Scholars@Duke
Jessica Cannavino

Selected Publications

Mesenchymal stromal cells as conductors of adipose tissue remodeling.

Journal Article Genes Dev · September 1, 2023 Adipose tissue exhibits a remarkable capacity to expand, contract, and remodel in response to changes in physiological and environmental conditions. Here, we describe recent advances in our understanding of how functionally distinct tissue-resident mesench ... Full text Link to item Cite

Regulation of cold-induced thermogenesis by the RNA binding protein FAM195A.

Journal Article Proc Natl Acad Sci U S A · June 8, 2021 Homeothermic vertebrates produce heat in cold environments through thermogenesis, in which brown adipose tissue (BAT) increases mitochondrial oxidation along with uncoupling of the electron transport chain and activation of uncoupling protein 1 (UCP1). Alt ... Full text Link to item Cite

A defect in myoblast fusion underlies Carey-Fineman-Ziter syndrome.

Journal Article Nat Commun · July 6, 2017 Multinucleate cellular syncytial formation is a hallmark of skeletal muscle differentiation. Myomaker, encoded by Mymk (Tmem8c), is a well-conserved plasma membrane protein required for myoblast fusion to form multinucleated myotubes in mouse, chick, and z ... Full text Link to item Cite

Control of muscle formation by the fusogenic micropeptide myomixer.

Journal Article Science · April 21, 2017 Skeletal muscle formation occurs through fusion of myoblasts to form multinucleated myofibers. From a genome-wide clustered regularly interspaced short palindromic repeats (CRISPR) loss-of-function screen for genes required for myoblast fusion and myogenes ... Full text Link to item Cite

Severe muscle wasting and denervation in mice lacking the RNA-binding protein ZFP106.

Journal Article Proc Natl Acad Sci U S A · August 2, 2016 Innervation of skeletal muscle by motor neurons occurs through the neuromuscular junction, a cholinergic synapse essential for normal muscle growth and function. Defects in nerve-muscle signaling cause a variety of neuromuscular disorders with features of ... Full text Link to item Cite

Human skeletal muscle fibre contractile properties and proteomic profile: adaptations to 3 weeks of unilateral lower limb suspension and active recovery.

Journal Article J Physiol · December 15, 2015 KEY POINTS: It is generally assumed that muscle fibres go through atrophy following disuse with a loss of specific force and an increase in unloaded shortening velocity. However, the underlying mechanisms remain to be clarified. Most studies have focused o ... Full text Link to item Cite

The role of alterations in mitochondrial dynamics and PGC-1α over-expression in fast muscle atrophy following hindlimb unloading.

Journal Article J Physiol · April 15, 2015 KEY POINTS: Skeletal muscle atrophy occurs as a result of disuse. Although several studies have established that a decrease in protein synthesis and increase in protein degradation lead to muscle atrophy, little is known about the triggers underlying such ... Full text Link to item Cite

PGC1-α over-expression prevents metabolic alterations and soleus muscle atrophy in hindlimb unloaded mice.

Journal Article J Physiol · October 15, 2014 Prolonged skeletal muscle inactivity causes muscle fibre atrophy. Redox imbalance has been considered one of the major triggers of skeletal muscle disuse atrophy, but whether redox imbalance is actually the major cause or simply a consequence of muscle dis ... Full text Link to item Cite

The time course of the adaptations of human muscle proteome to bed rest and the underlying mechanisms

Journal Article Journal of Physiology · October 1, 2012 In order to get a comprehensive picture of the complex adaptations of human skeletal muscle to disuse and further the understanding of the underlying mechanisms, we participated in two bed rest campaigns, one lasting 35 days and one 24 days. In the first b ... Full text Cite