Journal ArticleJ Surg Res · August 22, 2024
INTRODUCTION: Surgical stabilization of rib fractures (SSRF) has been associated with lower rates of mortality and fewer respiratory complications. This study sought to evaluate the association between SSRF timing and patient outcomes. METHODS: This retros ...
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Journal ArticleJ Surg Res · August 16, 2024
INTRODUCTION: Surgical stabilization of rib fractures (SSRF) is associated with lower rates of mortality and fewer complications. This study evaluates whether the decision to undergo SSRF is associated with age, race, ethnicity, and insurance status and as ...
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Journal ArticleJ Surg Res · June 27, 2024
INTRODUCTION: Firearm-related suicides among children present a significant public health concern and a tragic loss of young lives. This study explores the relationship between firearm-related suicides, gun ownership, and state-specific gun laws. METHODS: ...
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Journal ArticleEur J Trauma Emerg Surg · June 2024
PURPOSE: The inability to achieve primary fascial closure (PFC) after emergency laparotomy increases the rates of adverse outcomes including fistula formation, incisional hernia, and intraabdominal infection. Hypertonic saline (HTS) infusion improves early ...
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Journal ArticleClin Nutr ESPEN · April 2024
BACKGROUND AND AIMS: Currently, 40 million Americans are food insecure. They are forced to skip meals and buy non-nutritious food, leading to health disparities for those of low socioeconomic status. This study aims to investigate relationships between mal ...
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Chapter · October 30, 2023
Mesenchymal stem cells (MSCs) are multipotent stems cells that self-renew and differentiate into specialized cells such as chondrocytes (cartilage cells), osteoblasts (bone cells), and adipocytes (fat cells). MSCs can be isolated from various tissues throu ...
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Journal ArticleJ Am Coll Surg · September 1, 2023
BACKGROUND: Studying firearm-related mortality is important to reduce preventable firearm death in the US. This study aims to determine the relationship between firearm laws and assault death with firearms. STUDY DESIGN: This ecologic study used public dat ...
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Journal ArticleJ Spine Surg · June 30, 2023
BACKGROUND: Enterothecal fistulas are pathological connections between the gastrointestinal system and subarachnoid space. These rare fistulas occur mostly in pediatric patients with sacral developmental anomalies. They have yet to be characterized in an a ...
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Journal ArticleSurg Infect (Larchmt) · April 2023
The use of medical implants continues to grow as the population ages. Biofilm-related implant infection is the leading cause of medical implant failure and remains difficult to diagnose and treat. Recent technologies have enhanced our understanding of the ...
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Journal ArticleJ Am Coll Surg · January 1, 2023
BACKGROUND: There were 23,854 suicides by firearms in 2017 in the US, accounting for 60% of all gun deaths. Studying firearm-related mortalities is vital for reducing preventable gun deaths. This study aims to determine the association between state-level ...
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Chapter · January 1, 2023
Axillary artery injuries are uncommon. At times they are defined as axillo-subclavian injuries. Anatomy is complex. Exposure requires transecting the pectoralis minor tendon. They have associated brachial plexus injuries. ...
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Chapter · January 1, 2023
Carotid arterial injuries are the most difficult and certainly the most immediate life-threatening injuries found in penetrating neck trauma. Their propensity to bleed actively and potentially occlude the airway makes surgical intervention very challenging ...
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Chapter · January 1, 2023
Subclavian vessel injuries are uncommon and quite difficult to approach and manage. Most are due to penetrating injuries and require rapid surgical interventions, as they usually present in shock with exsanguinating hemorrhage. Their surgical exposure usua ...
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Chapter · January 1, 2023
These are among the most common vascular injuries seen in an urban trauma center. They are sometimes associated with median and ulnar nerve injuries. This vessel is much more amenable to surgical exposure. Injuries may require dissection below the elbow. T ...
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Journal ArticleJ Surg Res · August 22, 2024
INTRODUCTION: Surgical stabilization of rib fractures (SSRF) has been associated with lower rates of mortality and fewer respiratory complications. This study sought to evaluate the association between SSRF timing and patient outcomes. METHODS: This retros ...
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Journal ArticleJ Surg Res · August 16, 2024
INTRODUCTION: Surgical stabilization of rib fractures (SSRF) is associated with lower rates of mortality and fewer complications. This study evaluates whether the decision to undergo SSRF is associated with age, race, ethnicity, and insurance status and as ...
Full textLink to itemCite
Journal ArticleJ Surg Res · June 27, 2024
INTRODUCTION: Firearm-related suicides among children present a significant public health concern and a tragic loss of young lives. This study explores the relationship between firearm-related suicides, gun ownership, and state-specific gun laws. METHODS: ...
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Journal ArticleEur J Trauma Emerg Surg · June 2024
PURPOSE: The inability to achieve primary fascial closure (PFC) after emergency laparotomy increases the rates of adverse outcomes including fistula formation, incisional hernia, and intraabdominal infection. Hypertonic saline (HTS) infusion improves early ...
Full textLink to itemCite
Journal ArticleClin Nutr ESPEN · April 2024
BACKGROUND AND AIMS: Currently, 40 million Americans are food insecure. They are forced to skip meals and buy non-nutritious food, leading to health disparities for those of low socioeconomic status. This study aims to investigate relationships between mal ...
Full textLink to itemCite
Chapter · October 30, 2023
Mesenchymal stem cells (MSCs) are multipotent stems cells that self-renew and differentiate into specialized cells such as chondrocytes (cartilage cells), osteoblasts (bone cells), and adipocytes (fat cells). MSCs can be isolated from various tissues throu ...
Cite
Journal ArticleJ Am Coll Surg · September 1, 2023
BACKGROUND: Studying firearm-related mortality is important to reduce preventable firearm death in the US. This study aims to determine the relationship between firearm laws and assault death with firearms. STUDY DESIGN: This ecologic study used public dat ...
Full textLink to itemCite
Journal ArticleJ Spine Surg · June 30, 2023
BACKGROUND: Enterothecal fistulas are pathological connections between the gastrointestinal system and subarachnoid space. These rare fistulas occur mostly in pediatric patients with sacral developmental anomalies. They have yet to be characterized in an a ...
Full textLink to itemCite
Journal ArticleSurg Infect (Larchmt) · April 2023
The use of medical implants continues to grow as the population ages. Biofilm-related implant infection is the leading cause of medical implant failure and remains difficult to diagnose and treat. Recent technologies have enhanced our understanding of the ...
Full textLink to itemCite
Journal ArticleJ Am Coll Surg · January 1, 2023
BACKGROUND: There were 23,854 suicides by firearms in 2017 in the US, accounting for 60% of all gun deaths. Studying firearm-related mortalities is vital for reducing preventable gun deaths. This study aims to determine the association between state-level ...
Full textLink to itemCite
Chapter · January 1, 2023
Axillary artery injuries are uncommon. At times they are defined as axillo-subclavian injuries. Anatomy is complex. Exposure requires transecting the pectoralis minor tendon. They have associated brachial plexus injuries. ...
Full textCite
Chapter · January 1, 2023
Carotid arterial injuries are the most difficult and certainly the most immediate life-threatening injuries found in penetrating neck trauma. Their propensity to bleed actively and potentially occlude the airway makes surgical intervention very challenging ...
Full textCite
Chapter · January 1, 2023
Subclavian vessel injuries are uncommon and quite difficult to approach and manage. Most are due to penetrating injuries and require rapid surgical interventions, as they usually present in shock with exsanguinating hemorrhage. Their surgical exposure usua ...
Full textCite
Chapter · January 1, 2023
These are among the most common vascular injuries seen in an urban trauma center. They are sometimes associated with median and ulnar nerve injuries. This vessel is much more amenable to surgical exposure. Injuries may require dissection below the elbow. T ...
Full textCite
Journal ArticleEur J Trauma Emerg Surg · June 2022
BACKGROUND: The management of complicated ventral hernias (CVH), namely ventral hernias in actively or recently infected/contaminated operative fields, and open abdomens in which the native fascia cannot be primarily reapproximated, pose a surgical challen ...
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Journal ArticleAm Surg · February 2022
INTRODUCTION: Timing to start of chemoprophylaxis for venous thromboembolism (VTE) in patients with traumatic brain injury (TBI) remains controversial. We hypothesize that early administration is not associated with increased intracranial hemorrhage. METHO ...
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Chapter · January 1, 2022
Thoracoabdominal and transmediastinal injuries represent some of the most challenging injuries facing trauma surgeons. The diagnostic challenge of multiple body cavity injuries, the notorious difficulty of establishing the proper sequence for intervention, ...
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Journal ArticleJ Tissue Eng Regen Med · December 2021
Ventral hernia repair (VHR) with acellular dermal matrix (ADM) has high rates of recurrence that may be improved with allogeneic growth factor augmentation such as amniotic fluid allograft (AFA). We hypothesized that AFA would modulate the host response to ...
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Journal ArticleSurg Infect (Larchmt) · November 2021
Background: Infected hernia mesh is a cause of post-operative morbidity. Nitric oxide (NO) plays a key role in the endogenous immune response to infection. We sought to study the efficacy of a NO-releasing mesh against methicillin-resistant Staphylococcus ...
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Journal ArticleJ Tissue Eng Regen Med · November 2021
Platelet rich plasma (PRP) has been shown to improve incorporation and reduce inflammation in ventral hernia repair (VHR) with acellular dermal matrix (ADM). The concentration of platelets in PRP varies in clinical studies and an ideal concentration has ye ...
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Journal ArticleJ Tissue Eng Regen Med · July 2021
Incisional hernia is a common complication of hernia repair despite the development of various synthetic and bio-synthetic repair materials. Poor long-term mechanical strength, leading to high recurrence rates, has limited the use of acellular dermal matri ...
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Journal ArticleSurg Infect (Larchmt) · March 2021
Background: Surgical site infections (SSIs) increase mortality and the economic burden associated with emergency surgery (ES). A reliable and sensitive scoring system to predict SSIs can help guide clinician assessment and patient counseling of post-operat ...
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Journal ArticleAnn Thorac Surg · February 2021
Thoracic skeletal injury is a common outcome of motor vehicle accidents. Skeletal reconstruction is guided by anatomic and physiologic variables dictated by the injury complex. Here we describe a report of a patient who sustained complex trauma to the thor ...
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Journal ArticleJ Tissue Eng Regen Med · January 2021
The recurrence of ventral hernias continues to be a problem faced by surgeons, in spite of efforts toward implementing novel repair techniques and utilizing different materials to promote healing. Cadaveric acellular dermal matrices (Alloderm) have shown s ...
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Journal ArticleGeriatr Orthop Surg Rehabil · 2021
After-hours surgery represents a novel solution that can effectively combat surgical fatigue of care teams in addition to addressing the high volume of surgical backlog associated with the repercussions of the COVID-19 pandemic. This commentary seeks to ra ...
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Journal ArticleFront Bioeng Biotechnol · 2021
Remodeling of the human bony skeleton is constantly occurring with up to 10% annual bone volume turnover from osteoclastic and osteoblastic activity. A shift toward resorption can result in osteoporosis and pathologic fractures, while a shift toward deposi ...
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Journal ArticleWorld J Stem Cells · November 26, 2020
The potential clinical and economic impact of mesenchymal stem cell (MSC) therapy is immense. MSCs act through multiple pathways: (1) as "trophic" cells, secreting various factors that are immunomodulatory, anti-inflammatory, anti-apoptotic, proangiogenic, ...
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Journal ArticlePharmaceutics · February 1, 2020
Bone morphogenetic protein-2 (BMP-2) has been demonstrated to be one of the most vital osteogenic factors for bone augmentation. However, its uncontrolled administration has been associated with catastrophic side effects, which compromised its clinical use ...
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Journal ArticleJAMA Surg · January 1, 2020
IMPORTANCE: The outcomes of firearm injuries in the United States are devastating. Although firearm mortality and costs have been investigated, the long-term outcomes after surviving a gunshot wound (GSW) remain unstudied. OBJECTIVE: To determine the long- ...
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Journal ArticleMethodsX · 2020
The animal model of infection following ventral hernia repair (VHR) has previously been utilized in exploring treatments and innovative therapies, such as implantation of biologic mesh imbedded with various anti-bacterial properties. The rat model has been ...
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Journal ArticleFront Bioeng Biotechnol · 2020
Achieving bone fracture union after trauma represents a major challenge for the orthopedic surgeon. Fracture non-healing has a multifactorial etiology and there are many risk factors for non-fusion. Environmental factors such as wound contamination, infect ...
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Journal ArticleSurg Endosc · September 2019
BACKGROUND: Complications of ventral hernia repair (VHR) may be investigated by computed tomography or ultrasound (US) but neither modality gives a quantifiable metric of repair quality short of identifying hernia recurrence. Platelet-rich plasma (PRP), a ...
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Journal ArticleSurg Infect (Larchmt) · April 2019
Prosthetic contamination and biofilm formation continue to plague implanted materials. With increasing resistance to traditional antibiotic regimens, alternative approaches to preventing bacterial adhesion and biofilm formation have focused on the physioch ...
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Journal ArticleMater Today Bio · March 2019
Synthetic osteoinductive materials that mimic the human osteogenic niche have emerged as ideal candidates to address this area of unmet clinical need. In this study, we evaluated the osteoinductive potential in a rabbit orthotopic model of a magnesium-dope ...
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Journal ArticleBiomed Microdevices · February 21, 2019
Gemcitabine (GEM) is the first-line treatment for pancreatic adenocarcinoma (PAC) yet chemoresistance is common. Nitric oxide (NO) is the predominant species responsible for the cytotoxic action of macrophages against cancer cells yet localized delivery is ...
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Journal ArticleJ Trauma Acute Care Surg · January 2019
Medical emergency response teams (MERTs) are widespread throughout inpatient hospital care facilities. Besides the rise of the ubiquitous rapid response team, current MERTs span trauma, stroke, myocardial infarction, and sepsis in many hospitals. Given the ...
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Chapter · January 1, 2019
Endocrine emergencies are frequently encountered in the intensive care unit. This chapter will focus on several common disorders including diabetic ketoacidosis, hyperosmolar hyperglycemia, thyroid storm, myxedema coma, and vasopressin deficiency. Adrenal ...
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Journal ArticleBioconjug Chem · July 18, 2018
With the development of new biologics and bioconjugates, storage and preservation have become more critical than ever before. Lyophilization is a method of cell and protein preservation by removing a solvent such as water from a substance followed by freez ...
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Journal ArticleSAGE Open Medicine · March 9, 2018
Intervertebral disc degeneration is a disease of the discs connecting adjoining vertebrae in which structural damage leads to loss of disc integrity. Degeneration of the disc can be a normal process of ageing, but can also be precipitated by other factors. ...
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Journal ArticleNanomedicine (Lond) · June 2017
Infections following orthopedic device implantations often impose a substantial health burden and result in high medical costs. Currently, preventative methods are often employed following an orthopedic implant to reduce risk of infection; however, contami ...
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Journal ArticleJ Surg Res · April 2017
BACKGROUND: To assess the integrity of hernia repair, imaging modalities such as computed tomography or ultrasound (US) are commonly used. Neither modality has currently the capacity to simultaneously image the mesh and quantify a prosthetic and surroundin ...
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Journal ArticleSurg Endosc · February 2017
BACKGROUND: Surgical energy has been widely implemented because of ease of use, effective hemostasis, and surgical dissection. Studies demonstrate its use to be an independent risk factor for postoperative wound infection. Methicillin-resistant Staphylococ ...
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Journal ArticleInt J Surg Case Rep · 2017
INTRODUCTION: Deep vein thrombosis (DVT) continues to be a significant source of morbidity for surgical patients. Placement of a retrievable inferior vena cava (IVC) filter is used when patients have contraindications to anticoagulation or recurrent pulmon ...
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Journal ArticleInt J Surg Case Rep · 2017
INTRODUCTION: A de Garengeot hernia, a femoral hernia containing the appendix, is a difficult diagnosis often made intra-operatively when the hernia sac is opened. It is a rare finding, and complications are more frequent with a de Garengeot hernia. PRESEN ...
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Journal ArticleJ Surg Res · January 2017
Platelets are small anucleate cytoplasmic cell bodies released by megakaryocytes in response to various physiologic triggers. Traditionally thought to be solely involved in the mechanisms of hemostasis, platelets have gained much attention due to their inv ...
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Journal ArticleWound Repair Regen · January 2017
The degree of cross-linking within acellular dermal matrices (ADM) seems to correlate to neovascularization when used in ventral hernia repair (VHR). Platelet-rich plasma (PRP) enhances wound healing through several mechanisms including neovascularization, ...
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Journal ArticleSurg Endosc · August 2016
BACKGROUND: Recurrence after ventral hernia repair (VHR) remains a multifactorial problem still plaguing surgeons today. Some of the many contributing factors include mechanical strain, poor tissue-mesh integration, and degradation of matrices. The high re ...
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Journal ArticleJ Tissue Eng · 2016
Surgical wound healing applications require bioprosthetics that promote cellular infiltration and vessel formation, metrics associated with increased mechanical strength and resistance to infection. Porcine acellular lung matrix is a novel tissue scaffold ...
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Journal ArticleFront Bioeng Biotechnol · 2016
The evolution of medicine and medical technology hinges on the successful translation of basic science research from the bench to clinical implementation at the bedside. Out of the increasing need to facilitate the transfer of scientific knowledge to patie ...
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Journal ArticleInt J Surg Case Rep · 2016
INTRODUCTION: Appendicitis is a common surgical pathology with many clinical presentations. Diagnosis can be challenging if there is an alteration to the normal position of anatomical structures and their relationships. CASE PRESENTATION: In this case, we ...
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Journal ArticleJ Surg Res · December 2015
BACKGROUND: High recurrence rates because of poor tissue incorporation limit the use of acellular dermal matrices (ADMs) in ventral hernia repair (VHR). Platelet rich plasma (PRP) is a growth factor-rich autologous blood product known to enhance tissue rep ...
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Journal ArticleEur Spine J · November 2015
PURPOSE: Some patients will experience post-operative back pain following lumbar discectomy, and the potential sources for that pain are poorly understood. One potential source is the vertebral endplates. The goal of this study was to document the changes ...
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Journal ArticleStem Cell Res Ther · October 26, 2015
INTRODUCTION: Mesenchymal stem cells (MSCs) hold great promise for regenerative therapies in the musculoskeletal system. Although MSCs from bone marrow (BM-MSCs) and adipose tissue (AD-MSCs) have been extensively characterized, there is still debate as to ...
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Chapter · January 1, 2015
Soft tissue or 'whiplash' injuries following trauma, particularly motor vehicle accidents, are common. Estimated yearly incidence of whiplash injuries exceeds 1 million [1]. The impact of whiplash injuries extends beyond that of a short-lived soft tissue i ...
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Chapter · January 1, 2014
The human genome was once thought to be a redundant sequence containing few functional regions coding for proteins. This teaching is being rewritten as we continue to understand the vast complexity of the noncoding regions of the genetic code. These region ...
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Chapter · January 1, 2014
Advances in biomedical engineering have paved the way for medical innovation and expansion. Many diseases now have hope of a cure through technology brought to reality by the vision and creativity of basic researchers, translational scientists, and doctors ...
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Chapter · December 1, 2013
In this chapter, an attempt is made to highlight the differences between evolutionaryand revolutionary hypotheses. Most hypotheses about etiology or novel therapies areevolutionary in nature and advance the field of medicine incrementally. Revolutionaryhyp ...
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Chapter · December 1, 2013
The costs of healthcare have risen dramatically over the past several decades. In the United States, for instance, it is estimated that costs this year will exceed $28 Billion. Additionally the proportion of a family's income dedicated to healthcare costs ...
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Journal ArticleAdv Healthc Mater · May 2013
This manuscript constitutes a review of several innovative biomedical technologies fabricated using the precision and accuracy of silicon micro- and nanofabrication. The technologies to be reviewed are subcutaneous nanochannel drug delivery implants for th ...
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Journal ArticleAviat Space Environ Med · November 2012
One purpose of the International Space Station (ISS) is to explore powerful new areas of biomedical science in microgravity. Recent advances in nanotechnology applied to medicine--what we now refer to as nano-medicine--and regenerative medicine have enormo ...
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Journal ArticleMethodist Debakey Cardiovasc J · 2011
The biology of aortic aneurysm and dissection has evolved to where we now understand the genetic implications of changes in extracellular matrix proteins, smooth muscle cells, and growth factors and how they affect aortic wall homeostasis. These predetermi ...
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Journal ArticleVascul Pharmacol · October 2006
Breast cancer (BC) remains the cancer with highest mortality among women in the United States. Entry of BC cells (BCCs) in bone marrow (BM) leads to poor prognosis. This review discusses studies showing interactions between BCCs and BM stroma, consequently ...
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