Overview
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Certain ligands can selectively activate some of the multiple cellular responses downstream of G protein-coupled receptors (GPCRs), an enormous family of membrane proteins that is also the single largest class of drug targets. The Wingler lab seeks to understand the molecular mechanisms of how these ligands differentially modulate GPCR signaling. To accomplish this, the laboratory utilizes multidisciplinary approaches, including biochemistry, biophysics, pharmacology, cell biology and protein engineering. Ultimately, this work could inspire strategies to develop therapeutics for GPCRs that have greater specificity of action.
Certain ligands can selectively activate some of the multiple cellular responses downstream of G protein-coupled receptors (GPCRs), an enormous family of membrane proteins that is also the single largest class of drug targets. The Wingler lab seeks to understand the molecular mechanisms of how these ligands differentially modulate GPCR signaling. To accomplish this, the laboratory utilizes multidisciplinary approaches, including biochemistry, biophysics, pharmacology, cell biology and protein engineering. Ultimately, this work could inspire strategies to develop therapeutics for GPCRs that have greater specificity of action.
Current Appointments & Affiliations
Assistant Professor of Pharmacology and Cancer Biology
·
2020 - Present
Pharmacology & Cancer Biology,
Basic Science Departments
Assistant Professor of Cell Biology
·
2022 - Present
Cell Biology,
Basic Science Departments
Member of the Duke Cancer Institute
·
2020 - Present
Duke Cancer Institute,
Institutes and Centers
Recent Publications
Antibodies expand the scope of angiotensin receptor pharmacology.
Journal Article Nat Chem Biol · December 2024 G-protein-coupled receptors (GPCRs) are key regulators of human physiology and are the targets of many small-molecule research compounds and therapeutic drugs. While most of these ligands bind to their target GPCR with high affinity, selectivity is often l ... Full text Link to item CiteMolecular imaging in experimental pulmonary fibrosis reveals that nintedanib unexpectedly modulates CCR2 immune cell infiltration.
Journal Article EBioMedicine · December 2024 BACKGROUND: Pulmonary fibrosis is a challenging clinical problem with lung pathology featuring immune cell infiltrates, fibroblast expansion, and matrix deposition. Molecular analysis of diseased lungs and preclinical models have uncovered C-C chemokine re ... Full text Link to item CiteProgress on the development of Class A GPCR-biased ligands.
Journal Article Br J Pharmacol · September 11, 2024 Class A G protein-coupled receptors (GPCRs) continue to garner interest for their essential roles in cell signalling and their importance as drug targets. Although numerous drugs in the clinic target these receptors, over 60% GPCRs remain unexploited. More ... Full text Link to item CiteRecent Grants
ASPET SURF Institutional Award
Inst. Training Prgm or CMEParticipating Faculty Member · Awarded by American Society for Pharmacology and Experimental Therapeutics · 2018 - 2028Novel Approaches to Resolve Functional Specificity in the Chemokine System
ResearchPrincipal Investigator · Awarded by Pew Scholars Program · 2022 - 2027Molecular Determinants of Ligand-Induced Allosteric to Gq and Gi at the Angiotensin II Type 1 Receptor
FellowshipPrincipal Investigator · Awarded by American Heart Association · 2025 - 2026View All Grants
Education, Training & Certifications
Columbia University ·
2011
Ph.D.