Scholars@Duke
Margeaux W Marbrey

Margeaux W Marbrey

Assistant Professor in Obstetrics and Gynecology
Obstetrics and Gynecology, Reproductive Sciences
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Selected Publications

Coumestrol induces oxidative stress and impairs migration and embryonic growth.

Journal Article Reproduction · July 1, 2023 IN BRIEF: Healthy development of the placenta is dependent on trophoblast cell migration and reduced oxidative stress presence. This article describes how a phytoestrogen found in spinach and soy causes impaired placental development during pregnancy. ABST ... Full text Link to item Cite

The role of epithelial progesterone receptor isoforms in embryo implantation.

Journal Article iScience · December 17, 2021 The loss of uterine epithelial progesterone receptor (PGR) is crucial for successful embryo implantation in both humans and mice. The two major isoforms PGRA and PGRB have divergent functions under both physiological and pathological conditions. The presen ... Full text Link to item Cite

Progesterone receptor isoform B regulates the Oxtr-Plcl2-Trpc3 pathway to suppress uterine contractility.

Journal Article Proc Natl Acad Sci U S A · March 16, 2021 Uterine contractile dysfunction leads to pregnancy complications such as preterm birth and labor dystocia. In humans, it is hypothesized that progesterone receptor isoform PGR-B promotes a relaxed state of the myometrium, and PGR-A facilitates uterine cont ... Full text Link to item Cite

Constitutive expression of progesterone receptor isoforms promotes the development of hormone-dependent ovarian neoplasms.

Journal Article Sci Signal · October 6, 2020 Differences in the relative abundances of the progesterone receptor (PGR) isoforms PGRA and PGRB are often observed in women with reproductive tract cancers. To assess the importance of the PGR isoform ratio in the maintenance of the reproductive tract, we ... Full text Link to item Cite

Pinopodes: Recent advancements, current perspectives, and future directions.

Journal Article Mol Cell Endocrinol · February 5, 2020 Successful embryo implantation is a complex and highly regulated process involving precise synchronization between the fetal-derived trophoblast cells and maternal uterine luminal epithelium. Multiple endocrine-driven factors are important for controlling ... Full text Link to item Cite

E-Cigarette Exposure Delays Implantation and Causes Reduced Weight Gain in Female Offspring Exposed In Utero.

Journal Article J Endocr Soc · October 1, 2019 Electronic nicotine delivery system (e-cigarette) use is prevalent among pregnant women as a seemingly safe alternative to traditional tobacco use, known to result in fetal developmental abnormalities and impaired fertility of male offspring. However, litt ... Full text Link to item Cite

FOXO1 regulates uterine epithelial integrity and progesterone receptor expression critical for embryo implantation.

Journal Article PLoS Genet · November 2018 Successful embryo implantation requires a receptive endometrium. Poor uterine receptivity can account for implantation failure in women who experience recurrent pregnancy loss or multiple rounds of unsuccessful in vitro fertilization cycles. Here, we demon ... Full text Link to item Cite

A mouse model engineered to conditionally express the progesterone receptor-B isoform.

Journal Article Genesis · August 2018 Using a Rosa26 gene targeting strategy in mouse embryonic stem cells, we have generated a new transgenic mouse (Pgr-B LSL ), which is designed to conditionally express the epitope-tagged mouse progesterone receptor-B (PGR-B) isoform when crossed with a spe ... Full text Link to item Cite

Cover Image, Volume 56, Issue 8

Journal Article genesis · August 2018 Full text Cite

Decreased epithelial progesterone receptor A at the window of receptivity is required for preparation of the endometrium for embryo attachment.

Journal Article Biol Reprod · February 1, 2017 The precise timing of progesterone signaling through its cognate receptor, the progesterone receptor (PGR), is critical for the establishment and maintenance of pregnancy. Loss of PGR expression in the murine uterine epithelium during the preimplantation p ... Full text Link to item Cite

The epidermal growth factor receptor critically regulates endometrial function during early pregnancy.

Journal Article PLoS Genet · June 2014 Infertility and adverse gynecological outcomes such as preeclampsia and miscarriage represent significant female reproductive health concerns. The spatiotemporal expression of growth factors indicates that they play an important role in pregnancy. The goal ... Full text Link to item Cite

Progesterone receptor signaling in the initiation of pregnancy and preservation of a healthy uterus.

Journal Article Int J Dev Biol · 2014 Infertility and reproductive-associated disease are global problems in the world today affecting millions of women. A successful pregnancy requires a healthy uterus ready to receive and support an implanting embryo. As an endocrine organ, the uterus is dep ... Full text Link to item Cite

Contributors

Chapter · 2014 Full text Cite

The progesterone receptor regulates implantation, decidualization, and glandular development via a complex paracrine signaling network.

Journal Article Mol Cell Endocrinol · June 24, 2012 Many women are affected by infertility and reproductive-associated disease such as endometriosis or endometrial cancer. Successful pregnancy is dependent on a healthy uterus that is fit to receive and support a fertilized embryo. The uterus is an endocrine ... Full text Link to item Cite

Epithelial progesterone receptor exhibits pleiotropic roles in uterine development and function.

Journal Article FASEB J · March 2012 The ovarian steroid progesterone, acting through the progesterone receptor (PR), coordinates endometrial epithelial-stromal cell communication, which is critical for its development and function. PR expression in these cellular compartments is under tight ... Full text Link to item Cite