Journal ArticleCirculation. Genomic and precision medicine · June 2024
Wearable devices are increasingly used by a growing portion of the population to track health and illnesses. The data emerging from these devices can potentially transform health care. This requires an interoperability framework that enables the deployment ...
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Journal ArticleJ Card Fail · April 4, 2024
BACKGROUND: Data collected via wearables may complement in-clinic assessments to monitor subclinical heart failure (HF). OBJECTIVES: Evaluate the association of sensor-based digital walking measures with HF stage and characterize their correlation with in- ...
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Journal ArticleLancet Digit Health · April 2024
Respiratory diseases are a leading cause of morbidity and mortality globally. However, existing systems of care, built around scheduled appointments, are not well designed to support the needs of people with chronic and acute respiratory conditions that ca ...
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Journal ArticleNPJ Digit Med · March 16, 2024
Daily routines, including in-person school and extracurricular activities, are important for maintaining healthy physical activity and sleep habits in children. The COVID-19 pandemic significantly disrupted daily routines as in-person school and activities ...
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Journal ArticleNPJ digital medicine · February 2024
Smart portable devices- smartphones and smartwatches- are rapidly being adopted by the general population, which has brought forward an opportunity to use the large volumes of physiological, behavioral, and activity data continuously being collected by the ...
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Journal ArticlePacific Symposium on Biocomputing. Pacific Symposium on Biocomputing · January 2024
Data from digital health technologies (DHT), including wearable sensors like Apple Watch, Whoop, Oura Ring, and Fitbit, are increasingly being used in biomedical research. Research and development of DHT-related devices, platforms, and applications is happ ...
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Journal ArticleCell Genomics · November 8, 2023
Pioneering advances in genome engineering, and specifically in genome writing, have revolutionized the field of synthetic biology, propelling us toward the creation of synthetic genomes. The Sc2.0 project aims to build the first fully synthetic eukaryotic ...
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Journal ArticleJ Public Health Manag Pract · November 2023
OBJECTIVE: Scalable strategies to reduce the time burden and increase contact tracing efficiency are crucial during early waves and peaks of infectious transmission. DESIGN: We enrolled a cohort of SARS-CoV-2-positive seed cases into a peer recruitment stu ...
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Journal ArticlePhysiological measurement · November 2023
Photoplethysmography is a key sensing technology which is used in wearable devices such as smartwatches and fitness trackers. Currently, photoplethysmography sensors are used to monitor physiological parameters including heart rate and heart rhythm, and to ...
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Journal ArticlePLOS digital health · July 2023
Blood oxygen saturation (SpO2) is an important measurement for monitoring patients with acute and chronic conditions that are associated with low blood oxygen levels. While smartwatches may provide a new method for continuous and unobtrusive SpO2 monitorin ...
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Journal ArticleJ Am Heart Assoc · May 2, 2023
Recent advances in wearable technology through convenient and cuffless systems will enable continuous, noninvasive monitoring of blood pressure (BP), heart rate, and heart rhythm on both longitudinal 24-hour measurement scales and high-frequency beat-to-be ...
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Journal ArticleJMIR formative research · May 2023
BackgroundEffective monitoring of dietary habits is critical for promoting healthy lifestyles and preventing or delaying the onset and progression of diet-related diseases, such as type 2 diabetes. Recent advances in speech recognition technologie ...
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Journal ArticleThe Lancet. Digital health · April 2023
Wearable devices have made it easier to generate and share data collected on individuals. This systematic review seeks to investigate whether deidentifying data from wearable devices is sufficient to protect the privacy of individuals in datasets. We searc ...
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Journal ArticleJournal of medical Internet research · April 2023
BackgroundDigital sensing solutions represent a convenient, objective, relatively inexpensive method that could be leveraged for assessing symptoms of various health conditions. Recent progress in the capabilities of digital sensing products has t ...
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Journal ArticleCirculation research · March 2023
Wearable devices, such as smartwatches and activity trackers, are commonly used by patients in their everyday lives to manage their health and well-being. These devices collect and analyze long-term continuous data on measures of behavioral or physiologic ...
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Journal ArticleJMIR biomedical engineering · March 2023
BackgroundMeasuring the amount of physical activity and its patterns using wearable sensor technology in real-world settings can provide critical insights into health status.ObjectiveThis study's aim was to develop and evaluate the analyt ...
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Journal ArticleCirculation. Genomic and precision medicine · June 2024
Wearable devices are increasingly used by a growing portion of the population to track health and illnesses. The data emerging from these devices can potentially transform health care. This requires an interoperability framework that enables the deployment ...
Full textCite
Journal ArticleJ Card Fail · April 4, 2024
BACKGROUND: Data collected via wearables may complement in-clinic assessments to monitor subclinical heart failure (HF). OBJECTIVES: Evaluate the association of sensor-based digital walking measures with HF stage and characterize their correlation with in- ...
Full textLink to itemCite
Journal ArticleLancet Digit Health · April 2024
Respiratory diseases are a leading cause of morbidity and mortality globally. However, existing systems of care, built around scheduled appointments, are not well designed to support the needs of people with chronic and acute respiratory conditions that ca ...
Full textLink to itemCite
Journal ArticleNPJ Digit Med · March 16, 2024
Daily routines, including in-person school and extracurricular activities, are important for maintaining healthy physical activity and sleep habits in children. The COVID-19 pandemic significantly disrupted daily routines as in-person school and activities ...
Full textLink to itemCite
Journal ArticleNPJ digital medicine · February 2024
Smart portable devices- smartphones and smartwatches- are rapidly being adopted by the general population, which has brought forward an opportunity to use the large volumes of physiological, behavioral, and activity data continuously being collected by the ...
Full textCite
Journal ArticlePacific Symposium on Biocomputing. Pacific Symposium on Biocomputing · January 2024
Data from digital health technologies (DHT), including wearable sensors like Apple Watch, Whoop, Oura Ring, and Fitbit, are increasingly being used in biomedical research. Research and development of DHT-related devices, platforms, and applications is happ ...
Cite
Journal ArticleCell Genomics · November 8, 2023
Pioneering advances in genome engineering, and specifically in genome writing, have revolutionized the field of synthetic biology, propelling us toward the creation of synthetic genomes. The Sc2.0 project aims to build the first fully synthetic eukaryotic ...
Full textCite
Journal ArticleJ Public Health Manag Pract · November 2023
OBJECTIVE: Scalable strategies to reduce the time burden and increase contact tracing efficiency are crucial during early waves and peaks of infectious transmission. DESIGN: We enrolled a cohort of SARS-CoV-2-positive seed cases into a peer recruitment stu ...
Full textLink to itemCite
Journal ArticlePhysiological measurement · November 2023
Photoplethysmography is a key sensing technology which is used in wearable devices such as smartwatches and fitness trackers. Currently, photoplethysmography sensors are used to monitor physiological parameters including heart rate and heart rhythm, and to ...
Full textCite
Journal ArticlePLOS digital health · July 2023
Blood oxygen saturation (SpO2) is an important measurement for monitoring patients with acute and chronic conditions that are associated with low blood oxygen levels. While smartwatches may provide a new method for continuous and unobtrusive SpO2 monitorin ...
Full textCite
Journal ArticleJ Am Heart Assoc · May 2, 2023
Recent advances in wearable technology through convenient and cuffless systems will enable continuous, noninvasive monitoring of blood pressure (BP), heart rate, and heart rhythm on both longitudinal 24-hour measurement scales and high-frequency beat-to-be ...
Full textLink to itemCite
Journal ArticleJMIR formative research · May 2023
BackgroundEffective monitoring of dietary habits is critical for promoting healthy lifestyles and preventing or delaying the onset and progression of diet-related diseases, such as type 2 diabetes. Recent advances in speech recognition technologie ...
Full textCite
Journal ArticleThe Lancet. Digital health · April 2023
Wearable devices have made it easier to generate and share data collected on individuals. This systematic review seeks to investigate whether deidentifying data from wearable devices is sufficient to protect the privacy of individuals in datasets. We searc ...
Full textCite
Journal ArticleJournal of medical Internet research · April 2023
BackgroundDigital sensing solutions represent a convenient, objective, relatively inexpensive method that could be leveraged for assessing symptoms of various health conditions. Recent progress in the capabilities of digital sensing products has t ...
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Journal ArticleCirculation research · March 2023
Wearable devices, such as smartwatches and activity trackers, are commonly used by patients in their everyday lives to manage their health and well-being. These devices collect and analyze long-term continuous data on measures of behavioral or physiologic ...
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Journal ArticleJMIR biomedical engineering · March 2023
BackgroundMeasuring the amount of physical activity and its patterns using wearable sensor technology in real-world settings can provide critical insights into health status.ObjectiveThis study's aim was to develop and evaluate the analyt ...
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ConferencePacific Symposium on Biocomputing. Pacific Symposium on Biocomputing · January 2023
Data from digital health technologies (DHT), including wearable sensors like Apple Watch, Whoop, Oura Ring, and Fitbit, are increasingly being used in biomedical research. Research and development of DHT-related devices, platforms, and applications is happ ...
Cite
ConferenceProceedings - 2023 IEEE Conference on Virtual Reality and 3D User Interfaces Abstracts and Workshops, VRW 2023 · January 1, 2023
Dialectical behavior therapy (DBT) is an evidence-based psychotherapy that helps patients learn skills to regulate emotions as a central strategy to improve life functioning. However, DBT skills require a long-term and consistent commitment, typically to g ...
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Journal ArticleSleep Adv · 2023
STUDY OBJECTIVE: Shiftwork increases risk for numerous chronic diseases, which is hypothesized to be linked to disruption of circadian timing of lifestyle behaviors. However, empirical data on timing of lifestyle behaviors in real-world shift workers are l ...
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ConferenceComputing in Cardiology · January 1, 2023
Cardiac arrest leads to complex neurological outcomes, demanding accurate predictions to guide post-arrest care. Using the International Cardiac Arrest Research Consortium (I-CARE) dataset, we developed models to discern between 'good' and 'poor' neurologi ...
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Journal ArticleCell reports. Medicine · December 2022
Advancements in AI enable personalizing healthcare, for example by investigating disease origins at the genetic or molecular level, understanding intraindividual drug effects, and fusing multi-modal personal physiological, behavioral, laboratory, and clini ...
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Journal ArticleSensors (Basel, Switzerland) · October 2022
Background: Digital clinical measures collected via various digital sensing technologies such as smartphones, smartwatches, wearables, and ingestible and implantable sensors are increasingly used by individuals and clinicians to capture the health o ...
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Journal ArticleNPJ Digit Med · September 1, 2022
Mass surveillance testing can help control outbreaks of infectious diseases such as COVID-19. However, diagnostic test shortages are prevalent globally and continue to occur in the US with the onset of new COVID-19 variants and emerging diseases like monke ...
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ConferenceDigiBiom 2022 - Proceedings of the 2022 Emerging Devices for Digital Biomarkers · July 1, 2022
Meditation, a mental and physical exercise which helps to focus attention and reduce stress has gained more popularity in recent years. However, meditation requires a concerted effort and regular practice. To explore the feasibility of using Augmented Real ...
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Journal ArticleJ Biol Rhythms · June 2022
Circadian misalignment, as occurs in shiftwork, is associated with numerous negative health outcomes. Here, we sought to improve data labeling accuracy from wearable technology using a novel data pre-processing algorithm in 27 police trainees during shiftw ...
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Book · June 2022
Mounting clinical evidence suggests that viral infections can lead to detectable changes in an individual's normal physiologic and behavioral metrics, including heart and respiration rates, heart rate variability, temperature, activity, and sleep prior to ...
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Journal ArticleJMIR Mhealth Uhealth · April 8, 2022
Digital health technologies, such as smartphones and wearable devices, promise to revolutionize disease prevention, detection, and treatment. Recently, there has been a surge of digital health studies where data are collected through a bring-your-own-devic ...
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Journal ArticleRes Sq · April 1, 2022
Mass surveillance testing can help control outbreaks of infectious diseases such as COVID-19. However, diagnostic test shortages are prevalent globally and continue to occur in the US with the onset of new COVID-19 variants, demonstrating an unprecedented ...
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ConferenceProceedings - 2022 IEEE Conference on Virtual Reality and 3D User Interfaces Abstracts and Workshops, VRW 2022 · January 1, 2022
Robust pervasive context-aware augmented reality (AR) has the potential to enable a range of applications that support users in reaching their personal and professional goals. In such applications, AR can be used to deliver richer, more immersive, and more ...
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ConferenceBHI-BSN 2022 - IEEE-EMBS International Conference on Biomedical and Health Informatics and IEEE-EMBS International Conference on Wearable and Implantable Body Sensor Networks, Symposium Proceedings · January 1, 2022
Proper diet monitoring is a cornerstone of preventing and treating Type 2 Diabetes. However, this usually relies on burdensome manual meal logging. Continuous glucose monitors (CGMs), which have recently gained popularity as a tool to help Type 2 Diabetics ...
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ConferenceProceedings of the IEEE Conference on Decision and Control · January 1, 2022
In this paper, we consider a risk-averse multi-armed bandit (MAB) problem where the goal is to learn a policy that minimizes the risk of low expected return, as opposed to maximizing the expected return itself, which is the objective in the usual approach ...
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Journal ArticleJournal of medical Internet research · September 2021
BackgroundDigital clinical measures collected via various digital sensing technologies such as smartphones, smartwatches, wearables, ingestibles, and implantables are increasingly used by individuals and clinicians to capture health outcomes or be ...
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Journal ArticleJAMA Netw Open · September 1, 2021
IMPORTANCE: Currently, there are no presymptomatic screening methods to identify individuals infected with a respiratory virus to prevent disease spread and to predict their trajectory for resource allocation. OBJECTIVE: To evaluate the feasibility of usin ...
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Journal ArticleCell reports methods · August 2021
Consumer wearables, such as smart watches, are a promising tool for monitoring circadian health in "real world" settings. Bowman et al. demonstrate that circadian signals can be accurately captured through heart rate data obtained from wearables, opening u ...
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Journal ArticleNPJ Digit Med · June 2, 2021
Prediabetes affects one in three people and has a 10% annual conversion rate to type 2 diabetes without lifestyle or medical interventions. Management of glycemic health is essential to prevent progression to type 2 diabetes. However, there is currently no ...
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Journal ArticleNature medicine · June 2021
Vital signs, including heart rate and body temperature, are useful in detecting or monitoring medical conditions, but are typically measured in the clinic and require follow-up laboratory testing for more definitive diagnoses. Here we examined whether vita ...
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Journal ArticleBMJ Open Diabetes Res Care · June 2021
INTRODUCTION: Diabetes prevalence continues to grow and there remains a significant diagnostic gap in one-third of the US population that has pre-diabetes. Innovative, practical strategies to improve monitoring of glycemic health are desperately needed. In ...
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Journal ArticleJMIR mHealth and uHealth · February 2021
BackgroundThe field of digital medicine has seen rapid growth over the past decade. With this unfettered growth, challenges surrounding interoperability have emerged as a critical barrier to translating digital medicine into practice. In order to ...
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Journal ArticleSensors (Basel, Switzerland) · January 2021
A critical challenge to using longitudinal wearable sensor biosignal data for healthcare applications and digital biomarker development is the exacerbation of the healthcare "data deluge," leading to new data storage and organization challenges and costs. ...
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Journal ArticleIEEE open journal of engineering in medicine and biology · January 2021
Goal: Continuous glucose monitoring (CGM) is commonly used in Type 1 diabetes management by clinicians and patients and in diabetes research to understand how factors of longitudinal glucose and glucose variability relate to disease onset and severi ...
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Journal ArticleJMIR mHealth and uHealth · December 2020
Recently, companies such as Apple Inc, Fitbit Inc, and Garmin Ltd have released new wearable blood oxygenation measurement technologies. Although the release of these technologies has great potential for generating health-related information, it is importa ...
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Journal Article · October 19, 2020
UNSTRUCTUREDRecently, companies such as Apple Inc, Fitbit Inc, and Garmin Ltd have released new wearable blood oxygenation measurement technologies. Although the release of these technolo ...
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Journal Article · September 24, 2020
BACKGROUNDThe field of digital medicine has seen rapid growth over the past decade. With this unfettered growth, challenges surrounding interoperability have emerged as a critical barrier ...
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Journal ArticleJournal of clinical and translational science · August 2020
IntroductionPersonalized medicine has exposed wearable sensors as new sources of biomedical data which are expected to accrue annual data storage costs of approximately $7.2 trillion by 2020 (>2000 exabytes). To improve the usability of wearable d ...
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Journal ArticleJournal of clinical and translational science · July 2020
IntroductionDigital health is rapidly expanding due to surging healthcare costs, deteriorating health outcomes, and the growing prevalence and accessibility of mobile health (mHealth) and wearable technology. Data from Biometric Monitoring Technol ...
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Journal ArticleSensors (Basel, Switzerland) · May 2020
The dynamic time warping (DTW) algorithm is widely used in pattern matching and sequence alignment tasks, including speech recognition and time series clustering. However, DTW algorithms perform poorly when aligning sequences of uneven sampling frequencies ...
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Journal ArticleNPJ Digit Med · February 10, 2020
As wearable technologies are being increasingly used for clinical research and healthcare, it is critical to understand their accuracy and determine how measurement errors may affect research conclusions and impact healthcare decision-making. Accuracy of w ...
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Journal ArticleNPJ Digit Med · 2020
As wearable technologies are being increasingly used for clinical research and healthcare, it is critical to understand their accuracy and determine how measurement errors may affect research conclusions and impact healthcare decision-making. Accuracy of w ...
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Journal ArticleNPJ digital medicine · January 2020
Digital medicine is an interdisciplinary field, drawing together stakeholders with expertize in engineering, manufacturing, clinical science, data science, biostatistics, regulatory science, ethics, patient advocacy, and healthcare policy, to name a few. A ...
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Chapter · January 1, 2020
The growing desire for better control of health outcomes and the increasing healthcare costs associated with disease treatment has led to a shift in the healthcare paradigm from reactive to proactive. Advances in artificial intelligence (AI), the study of ...
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Journal ArticleAmerican journal of obstetrics & gynecology MFM · November 2019
BackgroundWhile there is a growing interest in addressing social determinants of health in clinical settings, there are limited data on the relationship between unstable housing and both obstetric outcomes and health care utilization.Objective ...
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Journal ArticleNature · May 2019
Type 2 diabetes mellitus (T2D) is a growing health problem, but little is known about its early disease stages, its effects on biological processes or the transition to clinical T2D. To understand the earliest stages of T2D better, we obtained samples from ...
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Journal ArticleNature medicine · May 2019
Precision health relies on the ability to assess disease risk at an individual level, detect early preclinical conditions and initiate preventive strategies. Recent technological advances in omics and wearable monitoring enable deep molecular and physiolog ...
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Conference2019 IEEE EMBS International Conference on Biomedical and Health Informatics, BHI 2019 - Proceedings · May 1, 2019
To date, there has not been a comprehensive evaluation of how to best characterize resting heart rate (RHR), which varies over time and between individuals with different activity/rest habits. Current methods for obtaining RHR require hands-on clinical mea ...
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Journal ArticleCurrent opinion in biomedical engineering · March 2019
BackgroundWearable sensors (wearables) have been commonly integrated into a wide variety of commercial products and are increasingly being used to collect and process raw physiological parameters into salient digital health information. The data c ...
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Journal ArticleCold Spring Harbor molecular case studies · December 2018
Exome sequencing is increasingly utilized in both clinical and nonclinical settings, but little is known about its utility in healthy individuals. Most previous studies on this topic have examined a small subset of genes known to be implicated in human dis ...
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Journal ArticlePLOS Biology · January 2017
A new wave of portable biosensors allows frequent measurement of health-related physiology. We investigated the use of these devices to monitor human physiological changes during various activities and their role in managing health and diagnosing and analy ...
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Journal ArticleThe International Journal of Biochemistry & Cell Biology · October 2015
Currently in the field of vascular biology, the role of epigenetics in endothelial cell biology and vascular disease has attracted more in-depth study. Using both in vitro and in vivo models of blood flow, investigators have recently begun to reveal the unde ...
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Journal ArticleArteriosclerosis, thrombosis, and vascular biology · July 2015
Epigenetic mechanisms that regulate endothelial cell gene expression are now emerging. DNA methylation is the most stable epigenetic mark that confers persisting changes in gene expression. Not only is DNA methylation important in rendering cell identity b ...
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Journal ArticleScience · April 2014
Rapid advances in DNA synthesis techniques have made it possible to engineer viruses, biochemical pathways and assemble bacterial genomes. Here, we report the synthesis of a functional 272,871 bp designer eukaryotic chromosome, synIII, which is based on th ...
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Journal ArticleAnnual Review of Fluid Mechanics · January 2014
This review places modern research developments in vascular mechanobiology in the context of hemodynamic phenomena in the cardiovascular system and the discrete localization of vascular disease. The modern origins of this field are traced, beginning in the ...
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Journal ArticleMolecular and Cellular Biochemistry · September 2011
Arginase constrains endothelial nitric oxide synthase activity by competing for the common substrate, L-Arginine. We have recently shown that inducible nitric oxide synthase (NOS2) Snitrosates and activates arginase 1 (Arg1) leading to age-associated vascu ...
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Journal ArticleCirculation Research · July 2010
Objective: We sought to determine whether endothelium-dependent NO regulates TG2 activity by S-nitrosylation and whether this contributes to age-related vascular stiffness. Methods and Results: We first demonstrate that NO suppresses activity and increases ...
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Journal Article
Normally, measures of cardiac autonomic function must be taken in the clinic, making it difficult to perform remote and continuous assessment. Cardiac autonomic function is one of several functions that become dysregulated in diabetes progression, and moni ...
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Journal Article
We developed MoveIt!, a smartphone application prototype that utilizes real-time GPS location and context awareness to make pertinent suggestions that seamlessly incorporate healthy living habits into daily life. ...
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