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Loreta Grecu

Associate Professor of Anesthesiology
Anesthesiology, Cardiothoracic

Selected Publications


Droxidopa or Atomoxetine for Refractory Hypotension in Critically Ill Cardiothoracic Surgery Patients.

Journal Article J Cardiothorac Vasc Anesth · January 2024 OBJECTIVE: To evaluate the effects of droxidopa or atomoxetine on intravenous (IV) vasoactive agent discontinuation in cardiothoracic intensive care unit (ICU) patients with hypotension refractory to midodrine. DESIGN: Single-center, retrospective cohort s ... Full text Link to item Cite

Postoperative pulmonary complications with adjuvant regional anesthesia versus general anesthesia alone: a sub-analysis of the Perioperative Research Network study.

Journal Article BMC Anesthesiol · May 3, 2022 BACKGROUND: Adjuvant regional anesthesia is often selected for patients or procedures with high risk of pulmonary complications after general anesthesia. The benefit of adjuvant regional anesthesia to reduce postoperative pulmonary complications remains un ... Full text Link to item Cite

Right Ventricular Function in Left Heart Disease.

Journal Article Semin Cardiothorac Vasc Anesth · March 2019 Right ventricular (RV) function is an independent prognostic factor for short- and long-term outcomes in cardiac surgical patients. Patients with mitral valve (MV) disease are at increased risk of RV dysfunction before and after MV operations. Yet RV funct ... Full text Link to item Cite

Central and autonomic nervous systems

Chapter · April 28, 2015 Cite

Efficient intratracheal delivery of airway epithelial cells in mice and pigs.

Journal Article Am J Physiol Lung Cell Mol Physiol · January 15, 2015 Cellular therapy via direct intratracheal delivery has gained interest as a novel therapeutic strategy for treating various pulmonary diseases including cystic fibrosis lung disease. However, concerns such as insufficient cell engraftment in lungs and lack ... Full text Link to item Cite

Symptomatic obstruction of the brachiocephalic and left subclavian arteries obscured by aortic stenosis.

Journal Article Ann Vasc Surg · April 2014 Stenosis or occlusion of the brachiocephalic artery represents an uncommon cause of cerebrovascular insufficiency. We report a patient with combined brachiocephalic and left subclavian obstruction with clinical manifestations of lightheadedness, syncope, a ... Full text Link to item Cite

Cardiac tamponade.

Journal Article Int Anesthesiol Clin · 2012 Full text Link to item Cite

Perioperative spinal cord infarction in nonaortic surgery: report of three cases and review of the literature.

Journal Article J Clin Anesth · June 2008 Paraplegia caused by a spinal cord infarction (SCI) is a devastating perioperative complication, most often associated with aortic and spine surgery. We present two other clinical scenarios in which perioperative SCI may occur. They happened during surgica ... Full text Link to item Cite

Haloperidol versus ondansetron for prophylaxis of postoperative nausea and vomiting.

Journal Article Anesth Analg · May 2008 BACKGROUND: Haloperidol is effective for postoperative nausea and vomiting prophylaxis, but there are almost no data comparing it to 5-HT(3) antagonists. METHODS: Two hundred forty-four adults were randomized to receive i.v. haloperidol 1 mg or ondansetron ... Full text Link to item Cite

Haloperidol plus ondansetron versus ondansetron alone for prophylaxis of postoperative nausea and vomiting.

Journal Article Anesth Analg · May 2008 INTRODUCTION: Haloperidol 1 mg and ondansetron 4 mg are equally safe and effective for postoperative nausea and vomiting prophylaxis. We compared the combination to ondansetron alone in a mixed surgical population. METHODS: Two-hundred and sixty-eight adul ... Full text Link to item Cite

Emergency room and acute care of the critically III burned patient

Chapter · December 1, 2007 The natural history of serious burns is characterized by burn shock, which can be fatal within the first few hours to days, particularly in those with untreated large burns. Burn wound sepsis is the major cause of mortality among those who survive the burn ... Full text Cite

Postoperative ST-segment elevation: was vasospasm caused by anaphylaxis or by its treatment with epinephrine?

Journal Article Ann Allergy Asthma Immunol · October 2006 BACKGROUND: Anaphylaxis must be recognized and treated promptly to avoid significant morbidity and mortality. In this clinical setting, electrocardiographic changes can be multifactorial. OBJECTIVE: To discuss vasospasm as a cause of myocardial ischemia an ... Full text Link to item Cite

Laryngospasm after autologous blood transfusion.

Journal Article Anesth Analg · July 2006 Although perioperative autologous blood transfusions are associated with few side effects, transfusion reactions can occur and can be life-threatening. We report the occurrence of postoperative laryngospasm in a patient who underwent spinal anesthesia for ... Full text Link to item Cite

Unilateral empyema as a complication of infectious mononucleosis: a pathogenic variant of Lemierre's syndrome.

Journal Article J Clin Microbiol · February 2006 We present a case of a healthy 19-year-old female who developed infectious mononucleosis complicated by unilateral empyema. ... Full text Link to item Cite

Droxidopa or Atomoxetine for Refractory Hypotension in Critically Ill Cardiothoracic Surgery Patients.

Journal Article J Cardiothorac Vasc Anesth · January 2024 OBJECTIVE: To evaluate the effects of droxidopa or atomoxetine on intravenous (IV) vasoactive agent discontinuation in cardiothoracic intensive care unit (ICU) patients with hypotension refractory to midodrine. DESIGN: Single-center, retrospective cohort s ... Full text Link to item Cite

Postoperative pulmonary complications with adjuvant regional anesthesia versus general anesthesia alone: a sub-analysis of the Perioperative Research Network study.

Journal Article BMC Anesthesiol · May 3, 2022 BACKGROUND: Adjuvant regional anesthesia is often selected for patients or procedures with high risk of pulmonary complications after general anesthesia. The benefit of adjuvant regional anesthesia to reduce postoperative pulmonary complications remains un ... Full text Link to item Cite

Right Ventricular Function in Left Heart Disease.

Journal Article Semin Cardiothorac Vasc Anesth · March 2019 Right ventricular (RV) function is an independent prognostic factor for short- and long-term outcomes in cardiac surgical patients. Patients with mitral valve (MV) disease are at increased risk of RV dysfunction before and after MV operations. Yet RV funct ... Full text Link to item Cite

Central and autonomic nervous systems

Chapter · April 28, 2015 Cite

Efficient intratracheal delivery of airway epithelial cells in mice and pigs.

Journal Article Am J Physiol Lung Cell Mol Physiol · January 15, 2015 Cellular therapy via direct intratracheal delivery has gained interest as a novel therapeutic strategy for treating various pulmonary diseases including cystic fibrosis lung disease. However, concerns such as insufficient cell engraftment in lungs and lack ... Full text Link to item Cite

Symptomatic obstruction of the brachiocephalic and left subclavian arteries obscured by aortic stenosis.

Journal Article Ann Vasc Surg · April 2014 Stenosis or occlusion of the brachiocephalic artery represents an uncommon cause of cerebrovascular insufficiency. We report a patient with combined brachiocephalic and left subclavian obstruction with clinical manifestations of lightheadedness, syncope, a ... Full text Link to item Cite

Cardiac tamponade.

Journal Article Int Anesthesiol Clin · 2012 Full text Link to item Cite

Perioperative spinal cord infarction in nonaortic surgery: report of three cases and review of the literature.

Journal Article J Clin Anesth · June 2008 Paraplegia caused by a spinal cord infarction (SCI) is a devastating perioperative complication, most often associated with aortic and spine surgery. We present two other clinical scenarios in which perioperative SCI may occur. They happened during surgica ... Full text Link to item Cite

Haloperidol versus ondansetron for prophylaxis of postoperative nausea and vomiting.

Journal Article Anesth Analg · May 2008 BACKGROUND: Haloperidol is effective for postoperative nausea and vomiting prophylaxis, but there are almost no data comparing it to 5-HT(3) antagonists. METHODS: Two hundred forty-four adults were randomized to receive i.v. haloperidol 1 mg or ondansetron ... Full text Link to item Cite

Haloperidol plus ondansetron versus ondansetron alone for prophylaxis of postoperative nausea and vomiting.

Journal Article Anesth Analg · May 2008 INTRODUCTION: Haloperidol 1 mg and ondansetron 4 mg are equally safe and effective for postoperative nausea and vomiting prophylaxis. We compared the combination to ondansetron alone in a mixed surgical population. METHODS: Two-hundred and sixty-eight adul ... Full text Link to item Cite

Emergency room and acute care of the critically III burned patient

Chapter · December 1, 2007 The natural history of serious burns is characterized by burn shock, which can be fatal within the first few hours to days, particularly in those with untreated large burns. Burn wound sepsis is the major cause of mortality among those who survive the burn ... Full text Cite

Postoperative ST-segment elevation: was vasospasm caused by anaphylaxis or by its treatment with epinephrine?

Journal Article Ann Allergy Asthma Immunol · October 2006 BACKGROUND: Anaphylaxis must be recognized and treated promptly to avoid significant morbidity and mortality. In this clinical setting, electrocardiographic changes can be multifactorial. OBJECTIVE: To discuss vasospasm as a cause of myocardial ischemia an ... Full text Link to item Cite

Laryngospasm after autologous blood transfusion.

Journal Article Anesth Analg · July 2006 Although perioperative autologous blood transfusions are associated with few side effects, transfusion reactions can occur and can be life-threatening. We report the occurrence of postoperative laryngospasm in a patient who underwent spinal anesthesia for ... Full text Link to item Cite

Unilateral empyema as a complication of infectious mononucleosis: a pathogenic variant of Lemierre's syndrome.

Journal Article J Clin Microbiol · February 2006 We present a case of a healthy 19-year-old female who developed infectious mononucleosis complicated by unilateral empyema. ... Full text Link to item Cite

Does metabolic recovery predict time to extubation after cardiac surgery?

Journal Article Critical Care Medicine · January 1, 1999 Introduction: Carbon dioxide production (VCO2), and oxygen consumption (VO2), measures of metabolic recovery, are significant determinants of outcome after CPB. The purpose of this study was to determine whether body temp (TB) is a surrogate of metabolic r ... Full text Cite

Arterial-venous CO2 tension difference reflects oxygen debt after cardiopulmonary bypass

Journal Article Critical Care Medicine · January 1, 1999 Introduction: The gradient between venous and arterial carbon dioxide tension (Pv-aCO2) increases with resuscitation from states of intravascular depletion such as hemorragic shock. We hypothesized that Pv-aCO2 might increase following hypothermic cardiopu ... Full text Cite

Arterial-venous CO2 tension gradient (Pa-vCO2) reflects oxygen debt after cardiopulmonary bypass

Journal Article Critical Care Medicine · January 1, 1999 INTRODUCTION: Pv-aCO2 increases with resuscitation from states of shock. We hypothesized that Pv-aCO2 increases following hypothermic cardiopulmonary bypass (CPB) due to the oxygen debt incurred. The recovery pattern of Pv-aCO2 was compared to those of O2 ... Full text Cite

Elevated pulmonary artery pressures are associated with longer duration of intubation following open heart surgery

Journal Article Chest · October 1, 1998 Background: The distinct differences in pulmonary circulatory loading between various cardiac lesions affect their postoperative outcomes. This study investigates hemodynamic and CPB factors affecting time to extubation in patients undergoing CABG and mitr ... Cite