Scholars@Duke
Meenal Kapoor Kheterpal

Meenal Kapoor Kheterpal

Associate Professor of Dermatology
Dermatology
meenal.kheterpal@duke.edu
40 Duke Medicine Cir, Box 3135, Durham, NC 27710
40 Duke Medicine Cir, Durham, NC 27710
Manage Profile
Embed Profile Data

Selected Publications

Image Quality Assessment Using Convolutional Neural Network in Clinical Skin Images.

Journal Article JID Innov · July 2024 The image quality received for clinical evaluation is often suboptimal. The goal is to develop an image quality analysis tool to assess patient- and primary care physician-derived images using deep learning model. Dataset included patient- and primary care ... Full text Link to item Cite

Evaluation of the Tolerability of Hedgehog Pathway Inhibitors in the Treatment of Advanced Basal Cell Carcinoma: A Narrative Review of Treatment Strategies

Journal Article American Journal of Clinical Dermatology · January 1, 2024 Hedgehog pathway inhibitors (HHIs) have broadened the treatment options available for patients with advanced basal cell carcinoma (BCC) for whom traditional therapeutic approaches are not feasible or effective. Sonidegib and vismodegib are oral HHIs that w ... Full text Cite

Implementation evaluation of a teledermatology virtual clinic at an academic medical center.

Journal Article Implement Sci Commun · October 27, 2023 BACKGROUND: Teledermatology (TD) is an evidence-based practice that may increase access to dermatologic care. We sought to use the Exploration, Preparation, Implementation, and Sustainment (EPIS) and the Reach, Efficacy, Adoption, Implementation, and Maint ... Full text Link to item Cite

Early Detection and Prognostic Assessment of Cutaneous Melanoma: Consensus on Optimal Practice and the Role of Gene Expression Profile Testing.

Journal Article JAMA Dermatol · May 1, 2023 IMPORTANCE: Therapy for advanced melanoma has transformed during the past decade, but early detection and prognostic assessment of cutaneous melanoma (CM) remain paramount goals. Best practices for screening and use of pigmented lesion evaluation tools and ... Full text Link to item Cite

Teledermatology May Benefit Marginalized Populations: National and Institutional Trends during the COVID-19 Pandemic.

Journal Article Dermatol Ther (Heidelb) · March 2023 INTRODUCTION: Limited data exist regarding demographic-specific teledermatology (TD) utilization during the coronavirus disease 2019 (COVID-19) pandemic. This study aimed to determine TD utilization trends during the pandemic. METHODS: A retrospective coho ... Full text Link to item Cite

Implementation Evaluation of a Teledermatology Virtual Clinic at an Academic Medical Center.

Journal Article Res Sq · February 28, 2023 BACKGROUND: Teledermatology (TD) is an evidence-based practice that may increase access to dermatologic care. We sought to evaluate implementation of TD at four Duke primary care practices. METHODS: We implemented a hybrid TD program where trained primary ... Full text Link to item Cite

Deep Learning in Dermatology: A Systematic Review of Current Approaches, Outcomes, and Limitations.

Journal Article JID Innov · January 2023 Artificial intelligence (AI) has recently made great advances in image classification and malignancy prediction in the field of dermatology. However, understanding the applicability of AI in clinical dermatology practice remains challenging owing to the va ... Full text Link to item Cite

Lesion identification and malignancy prediction from clinical dermatological images.

Journal Article Sci Rep · September 23, 2022 We consider machine-learning-based lesion identification and malignancy prediction from clinical dermatological images, which can be indistinctly acquired via smartphone or dermoscopy capture. Additionally, we do not assume that images contain single lesio ... Full text Link to item Cite

Development of a core outcome set for basal cell carcinoma.

Journal Article J Am Acad Dermatol · September 2022 BACKGROUND: There is variation in the outcomes reported in clinical studies of basal cell carcinoma. This can prevent effective meta-analyses from answering important clinical questions. OBJECTIVE: To identify a recommended minimum set of core outcomes for ... Full text Link to item Cite

Clinical and direct immunofluorescence characteristics of cutaneous toxicity associated with enfortumab vedotin.

Journal Article Br J Dermatol · July 2022 Enfortumab vedotin (EV), a novel antibody-drug conjugate approved for metastatic urothelial carcinoma, causes a variety of cutaneous adverse reactions. We present two cases of bullous eruptions following treatment with EV, both demonstrating IgG deposition ... Full text Link to item Cite

Successful Outpatient Management of Diffuse Photosensitive Bullous Dermatitis Following Pembrolizumab Therapy.

Journal Article J Drugs Dermatol · June 1, 2022 Immune checkpoint inhibitors including programmed death protein 1 inhibitors show great therapeutic benefit for numerous advanced malignancies but can cause a spectrum of immune-related adverse events, with cutaneous toxicity being a common presentation. T ... Full text Link to item Cite

Current Landscape of Generative Adversarial Networks for Facial Deidentification in Dermatology: Systematic Review and Evaluation

Journal Article JMIR Dermatology · May 1, 2022 Background: Deidentifying facial images is critical for protecting patient anonymity in the era of increasing tools for automatic image analysis in dermatology. Objective: The aim of this paper was to review the current literature in the field of automatic ... Full text Cite

Hedgehog inhibitors with and without adjunctive therapy in treatment of locally advanced basal cell carcinoma.

Journal Article Int J Dermatol · January 2022 BACKGROUND: Hedgehog inhibitor therapy (HHIT) is considered first-line treatment for locally advanced, unresectable basal cell carcinoma (laBCC). HHIT often results in a partial response, which requires adjunctive therapy (AT) post HHIT. We present real-wo ... Full text Link to item Cite

Use of convolutional neural networks in skin lesion analysis using real world image and non-image data.

Journal Article Front Med (Lausanne) · 2022 BACKGROUND: Understanding performance of convolutional neural networks (CNNs) for binary (benign vs. malignant) lesion classification based on real world images is important for developing a meaningful clinical decision support (CDS) tool. METHODS: We deve ... Full text Link to item Cite

Image Quality Assessment Using Convolutional Neural Network in Clinical Skin Images.

Journal Article JID Innov · July 2024 The image quality received for clinical evaluation is often suboptimal. The goal is to develop an image quality analysis tool to assess patient- and primary care physician-derived images using deep learning model. Dataset included patient- and primary care ... Full text Link to item Cite

Evaluation of the Tolerability of Hedgehog Pathway Inhibitors in the Treatment of Advanced Basal Cell Carcinoma: A Narrative Review of Treatment Strategies

Journal Article American Journal of Clinical Dermatology · January 1, 2024 Hedgehog pathway inhibitors (HHIs) have broadened the treatment options available for patients with advanced basal cell carcinoma (BCC) for whom traditional therapeutic approaches are not feasible or effective. Sonidegib and vismodegib are oral HHIs that w ... Full text Cite

Implementation evaluation of a teledermatology virtual clinic at an academic medical center.

Journal Article Implement Sci Commun · October 27, 2023 BACKGROUND: Teledermatology (TD) is an evidence-based practice that may increase access to dermatologic care. We sought to use the Exploration, Preparation, Implementation, and Sustainment (EPIS) and the Reach, Efficacy, Adoption, Implementation, and Maint ... Full text Link to item Cite

Early Detection and Prognostic Assessment of Cutaneous Melanoma: Consensus on Optimal Practice and the Role of Gene Expression Profile Testing.

Journal Article JAMA Dermatol · May 1, 2023 IMPORTANCE: Therapy for advanced melanoma has transformed during the past decade, but early detection and prognostic assessment of cutaneous melanoma (CM) remain paramount goals. Best practices for screening and use of pigmented lesion evaluation tools and ... Full text Link to item Cite

Teledermatology May Benefit Marginalized Populations: National and Institutional Trends during the COVID-19 Pandemic.

Journal Article Dermatol Ther (Heidelb) · March 2023 INTRODUCTION: Limited data exist regarding demographic-specific teledermatology (TD) utilization during the coronavirus disease 2019 (COVID-19) pandemic. This study aimed to determine TD utilization trends during the pandemic. METHODS: A retrospective coho ... Full text Link to item Cite

Implementation Evaluation of a Teledermatology Virtual Clinic at an Academic Medical Center.

Journal Article Res Sq · February 28, 2023 BACKGROUND: Teledermatology (TD) is an evidence-based practice that may increase access to dermatologic care. We sought to evaluate implementation of TD at four Duke primary care practices. METHODS: We implemented a hybrid TD program where trained primary ... Full text Link to item Cite

Deep Learning in Dermatology: A Systematic Review of Current Approaches, Outcomes, and Limitations.

Journal Article JID Innov · January 2023 Artificial intelligence (AI) has recently made great advances in image classification and malignancy prediction in the field of dermatology. However, understanding the applicability of AI in clinical dermatology practice remains challenging owing to the va ... Full text Link to item Cite

Lesion identification and malignancy prediction from clinical dermatological images.

Journal Article Sci Rep · September 23, 2022 We consider machine-learning-based lesion identification and malignancy prediction from clinical dermatological images, which can be indistinctly acquired via smartphone or dermoscopy capture. Additionally, we do not assume that images contain single lesio ... Full text Link to item Cite

Development of a core outcome set for basal cell carcinoma.

Journal Article J Am Acad Dermatol · September 2022 BACKGROUND: There is variation in the outcomes reported in clinical studies of basal cell carcinoma. This can prevent effective meta-analyses from answering important clinical questions. OBJECTIVE: To identify a recommended minimum set of core outcomes for ... Full text Link to item Cite

Clinical and direct immunofluorescence characteristics of cutaneous toxicity associated with enfortumab vedotin.

Journal Article Br J Dermatol · July 2022 Enfortumab vedotin (EV), a novel antibody-drug conjugate approved for metastatic urothelial carcinoma, causes a variety of cutaneous adverse reactions. We present two cases of bullous eruptions following treatment with EV, both demonstrating IgG deposition ... Full text Link to item Cite

Successful Outpatient Management of Diffuse Photosensitive Bullous Dermatitis Following Pembrolizumab Therapy.

Journal Article J Drugs Dermatol · June 1, 2022 Immune checkpoint inhibitors including programmed death protein 1 inhibitors show great therapeutic benefit for numerous advanced malignancies but can cause a spectrum of immune-related adverse events, with cutaneous toxicity being a common presentation. T ... Full text Link to item Cite

Current Landscape of Generative Adversarial Networks for Facial Deidentification in Dermatology: Systematic Review and Evaluation

Journal Article JMIR Dermatology · May 1, 2022 Background: Deidentifying facial images is critical for protecting patient anonymity in the era of increasing tools for automatic image analysis in dermatology. Objective: The aim of this paper was to review the current literature in the field of automatic ... Full text Cite

Hedgehog inhibitors with and without adjunctive therapy in treatment of locally advanced basal cell carcinoma.

Journal Article Int J Dermatol · January 2022 BACKGROUND: Hedgehog inhibitor therapy (HHIT) is considered first-line treatment for locally advanced, unresectable basal cell carcinoma (laBCC). HHIT often results in a partial response, which requires adjunctive therapy (AT) post HHIT. We present real-wo ... Full text Link to item Cite

Use of convolutional neural networks in skin lesion analysis using real world image and non-image data.

Journal Article Front Med (Lausanne) · 2022 BACKGROUND: Understanding performance of convolutional neural networks (CNNs) for binary (benign vs. malignant) lesion classification based on real world images is important for developing a meaningful clinical decision support (CDS) tool. METHODS: We deve ... Full text Link to item Cite

Early Implementation and Evaluation of a Teledermatology Virtual Clinic Within an Academic Medical Center

Journal Article Iproceedings · December 20, 2021 BackgroundTeledermatology can increase patient access; however, its optimal implementation remains unknown.Obj ... Full text Cite

Privacy Protection With Facial Deidentification Machine Learning Methods: Can Current Methods Be Applied to Dermatology?

Journal Article Iproceedings · December 17, 2021 BackgroundIn the era of increasing tools for automatic image analysis in dermatology, new machine learning models require high-quality image data sets. Facial image data are needed for de ... Full text Cite

Early Implementation and Evaluation of a Teledermatology Virtual Clinic Within an Academic Medical Center (Preprint)

Journal Article · December 3, 2021 BACKGROUNDTeledermatology can increase patient access; however, its optimal implementation remains unknown. ... Full text Cite

Privacy Protection With Facial Deidentification Machine Learning Methods: Can Current Methods Be Applied to Dermatology? (Preprint)

Journal Article · December 3, 2021 BACKGROUNDIn the era of increasing tools for automatic image analysis in dermatology, new machine learning models require high-quality image data sets. Facial image data are needed for de ... Full text Cite

Outcomes of adjunctive therapies post hedgehog inhibitors in the management of locally advanced basal cell carcinoma: A systematic review and pooled analysis.

Journal Article Dermatol Ther · November 2021 Management of patients with locally advanced basal cell carcinoma (laBCC) with traditional strategies has yielded suboptimal outcomes. Targeted treatments including hedgehog inhibitor therapy (HHIT) present limitations when utilized as monotherapy. Herein, ... Full text Link to item Cite

Key Clinical Adverse Events in Patients with Advanced Basal Cell Carcinoma Treated with Sonidegib or Vismodegib: A Post Hoc Analysis.

Journal Article Dermatol Ther (Heidelb) · October 2021 INTRODUCTION: Sonidegib is approved to treat locally advanced basal cell carcinoma (laBCC) in the USA, EU, Switzerland, and Australia and metastatic basal cell carcinoma (mBCC) in Switzerland and Australia in patients not amenable to surgery or radiotherap ... Full text Link to item Cite

Cutaneous involvement by T-cell prolymphocytic leukemia presenting as livedoid vasculopathy.

Journal Article J Cutan Pathol · July 2021 T-cell prolymphocytic leukemia (T-PLL) is a rare, aggressive neoplasm derived from post-thymic T-cells. Patients are typically middle aged with a slight male predominance who present with a high white blood cell count, hepatosplenomegaly, lymphadenopathy, ... Full text Link to item Cite

Malignancy Prediction and Lesion Identification from Clinical Dermatological Images

Journal Article · April 2, 2021 We consider machine-learning-based malignancy prediction and lesion identification from clinical dermatological images, which can be indistinctly acquired via smartphone or dermoscopy capture. Additionally, we do not assume that images contain single lesio ... Open Access Link to item Cite

Time to Onset of major adverse clinical Events with Sonidegib and Vismodegib: a Post hoc Analysis

Conference JOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT · 2021 Cite

Role of imaging in low-grade cutaneous B-cell lymphoma presenting in the skin.

Journal Article J Am Acad Dermatol · October 2019 BACKGROUND: Whole-body imaging is the current standard of care for staging all patients presenting with skin lesions of B-cell lymphomas (BCLs), regardless of skin disease extent; however, supporting data are lacking. OBJECTIVE: To determine the clinical u ... Full text Link to item Cite

Resolution of Pembrolizumab-Associated Steroid-Refractory Lichenoid Dermatitis with Cyclosporine.

Journal Article Oncologist · March 2019 Checkpoint inhibitors such as pembrolizumab, an anti-PD-1 monoclonal antibody, are a promising new category of oncological therapeutics, associated with a higher risk of immune-related adverse events including dermatological, autoimmune and endocrine seque ... Full text Link to item Cite

Survival, disease progression and prognostic factors in elderly patients with mycosis fungoides and Sézary syndrome: a retrospective analysis of 174 patients.

Journal Article J Eur Acad Dermatol Venereol · January 2019 BACKGROUND: Advanced age at diagnosis is considered a poor prognostic factor in mycosis fungoides (MF) and Sézary syndrome (SS). OBJECTIVE: To evaluate the outcomes and prognostic factors in patients diagnosed at an advanced age (≥65 years) with MF/SS. MET ... Full text Link to item Cite

Low-Grade Cutaneous B-cell Lymphoma in African American Patients.

Journal Article J Drugs Dermatol · December 1, 2018 Introduction: Cutaneous marginal zone lymphoma (CMZL) and cutaneous follicle center lymphoma (CFCL) are rare indolent cutaneous B-cell lymphomas (CBCL). Their incidence in African American (AA) patients is extremely low. While cutaneous T-cell lymphomas ap ... Link to item Cite

T-cell receptor-δ expression and γδ+ T-cell infiltrates in primary cutaneous γδ T-cell lymphoma and other cutaneous T-cell lymphoproliferative disorders.

Journal Article Histopathology · October 2018 AIMS: The diagnosis of cutaneous γδ T-cell lymphoma (GDTCL) requires the identification of γδ chains of the T-cell receptor (TCR). Our aim in this study was, by using a new monoclonal antibody (mAb) against TCRδ, to evaluate TCRδ expression in formalin-fix ... Full text Link to item Cite

Malignancy Risk and Recurrence with Psoriasis and its Treatments: A Concise Update.

Journal Article Am J Clin Dermatol · June 2018 Psoriasis is a common inflammatory cutaneous disease that affects approximately 120 million people worldwide. Systemic treatments have significantly improved disease burden, but concerns persist regarding their association with increased risk of malignancy ... Full text Link to item Cite

Unrelated immunodeficiency states may impact outcomes and immune checkpoint molecule expression in patients with mycosis fungoides: A clinicopathologic case-control study.

Journal Article J Am Acad Dermatol · March 2018 BACKGROUND: Immunodeficiency (ID) correlates with worse outcomes and decreased immune checkpoint molecule expression in melanoma. The impact of ID in mycosis fungoides (MF) is unknown. OBJECTIVE: Our goal was to evaluate the impact of ID in MF. METHODS: We ... Full text Link to item Cite

Global patterns of care in advanced stage mycosis fungoides/Sezary syndrome: a multicenter retrospective follow-up study from the Cutaneous Lymphoma International Consortium.

Journal Article Ann Oncol · October 1, 2017 BACKGROUND: Advanced-stage mycosis fungoides (MF)/Sézary syndrome (SS) patients are weighted by an unfavorable prognosis and share an unmet clinical need of effective treatments. International guidelines are available detailing treatment options for the di ... Full text Link to item Cite

335 Utility of imaging in cutaneous marginal zone lymphoma

Conference Journal of Investigative Dermatology · May 2017 Full text Cite

A Rare Case of Cutaneous Plasmacytosis in a Korean Male.

Journal Article Case Rep Pathol · 2017 Cutaneous and systemic plasmacytosis are reactive disease processes that occur in middle-aged Japanese and Chinese men. Systemic plasmacytosis, defined by plasmacytic infiltration of two organ systems, might rarely progress to lymphoma. Cutaneous plasmacyt ... Full text Link to item Cite

A Phase Ib/IIa Trial of the Combination of Romidepsin, Lenalidomide and Carfilzomib in Patients with Relapsed/Refractory Lymphoma Shows Complete Responses in Relapsed and Refractory T-Cell Lymphomas

Conference Blood · December 2, 2016 AbstractBackground:Epigenetic manipulation and immunomodulation are therapeutic strategies in hematologic malignancies. In our previous study, the combination of romidepsin and lenalidomide demonstrated a 58 ... Full text Cite

Managing Patients with Cutaneous B-Cell and T-Cell Lymphomas Other Than Mycosis Fungoides.

Journal Article Curr Hematol Malig Rep · June 2016 Cutaneous lymphomas (CL) are a heterogeneous group of neoplasms characterized with clinical and histopathological variation, as well as overlap with benign dermatoses. Diagnosis and treatment of CLs is challenging and often requires a multidisciplinary app ... Full text Link to item Cite

First line biologic agent therapy for moderate-to-severe psoriasis in cancer survivors

Conference JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY · 2016 Cite

The impact of dermatology in premier medicine journals.

Journal Article Skinmed · 2011 In the past 15 years, research in dermatology has significantly increased. Dermatology-related contributions in premier medical journals such as The New England Journal of Medicine (NEJM) and The Journal of the American Medical Association (JAMA) are the r ... Link to item Cite

NOM1 Targets Protein Phosphatase I to the Nucleolus

Journal Article Journal of Biological Chemistry · January 2008 Full text Cite