Overview
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Certain ligands can selectively activate some of the multiple cellular responses downstream of G protein-coupled receptors (GPCRs), an enormous family of membrane proteins that is also the single largest class of drug targets. The Wingler lab seeks to understand the molecular mechanisms of how these ligands differentially modulate GPCR signaling. To accomplish this, the laboratory utilizes multidisciplinary approaches, including biochemistry, biophysics, pharmacology, cell biology and protein engineering. Ultimately, this work could inspire strategies to develop therapeutics for GPCRs that have greater specificity of action.
Certain ligands can selectively activate some of the multiple cellular responses downstream of G protein-coupled receptors (GPCRs), an enormous family of membrane proteins that is also the single largest class of drug targets. The Wingler lab seeks to understand the molecular mechanisms of how these ligands differentially modulate GPCR signaling. To accomplish this, the laboratory utilizes multidisciplinary approaches, including biochemistry, biophysics, pharmacology, cell biology and protein engineering. Ultimately, this work could inspire strategies to develop therapeutics for GPCRs that have greater specificity of action.
Current Appointments & Affiliations
Assistant Professor of Pharmacology and Cancer Biology
·
2020 - Present
Pharmacology & Cancer Biology,
Basic Science Departments
Assistant Professor of Cell Biology
·
2022 - Present
Cell Biology,
Basic Science Departments
Member of the Duke Cancer
·
2020 - Present
Duke Cancer Institute,
Institutes and Centers
Education, Training & Certifications
Columbia University ·
2011
Ph.D.