https://orcid.org/0000-0002-7752-6380
Overview
Dr. Tadross' lab develops technologies to rapidly deliver drugs to genetically defined subsets of cells in the brain. By using these reagents in mouse models of neuropsychiatric disease, his group is mapping how specific receptors on defined cells and synapses in the brain give rise to diverse neural computations and behaviors. The approach leverages drugs currently in use to treat human neuropsychiatric disease, facilitating clinically relevant interpretation of the mapping effort.
He received his B.S. degree in Electrical & Computer Engineering at Rutgers University, an M.D.-Ph.D. degree in Biomedical Engineering at the Johns Hopkins School of Medicine, and completed his postdoctoral study in Cellular Neuroscience at Stanford University. He began his independent research program as a fellow at the HHMI Janelia Research Campus.
He received his B.S. degree in Electrical & Computer Engineering at Rutgers University, an M.D.-Ph.D. degree in Biomedical Engineering at the Johns Hopkins School of Medicine, and completed his postdoctoral study in Cellular Neuroscience at Stanford University. He began his independent research program as a fellow at the HHMI Janelia Research Campus.
Current Duke Appointments & Affiliations
Assistant Professor in Neurosurgery
·
2025 - Present
Neurosurgery,
Neurosurgery
Assistant Professor of Biomedical Engineering
·
2025 - Present
Biomedical Engineering,
Pratt School of Engineering
Recent Scholarly Works
A general one-step protocol to generate impermeable fluorescent HaloTag substrates for in situ live cell application and super-resolution imaging.
Journal article Nat Commun · January 12, 2026 Visualization of proteins can be achieved by genetically grafting HaloTag Protein (HTP) into the protein of interest followed by incubation with a dye-linked HaloTag Ligand (HTL). This approach allows for use of fluorophores optimized for specific optical ... Full text Link to item CiteBehavioral state and stimulus strength regulate the role of somatostatin interneurons in stabilizing network activity.
Journal article Cell Rep · July 22, 2025 Inhibition stabilization enables cortical circuits to encode sensory signals across diverse contexts. Somatostatin-expressing (SST) interneurons are well suited for this role through their strong recurrent connectivity with excitatory pyramidal cells. We t ... Full text Link to item CiteKetamine rescues anhedonia by cell-type- and input-specific adaptations in the nucleus accumbens.
Journal article Neuron · May 7, 2025 Ketamine is recognized as a rapid and sustained antidepressant, particularly for major depression unresponsive to conventional treatments. Anhedonia is a common symptom of depression for which ketamine is highly efficacious, but the underlying circuits and ... Full text Link to item CiteRecent Grants
Neurobiology Training Program
Inst. Training Prgm or CMEMentor · Awarded by National Institute of Neurological Disorders and Stroke · 2024 - 2029ElectroGLuE
FellowshipPrincipal Investigator · Awarded by Burroughs Wellcome Fund · 2025 - 2027DART.3-Revolutionizing Neuropsychiatric Treatment through Noninvasive, Programmable Cell-Type-Specific Neuropharmacology
ResearchPrincipal Investigator · Awarded by National Institute of Mental Health · 2024 - 2027View All Grants
Education
Johns Hopkins University ·
2009
M.D.
Johns Hopkins University ·
2009
Ph.D.