Overview
Dr. Tadross' lab develops technologies to rapidly deliver drugs to genetically defined subsets of cells in the brain. By using these reagents in mouse models of neuropsychiatric disease, his group is mapping how specific receptors on defined cells and synapses in the brain give rise to diverse neural computations and behaviors. The approach leverages drugs currently in use to treat human neuropsychiatric disease, facilitating clinically relevant interpretation of the mapping effort.
He received his B.S. degree in Electrical & Computer Engineering at Rutgers University, an M.D.-Ph.D. degree in Biomedical Engineering at the Johns Hopkins School of Medicine, and completed his postdoctoral study in Cellular Neuroscience at Stanford University. He began his independent research program as a fellow at the HHMI Janelia Research Campus.
He received his B.S. degree in Electrical & Computer Engineering at Rutgers University, an M.D.-Ph.D. degree in Biomedical Engineering at the Johns Hopkins School of Medicine, and completed his postdoctoral study in Cellular Neuroscience at Stanford University. He began his independent research program as a fellow at the HHMI Janelia Research Campus.
Current Appointments & Affiliations
Assistant Professor of Biomedical Engineering
·
2017 - Present
Biomedical Engineering,
Pratt School of Engineering
Assistant Professor in Neurobiology
·
2017 - Present
Neurobiology,
Basic Science Departments
Recent Publications
Ketamine rescues anhedonia by cell-type- and input-specific adaptations in the nucleus accumbens.
Journal Article Neuron · May 2025 Ketamine is recognized as a rapid and sustained antidepressant, particularly for major depression unresponsive to conventional treatments. Anhedonia is a common symptom of depression for which ketamine is highly efficacious, but the underlying circuits and ... Full text CiteA one-step protocol to generate impermeable fluorescent HaloTag substrates for in situ live cell application and super-resolution imaging.
Journal Article bioRxiv · September 23, 2024 Communication between cells is largely orchestrated by proteins on the cell surface, which allow information transfer across the cell membrane. Super-resolution and single-molecule visualization of these proteins can be achieved by genetically grafting HTP ... Full text Link to item CiteNatural phasic inhibition of dopamine neurons signals cognitive rigidity.
Journal Article bioRxiv · July 13, 2024 When animals unexpectedly fail, their dopamine neurons undergo phasic inhibition that canonically drives extinction learning-a cognitive-flexibility mechanism for discarding outdated strategies. However, the existing evidence equates natural and artificial ... Full text Link to item CiteRecent Grants
Neurobiology Training Program
Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 2024 - 2029The role of dystrophin in synapse development.
ResearchPrincipal Investigator · Awarded by University of Texas Health Science Center at San Antonio · 2024 - 2028DART.3-Revolutionizing Neuropsychiatric Treatment through Noninvasive, Programmable Cell-Type-Specific Neuropharmacology
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2024 - 2027View All Grants
Education, Training & Certifications
Johns Hopkins University ·
2009
M.D.
Johns Hopkins University ·
2009
Ph.D.