Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • Fellow, Women's and Perinatal Pathology, Harvard Medical School, Brigham and Women's Hospital 2016 - 2017
  • Fellow, Cytopathology, Harvard Medical School, Brigham and Women's Hospital 2015 - 2016
  • Resident, Anatomic Pathology, Harvard Medical School, Brigham and Women's Hospital 2013 - 2015
  • MD./PhD., Medical University of South Carolina School of Medicine 2013
  • B.A., College of Charleston 2005
  • B.S., College of Charleston 2005
• Research
• 

  Selected Grants

  • Point-of-care cellular and molecular pathology of breast tumors on a cell phone awarded by National Institutes of Health 2020 - 2025
  • Are ESR1 mutations associated with shorter progression free survival in copy number-low endometrial adenocarcinomas? awarded by Foundation for Women's Cancer 2020 - 2021
  • Population Health Research Support - Study of Pregnancy and Neonatal Health (SPAN) Task A awarded by National Institutes of Health 2019 - 2021
  • Immune modulation of CaMKK2 in the ovarian tumor microenvironment awarded by American Association of Obstetricians and Gynecologists Foundation 2019 - 2020
• 

  External Relationships

  • Almac Pharmaceuticals
  • Foundation Medicine, Inc.
• Publications & Artistic Works
• 

  Selected Publications

  • Academic Articles

    • Brouwer, Jan, Kyle C. Strickland, Gang Ning, Cindy B. Schmelkin, David L. Kolin, Jonathan Hecht, Marisa R. Nucci, Marian J. Mourits, Wa Xian, and Christopher P. Crum. “Evidence for a Novel Endometrioid Carcinogenic Sequence in the Fallopian Tube With Unique Beta-Catenin Expression.” Int J Gynecol Pathol 39, no. 2 (March 2020): 163–69. https://doi.org/10.1097/PGP.0000000000000590.
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    • Ahmadi, Sara, Rebecca Herbst, Taofik Oyekunle, Xiaoyin “Sara” Jiang, Kyle Strickland, Sanziana Roman, and Julie A. Sosa. “USING THE ATA AND ACR TI-RADS SONOGRAPHIC CLASSIFICATIONS AS ADJUNCTIVE PREDICTORS OF MALIGNANCY FOR INDETERMINATE THYROID NODULES.” Endocr Pract 25, no. 9 (September 2019): 908–17. https://doi.org/10.4158/EP-2018-0559.
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    • Meserve, Emily E., Kyle C. Strickland, Alexander Miron, Thing R. Soong, Frank Campbell, Brooke E. Howitt, and Christopher P. Crum. “Evidence of a Monoclonal Origin for Bilateral Serous Tubal Intraepithelial Neoplasia.” Int J Gynecol Pathol 38, no. 5 (September 2019): 443–48. https://doi.org/10.1097/PGP.0000000000000534.
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    • Cohen, Paul A., Aime Powell, Steffen Böhm, C Blake Gilks, Colin J. R. Stewart, Tarek M. Meniawy, Max Bulsara, et al. “Pathological chemotherapy response score is prognostic in tubo-ovarian high-grade serous carcinoma: A systematic review and meta-analysis of individual patient data.” Gynecol Oncol 154, no. 2 (August 2019): 441–48. https://doi.org/10.1016/j.ygyno.2019.04.679.
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    • Ditzel, Helena M., Kyle C. Strickland, Emily E. Meserve, Elizabeth Stover, Panagiotis A. Konstantinopoulos, Ursula A. Matulonis, Michael G. Muto, et al. “Assessment of a Chemotherapy Response Score (CRS) System for Tubo-Ovarian High-Grade Serous Carcinoma (HGSC).” Int J Gynecol Pathol 38, no. 3 (May 2019): 230–40. https://doi.org/10.1097/PGP.0000000000000513.
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    • Strickland, Kyle C., Liping Yuan, Bradley J. Quade, Marisa R. Nucci, and Brooke E. Howitt. “Clinicopathological and immunohistochemical features of uterine adenomyomatous polyps.” Hum Pathol 84 (February 2019): 239–45. https://doi.org/10.1016/j.humpath.2018.10.002.
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    • Glass, Carolyn H., Alexander Christakis, Gregory A. Fishbein, Jaclyn C. Watkins, Kyle C. Strickland, Richard N. Mitchell, and Robert F. Padera. “Thrombus on the inflow cannula of the HeartWare HVAD: an update.” Cardiovasc Pathol 38 (January 2019): 14–20. https://doi.org/10.1016/j.carpath.2018.09.002.
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    • Davis, Michelle, Kyle Strickland, Sarah Rae Easter, Michael Worley, Colleen Feltmate, Michael Muto, Neil Horowitz, Ross Berkowitz, and Sarah Feldman. “The impact of health insurance status on the stage of cervical cancer diagnosis at a tertiary care center in Massachusetts.” Gynecol Oncol 150, no. 1 (July 2018): 67–72. https://doi.org/10.1016/j.ygyno.2018.05.002.
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    • Angell, Trevor E., Chirag M. Vyas, Justine A. Barletta, Edmund S. Cibas, Nancy L. Cho, Gerard M. Doherty, Atul A. Gawande, et al. “Reasons Associated with Total Thyroidectomy as Initial Surgical Management of an Indeterminate Thyroid Nodule.” Ann Surg Oncol 25, no. 5 (May 2018): 1410–17. https://doi.org/10.1245/s10434-018-6421-x.
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    • Strickland, Kyle C., Markus Eszlinger, Ralf Paschke, Trevor E. Angell, Erik K. Alexander, Ellen Marqusee, Matthew A. Nehs, et al. “Molecular Testing of Nodules with a Suspicious or Malignant Cytologic Diagnosis in the Setting of Non-Invasive Follicular Thyroid Neoplasm with Papillary-Like Nuclear Features (NIFTP).” Endocr Pathol 29, no. 1 (March 2018): 68–74. https://doi.org/10.1007/s12022-018-9515-x.
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    • Strickland, Kyle C., Brooke E. Howitt, Justine A. Barletta, Edmund S. Cibas, and Jeffrey F. Krane. “Suggesting the cytologic diagnosis of noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP): A retrospective analysis of atypical and suspicious nodules.” Cancer Cytopathol 126, no. 2 (February 2018): 86–93. https://doi.org/10.1002/cncy.21922.
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    • Meserve, Emily E. K., Jelena Mirkovic, James R. Conner, Eric Yang, Michael G. Muto, Neil Horowitz, Kyle C. Strickland, Brooke E. Howitt, and Christopher P. Crum. “Frequency of "incidental" serous tubal intraepithelial carcinoma (STIC) in women without a history of or genetic risk factor for high-grade serous carcinoma: A six-year study.” Gynecol Oncol 146, no. 1 (July 2017): 69–73. https://doi.org/10.1016/j.ygyno.2017.04.015.
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    • Sullivan, Michael C., Paul H. Graham, Erik K. Alexander, Daniel T. Ruan, Matthew A. Nehs, Atul A. Gawande, Francis D. Moore, et al. “Prevalence of Contralateral Tumors in Patients with Follicular Variant of Papillary Thyroid Cancer.” J Am Coll Surg 224, no. 6 (June 2017): 1021–27. https://doi.org/10.1016/j.jamcollsurg.2016.12.007.
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    • Wong, Kristine S., Kyle C. Strickland, Trevor E. Angell, Matthew A. Nehs, Erik K. Alexander, Edmund S. Cibas, Jeffrey F. Krane, Brooke E. Howitt, and Justine A. Barletta. “The Flip Side of NIFTP: an Increase in Rates of Unfavorable Histologic Parameters in the Remainder of Papillary Thyroid Carcinomas.” Endocr Pathol 28, no. 2 (June 2017): 171–76. https://doi.org/10.1007/s12022-017-9476-5.
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    • Baca, Sylvan C., Kristine S. Wong, Kyle C. Strickland, Howard T. Heller, Matthew I. Kim, Justine A. Barletta, Edmund S. Cibas, Jeffrey F. Krane, Ellen Marqusee, and Trevor E. Angell. “Qualifiers of atypia in the cytologic diagnosis of thyroid nodules are associated with different Afirma gene expression classifier results and clinical outcomes.” Cancer Cytopathol 125, no. 5 (May 2017): 313–22. https://doi.org/10.1002/cncy.21827.
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    • Howitt, Brooke E., Kyle C. Strickland, Lynette M. Sholl, Scott Rodig, Lauren L. Ritterhouse, Dipanjan Chowdhury, Alan D. D’Andrea, Ursula A. Matulonis, and Panagiotis A. Konstantinopoulos. “Clear cell ovarian cancers with microsatellite instability: A unique subset of ovarian cancers with increased tumor-infiltrating lymphocytes and PD-1/PD-L1 expression.” Oncoimmunology 6, no. 2 (2017): e1277308. https://doi.org/10.1080/2162402X.2016.1277308.
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    • Strickland, Kyle C., Marina Vivero, Vickie Y. Jo, Alarice C. Lowe, Monica Hollowell, Xiaohua Qian, Tad J. Wieczorek, et al. “Preoperative Cytologic Diagnosis of Noninvasive Follicular Thyroid Neoplasm with Papillary-Like Nuclear Features: A Prospective Analysis.” Thyroid 26, no. 10 (October 2016): 1466–71. https://doi.org/10.1089/thy.2016.0280.
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    • Ritterhouse, Lauren L., Jonathan A. Nowak, Kyle C. Strickland, Elizabeth P. Garcia, Yonghui Jia, Neal I. Lindeman, Laura E. Macconaill, et al. “Morphologic correlates of molecular alterations in extrauterine Müllerian carcinomas.” Mod Pathol 29, no. 8 (August 2016): 893–903. https://doi.org/10.1038/modpathol.2016.82.
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    • Strickland, Kyle C., Jaclyn C. Watkins, Gregory S. Couper, Michael M. Givertz, and Robert F. Padera. “Thrombus around the redesigned HeartWare HVAD inflow cannula: A pathologic case series.” J Heart Lung Transplant 35, no. 7 (July 2016): 926–30. https://doi.org/10.1016/j.healun.2016.01.1230.
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    • Wong, Kristine S., Trevor E. Angell, Kyle C. Strickland, Erik K. Alexander, Edmund S. Cibas, Jeffrey F. Krane, and Justine A. Barletta. “Noninvasive Follicular Variant of Papillary Thyroid Carcinoma and the Afirma Gene-Expression Classifier.” Thyroid 26, no. 7 (July 2016): 911–15. https://doi.org/10.1089/thy.2015.0644.
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    • Strickland, Kyle C., Brooke E. Howitt, Sachet A. Shukla, Scott Rodig, Lauren L. Ritterhouse, Joyce F. Liu, Judy E. Garber, et al. “Association and prognostic significance of BRCA1/2-mutation status with neoantigen load, number of tumor-infiltrating lymphocytes and expression of PD-1/PD-L1 in high grade serous ovarian cancer.” Oncotarget 7, no. 12 (March 22, 2016): 13587–98. https://doi.org/10.18632/oncotarget.7277.
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    • Strickland, Kyle C., Marisa R. Nucci, Katharine M. Esselen, Michael G. Muto, Sameer Chopra, Suzanne George, and Brooke E. Howitt. “Solitary Fibrous Tumor of the Uterus Presenting With Lung Metastases: A Case Report.” Int J Gynecol Pathol 35, no. 1 (January 2016): 25–29. https://doi.org/10.1097/PGP.0000000000000197.
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    • Howitt, Brooke E., Sachet A. Shukla, Lynette M. Sholl, Lauren L. Ritterhouse, Jaclyn C. Watkins, Scott Rodig, Elizabeth Stover, et al. “Association of Polymerase e-Mutated and Microsatellite-Instable Endometrial Cancers With Neoantigen Load, Number of Tumor-Infiltrating Lymphocytes, and Expression of PD-1 and PD-L1.” Jama Oncol 1, no. 9 (December 2015): 1319–23. https://doi.org/10.1001/jamaoncol.2015.2151.
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    • Strickland, Kyle C., Brooke E. Howitt, Ellen Marqusee, Erik K. Alexander, Edmund S. Cibas, Jeffrey F. Krane, and Justine A. Barletta. “The Impact of Noninvasive Follicular Variant of Papillary Thyroid Carcinoma on Rates of Malignancy for Fine-Needle Aspiration Diagnostic Categories.” Thyroid 25, no. 9 (September 2015): 987–92. https://doi.org/10.1089/thy.2014.0612.
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    • Strickland, Kyle C., Natalia I. Krupenko, and Sergey A. Krupenko. “Molecular mechanisms underlying the potentially adverse effects of folate.” Clin Chem Lab Med 51, no. 3 (March 1, 2013): 607–16. https://doi.org/10.1515/cclm-2012-0561.
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    • Tsybovsky, Yaroslav, Yuryi Malakhau, Kyle C. Strickland, and Sergey A. Krupenko. “The mechanism of discrimination between oxidized and reduced coenzyme in the aldehyde dehydrogenase domain of Aldh1l1.” Chem Biol Interact 202, no. 1–3 (February 25, 2013): 62–69. https://doi.org/10.1016/j.cbi.2012.12.015.
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    • Strickland, Kyle C., Natalia I. Krupenko, Marianne E. Dubard, Calvin J. Hu, Yaroslav Tsybovsky, and Sergey A. Krupenko. “Enzymatic properties of ALDH1L2, a mitochondrial 10-formyltetrahydrofolate dehydrogenase.” Chem Biol Interact 191, no. 1–3 (May 30, 2011): 129–36. https://doi.org/10.1016/j.cbi.2011.01.008.
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    • Strickland, Kyle C., Roger S. Holmes, Natalia V. Oleinik, Natalia I. Krupenko, and Sergey A. Krupenko. “Phylogeny and evolution of aldehyde dehydrogenase-homologous folate enzymes.” Chem Biol Interact 191, no. 1–3 (May 30, 2011): 122–28. https://doi.org/10.1016/j.cbi.2010.12.025.
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    • Krupenko, Natalia I., Marianne E. Dubard, Kyle C. Strickland, Kelly M. Moxley, Natalia V. Oleinik, and Sergey A. Krupenko. “ALDH1L2 is the mitochondrial homolog of 10-formyltetrahydrofolate dehydrogenase.” J Biol Chem 285, no. 30 (July 23, 2010): 23056–63. https://doi.org/10.1074/jbc.M110.128843.
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    • Strickland, Kyle C., L Alexis Hoeferlin, Natalia V. Oleinik, Natalia I. Krupenko, and Sergey A. Krupenko. “Acyl carrier protein-specific 4'-phosphopantetheinyl transferase activates 10-formyltetrahydrofolate dehydrogenase.” J Biol Chem 285, no. 3 (January 15, 2010): 1627–33. https://doi.org/10.1074/jbc.M109.080556.
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    • Dellis, Stephanie, Kyle C. Strickland, William J. McCrary, Ashwin Patel, Eileen Stocum, and Cynthia F. Wright. “Protein interactions among the vaccinia virus late transcription factors.” Virology 329, no. 2 (November 24, 2004): 328–36. https://doi.org/10.1016/j.virol.2004.08.017.
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  • Book Sections

    • Medeiros, F., and K. C. Strickland. “Chapter 26 - Germ Cell Tumors of the Ovary.” In Diagnostic Gynecologic and Obstetric Pathology, 949–1010, 2017. https://doi.org/10.1016/B978-0-323-44732-4.00026-1.
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    • Strickland, K. C., M. R. Nucci, K. R. Lee, and C. P. Crum. “Chapter 27 - Sex Cord-Stromal and Miscellaneous Tumors of the Ovary.” In Diagnostic Gynecologic and Obstetric Pathology, 1011–49, 2017. https://doi.org/10.1016/B978-0-323-44732-4.00027-3.
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  • Conference Papers

    • Brouwer, Jan, Kyle C. Strickland, Cindy Schmelkin, David Kolin, Jonathan Hecht, Marisa Nucci, Wa Xian, and Christopher Crum. “Evidence for a Unique Endometrioid Carcinogenic Sequence in the Fallopian Tube Associated with a type II (Endometrioid) Secretory Cell Outgrowth (SCOUT).” In Modern Pathology, 31:409–409. NATURE PUBLISHING GROUP, 2018.
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    • Strickland, Kyle C., Frank Campbell, Alexander Miron, Brooke E. Howitt, and Christopher Crum. “Detection of Tumor-Specific TP53 Signatures from Archival Endometrial Biopsies Obtained Prior to the Diagnosis of High-Grade Serous Carcinoma.” In Modern Pathology, 31:455–455. NATURE PUBLISHING GROUP, 2018.
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