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Margeaux W Marbrey

Assistant Professor in Obstetrics and Gynecology
Obstetrics and Gynecology, Reproductive Sciences

Overview


Dr. Margeaux W. Marbrey received her PhD from Baylor College of Medicine while studying how progesterone signaling regulates implantation in a spatiotemporal manner under the mentorship of Dr. Francesco DeMayo. Dr. Marbrey then completed a postdoctoral fellowship at the University of North Carolina Chapel Hill School of Medicine with Dr. Kathleen Caron discerning effects of toxicants, environmental exposures, and tobacco products on pregnancy health, timing, and disease.

The chief aim of the Marbrey Laboratory is to understand molecular regulators of early and mid pregnancy success using exposure paradigms and cutting-edge models to further understand human reproduction, promote healthy pregnancies, and improve patient care. The Marbrey laboratory builds upon Dr. Marbrey's strong experience using innovative models and exposure systems to answer important questions in pregnancy that ultimately lead to public health awareness, risk assessment, and preserved lives of mother and baby.

Current Appointments & Affiliations


Assistant Professor in Obstetrics and Gynecology · 2023 - Present Obstetrics and Gynecology, Reproductive Sciences, Obstetrics and Gynecology
Assistant Professor in the Division of Environmental Natural Sciences · 2024 - Present Environmental Natural Science, Nicholas School of the Environment

In the News


Published October 21, 2025
Vaping While Pregnant? Duke Research Highlights the Danger

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Recent Publications


Flavored e-cigarettes modulate embryo development, fetal growth, and potentiate early fetal demise without nicotine.

Journal Article Commun Med (Lond) · August 28, 2025 BACKGROUND: Electronic cigarettes (e-cigarettes) function by aerosolizing a base liquid containing nicotine and flavoring, used by an estimated 15% of pregnant women as a supposed safer alternative to traditional cigarettes. Our previous studies demonstrat ... Full text Link to item Cite

AHR activated placental adrenomedullin: A plausible factor in smoke-induced preeclampsia protection.

Journal Article Placenta · June 26, 2025 INTRODUCTION: The placenta develops as trophectoderm cells invade and secrete peptides to remodel the maternal vasculature. Impaired invasion can lead to preeclampsia. Maternal smoking during pregnancy can cause miscarriage and fetal developmental problems ... Full text Link to item Cite

Coumestrol induces oxidative stress and impairs migration and embryonic growth.

Journal Article Reproduction · July 1, 2023 IN BRIEF: Healthy development of the placenta is dependent on trophoblast cell migration and reduced oxidative stress presence. This article describes how a phytoestrogen found in spinach and soy causes impaired placental development during pregnancy. ABST ... Full text Link to item Cite
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Recent Grants


Duke Women's Reproductive Health Research Scholars

Inst. Training Prgm or CMEMentor · Awarded by Eunice Kennedy Shriver National Institute of Child Health and Human Development · 2020 - 2030

Duke University Program in Environmental Health

Inst. Training Prgm or CMEMentor · Awarded by National Institute of Environmental Health Sciences · 2019 - 2029

Investigating Implications of E-Cigarettes on Pregnancy Success and Reproductive Fitness

ResearchPrincipal Investigator · Awarded by Eunice Kennedy Shriver National Institute of Child Health and Human Development · 2023 - 2026

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Education, Training & Certifications


Baylor, College of Medicine · 2016 Ph.D.

External Links


Marbrey Lab Website