Research Interests
I am an academic surgeon with a practice in trauma, critical care and acute care surgery with an active research program focused on the development and translation of therapeutic strategies to improve the healing of acute traumatic injuries. My motivation for this works lies in the lack of available therapeutics for acute traumatic wounds which are often left to heal without intervention. Rib fractures exemplify this problem. I want to provide treatment solutions to the trauma patient where none exist. As the principle investigator of the Duke STAT lab my work is focused on enhancing the innate capacity of the body to heal broken bones and acute traumatic wounds through the use of engineered scaffolds, nanomaterials, and drug delivery systems. We are applying biomedical engineering principles to common traumatic injuries and in particular, rib fractures. We lack minimally invasive approaches to rib fracture repair and I have focused my lab on developing therapeutic solutions to this common injury. Using biologically derived materials we have studied the innate immune response to wound healing.As the Medical Director of the Duke Thoracic Injury Program, I have been actively involved in the development of instruments and devices to improve the safety and reduce the invasiveness of surgical approach to thoracic injuries.
Selected Grants
Resorbable, Phsophorylated Poly(ester urea) Surgical Adhesive to Enhance Fracture Healing
ResearchPrincipal Investigator · Awarded by National Institute of Arthritis and Musculoskeletal and Skin Diseases · 2021 - 2026CD154 mediated local immune modulation in rib fracture healing in the elderly: A targeted approach
ResearchPrincipal Investigator · Awarded by American College of Surgeons · 2024 - 2026Surgical Critical Care Initiative (SC2I): Civilian application of military decision support tools for critically injured patients.
ResearchInvestigator · Awarded by Henry M. Jackson Foundation · 2021 - 2025System for video-assisted thoracoscopic intrathoracic stabilization of rib fractures
ResearchPrincipal Investigator · Awarded by North Carolina Biotechnology Center · 2023 - 2024Improving the safety and effectiveness of adhesion prevention following colorectal procedures with high risk of cancer or infection
ResearchPrincipal Investigator · Awarded by TYBR Health · 2023 - 2024Resorbable, Phsophorylated Poly(ester urea) Surgical Adhesive to Enhance Fracture Healing
ResearchPrincipal Investigator · Awarded by National Institute of Arthritis and Musculoskeletal and Skin Diseases · 2021 - 2026CD154 mediated local immune modulation in rib fracture healing in the elderly: A targeted approach
ResearchPrincipal Investigator · Awarded by American College of Surgeons · 2024 - 2026Surgical Critical Care Initiative (SC2I): Civilian application of military decision support tools for critically injured patients.
ResearchInvestigator · Awarded by Henry M. Jackson Foundation · 2021 - 2025System for video-assisted thoracoscopic intrathoracic stabilization of rib fractures
ResearchPrincipal Investigator · Awarded by North Carolina Biotechnology Center · 2023 - 2024Improving the safety and effectiveness of adhesion prevention following colorectal procedures with high risk of cancer or infection
ResearchPrincipal Investigator · Awarded by TYBR Health · 2023 - 2024Biomimetic Proteo-Lipid Nanovesicles Protect Against Septic Leukocyte-Endothelial Dysfunction
ResearchPrincipal Investigator · Awarded by Surgical Infection Society · 2019 - 2022Human Fresh Tissue Lab-Corporate non-CME Educational Program Agreement
Inst. Training Prgm or CMEPrincipal Investigator · Awarded by AtriCure, Inc. · 2021 - 2021Fellowships, Gifts, and Supported Research
Biomimetic Proteo-Lipid Nanovesicles Protect Against Septic Leukocyte-Endothelial Dysfunction ·
2019
- 2020
Primary Investigator ·
Surgical Infection Society
· $35,000.00
Use of proteolipid nanovescicles derived from leukocytes for protection of host from leukocyte-endothelial dysfunction in sepsis
Immunologic Effect of PRP on Synthetic and Non-Synthetic Mesh ·
2015
- 2019
Primary Investigator ·
DSM Biomedical
· $60,000.00
Defining the mechanisms of platelet rich plasma on the innate immune response to acellular dermal matrices in ventral hernia repair
Controlled Release of Nitric Oxide and Paclitaxel via Nanomaterial Functionalized Arteriovenous Hemodialysis Graft for Reduction of Venous Intimal Hyperplasia ·
2014
- 2016
Primary Investigator ·
The Chairs’ Seed Grant Awards in Cardiovascular Sciences- Houston Methodist Hospital
· $25,000.00
Development of films capable of sustained nitric oxide release for the prevention of neointimal hyperplasia and stenosis following arteriovenous fistula formation
Nanotechnology Enabled Antibacterial Mesh ·
2012
- 2013
Primary Investigator ·
Americas Hernia Society
· $35,000.00
Functionalization of composite polyester hernia mesh using nitric oxide releasing silica nanoparticles for use in infected field hernia repair
External Relationships
- Chorus Cardiothoracic Technologies, LLC
- GuidSET
This faculty member (or a member of their immediate family) has reported outside activities with the companies, institutions, or organizations listed above. This information is available to institutional leadership and, when appropriate, management plans are in place to address potential conflicts of interest.