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Laura M. Wingler

Assistant Professor of Pharmacology and Cancer Biology
Pharmacology & Cancer Biology
C259 LSRC, Durham, NC 27710
Box 3813, Durham, NC 27710

Overview


Visit our lab website for additional information.

Certain ligands can selectively activate some of the multiple cellular responses downstream of G protein-coupled receptors (GPCRs), an enormous family of membrane proteins that is also the single largest class of drug targets. The Wingler lab seeks to understand the molecular mechanisms of how these ligands differentially modulate GPCR signaling. To accomplish this, the laboratory utilizes multidisciplinary approaches, including biochemistry, biophysics, pharmacology, cell biology and protein engineering. Ultimately, this work could inspire strategies to develop therapeutics for GPCRs that have greater specificity of action.

Current Appointments & Affiliations


Assistant Professor of Pharmacology and Cancer Biology · 2020 - Present Pharmacology & Cancer Biology, Basic Science Departments
Assistant Professor of Cell Biology · 2022 - Present Cell Biology, Basic Science Departments
Member of the Duke Cancer Institute · 2020 - Present Duke Cancer Institute, Institutes and Centers

Recent Publications


Antibodies expand the scope of angiotensin receptor pharmacology.

Journal Article Nat Chem Biol · December 2024 G-protein-coupled receptors (GPCRs) are key regulators of human physiology and are the targets of many small-molecule research compounds and therapeutic drugs. While most of these ligands bind to their target GPCR with high affinity, selectivity is often l ... Full text Link to item Cite

Molecular imaging in experimental pulmonary fibrosis reveals that nintedanib unexpectedly modulates CCR2 immune cell infiltration.

Journal Article EBioMedicine · December 2024 BACKGROUND: Pulmonary fibrosis is a challenging clinical problem with lung pathology featuring immune cell infiltrates, fibroblast expansion, and matrix deposition. Molecular analysis of diseased lungs and preclinical models have uncovered C-C chemokine re ... Full text Link to item Cite

Progress on the development of Class A GPCR-biased ligands.

Journal Article Br J Pharmacol · September 11, 2024 Class A G protein-coupled receptors (GPCRs) continue to garner interest for their essential roles in cell signalling and their importance as drug targets. Although numerous drugs in the clinic target these receptors, over 60% GPCRs remain unexploited. More ... Full text Link to item Cite
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Recent Grants


ASPET SURF Institutional Award

Inst. Training Prgm or CMEParticipating Faculty Member · Awarded by American Society for Pharmacology and Experimental Therapeutics · 2018 - 2028

Novel Approaches to Resolve Functional Specificity in the Chemokine System

ResearchPrincipal Investigator · Awarded by Pew Scholars Program · 2022 - 2027

Molecular Determinants of Ligand-Induced Allosteric to Gq and Gi at the Angiotensin II Type 1 Receptor

FellowshipPrincipal Investigator · Awarded by American Heart Association · 2025 - 2026

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Education, Training & Certifications


Columbia University · 2011 Ph.D.

External Links


Wingler Lab website