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Joseph Fernandez-Moure

Assistant Professor of Surgery
Trauma, Acute, and Critical Care Surgery
DUMC 2837, Durham, NC 27710
DUMC 2837, Durham, NC 27710

Research Interests


I am an academic surgeon with a practice in trauma, critical care and acute care surgery with an active research program focused on the development and translation of therapeutic strategies to improve the healing of acute traumatic injuries. My motivation for this works lies in the lack of available therapeutics for acute traumatic wounds which are often left to heal without intervention. Rib fractures exemplify this problem. I want to provide treatment solutions to the trauma patient where none exist. As the principle investigator of the Duke STAT lab my work is focused on enhancing the innate capacity of the body to heal broken bones and acute traumatic wounds through the use of engineered scaffolds, nanomaterials, and drug delivery systems. We are applying biomedical engineering principles to common traumatic injuries and in particular, rib fractures. We lack minimally invasive approaches to rib fracture repair and I have focused my lab on developing therapeutic solutions to this common injury. Using biologically derived materials we have studied the innate immune response to wound healing.As the Medical Director of the Duke Thoracic Injury Program,  I have been actively involved in the development of instruments and devices to improve the safety and reduce the invasiveness of surgical approach to thoracic injuries. 


Selected Grants


Resorbable, Phsophorylated Poly(ester urea) Surgical Adhesive to Enhance Fracture Healing

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2021 - 2026

CD154 mediated local immune modulation in rib fracture healing in the elderly: A targeted approach

ResearchPrincipal Investigator · Awarded by American College of Surgeons · 2024 - 2026

System for video-assisted thoracoscopic intrathoracic stabilization of rib fractures

ResearchPrincipal Investigator · Awarded by North Carolina Biotechnology Center · 2023 - 2024

Resorbable, Phsophorylated Poly(ester urea) Surgical Adhesive to Enhance Fracture Healing

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2021 - 2026

CD154 mediated local immune modulation in rib fracture healing in the elderly: A targeted approach

ResearchPrincipal Investigator · Awarded by American College of Surgeons · 2024 - 2026

System for video-assisted thoracoscopic intrathoracic stabilization of rib fractures

ResearchPrincipal Investigator · Awarded by North Carolina Biotechnology Center · 2023 - 2024

Biomimetic Proteo-Lipid Nanovesicles Protect Against Septic Leukocyte-Endothelial Dysfunction

ResearchPrincipal Investigator · Awarded by Surgical Infection Society · 2019 - 2022

Human Fresh Tissue Lab-Corporate non-CME Educational Program Agreement

Inst. Training Prgm or CMEPrincipal Investigator · Awarded by AtriCure, Inc. · 2021 - 2021

Fellowships, Gifts, and Supported Research


Nanotechnology Enabled Antibacterial Mesh · 2012 - 2013 Primary Investigator · Americas Hernia Society · $35,000.00 Functionalization of composite polyester hernia mesh using nitric oxide releasing silica nanoparticles for use in infected field hernia repair
Immunologic Effect of PRP on Synthetic and Non-Synthetic Mesh · 2015 - 2019 Primary Investigator · DSM Biomedical · $60,000.00 Defining the mechanisms of platelet rich plasma on the innate immune response to acellular dermal matrices in ventral hernia repair
Controlled Release of Nitric Oxide and Paclitaxel via Nanomaterial Functionalized Arteriovenous Hemodialysis Graft for Reduction of Venous Intimal Hyperplasia · 2014 - 2016 Primary Investigator · The Chairs’ Seed Grant Awards in Cardiovascular Sciences- Houston Methodist Hospital · $25,000.00 Development of films capable of sustained nitric oxide release for the prevention of neointimal hyperplasia and stenosis following arteriovenous fistula formation
Biomimetic Proteo-Lipid Nanovesicles Protect Against Septic Leukocyte-Endothelial Dysfunction · 2019 - 2020 Primary Investigator · Surgical Infection Society · $35,000.00 Use of proteolipid nanovescicles derived from leukocytes for protection of host from leukocyte-endothelial dysfunction in sepsis

External Relationships


  • Chorus Cardiothoracic Technologies, LLC
  • GuidSET

This faculty member (or a member of their immediate family) has reported outside activities with the companies, institutions, or organizations listed above. This information is available to institutional leadership and, when appropriate, management plans are in place to address potential conflicts of interest.