Scholars@Duke
Joseph Fernandez-Moure

Joseph Fernandez-Moure

Associate Professor of Surgery
Trauma, Acute, and Critical Care Surgery
joseph.fernandezmoure@duke.edu
DUMC 2837, Durham, NC 27710
DUMC 2837, Durham, NC 27710
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Selected Publications

Platelet-rich plasma enhances rib fracture strength and callus formation in vivo.

Journal Article J Trauma Acute Care Surg · September 6, 2024 BACKGROUND: Rib fractures are a common traumatic injury affecting more than 350,000 patients a year. Early stabilization has shown to be effective in reducing pulmonary complications. Platelet-rich plasma (PRP) is a growth factor-rich blood product known t ... Full text Link to item Cite

Firearm Ownership: A Key Factor to Consider in Firearm Suicide Deaths in Children, Despite State Gun Laws.

Journal Article J Surg Res · September 2024 INTRODUCTION: Firearm-related suicides among children present a significant public health concern and a tragic loss of young lives. This study explores the relationship between firearm-related suicides, gun ownership, and state-specific gun laws. METHODS: ... Full text Link to item Cite

The Earlier the Better: Surgical Stabilization of Rib Fractures Associated With Improved Outcomes.

Journal Article J Surg Res · August 22, 2024 INTRODUCTION: Surgical stabilization of rib fractures (SSRF) has been associated with lower rates of mortality and fewer respiratory complications. This study sought to evaluate the association between SSRF timing and patient outcomes. METHODS: This retros ... Full text Link to item Cite

Age-Neutral Surgical Stabilization of Rib Fractures: Breaking the Ageism Barrier.

Journal Article J Surg Res · August 16, 2024 INTRODUCTION: Surgical stabilization of rib fractures (SSRF) is associated with lower rates of mortality and fewer complications. This study evaluates whether the decision to undergo SSRF is associated with age, race, ethnicity, and insurance status and as ... Full text Link to item Cite

The impact of hypertonic saline on damage control laparotomy after penetrating abdominal trauma.

Journal Article Eur J Trauma Emerg Surg · June 2024 PURPOSE: The inability to achieve primary fascial closure (PFC) after emergency laparotomy increases the rates of adverse outcomes including fistula formation, incisional hernia, and intraabdominal infection. Hypertonic saline (HTS) infusion improves early ... Full text Link to item Cite

Racial and ethnic demographics in malnutrition related deaths.

Journal Article Clin Nutr ESPEN · April 2024 BACKGROUND AND AIMS: Currently, 40 million Americans are food insecure. They are forced to skip meals and buy non-nutritious food, leading to health disparities for those of low socioeconomic status. This study aims to investigate relationships between mal ... Full text Link to item Cite

The impact of hypertonic saline on damage control laparotomy after penetrating abdominal trauma

Journal Article EUROPEAN JOURNAL OF TRAUMA AND EMERGENCY SURGERY · 2024 Full text Cite

Isolating compact bone-derived mesenchymal stem cells from rodent and rabbit femurs

Chapter · October 30, 2023 Mesenchymal stem cells (MSCs) are multipotent stems cells that self-renew and differentiate into specialized cells such as chondrocytes (cartilage cells), osteoblasts (bone cells), and adipocytes (fat cells). MSCs can be isolated from various tissues throu ... Cite

State Firearm Laws and Rate of Assault-Related Firearm Death.

Journal Article J Am Coll Surg · September 1, 2023 BACKGROUND: Studying firearm-related mortality is important to reduce preventable firearm death in the US. This study aims to determine the relationship between firearm laws and assault death with firearms. STUDY DESIGN: This ecologic study used public dat ... Full text Link to item Cite

Enterothecal fistula as a rare cause of adult pneumocephalus and meningitis: a case report.

Journal Article J Spine Surg · June 30, 2023 BACKGROUND: Enterothecal fistulas are pathological connections between the gastrointestinal system and subarachnoid space. These rare fistulas occur mostly in pediatric patients with sacral developmental anomalies. They have yet to be characterized in an a ... Full text Link to item Cite

Role of Resident Microbial Communities in Biofilm-Related Implant Infections: Recent Insights and Implications.

Journal Article Surg Infect (Larchmt) · April 2023 The use of medical implants continues to grow as the population ages. Biofilm-related implant infection is the leading cause of medical implant failure and remains difficult to diagnose and treat. Recent technologies have enhanced our understanding of the ... Full text Link to item Cite

Restrictive Firearm Laws and Firearm-Related Suicide.

Journal Article J Am Coll Surg · January 1, 2023 BACKGROUND: There were 23,854 suicides by firearms in 2017 in the US, accounting for 60% of all gun deaths. Studying firearm-related mortalities is vital for reducing preventable gun deaths. This study aims to determine the association between state-level ... Full text Link to item Cite

Operative exposure and management of axillary vessel injuries

Chapter · January 1, 2023 Axillary artery injuries are uncommon. At times they are defined as axillo-subclavian injuries. Anatomy is complex. Exposure requires transecting the pectoralis minor tendon. They have associated brachial plexus injuries. ... Full text Cite

Penetrating carotid artery injuries

Chapter · January 1, 2023 Carotid arterial injuries are the most difficult and certainly the most immediate life-threatening injuries found in penetrating neck trauma. Their propensity to bleed actively and potentially occlude the airway makes surgical intervention very challenging ... Full text Cite

Subclavian vessel injuries: Difficult anatomy and difficult territory

Chapter · January 1, 2023 Subclavian vessel injuries are uncommon and quite difficult to approach and manage. Most are due to penetrating injuries and require rapid surgical interventions, as they usually present in shock with exsanguinating hemorrhage. Their surgical exposure usua ... Full text Cite

Brachial vessel injuries: High morbidity and low mortality injuries

Chapter · January 1, 2023 These are among the most common vascular injuries seen in an urban trauma center. They are sometimes associated with median and ulnar nerve injuries. This vessel is much more amenable to surgical exposure. Injuries may require dissection below the elbow. T ... Full text Cite

Exercise Attenuates Septic Inflammatory Response in Murine Model

Conference JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS · 2023 Cite

Exercise Attenuates Septic Inflammatory Response in Murine Model

Conference JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS · 2023 Cite

Restrictive Firearm Laws Are Associated with Decreased Firearm-Related Suicides

Conference Journal of the American College of Surgeons · November 2022 Full text Cite

Platelet-rich plasma enhances rib fracture strength and callus formation in vivo.

Journal Article J Trauma Acute Care Surg · September 6, 2024 BACKGROUND: Rib fractures are a common traumatic injury affecting more than 350,000 patients a year. Early stabilization has shown to be effective in reducing pulmonary complications. Platelet-rich plasma (PRP) is a growth factor-rich blood product known t ... Full text Link to item Cite

Firearm Ownership: A Key Factor to Consider in Firearm Suicide Deaths in Children, Despite State Gun Laws.

Journal Article J Surg Res · September 2024 INTRODUCTION: Firearm-related suicides among children present a significant public health concern and a tragic loss of young lives. This study explores the relationship between firearm-related suicides, gun ownership, and state-specific gun laws. METHODS: ... Full text Link to item Cite

The Earlier the Better: Surgical Stabilization of Rib Fractures Associated With Improved Outcomes.

Journal Article J Surg Res · August 22, 2024 INTRODUCTION: Surgical stabilization of rib fractures (SSRF) has been associated with lower rates of mortality and fewer respiratory complications. This study sought to evaluate the association between SSRF timing and patient outcomes. METHODS: This retros ... Full text Link to item Cite

Age-Neutral Surgical Stabilization of Rib Fractures: Breaking the Ageism Barrier.

Journal Article J Surg Res · August 16, 2024 INTRODUCTION: Surgical stabilization of rib fractures (SSRF) is associated with lower rates of mortality and fewer complications. This study evaluates whether the decision to undergo SSRF is associated with age, race, ethnicity, and insurance status and as ... Full text Link to item Cite

The impact of hypertonic saline on damage control laparotomy after penetrating abdominal trauma.

Journal Article Eur J Trauma Emerg Surg · June 2024 PURPOSE: The inability to achieve primary fascial closure (PFC) after emergency laparotomy increases the rates of adverse outcomes including fistula formation, incisional hernia, and intraabdominal infection. Hypertonic saline (HTS) infusion improves early ... Full text Link to item Cite

Racial and ethnic demographics in malnutrition related deaths.

Journal Article Clin Nutr ESPEN · April 2024 BACKGROUND AND AIMS: Currently, 40 million Americans are food insecure. They are forced to skip meals and buy non-nutritious food, leading to health disparities for those of low socioeconomic status. This study aims to investigate relationships between mal ... Full text Link to item Cite

The impact of hypertonic saline on damage control laparotomy after penetrating abdominal trauma

Journal Article EUROPEAN JOURNAL OF TRAUMA AND EMERGENCY SURGERY · 2024 Full text Cite

Isolating compact bone-derived mesenchymal stem cells from rodent and rabbit femurs

Chapter · October 30, 2023 Mesenchymal stem cells (MSCs) are multipotent stems cells that self-renew and differentiate into specialized cells such as chondrocytes (cartilage cells), osteoblasts (bone cells), and adipocytes (fat cells). MSCs can be isolated from various tissues throu ... Cite

State Firearm Laws and Rate of Assault-Related Firearm Death.

Journal Article J Am Coll Surg · September 1, 2023 BACKGROUND: Studying firearm-related mortality is important to reduce preventable firearm death in the US. This study aims to determine the relationship between firearm laws and assault death with firearms. STUDY DESIGN: This ecologic study used public dat ... Full text Link to item Cite

Enterothecal fistula as a rare cause of adult pneumocephalus and meningitis: a case report.

Journal Article J Spine Surg · June 30, 2023 BACKGROUND: Enterothecal fistulas are pathological connections between the gastrointestinal system and subarachnoid space. These rare fistulas occur mostly in pediatric patients with sacral developmental anomalies. They have yet to be characterized in an a ... Full text Link to item Cite

Role of Resident Microbial Communities in Biofilm-Related Implant Infections: Recent Insights and Implications.

Journal Article Surg Infect (Larchmt) · April 2023 The use of medical implants continues to grow as the population ages. Biofilm-related implant infection is the leading cause of medical implant failure and remains difficult to diagnose and treat. Recent technologies have enhanced our understanding of the ... Full text Link to item Cite

Restrictive Firearm Laws and Firearm-Related Suicide.

Journal Article J Am Coll Surg · January 1, 2023 BACKGROUND: There were 23,854 suicides by firearms in 2017 in the US, accounting for 60% of all gun deaths. Studying firearm-related mortalities is vital for reducing preventable gun deaths. This study aims to determine the association between state-level ... Full text Link to item Cite

Operative exposure and management of axillary vessel injuries

Chapter · January 1, 2023 Axillary artery injuries are uncommon. At times they are defined as axillo-subclavian injuries. Anatomy is complex. Exposure requires transecting the pectoralis minor tendon. They have associated brachial plexus injuries. ... Full text Cite

Penetrating carotid artery injuries

Chapter · January 1, 2023 Carotid arterial injuries are the most difficult and certainly the most immediate life-threatening injuries found in penetrating neck trauma. Their propensity to bleed actively and potentially occlude the airway makes surgical intervention very challenging ... Full text Cite

Subclavian vessel injuries: Difficult anatomy and difficult territory

Chapter · January 1, 2023 Subclavian vessel injuries are uncommon and quite difficult to approach and manage. Most are due to penetrating injuries and require rapid surgical interventions, as they usually present in shock with exsanguinating hemorrhage. Their surgical exposure usua ... Full text Cite

Brachial vessel injuries: High morbidity and low mortality injuries

Chapter · January 1, 2023 These are among the most common vascular injuries seen in an urban trauma center. They are sometimes associated with median and ulnar nerve injuries. This vessel is much more amenable to surgical exposure. Injuries may require dissection below the elbow. T ... Full text Cite

Exercise Attenuates Septic Inflammatory Response in Murine Model

Conference JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS · 2023 Cite

Exercise Attenuates Septic Inflammatory Response in Murine Model

Conference JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS · 2023 Cite

Restrictive Firearm Laws Are Associated with Decreased Firearm-Related Suicides

Conference Journal of the American College of Surgeons · November 2022 Full text Cite

Bovine versus porcine acellular dermal matrix for abdominal wall herniorrhaphy or bridging.

Journal Article Eur J Trauma Emerg Surg · June 2022 BACKGROUND: The management of complicated ventral hernias (CVH), namely ventral hernias in actively or recently infected/contaminated operative fields, and open abdomens in which the native fascia cannot be primarily reapproximated, pose a surgical challen ... Full text Link to item Cite

Early Chemoprophylaxis Against Venous Thromboembolism in Patients With Traumatic Brain Injury.

Journal Article Am Surg · February 2022 INTRODUCTION: Timing to start of chemoprophylaxis for venous thromboembolism (VTE) in patients with traumatic brain injury (TBI) remains controversial. We hypothesize that early administration is not associated with increased intracranial hemorrhage. METHO ... Full text Link to item Cite

Transmediastinal and Thoracoabdominal Injuries: Damage Control and Surgical Techniques for Their Management

Chapter · January 1, 2022 Thoracoabdominal and transmediastinal injuries represent some of the most challenging injuries facing trauma surgeons. The diagnostic challenge of multiple body cavity injuries, the notorious difficulty of establishing the proper sequence for intervention, ... Full text Cite

Amniotic fluid allograft enhances the host response to ventral hernia repair using acellular dermal matrix.

Journal Article J Tissue Eng Regen Med · December 2021 Ventral hernia repair (VHR) with acellular dermal matrix (ADM) has high rates of recurrence that may be improved with allogeneic growth factor augmentation such as amniotic fluid allograft (AFA). We hypothesized that AFA would modulate the host response to ... Full text Link to item Cite

Polyester Mesh Functionalization with Nitric Oxide-Releasing Silica Nanoparticles Reduces Early Methicillin-Resistant Staphylococcus aureus Contamination.

Journal Article Surg Infect (Larchmt) · November 2021 Background: Infected hernia mesh is a cause of post-operative morbidity. Nitric oxide (NO) plays a key role in the endogenous immune response to infection. We sought to study the efficacy of a NO-releasing mesh against methicillin-resistant Staphylococcus ... Full text Link to item Cite

Platelet rich plasma concentration improves biologic mesh incorporation and decreases multinucleated giant cells in a dose dependent fashion.

Journal Article J Tissue Eng Regen Med · November 2021 Platelet rich plasma (PRP) has been shown to improve incorporation and reduce inflammation in ventral hernia repair (VHR) with acellular dermal matrix (ADM). The concentration of platelets in PRP varies in clinical studies and an ideal concentration has ye ... Full text Link to item Cite

Platelet-rich plasma enhances mechanical strength of strattice in rat model of ventral hernia repair.

Journal Article J Tissue Eng Regen Med · July 2021 Incisional hernia is a common complication of hernia repair despite the development of various synthetic and bio-synthetic repair materials. Poor long-term mechanical strength, leading to high recurrence rates, has limited the use of acellular dermal matri ... Full text Link to item Cite

Actionable Risk Model for the Development of Surgical Site Infection after Emergency Surgery.

Journal Article Surg Infect (Larchmt) · March 2021 Background: Surgical site infections (SSIs) increase mortality and the economic burden associated with emergency surgery (ES). A reliable and sensitive scoring system to predict SSIs can help guide clinician assessment and patient counseling of post-operat ... Full text Link to item Cite

Four Columns of the Thorax: Operative Decision-Making in the Setting of Complete Bony Instability.

Journal Article Ann Thorac Surg · February 2021 Thoracic skeletal injury is a common outcome of motor vehicle accidents. Skeletal reconstruction is guided by anatomic and physiologic variables dictated by the injury complex. Here we describe a report of a patient who sustained complex trauma to the thor ... Full text Link to item Cite

Addition of platelet-rich plasma supports immune modulation and improved mechanical integrity in Alloderm mesh for ventral hernia repair in a rat model.

Journal Article J Tissue Eng Regen Med · January 2021 The recurrence of ventral hernias continues to be a problem faced by surgeons, in spite of efforts toward implementing novel repair techniques and utilizing different materials to promote healing. Cadaveric acellular dermal matrices (Alloderm) have shown s ... Full text Link to item Cite

A Solution to After-Hours Fatigue and Surgical Backlog.

Journal Article Geriatr Orthop Surg Rehabil · 2021 After-hours surgery represents a novel solution that can effectively combat surgical fatigue of care teams in addition to addressing the high volume of surgical backlog associated with the repercussions of the COVID-19 pandemic. This commentary seeks to ra ... Full text Open Access Link to item Cite

Improved Posterolateral Lumbar Spinal Fusion Using a Biomimetic, Nanocomposite Scaffold Augmented by Autologous Platelet-Rich Plasma.

Journal Article Front Bioeng Biotechnol · 2021 Remodeling of the human bony skeleton is constantly occurring with up to 10% annual bone volume turnover from osteoclastic and osteoblastic activity. A shift toward resorption can result in osteoporosis and pathologic fractures, while a shift toward deposi ... Full text Open Access Link to item Cite

Isolation and characterization of mesenchymal stem cells in orthopaedics and the emergence of compact bone mesenchymal stem cells as a promising surgical adjunct.

Journal Article World J Stem Cells · November 26, 2020 The potential clinical and economic impact of mesenchymal stem cell (MSC) therapy is immense. MSCs act through multiple pathways: (1) as "trophic" cells, secreting various factors that are immunomodulatory, anti-inflammatory, anti-apoptotic, proangiogenic, ... Full text Open Access Link to item Cite

Biocompatible PLGA-Mesoporous Silicon Microspheres for the Controlled Release of BMP-2 for Bone Augmentation.

Journal Article Pharmaceutics · February 1, 2020 Bone morphogenetic protein-2 (BMP-2) has been demonstrated to be one of the most vital osteogenic factors for bone augmentation. However, its uncontrolled administration has been associated with catastrophic side effects, which compromised its clinical use ... Full text Open Access Link to item Cite

Long-term Functional, Psychological, Emotional, and Social Outcomes in Survivors of Firearm Injuries.

Journal Article JAMA Surg · January 1, 2020 IMPORTANCE: The outcomes of firearm injuries in the United States are devastating. Although firearm mortality and costs have been investigated, the long-term outcomes after surviving a gunshot wound (GSW) remain unstudied. OBJECTIVE: To determine the long- ... Full text Link to item Cite

Surgical technique for development of a clinically-representative ventral hernia repair infection rat model.

Journal Article MethodsX · 2020 The animal model of infection following ventral hernia repair (VHR) has previously been utilized in exploring treatments and innovative therapies, such as implantation of biologic mesh imbedded with various anti-bacterial properties. The rat model has been ... Full text Open Access Link to item Cite

Nanomaterial Nitric Oxide Delivery in Traumatic Orthopedic Regenerative Medicine.

Journal Article Front Bioeng Biotechnol · 2020 Achieving bone fracture union after trauma represents a major challenge for the orthopedic surgeon. Fracture non-healing has a multifactorial etiology and there are many risk factors for non-fusion. Environmental factors such as wound contamination, infect ... Full text Open Access Link to item Cite

Ultrasound shear wave elastography effectively predicts integrity of ventral hernia repair using acellular dermal matrix augmented with platelet-rich plasma (PRP).

Journal Article Surg Endosc · September 2019 BACKGROUND: Complications of ventral hernia repair (VHR) may be investigated by computed tomography or ultrasound (US) but neither modality gives a quantifiable metric of repair quality short of identifying hernia recurrence. Platelet-rich plasma (PRP), a ... Full text Link to item Cite

Nanometric Considerations in Biofilm Formation.

Journal Article Surg Infect (Larchmt) · April 2019 Prosthetic contamination and biofilm formation continue to plague implanted materials. With increasing resistance to traditional antibiotic regimens, alternative approaches to preventing bacterial adhesion and biofilm formation have focused on the physioch ... Full text Link to item Cite

Biomimetic hydroxyapatite/collagen composite drives bone niche recapitulation in a rabbit orthotopic model.

Journal Article Mater Today Bio · March 2019 Synthetic osteoinductive materials that mimic the human osteogenic niche have emerged as ideal candidates to address this area of unmet clinical need. In this study, we evaluated the osteoinductive potential in a rabbit orthotopic model of a magnesium-dope ... Full text Open Access Link to item Cite

Enhancement of gemcitabine cytotoxicity in pancreatic adenocarcinoma through controlled release of nitric oxide.

Journal Article Biomed Microdevices · February 21, 2019 Gemcitabine (GEM) is the first-line treatment for pancreatic adenocarcinoma (PAC) yet chemoresistance is common. Nitric oxide (NO) is the predominant species responsible for the cytotoxic action of macrophages against cancer cells yet localized delivery is ... Full text Link to item Cite

Emergency response teams in and outside of medicine-structurally crafted to be worlds apart.

Journal Article J Trauma Acute Care Surg · January 2019 Medical emergency response teams (MERTs) are widespread throughout inpatient hospital care facilities. Besides the rise of the ubiquitous rapid response team, current MERTs span trauma, stroke, myocardial infarction, and sepsis in many hospitals. Given the ... Full text Link to item Cite

How do I diagnose and manage acute endocrine emergencies in the ICU?

Chapter · January 1, 2019 Endocrine emergencies are frequently encountered in the intensive care unit. This chapter will focus on several common disorders including diabetic ketoacidosis, hyperosmolar hyperglycemia, thyroid storm, myxedema coma, and vasopressin deficiency. Adrenal ... Full text Cite

The Chemistry of Lyophilized Blood Products.

Journal Article Bioconjug Chem · July 18, 2018 With the development of new biologics and bioconjugates, storage and preservation have become more critical than ever before. Lyophilization is a method of cell and protein preservation by removing a solvent such as water from a substance followed by freez ... Full text Link to item Cite

Novel therapeutic strategies for degenerative disc disease: Review of cell biology and intervertebral disc cell therapy

Journal Article SAGE Open Medicine · March 9, 2018 Intervertebral disc degeneration is a disease of the discs connecting adjoining vertebrae in which structural damage leads to loss of disc integrity. Degeneration of the disc can be a normal process of ageing, but can also be precipitated by other factors. ... Full text Cite

Nanoantibiotics: a new paradigm for the treatment of surgical infection.

Journal Article Nanomedicine (Lond) · June 2017 Infections following orthopedic device implantations often impose a substantial health burden and result in high medical costs. Currently, preventative methods are often employed following an orthopedic implant to reduce risk of infection; however, contami ... Full text Link to item Cite

Characterization of ventral incisional hernia and repair using shear wave elastography.

Journal Article J Surg Res · April 2017 BACKGROUND: To assess the integrity of hernia repair, imaging modalities such as computed tomography or ultrasound (US) are commonly used. Neither modality has currently the capacity to simultaneously image the mesh and quantify a prosthetic and surroundin ... Full text Link to item Cite

Increased use of surgical energy promotes methicillin-resistant Staphylococcus aureus colonization in rabbits following open ventral hernia mesh repair.

Journal Article Surg Endosc · February 2017 BACKGROUND: Surgical energy has been widely implemented because of ease of use, effective hemostasis, and surgical dissection. Studies demonstrate its use to be an independent risk factor for postoperative wound infection. Methicillin-resistant Staphylococ ... Full text Link to item Cite

Case report on the non-operative management of a retrievable inferior vena cava filter perforating the duodenum.

Journal Article Int J Surg Case Rep · 2017 INTRODUCTION: Deep vein thrombosis (DVT) continues to be a significant source of morbidity for surgical patients. Placement of a retrievable inferior vena cava (IVC) filter is used when patients have contraindications to anticoagulation or recurrent pulmon ... Full text Link to item Cite

Diagnosis and operative management of a perforated de Garengeot hernia.

Journal Article Int J Surg Case Rep · 2017 INTRODUCTION: A de Garengeot hernia, a femoral hernia containing the appendix, is a difficult diagnosis often made intra-operatively when the hernia sac is opened. It is a rare finding, and complications are more frequent with a de Garengeot hernia. PRESEN ... Full text Link to item Cite

Platelet-rich plasma: a biomimetic approach to enhancement of surgical wound healing.

Journal Article J Surg Res · January 2017 Platelets are small anucleate cytoplasmic cell bodies released by megakaryocytes in response to various physiologic triggers. Traditionally thought to be solely involved in the mechanisms of hemostasis, platelets have gained much attention due to their inv ... Full text Link to item Cite

Cross-linking of porcine acellular dermal matrices negatively affects induced neovessel formation using platelet-rich plasma in a rat model of hernia repair.

Journal Article Wound Repair Regen · January 2017 The degree of cross-linking within acellular dermal matrices (ADM) seems to correlate to neovascularization when used in ventral hernia repair (VHR). Platelet-rich plasma (PRP) enhances wound healing through several mechanisms including neovascularization, ... Full text Link to item Cite

Decreased hernia recurrence using autologous platelet-rich plasma (PRP) with Strattice™ mesh in a rodent ventral hernia model.

Journal Article Surg Endosc · August 2016 BACKGROUND: Recurrence after ventral hernia repair (VHR) remains a multifactorial problem still plaguing surgeons today. Some of the many contributing factors include mechanical strain, poor tissue-mesh integration, and degradation of matrices. The high re ... Full text Open Access Link to item Cite

Porcine acellular lung matrix for wound healing and abdominal wall reconstruction: A pilot study.

Journal Article J Tissue Eng · 2016 Surgical wound healing applications require bioprosthetics that promote cellular infiltration and vessel formation, metrics associated with increased mechanical strength and resistance to infection. Porcine acellular lung matrix is a novel tissue scaffold ... Full text Open Access Link to item Cite

Lost in Translation: The Gap in Scientific Advancements and Clinical Application.

Journal Article Front Bioeng Biotechnol · 2016 The evolution of medicine and medical technology hinges on the successful translation of basic science research from the bench to clinical implementation at the bedside. Out of the increasing need to facilitate the transfer of scientific knowledge to patie ... Full text Open Access Link to item Cite

An unusual presentation of congenital intestinal malrotation in a nonagenarian.

Journal Article Int J Surg Case Rep · 2016 INTRODUCTION: Appendicitis is a common surgical pathology with many clinical presentations. Diagnosis can be challenging if there is an alteration to the normal position of anatomical structures and their relationships. CASE PRESENTATION: In this case, we ... Full text Link to item Cite

Characterization of Mesenchymal Stem Cells from Human Cortical Bone

Journal Article International Journal of Translational Science · 2016 Full text Open Access Cite

Platelet rich plasma enhances tissue incorporation of biologic mesh.

Journal Article J Surg Res · December 2015 BACKGROUND: High recurrence rates because of poor tissue incorporation limit the use of acellular dermal matrices (ADMs) in ventral hernia repair (VHR). Platelet rich plasma (PRP) is a growth factor-rich autologous blood product known to enhance tissue rep ... Full text Link to item Cite

Endplate changes following discectomy: natural history and associations between imaging and clinical data.

Journal Article Eur Spine J · November 2015 PURPOSE: Some patients will experience post-operative back pain following lumbar discectomy, and the potential sources for that pain are poorly understood. One potential source is the vertebral endplates. The goal of this study was to document the changes ... Full text Link to item Cite

Enhanced osteogenic potential of mesenchymal stem cells from cortical bone: a comparative analysis.

Journal Article Stem Cell Res Ther · October 26, 2015 INTRODUCTION: Mesenchymal stem cells (MSCs) hold great promise for regenerative therapies in the musculoskeletal system. Although MSCs from bone marrow (BM-MSCs) and adipose tissue (AD-MSCs) have been extensively characterized, there is still debate as to ... Full text Open Access Link to item Cite

Soft tissue and whiplash injuries: The current evidence base

Chapter · January 1, 2015 Soft tissue or 'whiplash' injuries following trauma, particularly motor vehicle accidents, are common. Estimated yearly incidence of whiplash injuries exceeds 1 million [1]. The impact of whiplash injuries extends beyond that of a short-lived soft tissue i ... Cite

MicroRNA and drug delivery

Chapter · January 1, 2014 The human genome was once thought to be a redundant sequence containing few functional regions coding for proteins. This teaching is being rewritten as we continue to understand the vast complexity of the noncoding regions of the genetic code. These region ... Full text Cite

Multistage porous silicon for cancer therapy

Chapter · January 1, 2014 Advances in biomedical engineering have paved the way for medical innovation and expansion. Many diseases now have hope of a cure through technology brought to reality by the vision and creativity of basic researchers, translational scientists, and doctors ... Full text Cite

From hypothesis to evidence-based medicine: Connecting the dots

Chapter · December 1, 2013 In this chapter, an attempt is made to highlight the differences between evolutionaryand revolutionary hypotheses. Most hypotheses about etiology or novel therapies areevolutionary in nature and advance the field of medicine incrementally. Revolutionaryhyp ... Cite

Incorporating cost considerations into medical decision making

Chapter · December 1, 2013 The costs of healthcare have risen dramatically over the past several decades. In the United States, for instance, it is estimated that costs this year will exceed $28 Billion. Additionally the proportion of a family's income dedicated to healthcare costs ... Cite

A nanostructured lidocaine delivery system decreases postsurgical pain in Lewis rats

Conference Journal of the American College of Surgeons · September 2013 Full text Cite

Silicon micro- and nanofabrication for medicine.

Journal Article Adv Healthc Mater · May 2013 This manuscript constitutes a review of several innovative biomedical technologies fabricated using the precision and accuracy of silicon micro- and nanofabrication. The technologies to be reviewed are subcutaneous nanochannel drug delivery implants for th ... Full text Link to item Cite

Nanotechnologies and regenerative medical approaches for space and terrestrial medicine.

Journal Article Aviat Space Environ Med · November 2012 One purpose of the International Space Station (ISS) is to explore powerful new areas of biomedical science in microgravity. Recent advances in nanotechnology applied to medicine--what we now refer to as nano-medicine--and regenerative medicine have enormo ... Full text Link to item Cite

Biology of aortic aneurysms and dissections.

Journal Article Methodist Debakey Cardiovasc J · 2011 The biology of aortic aneurysm and dissection has evolved to where we now understand the genetic implications of changes in extracellular matrix proteins, smooth muscle cells, and growth factors and how they affect aortic wall homeostasis. These predetermi ... Full text Link to item Cite

Oncogenic and metastatic properties of preprotachykinin-I and neurokinin-1 genes.

Journal Article Vascul Pharmacol · October 2006 Breast cancer (BC) remains the cancer with highest mortality among women in the United States. Entry of BC cells (BCCs) in bone marrow (BM) leads to poor prognosis. This review discusses studies showing interactions between BCCs and BM stroma, consequently ... Full text Link to item Cite