. Hornik, Carrie Elliott, Adam Silverstein, Chi Hornik, Amira Al-Uzri, Miroslava Bosheva, et al. “Solithromycin in Children and Adolescents With Community-acquired Bacterial Pneumonia.” Pediatr Infect Dis J 41, no. 7 (July 1, 2022): 556–62. https://doi.org/10.1097/INF.0000000000003559.
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    • Rao, Saahithi, Jillian H. Hurst, Congwen Zhao, Benjamin A. Goldstein, Laine Thomas, Jason E. Lang, and Matthew S. Kelly. “Asthma and the Risk of SARS-CoV-2 Infection Among Children and Adolescents.” Pediatrics 149, no. 6 (June 1, 2022). https://doi.org/10.1542/peds.2021-056164.
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    • Hurst, Jillian H., Congwen Zhao, Haley P. Hostetler, Mohsen Ghiasi Gorveh, Jason E. Lang, and Benjamin A. Goldstein. “Environmental and clinical data utility in pediatric asthma exacerbation risk prediction models.” Bmc Med Inform Decis Mak 22, no. 1 (April 22, 2022): 108. https://doi.org/10.1186/s12911-022-01847-0.
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    • Bamat, Nicolas A., Elizabeth J. Thompson, Rachel G. Greenberg, Scott A. Lorch, Athena F. Zuppa, Eric C. Eichenwald, Veeral N. Tolia, et al. “Association between postmenstrual age and furosemide dosing practices in very preterm infants.” J Perinatol 42, no. 4 (April 2022): 461–67. https://doi.org/10.1038/s41372-022-01320-w.
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    • Krishnan, Jerry A., Stephen C. Lazarus, Kathryn V. Blake, Christine A. Sorkness, Ronina Covar, Anne-Marie Dyer, Jason E. Lang, et al. “Biomarkers to Predict Response to Inhaled Corticosteroids and Long-Acting Muscarinic Antagonists in Adolescents and Adults with Mild Persistent Asthma.” Ann Am Thorac Soc 19, no. 3 (March 2022): 372–80. https://doi.org/10.1513/AnnalsATS.202105-613OC.
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    • Bhammar, Dharini M., Harrison N. Jones, and Jason E. Lang. “Inspiratory Muscle Rehabilitation Training in Pediatrics: What Is the Evidence?” Can Respir J 2022 (2022): 5680311. https://doi.org/10.1155/2022/5680311.
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    • Mathews, Anne M., Isaretta Riley, Robert Henderson, Janet T. Holbrook, Jason E. Lang, Anne E. Dixon, Robert A. Wise, and Loretta G. Que. “Subgroup Analysis of a Randomized Trial of the Effects of Positive Messaging on Patient-Reported Outcomes with Asthma - Effect of Obesity.” J Asthma Allergy 15 (2022): 1743–51. https://doi.org/10.2147/JAA.S336945.
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    • Ortega, Victor E., Michelle Daya, Stanley J. Szefler, Eugene R. Bleecker, Vernon M. Chinchilli, Wanda Phipatanakul, Dave Mauger, et al. “Pharmacogenetic studies of long-acting beta agonist and inhaled corticosteroid responsiveness in randomised controlled trials of individuals of African descent with asthma.” Lancet Child Adolesc Health 5, no. 12 (December 2021): 862–72. https://doi.org/10.1016/S2352-4642(21)00268-6.
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    • Hurst, Jillian H., Congwen Zhao, Nicholas S. Fitzpatrick, Benjamin A. Goldstein, and Jason E. Lang. “Reduced pediatric urgent asthma utilization and exacerbations during the COVID-19 pandemic.” Pediatr Pulmonol 56, no. 10 (October 2021): 3166–73. https://doi.org/10.1002/ppul.25578.
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    • Avery, Carolyn, Eliana M. Perrin, and Jason E. Lang. “Updates to the Pediatrics Asthma Management Guidelines.” Jama Pediatrics 175, no. 9 (September 2021): 966–67. https://doi.org/10.1001/jamapediatrics.2021.1494.
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    • Kahhan, Nicole, Md Jobayer Hossain, Jason Lang, Charles Harrison, Jose Canas, Tim Wysocki, Amanda Lochrie, and P Babu Balagopal. “Durability of Changes in Biomarkers of Cardiometabolic Disease: 1-Year Family-Based Intervention in Children with Obesity.” Metab Syndr Relat Disord 19, no. 5 (June 2021): 264–71. https://doi.org/10.1089/met.2020.0097.
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    • Clougherty, Jane E., Ellen J. Kinnee, Juan Carlos Cardet, David Mauger, Leonard Bacharier, Avraham Beigelman, Kathryn V. Blake, et al. “Geography, generalisability, and susceptibility in clinical trials.” Lancet Respir Med 9, no. 4 (April 2021): 330–32. https://doi.org/10.1016/S2213-2600(21)00046-1.
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    • Lang, J. E. “Contribution of comorbidities to obesity-related asthma in children.” Paediatr Respir Rev 37 (March 2021): 22–29. https://doi.org/10.1016/j.prrv.2020.07.006.
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    • O’Sullivan, Brian P., Laura James, Joseph M. Majure, Scott Bickel, Ly-Thao Phan, Monica Serrano Gonzalez, Heather Staples, et al. “Obesity-related asthma in children: A role for vitamin D.” Pediatr Pulmonol 56, no. 2 (February 2021): 354–61. https://doi.org/10.1002/ppul.25053.
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    • Lang, Jason E., Monica Tang, Congwen Zhao, Jillian Hurst, Angie Wu, and Benjamin A. Goldstein. “Well-Child Care Attendance and Risk of Asthma Exacerbations.” Pediatrics 146, no. 6 (December 2020). https://doi.org/10.1542/peds.2020-1023.
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    • Rastogi, Deepa, and Jason Lang. “Leptin as a Predictor of Incident Asthma in Offspring of Obese Mothers.” Ann Am Thorac Soc 17, no. 12 (December 2020): 1530–32. https://doi.org/10.1513/AnnalsATS.202008-1000ED.
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    • Tang, Monica, Benjamin A. Goldstein, Jingye He, Jillian H. Hurst, and Jason E. Lang. “Performance of a computable phenotype for pediatric asthma using the problem list.” Ann Allergy Asthma Immunol 125, no. 5 (November 2020): 611-613.e1. https://doi.org/10.1016/j.anai.2020.07.009.
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    • He, Jingyi, Mohsen Ghiasi Ghorveh, Jillian H. Hurst, Monica Tang, Brooke Alhanti, Jason E. Lang, and Benjamin A. Goldstein. “Evaluation of associations between asthma exacerbations and distance to roadways using geocoded electronic health records data.” Bmc Public Health 20, no. 1 (October 29, 2020): 1626. https://doi.org/10.1186/s12889-020-09731-0.
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    • Gibson-Young, Linda M., Karen J. Aroian, Linda S. Weglicki, Jason E. Lang, and Casey L. Norris. “Interviews with caregivers during acute asthma hospitalisations.” J Asthma 57, no. 7 (July 2020): 778–86. https://doi.org/10.1080/02770903.2019.1602875.
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    • Beechinor, Ryan J., Michael Cohen-Wolkowiez, Theresa Jasion, Christoph P. Hornik, Jason E. Lang, Robert Hernandez, and Daniel Gonzalez. “A Dried Blood Spot Analysis for Solithromycin in Adolescents, Children, and Infants: A Short Communication.” Ther Drug Monit 41, no. 6 (December 2019): 761–65. https://doi.org/10.1097/FTD.0000000000000670.
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    • Lang, Jason E., H Timothy Bunnell, John J. Lima, Md Jobayer Hossain, Tim Wysocki, Leonard Bacharier, Amanda Dempsey, Lisa Ulrich, Matthew R. Test, and Christopher B. Forrest. “Effects of age, sex, race/ethnicity, and allergy status in obesity-related pediatric asthma.” Pediatr Pulmonol 54, no. 11 (November 2019): 1684–93. https://doi.org/10.1002/ppul.24470.
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    • Wechsler, Michael E., Stanley J. Szefler, Victor E. Ortega, Jacqueline A. Pongracic, Vernon Chinchilli, John J. Lima, Jerry A. Krishnan, et al. “Step-Up Therapy in Black Children and Adults with Poorly Controlled Asthma.” N Engl J Med 381, no. 13 (September 26, 2019): 1227–39. https://doi.org/10.1056/NEJMoa1905560.
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    • Krishnan, Sankaran, Allen J. Dozor, Leonard Bacharier, Jason E. Lang, Charles G. Irvin, David Kaminsky, Harold J. Farber, et al. “Clinical characterization of children with resistant airflow obstruction, a multicenter study.” J Asthma 56, no. 6 (June 2019): 611–17. https://doi.org/10.1080/02770903.2018.1477956.
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    • Lang, Jason E., and Anusha Vadlamudi. “Informed consent - current challenges and lessons learned from the American lung association asthma/airways clinical research centers network (ALA-ACRC).” J Asthma 56, no. 6 (June 2019): 581–83. https://doi.org/10.1080/02770903.2018.1474924.
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    • Tang, Monica, Kanecia O. Zimmerman, and Jason E. Lang. “Severe childhood asthma exacerbations: Is treatment response variability in the genes?” Pediatr Pulmonol 54, no. 6 (June 2019): 680–82. https://doi.org/10.1002/ppul.24309.
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    • Lazarus, Stephen C., Jerry A. Krishnan, Tonya S. King, Jason E. Lang, Kathryn V. Blake, Ronina Covar, Njira Lugogo, et al. “Mometasone or Tiotropium in Mild Asthma with a Low Sputum Eosinophil Level.” N Engl J Med 380, no. 21 (May 23, 2019): 2009–19. https://doi.org/10.1056/NEJMoa1814917.
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    • Lang, Jason E., Edward B. Mougey, Md Jobayer Hossain, Floyd Livingston, P Babu Balagopal, Scott Langdon, and John J. Lima. “Fish Oil Supplementation in Overweight/Obese Patients with Uncontrolled Asthma. A Randomized Trial.” Ann Am Thorac Soc 16, no. 5 (May 2019): 554–62. https://doi.org/10.1513/AnnalsATS.201807-446OC.
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    • Lang, Jason E. “The impact of exercise on asthma.” Curr Opin Allergy Clin Immunol 19, no. 2 (April 2019): 118–25. https://doi.org/10.1097/ACI.0000000000000510.
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    • Fitzpatrick, Anne M., Leonard B. Bacharier, Theresa W. Guilbert, Daniel J. Jackson, Stanley J. Szefler, Avraham Beigelman, Michael D. Cabana, et al. “Phenotypes of Recurrent Wheezing in Preschool Children: Identification by Latent Class Analysis and Utility in Prediction of Future Exacerbation.” J Allergy Clin Immunol Pract 7, no. 3 (March 2019): 915-924.e7. https://doi.org/10.1016/j.jaip.2018.09.016.
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    • Tang, Monica, Kathryn V. Blake, John J. Lima, Edward B. Mougey, James Franciosi, Stephan Schmidt, Md Jobayer Hossain, Marjan Cobbaert, Bernard M. Fischer, and Jason E. Lang. “Genotype tailored treatment of mild symptomatic acid reflux in children with uncontrolled asthma (GenARA): Rationale and methods.” Contemp Clin Trials 78 (March 2019): 27–33. https://doi.org/10.1016/j.cct.2019.01.009.
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    • Sorkness, Christine A., Tonya S. King, Anne-Marie Dyer, Vernon M. Chinchilli, David T. Mauger, Jerry A. Krishnan, Kathryn Blake, et al. “Adapting clinical trial design to maintain meaningful outcomes during a multicenter asthma trial in the precision medicine era.” Contemp Clin Trials 77 (February 2019): 98–103. https://doi.org/10.1016/j.cct.2018.12.012.
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    • Lang, Jason E. “Obesity and childhood asthma.” Curr Opin Pulm Med 25, no. 1 (January 2019): 34–43. https://doi.org/10.1097/MCP.0000000000000537.
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    • Lang, Jason E., and Monica Tang. “Smoking: it's still a big problem in children with asthma.” J Pediatr (Rio J) 95, no. 5 (2019): 506–8. https://doi.org/10.1016/j.jped.2018.12.005.
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    • Lang, Jason E., H Timothy Bunnell, Md Jobayer Hossain, Tim Wysocki, John J. Lima, Terri H. Finkel, Leonard Bacharier, et al. “Being Overweight or Obese and the Development of Asthma.” Pediatrics 142, no. 6 (December 2018). https://doi.org/10.1542/peds.2018-2119.
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    • Lima, John J., Mario Castro, Tonya S. King, Jason E. Lang, Victor E. Ortega, Stephen P. Peters, Loren C. Denlinger, et al. “Association of free vitamin D3 concentrations and asthma treatment failures in the VIDA Trial.” Ann Allergy Asthma Immunol 121, no. 4 (October 2018): 444-450.e1. https://doi.org/10.1016/j.anai.2018.06.001.
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    • Morris, Claudia R., David T. Mauger, Jung H. Suh, Wanda Phipatanakul, William J. Sheehan, James N. Moy, Ian M. Paul, et al. “Glutathione and arginine levels: Predictors for acetaminophen-associated asthma exacerbation?” J Allergy Clin Immunol 142, no. 1 (July 2018): 308-311.e9. https://doi.org/10.1016/j.jaci.2018.01.045.
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    • Kanagalingam, S., S. S. Shehab, D. A. Kaminsky, R. A. Wise, J. E. Lang, and A. E. Dixon. “Effect of obesity on sinonasal disease in asthma.” J Asthma 55, no. 5 (May 2018): 525–31. https://doi.org/10.1080/02770903.2017.1341522.
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    • Ahmadizar, F., S. J. H. Vijverberg, H. G. M. Arets, A. de Boer, J. E. Lang, J. Garssen, A. Kraneveld, and A. H. Maitland-van der Zee. “Early-life antibiotic exposure increases the risk of developing allergic symptoms later in life: A meta-analysis.” Allergy 73, no. 5 (May 2018): 971–86. https://doi.org/10.1111/all.13332.
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    • Sobieraj, Diana M., Erin R. Weeda, Elaine Nguyen, Craig I. Coleman, C Michael White, Stephen C. Lazarus, Kathryn V. Blake, Jason E. Lang, and William L. Baker. “Association of Inhaled Corticosteroids and Long-Acting β-Agonists as Controller and Quick Relief Therapy With Exacerbations and Symptom Control in Persistent Asthma: A Systematic Review and Meta-analysis.” Jama 319, no. 14 (April 10, 2018): 1485–96. https://doi.org/10.1001/jama.2018.2769.
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    • Sobieraj, Diana M., William L. Baker, Elaine Nguyen, Erin R. Weeda, Craig I. Coleman, C Michael White, Stephen C. Lazarus, Kathryn V. Blake, and Jason E. Lang. “Association of Inhaled Corticosteroids and Long-Acting Muscarinic Antagonists With Asthma Control in Patients With Uncontrolled, Persistent Asthma: A Systematic Review and Meta-analysis.” Jama 319, no. 14 (April 10, 2018): 1473–84. https://doi.org/10.1001/jama.2018.2757.
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    • Lang, Jason E., Anne M. Fitzpatrick, David T. Mauger, Theresa W. Guilbert, Daniel J. Jackson, Robert F. Lemanske, Fernando D. Martinez, et al. “Overweight/obesity status in preschool children associates with worse asthma but robust improvement on inhaled corticosteroids.” J Allergy Clin Immunol 141, no. 4 (April 2018): 1459-1467.e2. https://doi.org/10.1016/j.jaci.2017.09.043.
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    • Jackson, Daniel J., Leonard B. Bacharier, David T. Mauger, Susan Boehmer, Avraham Beigelman, James F. Chmiel, Anne M. Fitzpatrick, et al. “Quintupling Inhaled Glucocorticoids to Prevent Childhood Asthma Exacerbations.” N Engl J Med 378, no. 10 (March 8, 2018): 891–901. https://doi.org/10.1056/NEJMoa1710988.
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    • Jónsdóttir, Urður, and Jason E. Lang. “How does autism spectrum disorder affect the risk and severity of childhood asthma?” Ann Allergy Asthma Immunol 118, no. 5 (May 2017): 570–76. https://doi.org/10.1016/j.anai.2017.02.020.
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    • Ali-Dinar, Tarig, and Jason E. Lang. “Is impaired glucose metabolism the missing piece in the obesity-asthma puzzle?” Pediatr Pulmonol 52, no. 2 (February 2017): 147–50. https://doi.org/10.1002/ppul.23625.
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    • Fitzpatrick, Anne M., Daniel J. Jackson, David T. Mauger, Susan J. Boehmer, Wanda Phipatanakul, William J. Sheehan, James N. Moy, et al. “Individualized therapy for persistent asthma in young children.” J Allergy Clin Immunol 138, no. 6 (December 2016): 1608-1618.e12. https://doi.org/10.1016/j.jaci.2016.09.028.
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    • Ahmadizar, Fariba, Susanne J. H. Vijverberg, Hubertus G. M. Arets, Anthonius de Boer, Jason E. Lang, Meyer Kattan, Colin N. A. Palmer, Somnath Mukhopadhyay, Steve Turner, and Anke H. Maitland-van der Zee. “Childhood obesity in relation to poor asthma control and exacerbation: a meta-analysis.” Eur Respir J 48, no. 4 (October 2016): 1063–73. https://doi.org/10.1183/13993003.00766-2016.
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    • Sheehan, William J., David T. Mauger, Ian M. Paul, James N. Moy, Susan J. Boehmer, Stanley J. Szefler, Anne M. Fitzpatrick, et al. “Acetaminophen versus Ibuprofen in Young Children with Mild Persistent Asthma.” N Engl J Med 375, no. 7 (August 18, 2016): 619–30. https://doi.org/10.1056/NEJMoa1515990.
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    • Lang, Jason E., Jobayer Hossain, Janet T. Holbrook, W Gerald Teague, Benjamin D. Gold, Robert A. Wise, and John J. Lima. “Gastro-oesophageal reflux and worse asthma control in obese children: a case of symptom misattribution?” Thorax 71, no. 3 (March 2016): 238–46. https://doi.org/10.1136/thoraxjnl-2015-207662.
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    • Lang, Jason E. “Stress, ADCYAP1R1, and Childhood Asthma. No Sigh of Relief.” Am J Respir Crit Care Med 192, no. 1 (July 1, 2015): 3–5. https://doi.org/10.1164/rccm.201505-0890ED.
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    • Lang, Jason E., Janet T. Holbrook, John J. Lima, and John J. American Lung Association-Asthma Clinical Research Centers. “Reply: worsening asthma control in children taking lansoprazole: possible mechanisms.” Ann Am Thorac Soc 12, no. 7 (July 2015): 1110–11. https://doi.org/10.1513/AnnalsATS.201505-298LE.
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    • Lang, Jason E., Janet T. Holbrook, Edward B. Mougey, Christine Y. Wei, Robert A. Wise, W Gerald Teague, John J. Lima, and John J. American Lung Association-Airways Clinical Research Centers. “Lansoprazole Is Associated with Worsening Asthma Control in Children with the CYP2C19 Poor Metabolizer Phenotype.” Ann Am Thorac Soc 12, no. 6 (June 2015): 878–85. https://doi.org/10.1513/AnnalsATS.201408-391OC.
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    • Smith, Lewis J., Ravi Kalhan, Robert A. Wise, Elizabeth A. Sugar, John J. Lima, Charles G. Irvin, Allen J. Dozor, Janet T. Holbrook, and Janet T. American Lung Association Asthma Clinical Research Centers. “Effect of a soy isoflavone supplement on lung function and clinical outcomes in patients with poorly controlled asthma: a randomized clinical trial.” Jama 313, no. 20 (May 26, 2015): 2033–43. https://doi.org/10.1001/jama.2015.5024.
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    • Lang, Jason E., Md Jobayer Hossain, and John J. Lima. “Overweight children report qualitatively distinct asthma symptoms: analysis of validated symptom measures.” J Allergy Clin Immunol 135, no. 4 (April 2015): 886-893.e3. https://doi.org/10.1016/j.jaci.2014.08.029.
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    • Hossain, Md Jobayer, Li Xie, Jason E. Lang, Timothy T. Wysocki, Thomas H. Shaffer, and H Timothy Bunnell. “Piecewise Mixed Effects Model to Compare the Weight-gain Patter ns Before and After Diagnosis of Asthma in Children Younger than 5 Years.” J Biom Biostat 6, no. 4 (January 2015): 248. https://doi.org/10.4172/2155-6180.1000248.
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    • Lang, Jason E. “Behavioral weight loss intervention in obese individuals with asthma. A lot goes a long way.” Ann Am Thorac Soc 12, no. 1 (January 2015): 105–6. https://doi.org/10.1513/AnnalsATS.201411-544ED.
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    • Kapadia, S. G., C. Wei, S. J. Bartlett, J. Lang, R. A. Wise, A. E. Dixon, and A. E. American Lung Association Asthma Clinical Research Centers. “Obesity and symptoms of depression contribute independently to the poor asthma control of obesity.” Respir Med 108, no. 8 (August 2014): 1100–1107. https://doi.org/10.1016/j.rmed.2014.05.012.
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    • Lang, Jason E. “Obesity and asthma in children: current and future therapeutic options.” Paediatr Drugs 16, no. 3 (June 2014): 179–88. https://doi.org/10.1007/s40272-014-0069-1.
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    • Lang, Jason E. “Exercise, obesity, and asthma in children and adolescents.” J Pediatr (Rio J) 90, no. 3 (2014): 215–17. https://doi.org/10.1016/j.jped.2014.01.002.
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    • Lang, Jason E., Janet T. Holbrook, Robert A. Wise, Anne E. Dixon, W Gerald Teague, Christine Y. Wei, Charles G. Irvin, David Shade, John J. Lima, and John J. American Lung Association-Asthma Clinical Research Centers. “Obesity in children with poorly controlled asthma: Sex differences.” Pediatr Pulmonol 48, no. 9 (September 2013): 847–56. https://doi.org/10.1002/ppul.22707.
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    • Lima, John J., Jason E. Lang, Edward B. Mougey, Kathryn B. Blake, Yan Gong, Janet T. Holbrook, Robert A. Wise, and W. G. Teague. “Association of CYP2C19 polymorphisms and lansoprazole-associated respiratory adverse effects in children.” J Pediatr 163, no. 3 (September 2013): 686–91. https://doi.org/10.1016/j.jpeds.2013.03.017.
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    • Lang, Jason E., and Kathryn V. Blake. “Role of biomarkers in understanding and treating children with asthma: towards personalized care.” Pharmgenomics Pers Med 6 (August 21, 2013): 73–84. https://doi.org/10.2147/PGPM.S30626.
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    • Mougey, E., J. E. Lang, H. Allayee, W. G. Teague, A. J. Dozor, R. A. Wise, and J. J. Lima. “ALOX5 polymorphism associates with increased leukotriene production and reduced lung function and asthma control in children with poorly controlled asthma.” Clin Exp Allergy 43, no. 5 (May 2013): 512–20. https://doi.org/10.1111/cea.12076.
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    • Lang, Jason E., Allen J. Dozor, Janet T. Holbrook, Edward Mougey, Sankaran Krishnan, Shawn Sweeten, Robert A. Wise, et al. “Biologic mechanisms of environmental tobacco smoke in children with poorly controlled asthma: results from a multicenter clinical trial.” J Allergy Clin Immunol Pract 1, no. 2 (March 2013): 172–80. https://doi.org/10.1016/j.jaip.2012.11.006.
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    • Lang, Jason E., Edward B. Mougey, Hooman Allayee, Kathryn V. Blake, Richard Lockey, Yan Gong, Jobayer Hossain, Kelleigh Killen, John J. Lima, and John J. Nemours Network for Asthma Research. “Nutrigenetic response to omega-3 fatty acids in obese asthmatics (NOOA): rationale and methods.” Contemp Clin Trials 34, no. 2 (March 2013): 326–35. https://doi.org/10.1016/j.cct.2012.12.009.
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    • Lang, Jason E., Jobayer Hossain, Kathryn Blake, Arnel Mercado, and John J. Lima. “Sickle-Cell Trait and Atopic and Inflammatory Disease in Children.” Pediatr Allergy Immunol Pulmonol 26, no. 1 (March 2013): 11–17. https://doi.org/10.1089/ped.2012.0205.
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    • Lochrie, A. S., T. Wysocki, J. Hossain, A. Milkes, H. Antal, L. Buckloh, J. A. Canas, E. Bobo, and J. Lang. “The effects of a family-based intervention (FBI) for overweight/obese children on health and psychological functioning.” Clinical Practice in Pediatric Psychology 1, no. 2 (January 1, 2013): 159–70. https://doi.org/10.1037/cpp0000020.
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    • McDonough, Caitrin W., Nancy K. Gillis, Abdullah Alsultan, Shin-Wen Chang, Marina Kawaguchi-Suzuki, Jason E. Lang, Mohamed Hossam A. Shahin, et al. “Atenolol induced HDL-C change in the pharmacogenomic evaluation of antihypertensive responses (PEAR) study.” Plos One 8, no. 10 (2013): e76984. https://doi.org/10.1371/journal.pone.0076984.
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    • Lang, Jason E. “Obesity, Nutrition, and Asthma in Children.” Pediatr Allergy Immunol Pulmonol 25, no. 2 (June 2012): 64–75. https://doi.org/10.1089/ped.2011.0137.
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    • Lang, Jason E., Jobayer Hossain, Kareema Smith, and John J. Lima. “Asthma severity, exacerbation risk, and controller treatment burden in underweight and obese children.” J Asthma 49, no. 5 (June 2012): 456–63. https://doi.org/10.3109/02770903.2012.677895.
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    • Lang, Jason E., Jobayer Hossain, Anne E. Dixon, David Shade, Robert A. Wise, Stephen P. Peters, John J. Lima, and John J. American Lung Association-Asthma Clinical Research Centers. “Does age impact the obese asthma phenotype? Longitudinal asthma control, airway function, and airflow perception among mild persistent asthmatics.” Chest 140, no. 6 (December 2011): 1524–33. https://doi.org/10.1378/chest.11-0675.
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    • Dixon, Anne E., Emmanuelle M. Clerisme-Beaty, Elizabeth A. Sugar, Rubin I. Cohen, Jason E. Lang, Ellen D. Brown, Joel E. Richter, Charles G. Irvin, and John G. Mastronarde. “Effects of obstructive sleep apnea and gastroesophageal reflux disease on asthma control in obesity.” J Asthma 48, no. 7 (September 2011): 707–13. https://doi.org/10.3109/02770903.2011.601778.
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    • Mougey, E. B., J. E. Lang, X. Wen, and J. J. Lima. “Effect of citrus juice and SLCO2B1 genotype on the pharmacokinetics of montelukast.” J Clin Pharmacol 51, no. 5 (May 2011): 751–60. https://doi.org/10.1177/0091270010374472.
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    • Shore, Stephanie A., Jason E. Lang, David I. Kasahara, Frank L. Lu, Norah G. Verbout, Huiqing Si, Erin S. Williams, Raya D. Terry, Anna Lee, and Richard A. Johnston. “Pulmonary responses to subacute ozone exposure in obese vs. lean mice.” J Appl Physiol (1985) 107, no. 5 (November 2009): 1445–52. https://doi.org/10.1152/japplphysiol.00456.2009.
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    • American Lung Association Asthma Clinical Research Centers, Robert A., John G. Mastronarde, Nicholas R. Anthonisen, Mario Castro, Janet T. Holbrook, Frank T. Leone, W Gerald Teague, and Robert A. Wise. “Efficacy of esomeprazole for treatment of poorly controlled asthma.” N Engl J Med 360, no. 15 (April 9, 2009): 1487–99. https://doi.org/10.1056/NEJMoa0806290.
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    • Lang, Jason E., Hua Feng, and John J. Lima. “Body mass index-percentile and diagnostic accuracy of childhood asthma.” J Asthma 46, no. 3 (April 2009): 291–99. https://doi.org/10.1080/02770900802712963.
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    • Lang, Jason E., Erin S. Williams, Joseph P. Mizgerd, and Stephanie A. Shore. “Effect of obesity on pulmonary inflammation induced by acute ozone exposure: role of interleukin-6.” Am J Physiol Lung Cell Mol Physiol 294, no. 5 (May 2008): L1013–20. https://doi.org/10.1152/ajplung.00122.2007.
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    • Lang, J. E., and A. A. Colin. “Chest pain in children.” Current Pediatric Reviews 2, no. 3 (August 1, 2006): 245–58. https://doi.org/10.2174/157339606778019710.
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    • Potter, A., J. Corwin, J. Lang, M. Piasecki, R. Lenox, and P. A. Newhouse. “Acute effects of the selective cholinergic channel activator (nicotinic agonist) ABT-418 in Alzheimer's disease.” Psychopharmacology (Berl) 142, no. 4 (March 1999): 334–42. https://doi.org/10.1007/s002130050897.
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  • Book Sections

    • Lang, J. E., R. H. Cleveland, K. Palm, N. Mardis, E. Y. Lee, and U. Khatwa. “Congenital and miscellaneous abnormalities.” In Imaging in Pediatric Pulmonology, 9781441958723:39–56, 2013. https://doi.org/10.1007/978-1-4419-5872-3_5.
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    • Rosen, D., J. E. Lang, and A. A. Colin. “Clinical algorithms.” In Imaging in Pediatric Pulmonology, 9781441958723:1–14, 2012. https://doi.org/10.1007/978-1-4419-5872-3_1.
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  • Journal Issues

    • Tang, Monica, Robert J. Henderson, Janet T. Holbrook, Loretta G. Que, Anne M. Mathews, Robert A. Wise, Anne E. Dixon, et al. “Does Obesity Increase Respiratory Tract Infections in Patients with Asthma?” J Allergy Clin Immunol Pract, March 2019. https://doi.org/10.1016/j.jaip.2018.09.033.
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  • Conference Papers

    • Tang, Monica, Anusha Vadlamudi, Matthew McCulloch, Nicole Koutlas, Olga Hardin, Benjamin Goldstein, Jillian Hurst, and Jason Lang. “Performance of an electronic health record definition for pediatric asthma.” In Journal of Allergy and Clinical Immunology, 145:AB213–AB213. MOSBY-ELSEVIER, 2020.
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    • Covar, R., T. King, J. A. Krishnan, C. A. Sorkness, K. Blake, S. E. Wenzel, N. Lugogo, et al. “T2 Inflammatory Biomarkers in Mild Persistent Asthma.” In American Journal of Respiratory and Critical Care Medicine, Vol. 201, 2020.
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    • Tang, Monica, Robert J. Henderson, Janet T. Holbrook, and Jason E. Lang. “The effect of gastroesophageal reflux and proton pump inhibitors on respiratory tract infections in patients with asthma.” In Journal of Allergy and Clinical Immunology, 143:AB8–AB8. MOSBY-ELSEVIER, 2019.
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    • Lang, J., E. McGuire, R. Henderson, and J. T. Holbrook. “The Opening Index to Measure Airway Closure in Children and Adults with Asthma.” In American Journal of Respiratory and Critical Care Medicine, Vol. 199. AMER THORACIC SOC, 2019.
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    • Lang, J., E. B. Mougey, M. Hossain, and J. J. Lima. “Omega-3 Fatty Acid Supplementation in Obese Adolescents and Young Adults with Poor Asthma Control.” In American Journal of Respiratory and Critical Care Medicine, Vol. 197. AMER THORACIC SOC, 2018.
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    • Lang, J., M. Hossain, T. Wysocki, and T. Bunnell. “Effect of Obesity on Incident Childhood Asthma: Results from the National PEDSnet Clinical Data Research Network.” In American Journal of Respiratory and Critical Care Medicine, Vol. 197. AMER THORACIC SOC, 2018.
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    • Tang, M., R. J. Henderson, J. T. Holbrook, and J. Lang. “Does Obesity Increase Respiratory Tract Infections (RTI) and Respiratory Sequelae in Patients with Asthma.” In American Journal of Respiratory and Critical Care Medicine, Vol. 197. AMER THORACIC SOC, 2018.
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    • Lang, J. E., E. Mougey, and J. J. Lima. “Candidate Gene Association Study Of Obese Asthma: Vdr Gene Variant Associates With Both Obesity And Early Onset Asthma.” In American Journal of Respiratory and Critical Care Medicine, Vol. 195. AMER THORACIC SOC, 2017.
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    • Ahmadizar, Fariba, Susanne Vijverberg, Hubertus Arets, Anthonius de Boer, Jason Lang, Meyer Kattan, Colin Palmer, Somnath Mukhopadhyay, Steve Turner, and Anke Hilse Maitland-Van der Zee. “Childhood obesity in relation to poor asthma control and exacerbations.” In 7.2 Paediatric Asthma and Allergy. European Respiratory Society, 2016. https://doi.org/10.1183/13993003.congress-2016.pa318.
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    • Ahmadizar, Fariba, Susanne Vijverberg, Hubertus Arets, Anthonius De Boer, Jason Lang, Meyer Kattan, Colin Palmer, Somnath Mukhopadhyay, Steve Turner, and Anke-Hilse Maitland Van der Zee. “Childhood Obesity in Relation to Poor Asthma Control and Exacerbations.” In Pharmacoepidemiology and Drug Safety, 25:179–80. WILEY-BLACKWELL, 2016.
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    • Blake, K., J. Klawitter, E. B. Mougey, J. E. Lang, C. Gauger, M. Bansal, R. Miller, R. Nagasubramanian, U. Christians, and J. Lima. “Metabolomics Characterizes Asthma In Children With Sickle Cell Disease.” In American Journal of Respiratory and Critical Care Medicine, Vol. 191. AMER THORACIC SOC, 2015.
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    • Lang, J. E., A. Chidekel, T. Phan, S. Hill, K. Reichard, and G. A. Datto. “Surgical Weight Loss And Exercise-Related Bronchial Reactivity In Adolescents With Severe Obesity With And Without Asthma.” In American Journal of Respiratory and Critical Care Medicine, Vol. 191. AMER THORACIC SOC, 2015.
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    • Dixon, A. E., S. G. Kapadia, C. Wei, S. Bartlett, J. E. Lang, and R. A. Wise. “Symptoms Of Depression And High BMI Contribute Independently To Poor Asthma Control In Obesity.” In American Journal of Respiratory and Critical Care Medicine, Vol. 189. AMER THORACIC SOC, 2014.
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    • Lang, J. E., K. V. Blake, E. Mougey, T. Wysocki, R. A. Wise, J. Holbrook, and J. J. Lima. “A Decade Of Experience With Genetic Material And Testing In American Lung Association Asthma Clinical Research Trials.” In American Journal of Respiratory and Critical Care Medicine, Vol. 189. AMER THORACIC SOC, 2014.
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  • Preprints

    • Rao, Saahithi, Jillian H. Hurst, Congwen Zhao, Benjamin A. Goldstein, Laine Thomas, Jason E. Lang, and Matthew S. Kelly. “Asthma and the Risk of SARS-CoV-2 Infection Among Children and Adolescents.” Cold Spring Harbor Laboratory, July 22, 2021. https://doi.org/10.1101/2021.07.20.21260871.
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