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Jessilyn Dunn

Assistant Professor of Biomedical Engineering
Biomedical Engineering
534 Research Dr, Room #448, Durham, NC 27705
534 Research Dr, Room #448, Durham, NC 27708

Selected Publications


Real-world walking behaviors are associated with early-stage heart failure: a Project Baseline Health Study.

Journal Article J Card Fail · April 4, 2024 BACKGROUND: Data collected via wearables may complement in-clinic assessments to monitor subclinical heart failure (HF). OBJECTIVES: Evaluate the association of sensor-based digital walking measures with HF stage and characterize their correlation with in- ... Full text Link to item Cite

Remote digital health technologies for improving the care of people with respiratory disorders.

Journal Article The Lancet. Digital health · April 2024 Respiratory diseases are a leading cause of morbidity and mortality globally. However, existing systems of care, built around scheduled appointments, are not well designed to support the needs of people with chronic and acute respiratory conditions that ca ... Full text Cite

Physical activity and sleep changes among children during the COVID-19 pandemic.

Journal Article NPJ Digit Med · March 16, 2024 Daily routines, including in-person school and extracurricular activities, are important for maintaining healthy physical activity and sleep habits in children. The COVID-19 pandemic significantly disrupted daily routines as in-person school and activities ... Full text Link to item Cite

Assessment of ownership of smart devices and the acceptability of digital health data sharing.

Journal Article NPJ digital medicine · February 2024 Smart portable devices- smartphones and smartwatches- are rapidly being adopted by the general population, which has brought forward an opportunity to use the large volumes of physiological, behavioral, and activity data continuously being collected by the ... Full text Cite

Session Introduction: Digital health technology data in biocomputing: Research efforts and considerations for expanding access (PSB2024).

Journal Article Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing · January 2024 Data from digital health technologies (DHT), including wearable sensors like Apple Watch, Whoop, Oura Ring, and Fitbit, are increasingly being used in biomedical research. Research and development of DHT-related devices, platforms, and applications is happ ... Cite

Context-dependent neocentromere activity in synthetic yeast chromosome VIII

Journal Article Cell Genomics · November 8, 2023 Pioneering advances in genome engineering, and specifically in genome writing, have revolutionized the field of synthetic biology, propelling us toward the creation of synthetic genomes. The Sc2.0 project aims to build the first fully synthetic eukaryotic ... Full text Cite

Scalable Strategies to Increase Efficiency and Augment Public Health Activities During Epidemic Peaks.

Journal Article J Public Health Manag Pract · November 2023 OBJECTIVE: Scalable strategies to reduce the time burden and increase contact tracing efficiency are crucial during early waves and peaks of infectious transmission. DESIGN: We enrolled a cohort of SARS-CoV-2-positive seed cases into a peer recruitment stu ... Full text Link to item Cite

The 2023 wearable photoplethysmography roadmap.

Journal Article Physiological measurement · November 2023 Photoplethysmography is a key sensing technology which is used in wearable devices such as smartwatches and fitness trackers. Currently, photoplethysmography sensors are used to monitor physiological parameters including heart rate and heart rhythm, and to ... Full text Cite

Investigating the accuracy of blood oxygen saturation measurements in common consumer smartwatches.

Journal Article PLOS digital health · July 2023 Blood oxygen saturation (SpO2) is an important measurement for monitoring patients with acute and chronic conditions that are associated with low blood oxygen levels. While smartwatches may provide a new method for continuous and unobtrusive SpO2 monitorin ... Full text Cite

Blood Pressure Variability in Clinical Practice: Past, Present and the Future.

Journal Article J Am Heart Assoc · May 2, 2023 Recent advances in wearable technology through convenient and cuffless systems will enable continuous, noninvasive monitoring of blood pressure (BP), heart rate, and heart rhythm on both longitudinal 24-hour measurement scales and high-frequency beat-to-be ... Full text Link to item Cite

Automated Diet Capture Using Voice Alerts and Speech Recognition on Smartphones: Pilot Usability and Acceptability Study.

Journal Article JMIR formative research · May 2023 BackgroundEffective monitoring of dietary habits is critical for promoting healthy lifestyles and preventing or delaying the onset and progression of diet-related diseases, such as type 2 diabetes. Recent advances in speech recognition technologie ... Full text Cite

Does deidentification of data from wearable devices give us a false sense of security? A systematic review.

Journal Article The Lancet. Digital health · April 2023 Wearable devices have made it easier to generate and share data collected on individuals. This systematic review seeks to investigate whether deidentifying data from wearable devices is sufficient to protect the privacy of individuals in datasets. We searc ... Full text Cite

Defining the Digital Measurement of Scratching During Sleep or Nocturnal Scratching: Review of the Literature.

Journal Article Journal of medical Internet research · April 2023 BackgroundDigital sensing solutions represent a convenient, objective, relatively inexpensive method that could be leveraged for assessing symptoms of various health conditions. Recent progress in the capabilities of digital sensing products has t ... Full text Cite

An Algorithm to Classify Real-World Ambulatory Status From a Wearable Device Using Multimodal and Demographically Diverse Data: Validation Study

Journal Article JMIR Biomedical Engineering · March 7, 2023 BackgroundMeasuring the amount of physical activity and its patterns using wearable sensor technology in real-world settings can provide critical insights into health status. ... Full text Cite

Wearable Devices in Cardiovascular Medicine.

Journal Article Circulation research · March 2023 Wearable devices, such as smartwatches and activity trackers, are commonly used by patients in their everyday lives to manage their health and well-being. These devices collect and analyze long-term continuous data on measures of behavioral or physiologic ... Full text Cite

Session Introduction: Digital health technology data in biocomputing: Research efforts and considerations for expanding access.

Conference Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing · January 2023 Data from digital health technologies (DHT), including wearable sensors like Apple Watch, Whoop, Oura Ring, and Fitbit, are increasingly being used in biomedical research. Research and development of DHT-related devices, platforms, and applications is happ ... Cite

Real-world walking behaviors are associated with early-stage heart failure: a Project Baseline Health Study.

Journal Article J Card Fail · April 4, 2024 BACKGROUND: Data collected via wearables may complement in-clinic assessments to monitor subclinical heart failure (HF). OBJECTIVES: Evaluate the association of sensor-based digital walking measures with HF stage and characterize their correlation with in- ... Full text Link to item Cite

Remote digital health technologies for improving the care of people with respiratory disorders.

Journal Article The Lancet. Digital health · April 2024 Respiratory diseases are a leading cause of morbidity and mortality globally. However, existing systems of care, built around scheduled appointments, are not well designed to support the needs of people with chronic and acute respiratory conditions that ca ... Full text Cite

Physical activity and sleep changes among children during the COVID-19 pandemic.

Journal Article NPJ Digit Med · March 16, 2024 Daily routines, including in-person school and extracurricular activities, are important for maintaining healthy physical activity and sleep habits in children. The COVID-19 pandemic significantly disrupted daily routines as in-person school and activities ... Full text Link to item Cite

Assessment of ownership of smart devices and the acceptability of digital health data sharing.

Journal Article NPJ digital medicine · February 2024 Smart portable devices- smartphones and smartwatches- are rapidly being adopted by the general population, which has brought forward an opportunity to use the large volumes of physiological, behavioral, and activity data continuously being collected by the ... Full text Cite

Session Introduction: Digital health technology data in biocomputing: Research efforts and considerations for expanding access (PSB2024).

Journal Article Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing · January 2024 Data from digital health technologies (DHT), including wearable sensors like Apple Watch, Whoop, Oura Ring, and Fitbit, are increasingly being used in biomedical research. Research and development of DHT-related devices, platforms, and applications is happ ... Cite

Context-dependent neocentromere activity in synthetic yeast chromosome VIII

Journal Article Cell Genomics · November 8, 2023 Pioneering advances in genome engineering, and specifically in genome writing, have revolutionized the field of synthetic biology, propelling us toward the creation of synthetic genomes. The Sc2.0 project aims to build the first fully synthetic eukaryotic ... Full text Cite

Scalable Strategies to Increase Efficiency and Augment Public Health Activities During Epidemic Peaks.

Journal Article J Public Health Manag Pract · November 2023 OBJECTIVE: Scalable strategies to reduce the time burden and increase contact tracing efficiency are crucial during early waves and peaks of infectious transmission. DESIGN: We enrolled a cohort of SARS-CoV-2-positive seed cases into a peer recruitment stu ... Full text Link to item Cite

The 2023 wearable photoplethysmography roadmap.

Journal Article Physiological measurement · November 2023 Photoplethysmography is a key sensing technology which is used in wearable devices such as smartwatches and fitness trackers. Currently, photoplethysmography sensors are used to monitor physiological parameters including heart rate and heart rhythm, and to ... Full text Cite

Investigating the accuracy of blood oxygen saturation measurements in common consumer smartwatches.

Journal Article PLOS digital health · July 2023 Blood oxygen saturation (SpO2) is an important measurement for monitoring patients with acute and chronic conditions that are associated with low blood oxygen levels. While smartwatches may provide a new method for continuous and unobtrusive SpO2 monitorin ... Full text Cite

Blood Pressure Variability in Clinical Practice: Past, Present and the Future.

Journal Article J Am Heart Assoc · May 2, 2023 Recent advances in wearable technology through convenient and cuffless systems will enable continuous, noninvasive monitoring of blood pressure (BP), heart rate, and heart rhythm on both longitudinal 24-hour measurement scales and high-frequency beat-to-be ... Full text Link to item Cite

Automated Diet Capture Using Voice Alerts and Speech Recognition on Smartphones: Pilot Usability and Acceptability Study.

Journal Article JMIR formative research · May 2023 BackgroundEffective monitoring of dietary habits is critical for promoting healthy lifestyles and preventing or delaying the onset and progression of diet-related diseases, such as type 2 diabetes. Recent advances in speech recognition technologie ... Full text Cite

Does deidentification of data from wearable devices give us a false sense of security? A systematic review.

Journal Article The Lancet. Digital health · April 2023 Wearable devices have made it easier to generate and share data collected on individuals. This systematic review seeks to investigate whether deidentifying data from wearable devices is sufficient to protect the privacy of individuals in datasets. We searc ... Full text Cite

Defining the Digital Measurement of Scratching During Sleep or Nocturnal Scratching: Review of the Literature.

Journal Article Journal of medical Internet research · April 2023 BackgroundDigital sensing solutions represent a convenient, objective, relatively inexpensive method that could be leveraged for assessing symptoms of various health conditions. Recent progress in the capabilities of digital sensing products has t ... Full text Cite

An Algorithm to Classify Real-World Ambulatory Status From a Wearable Device Using Multimodal and Demographically Diverse Data: Validation Study

Journal Article JMIR Biomedical Engineering · March 7, 2023 BackgroundMeasuring the amount of physical activity and its patterns using wearable sensor technology in real-world settings can provide critical insights into health status. ... Full text Cite

Wearable Devices in Cardiovascular Medicine.

Journal Article Circulation research · March 2023 Wearable devices, such as smartwatches and activity trackers, are commonly used by patients in their everyday lives to manage their health and well-being. These devices collect and analyze long-term continuous data on measures of behavioral or physiologic ... Full text Cite

Session Introduction: Digital health technology data in biocomputing: Research efforts and considerations for expanding access.

Conference Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing · January 2023 Data from digital health technologies (DHT), including wearable sensors like Apple Watch, Whoop, Oura Ring, and Fitbit, are increasingly being used in biomedical research. Research and development of DHT-related devices, platforms, and applications is happ ... Cite

Investigation of Thermal Perception and Emotional Response in Augmented Reality using Digital Biomarkers: A Pilot Study

Conference Proceedings - 2023 IEEE Conference on Virtual Reality and 3D User Interfaces Abstracts and Workshops, VRW 2023 · January 1, 2023 Dialectical behavior therapy (DBT) is an evidence-based psychotherapy that helps patients learn skills to regulate emotions as a central strategy to improve life functioning. However, DBT skills require a long-term and consistent commitment, typically to g ... Full text Cite

Nightshift imposes irregular lifestyle behaviors in police academy trainees.

Journal Article Sleep Adv · 2023 STUDY OBJECTIVE: Shiftwork increases risk for numerous chronic diseases, which is hypothesized to be linked to disruption of circadian timing of lifestyle behaviors. However, empirical data on timing of lifestyle behaviors in real-world shift workers are l ... Full text Open Access Link to item Cite

Neurological Outcome Prediction After Cardiac Arrest: A Multi-Level Deep Learning Approach with Feature and Decision Fusion

Conference Computing in Cardiology · January 1, 2023 Cardiac arrest leads to complex neurological outcomes, demanding accurate predictions to guide post-arrest care. Using the International Cardiac Arrest Research Consortium (I-CARE) dataset, we developed models to discern between 'good' and 'poor' neurologi ... Full text Cite

AI in medicine: Where are we now and where are we going?

Journal Article Cell reports. Medicine · December 2022 Advancements in AI enable personalizing healthcare, for example by investigating disease origins at the genetic or molecular level, understanding intraindividual drug effects, and fusing multi-modal personal physiological, behavioral, laboratory, and clini ... Full text Cite

A Systematic Review of Time Series Classification Techniques Used in Biomedical Applications.

Journal Article Sensors (Basel, Switzerland) · October 2022 Background: Digital clinical measures collected via various digital sensing technologies such as smartphones, smartwatches, wearables, and ingestible and implantable sensors are increasingly used by individuals and clinicians to capture the health o ... Full text Cite

A method for intelligent allocation of diagnostic testing by leveraging data from commercial wearable devices: a case study on COVID-19.

Journal Article NPJ Digit Med · September 1, 2022 Mass surveillance testing can help control outbreaks of infectious diseases such as COVID-19. However, diagnostic test shortages are prevalent globally and continue to occur in the US with the onset of new COVID-19 variants and emerging diseases like monke ... Full text Link to item Cite

Digital biomarkers reflect stress reduction after Augmented Reality guided meditation: A feasibility study

Conference DigiBiom 2022 - Proceedings of the 2022 Emerging Devices for Digital Biomarkers · July 1, 2022 Meditation, a mental and physical exercise which helps to focus attention and reduce stress has gained more popularity in recent years. However, meditation requires a concerted effort and regular practice. To explore the feasibility of using Augmented Real ... Full text Cite

Field-Based Assessments of Behavioral Patterns During Shiftwork in Police Academy Trainees Using Wearable Technology.

Journal Article J Biol Rhythms · June 2022 Circadian misalignment, as occurs in shiftwork, is associated with numerous negative health outcomes. Here, we sought to improve data labeling accuracy from wearable technology using a novel data pre-processing algorithm in 27 police trainees during shiftw ... Full text Open Access Link to item Cite

Detection and Monitoring of Viral Infections via Wearable Devices and Biometric Data.

Book · June 2022 Mounting clinical evidence suggests that viral infections can lead to detectable changes in an individual's normal physiologic and behavioral metrics, including heart and respiration rates, heart rate variability, temperature, activity, and sleep prior to ... Full text Cite

Demographic Imbalances Resulting From the Bring-Your-Own-Device Study Design.

Journal Article JMIR Mhealth Uhealth · April 8, 2022 Digital health technologies, such as smartphones and wearable devices, promise to revolutionize disease prevention, detection, and treatment. Recently, there has been a surge of digital health studies where data are collected through a bring-your-own-devic ... Full text Link to item Cite

A Method for Intelligent Allocation of Diagnostic Testing by Leveraging Data from Commercial Wearable Devices: A Case Study on COVID-19.

Journal Article Res Sq · April 1, 2022 Mass surveillance testing can help control outbreaks of infectious diseases such as COVID-19. However, diagnostic test shortages are prevalent globally and continue to occur in the US with the onset of new COVID-19 variants, demonstrating an unprecedented ... Full text Link to item Cite

Environmental, User, and Social Context-Aware Augmented Reality for Supporting Personal Development and Change

Conference Proceedings - 2022 IEEE Conference on Virtual Reality and 3D User Interfaces Abstracts and Workshops, VRW 2022 · January 1, 2022 Robust pervasive context-aware augmented reality (AR) has the potential to enable a range of applications that support users in reaching their personal and professional goals. In such applications, AR can be used to deliver richer, more immersive, and more ... Full text Cite

Enhancing Continuous Glucose Monitoring-based Eating Detection with Wearable Biomarkers

Conference BHI-BSN 2022 - IEEE-EMBS International Conference on Biomedical and Health Informatics and IEEE-EMBS International Conference on Wearable and Implantable Body Sensor Networks, Symposium Proceedings · January 1, 2022 Proper diet monitoring is a cornerstone of preventing and treating Type 2 Diabetes. However, this usually relies on burdensome manual meal logging. Continuous glucose monitors (CGMs), which have recently gained popularity as a tool to help Type 2 Diabetics ... Full text Cite

Risk-Averse Multi-Armed Bandits with Unobserved Confounders: A Case Study in Emotion Regulation in Mobile Health

Conference Proceedings of the IEEE Conference on Decision and Control · January 1, 2022 In this paper, we consider a risk-averse multi-armed bandit (MAB) problem where the goal is to learn a policy that minimizes the risk of low expected return, as opposed to maximizing the expected return itself, which is the objective in the usual approach ... Full text Cite

Recent Academic Research on Clinically Relevant Digital Measures: Systematic Review.

Journal Article Journal of medical Internet research · September 2021 BackgroundDigital clinical measures collected via various digital sensing technologies such as smartphones, smartwatches, wearables, ingestibles, and implantables are increasingly used by individuals and clinicians to capture health outcomes or be ... Full text Cite

Assessment of the Feasibility of Using Noninvasive Wearable Biometric Monitoring Sensors to Detect Influenza and the Common Cold Before Symptom Onset.

Journal Article JAMA Netw Open · September 1, 2021 IMPORTANCE: Currently, there are no presymptomatic screening methods to identify individuals infected with a respiratory virus to prevent disease spread and to predict their trajectory for resource allocation. OBJECTIVE: To evaluate the feasibility of usin ... Full text Open Access Link to item Cite

Taking the time for our bodies: How wearables can be used to assess circadian physiology.

Journal Article Cell reports methods · August 2021 Consumer wearables, such as smart watches, are a promising tool for monitoring circadian health in "real world" settings. Bowman et al. demonstrate that circadian signals can be accurately captured through heart rate data obtained from wearables, opening u ... Full text Cite

Engineering digital biomarkers of interstitial glucose from noninvasive smartwatches.

Journal Article NPJ Digit Med · June 2, 2021 Prediabetes affects one in three people and has a 10% annual conversion rate to type 2 diabetes without lifestyle or medical interventions. Management of glycemic health is essential to prevent progression to type 2 diabetes. However, there is currently no ... Full text Link to item Cite

Wearable sensors enable personalized predictions of clinical laboratory measurements.

Journal Article Nature medicine · June 2021 Vital signs, including heart rate and body temperature, are useful in detecting or monitoring medical conditions, but are typically measured in the clinic and require follow-up laboratory testing for more definitive diagnoses. Here we examined whether vita ... Full text Cite

Non-invasive wearables for remote monitoring of HbA1c and glucose variability: proof of concept.

Journal Article BMJ Open Diabetes Res Care · June 2021 INTRODUCTION: Diabetes prevalence continues to grow and there remains a significant diagnostic gap in one-third of the US population that has pre-diabetes. Innovative, practical strategies to improve monitoring of glycemic health are desperately needed. In ... Full text Link to item Cite

Digital Medicine Community Perspectives and Challenges: Survey Study.

Journal Article JMIR mHealth and uHealth · February 2021 BackgroundThe field of digital medicine has seen rapid growth over the past decade. With this unfettered growth, challenges surrounding interoperability have emerged as a critical barrier to translating digital medicine into practice. In order to ... Full text Cite

Biosignal Compression Toolbox for Digital Biomarker Discovery.

Journal Article Sensors (Basel, Switzerland) · January 2021 A critical challenge to using longitudinal wearable sensor biosignal data for healthcare applications and digital biomarker development is the exacerbation of the healthcare "data deluge," leading to new data storage and organization challenges and costs. ... Full text Cite

Cgmquantify: Python and R Software Packages for Comprehensive Analysis of Interstitial Glucose and Glycemic Variability from Continuous Glucose Monitor Data.

Journal Article IEEE open journal of engineering in medicine and biology · January 2021 Goal: Continuous glucose monitoring (CGM) is commonly used in Type 1 diabetes management by clinicians and patients and in diabetes research to understand how factors of longitudinal glucose and glucose variability relate to disease onset and severi ... Full text Cite

Wearables in the SARS-CoV-2 Pandemic: What Are They Good for?

Journal Article JMIR mHealth and uHealth · December 2020 Recently, companies such as Apple Inc, Fitbit Inc, and Garmin Ltd have released new wearable blood oxygenation measurement technologies. Although the release of these technologies has great potential for generating health-related information, it is importa ... Full text Cite

Wearables in the SARS-CoV-2 Pandemic: What Are They Good for? (Preprint)

Journal Article · October 19, 2020 UNSTRUCTUREDRecently, companies such as Apple Inc, Fitbit Inc, and Garmin Ltd have released new wearable blood oxygenation measurement technologies. Although the release of these technolo ... Full text Cite

Digital Medicine Community Perspectives and Challenges: Survey Study (Preprint)

Journal Article · September 24, 2020 BACKGROUNDThe field of digital medicine has seen rapid growth over the past decade. With this unfettered growth, challenges surrounding interoperability have emerged as a critical barrier ... Full text Cite

Optimizing sampling rate of wrist-worn optical sensors for physiologic monitoring.

Journal Article Journal of clinical and translational science · August 2020 IntroductionPersonalized medicine has exposed wearable sensors as new sources of biomedical data which are expected to accrue annual data storage costs of approximately $7.2 trillion by 2020 (>2000 exabytes). To improve the usability of wearable d ... Full text Cite

The digital biomarker discovery pipeline: An open-source software platform for the development of digital biomarkers using mHealth and wearables data.

Journal Article Journal of clinical and translational science · July 2020 IntroductionDigital health is rapidly expanding due to surging healthcare costs, deteriorating health outcomes, and the growing prevalence and accessibility of mobile health (mHealth) and wearable technology. Data from Biometric Monitoring Technol ... Full text Cite

EventDTW: An Improved Dynamic Time Warping Algorithm for Aligning Biomedical Signals of Nonuniform Sampling Frequencies.

Journal Article Sensors (Basel, Switzerland) · May 2020 The dynamic time warping (DTW) algorithm is widely used in pattern matching and sequence alignment tasks, including speech recognition and time series clustering. However, DTW algorithms perform poorly when aligning sequences of uneven sampling frequencies ... Full text Cite

Investigating sources of inaccuracy in wearable optical heart rate sensors.

Journal Article NPJ Digit Med · February 10, 2020 As wearable technologies are being increasingly used for clinical research and healthcare, it is critical to understand their accuracy and determine how measurement errors may affect research conclusions and impact healthcare decision-making. Accuracy of w ... Full text Link to item Cite

Investigating sources of inaccuracy in wearable optical heart rate sensors.

Journal Article NPJ Digit Med · 2020 As wearable technologies are being increasingly used for clinical research and healthcare, it is critical to understand their accuracy and determine how measurement errors may affect research conclusions and impact healthcare decision-making. Accuracy of w ... Full text Open Access Link to item Cite

Verification, analytical validation, and clinical validation (V3): the foundation of determining fit-for-purpose for Biometric Monitoring Technologies (BioMeTs).

Journal Article NPJ digital medicine · January 2020 Digital medicine is an interdisciplinary field, drawing together stakeholders with expertize in engineering, manufacturing, clinical science, data science, biostatistics, regulatory science, ethics, patient advocacy, and healthcare policy, to name a few. A ... Full text Cite

Roles of artificial intelligence in wellness, healthy living, and healthy status sensing

Chapter · January 1, 2020 The growing desire for better control of health outcomes and the increasing healthcare costs associated with disease treatment has led to a shift in the healthcare paradigm from reactive to proactive. Advances in artificial intelligence (AI), the study of ... Full text Cite

Associations between unstable housing, obstetric outcomes, and perinatal health care utilization.

Journal Article American journal of obstetrics & gynecology MFM · November 2019 BackgroundWhile there is a growing interest in addressing social determinants of health in clinical settings, there are limited data on the relationship between unstable housing and both obstetric outcomes and health care utilization.Objective ... Full text Cite

Longitudinal multi-omics of host-microbe dynamics in prediabetes.

Journal Article Nature · May 2019 Type 2 diabetes mellitus (T2D) is a growing health problem, but little is known about its early disease stages, its effects on biological processes or the transition to clinical T2D. To understand the earliest stages of T2D better, we obtained samples from ... Full text Cite

A longitudinal big data approach for precision health.

Journal Article Nature medicine · May 2019 Precision health relies on the ability to assess disease risk at an individual level, detect early preclinical conditions and initiate preventive strategies. Recent technological advances in omics and wearable monitoring enable deep molecular and physiolog ... Full text Cite

Estimating personal resting heart rate from wearable biosensor data

Conference 2019 IEEE EMBS International Conference on Biomedical and Health Informatics, BHI 2019 - Proceedings · May 1, 2019 To date, there has not been a comprehensive evaluation of how to best characterize resting heart rate (RHR), which varies over time and between individuals with different activity/rest habits. Current methods for obtaining RHR require hands-on clinical mea ... Full text Cite

Windows Into Human Health Through Wearables Data Analytics.

Journal Article Current opinion in biomedical engineering · March 2019 BackgroundWearable sensors (wearables) have been commonly integrated into a wide variety of commercial products and are increasingly being used to collect and process raw physiological parameters into salient digital health information. The data c ... Full text Open Access Cite

High-frequency actionable pathogenic exome variants in an average-risk cohort.

Journal Article Cold Spring Harbor molecular case studies · December 2018 Exome sequencing is increasingly utilized in both clinical and nonclinical settings, but little is known about its utility in healthy individuals. Most previous studies on this topic have examined a small subset of genes known to be implicated in human dis ... Full text Cite

Wearables and the medical revolution

Journal Article Personalized Medicine · September 2018 Full text Open Access Cite

Personal Omics for Precision Health

Journal Article Circulation Research · April 2018 Full text Open Access Cite

Digital Health: Tracking Physiomes and Activity Using Wearable Biosensors Reveals Useful Health-Related Information

Journal Article PLOS Biology · January 2017 A new wave of portable biosensors allows frequent measurement of health-related physiology. We investigated the use of these devices to monitor human physiological changes during various activities and their role in managing health and diagnosing and analy ... Full text Open Access Cite

The role of epigenetics in the endothelial cell shear stress response and atherosclerosis

Journal Article The International Journal of Biochemistry & Cell Biology · October 2015 Currently in the field of vascular biology, the role of epigenetics in endothelial cell biology and vascular disease has attracted more in-depth study. Using both in vitro and in vivo models of blood flow, investigators have recently begun to reveal the unde ... Full text Cite

Flow-Dependent Epigenetic DNA Methylation in Endothelial Gene Expression and Atherosclerosis.

Journal Article Arteriosclerosis, thrombosis, and vascular biology · July 2015 Epigenetic mechanisms that regulate endothelial cell gene expression are now emerging. DNA methylation is the most stable epigenetic mark that confers persisting changes in gene expression. Not only is DNA methylation important in rendering cell identity b ... Full text Cite

Total Synthesis of a Functional Designer Eukaryotic Chromosome

Journal Article Science · April 2014 Rapid advances in DNA synthesis techniques have made it possible to engineer viruses, biochemical pathways and assemble bacterial genomes. Here, we report the synthesis of a functional 272,871 bp designer eukaryotic chromosome, synIII, which is based on th ... Full text Cite

Fluid Mechanics, Arterial Disease, and Gene Expression

Journal Article Annual Review of Fluid Mechanics · January 2014 This review places modern research developments in vascular mechanobiology in the context of hemodynamic phenomena in the cardiovascular system and the discrete localization of vascular disease. The modern origins of this field are traced, beginning in the ... Full text Cite

S-Nitrosation of arginase 1 requires direct interaction with inducible nitric oxide synthase

Journal Article Molecular and Cellular Biochemistry · September 2011 Arginase constrains endothelial nitric oxide synthase activity by competing for the common substrate, L-Arginine. We have recently shown that inducible nitric oxide synthase (NOS2) Snitrosates and activates arginase 1 (Arg1) leading to age-associated vascu ... Full text Cite

Decreased S -Nitrosylation of Tissue Transglutaminase Contributes to Age-Related Increases in Vascular Stiffness

Journal Article Circulation Research · July 2010 Objective: We sought to determine whether endothelium-dependent NO regulates TG2 activity by S-nitrosylation and whether this contributes to age-related vascular stiffness. Methods and Results: We first demonstrate that NO suppresses activity and increases ... Full text Cite

Consumer-grade wrist-worn PPG sensors can be used to detect differences in heart rate variability among a heterogeneous prediabetic population

Journal Article Normally, measures of cardiac autonomic function must be taken in the clinic, making it difficult to perform remote and continuous assessment. Cardiac autonomic function is one of several functions that become dysregulated in diabetes progression, and moni ... Cite

MoveIt! Smartphone Application for Promoting Healthy Living

Journal Article We developed MoveIt!, a smartphone application prototype that utilizes real-time GPS location and context awareness to make pertinent suggestions that seamlessly incorporate healthy living habits into daily life. ... Cite