Moira Ann Rynn

Journal Article Addiction · February 2024 BACKGROUND AND AIMS: Benzodiazepines (BZDs) carry a risk for drug overdose and are prescribed alone or simultaneously with selective-serotonin reuptake inhibitors (SSRIs) for the treatment of anxiety and depression in young adults. We aimed to measure risk ... Full text Link to item Cite

Impact of the Youth Behavioral Health Crisis in North Carolina

Journal Article North Carolina Medical Journal · September 1, 2023 More than 70% of children with one or more mental health diagnoses in North Carolina are not receiving treatment. For many families, emergency departments have become the frontline providers of pediatric behavioral health care. There is a great need for mo ... Full text Cite

Subcortical shape in pediatric and adult obsessive-compulsive disorder.

Journal Article Depress Anxiety · June 2022 BACKGROUND: Obsessive-compulsive disorder (OCD) implicates alterations in cortico-striato-thalamo-cortical and fronto-limbic circuits. Building on prior structural findings, this is the largest study to date examining subcortical surface morphometry in OCD ... Full text Link to item Cite

Simultaneous Benzodiazepine and SSRI Initiation in Young People With Anxiety Disorders.

Journal Article J Clin Psychiatry · October 19, 2021 Objective: There are potential risks and benefits of combining benzodiazepine (BZD) and selective serotonin reuptake inhibitor (SSRI) therapy at anxiety disorder treatment onset. We investigated how often adolescents and young adults with anxiety disorders ... Full text Link to item Cite

Machine learning approach to measurement of criticism: The core dimension of expressed emotion.

Journal Article J Fam Psychol · October 2021 Expressed emotion (EE), a measure of the family's emotional climate, is a fundamental measure in caregiving research. A core dimension of EE is the level of criticism expressed by the caregiver to the care recipient, with a high level of criticism a marker ... Full text Link to item Cite

Altered fronto-amygdalar functional connectivity predicts response to cognitive behavioral therapy in pediatric obsessive-compulsive disorder.

Journal Article Depress Anxiety · August 2021 BACKGROUND: Based on findings from adults with obsessive-compulsive disorder (OCD), this study examined alterations in resting-state functional connectivity (rs-fc) between the basolateral amygdala (BLA) and the ventromedial prefrontal cortex (vmPFC) in ch ... Full text Link to item Cite

Specialty knowledge and competency standards for pharmacotherapy for pediatric obsessive-compulsive disorder.

Journal Article Psychiatry Res · May 2021 Evidence based treatments for pediatric Obsessive-Compulsive Disorder (OCD) are delivered with varying levels of expertise. This paper is part of the phase two series by the International OCD Accreditation Task Force (ATF) to advance a standardized high le ... Full text Link to item Cite

Structural neural markers of response to cognitive behavioral therapy in pediatric obsessive-compulsive disorder.

Journal Article J Child Psychol Psychiatry · December 2020 BACKGROUND: Cognitive behavioral therapy (CBT) is an effective, first-line treatment for pediatric obsessive-compulsive disorder (OCD). While neural predictors of treatment outcomes have been identified in adults with OCD, robust predictors are lacking for ... Full text Link to item Cite

Altered network connectivity predicts response to cognitive-behavioral therapy in pediatric obsessive-compulsive disorder.

Journal Article Neuropsychopharmacology · June 2020 Obsessive-compulsive disorder (OCD) is commonly associated with alterations in cortico-striato-thalamo-cortical brain networks. Yet, recent investigations of large-scale brain networks suggest that more diffuse alterations in brain connectivity may underli ... Full text Link to item Cite

Correction: Altered network connectivity predicts response to cognitive-behavioral therapy in pediatric obsessive-compulsive disorder.

Journal Article Neuropsychopharmacology · June 2020 An amendment to this paper has been published and can be accessed via a link at the top of the paper. ... Full text Link to item Cite

The Effects of Youth Anxiety Treatment on School Impairment: Differential Outcomes Across CBT, Sertraline, and their Combination.

Journal Article Child Psychiatry Hum Dev · December 2019 Youth anxiety disorders are highly prevalent and are associated with considerable school impairment. Despite the identification of well-supported strategies for treating youth anxiety, research has yet to evaluate the differential effects of these treatmen ... Full text Link to item Cite

Primary Care: Meeting the Mental Health Care Needs of Adolescents With Depression.

Journal Article J Am Acad Child Adolesc Psychiatry · April 2019 There is considerable evidence demonstrating the negative impact adolescent depression has on youth outcomes, such as poor school performance, social isolation, comorbid substance abuse, lack of employment, and, most concerning, the development of suicidal ... Full text Link to item Cite

Lithium for the Maintenance Treatment of Bipolar I Disorder: A Double-Blind, Placebo-Controlled Discontinuation Study.

Journal Article J Am Acad Child Adolesc Psychiatry · February 2019 OBJECTIVE: This study examined the role of lithium in the maintenance treatment of pediatric patients with bipolar I disorder (BP-I). METHOD: Participants aged 7 to 17 years who presented with a manic or mixed episode received 24 weeks of lithium treatment ... Full text Link to item Cite

Pharmacologic treatment of pediatric anxiety disorders

Chapter · January 1, 2019 The evidence base for the psychopharmacologic treatment of anxiety disorders in children and adolescents has dramatically increased over the past two decades. Current data suggest that, for fear-based anxiety disorders (e.g., generalized anxiety disorder, ... Full text Cite

Treating Pediatric Anxiety: Initial Use of SSRIs and Other Antianxiety Prescription Medications.

Journal Article J Clin Psychiatry · 2018 OBJECTIVE: Multiple pharmacotherapies for treating anxiety disorders exist, including selective serotonin reuptake inhibitors (SSRIs), the recommended first-line pharmacotherapy for pediatric anxiety. We sought to describe initial antianxiety medication us ... Full text Link to item Cite

The Interplay of Familial and Individual Risk in Predicting Clinical Improvements in Pediatric Anxiety Disorders.

Journal Article J Clin Child Adolesc Psychol · 2018 Bioecological models of developmental psychopathology underscore the role of familial experiences of adversity and children's individual-level characteristics in heightening risk for pediatric anxiety through direct, combined, and interactive effects. To d ... Full text Link to item Cite

Secondary Outcomes From the Child/Adolescent Anxiety Multimodal Study: Implications for Clinical Practice.

Journal Article Evid Based Pract Child Adolesc Ment Health · 2018 BACKGROUND: Controlled evaluations comparing medication, cognitive-behavioral therapy (CBT), and their combination in the treatment of youth anxiety have predominantly focused on global ratings by independent evaluators. Such ratings are resource-intensive ... Full text Link to item Cite

Placebo Response in Pediatric Anxiety Disorders: Results from the Child/Adolescent Anxiety Multimodal Study.

Journal Article J Child Adolesc Psychopharmacol · August 2017 OBJECTIVES: The aim of this study is to identify predictors of pill placebo response and to characterize the temporal course of pill placebo response in anxious youth. METHODS: Data from placebo-treated patients (N = 76) in the Child/Adolescent Anxiety Mul ... Full text Link to item Cite

Extended Release Guanfacine in Pediatric Anxiety Disorders: A Pilot, Randomized, Placebo-Controlled Trial.

Journal Article J Child Adolesc Psychopharmacol · February 2017 OBJECTIVE: This is a feasibility study evaluating the safety, tolerability, and potential anxiolytic efficacy of the α2 agonist guanfacine extended-release (GXR) in children and adolescents with generalized anxiety disorder (GAD), separation anxiety disord ... Full text Link to item Cite

21.1 COGNITIVE-BEHAVIORAL THERAPY–BASED CHANGES IN CONTROL AND REWARD CIRCUITS IN PEDIATRIC OBSESSIVE-COMPULSIVE DISORDER

Conference Journal of the American Academy of Child & Adolescent Psychiatry · October 2016 Full text Cite

Drug overdose risk with benzodiazepine treatment in young adults: Comparative analysis in privately and publicly insured individuals.

Impact of the Youth Behavioral Health Crisis in North Carolina

Subcortical shape in pediatric and adult obsessive-compulsive disorder.

Simultaneous Benzodiazepine and SSRI Initiation in Young People With Anxiety Disorders.

Machine learning approach to measurement of criticism: The core dimension of expressed emotion.

Altered fronto-amygdalar functional connectivity predicts response to cognitive behavioral therapy in pediatric obsessive-compulsive disorder.

Specialty knowledge and competency standards for pharmacotherapy for pediatric obsessive-compulsive disorder.

Structural neural markers of response to cognitive behavioral therapy in pediatric obsessive-compulsive disorder.

Altered network connectivity predicts response to cognitive-behavioral therapy in pediatric obsessive-compulsive disorder.

Correction: Altered network connectivity predicts response to cognitive-behavioral therapy in pediatric obsessive-compulsive disorder.

Journal Article Neuropsychopharmacology · June 2020 An amendment to this paper has been published and can be accessed via a link at the top of the paper. ... Full text Link to item Cite

The Effects of Youth Anxiety Treatment on School Impairment: Differential Outcomes Across CBT, Sertraline, and their Combination.

Primary Care: Meeting the Mental Health Care Needs of Adolescents With Depression.

Lithium for the Maintenance Treatment of Bipolar I Disorder: A Double-Blind, Placebo-Controlled Discontinuation Study.

Pharmacologic treatment of pediatric anxiety disorders

Treating Pediatric Anxiety: Initial Use of SSRIs and Other Antianxiety Prescription Medications.

The Interplay of Familial and Individual Risk in Predicting Clinical Improvements in Pediatric Anxiety Disorders.

Secondary Outcomes From the Child/Adolescent Anxiety Multimodal Study: Implications for Clinical Practice.

Placebo Response in Pediatric Anxiety Disorders: Results from the Child/Adolescent Anxiety Multimodal Study.

Extended Release Guanfacine in Pediatric Anxiety Disorders: A Pilot, Randomized, Placebo-Controlled Trial.

21.1 COGNITIVE-BEHAVIORAL THERAPY–BASED CHANGES IN CONTROL AND REWARD CIRCUITS IN PEDIATRIC OBSESSIVE-COMPULSIVE DISORDER

Conference Journal of the American Academy of Child & Adolescent Psychiatry · October 2016 Full text Cite

3.21 DSM-5 ANXIETY DISORDERS AMONG YOUNG ADULTS IN THE UNITED STATES

Conference Journal of the American Academy of Child & Adolescent Psychiatry · October 2016 Full text Cite

21.0 Abnormal Neural Substrate for Performance Monitoring in Pediatric Obsessive-Compulsive Disorder: Implications for Understanding Treatment Response

Conference Journal of the American Academy of Child & Adolescent Psychiatry · October 2016 Full text Cite

Interpersonal Psychotherapy for Depression: Understanding the Core of the Interpersonal Psychotherapy for Depressed Adolescents Model and Its Adaptations

Conference Journal of the American Academy of Child & Adolescent Psychiatry · October 2016 Full text Cite

9.0 Research Symposium: Behavioral Neuroscience

Conference Journal of the American Academy of Child & Adolescent Psychiatry · October 2016 Full text Cite

47.0 Bringing Evidence-Based Treatment to Emerging Adults With Anxiety Disorders in Three Clinical Settings: The Youth Anxiety Center

Conference Journal of the American Academy of Child & Adolescent Psychiatry · October 2016 Full text Cite

6.80 PLACEBO RESPONSE IN PEDIATRIC ANXIETY DISORDERS: RESULTS FROM THE CHILD AND ADOLESCENT ANXIETY MULTIMODAL STUDY

Conference Journal of the American Academy of Child & Adolescent Psychiatry · October 2016 Full text Cite

Trajectories of change in youth anxiety during cognitive-behavior therapy.

Journal Article J Consult Clin Psychol · April 2015 OBJECTIVE: To evaluate changes in the trajectory of youth anxiety following the introduction of specific cognitive-behavior therapy (CBT) components: relaxation training, cognitive restructuring, and exposure tasks. METHOD: Four hundred eighty-eight youths ... Full text Link to item Cite

Child/Adolescent anxiety multimodal study: evaluating safety.

Journal Article J Am Acad Child Adolesc Psychiatry · March 2015 OBJECTIVE: To evaluate the frequency of adverse events (AEs) across 4 treatment conditions in the Child/Adolescent Anxiety Multimodal Study (CAMS), and to compare the frequency of AEs between children and adolescents. METHOD: Participants ages 7 to 17 year ... Full text Link to item Cite

Predicting Anxiety Diagnoses and Severity with the CBCL-A: Improvement Relative to Other CBCL Scales?

Journal Article J Psychopathol Behav Assess · March 1, 2015 The Child Behavior Checklist (CBCL) is a widely used parent-report of child and adolescent behavior. We examined the ability of the CBCL-A scale, a previously published subset of CBCL items, to predict the presence of generalized anxiety disorder (GAD), se ... Full text Link to item Cite

Efficacy and tolerability of antidepressants in pediatric anxiety disorders: a systematic review and meta-analysis.

Journal Article Depress Anxiety · March 2015 BACKGROUND: Randomized controlled trials have demonstrated that antidepressants are efficacious in the treatment of anxiety disorders in youth. However, there are no recent, systematic analyses of the efficacy, safety, or tolerability of these medications ... Full text Link to item Cite

Parental anxiety as a predictor of medication and CBT response for anxious youth.

Journal Article Child Psychiatry Hum Dev · February 2015 The aim of this investigation was to evaluate how parental anxiety predicted change in pediatric anxiety symptoms across four different interventions: cognitive-behavioral therapy, medication (sertraline; SRT), their combination (COMB), and pill placebo. P ... Full text Link to item Cite

Web-based interventions for youth internalizing problems: a systematic review.

Journal Article J Am Acad Child Adolesc Psychiatry · December 2014 OBJECTIVE: To review published reports on Web-based treatment and prevention programs for depression, anxiety, and suicide prevention in children, adolescents, and emerging adults. METHOD: A systematic search of the PsycINFO, PubMed, Medline, and Web of Sc ... Full text Link to item Cite

Somatic complaints in anxious youth.

Journal Article Child Psychiatry Hum Dev · August 2014 This study examined (a) demographic and clinical characteristics associated with physical symptoms in anxiety-disordered youth and (b) the impact of cognitive-behavioral therapy (Coping Cat), medication (sertraline), their combination, and pill placebo on ... Full text Link to item Cite

Predictors and moderators of treatment response in childhood anxiety disorders: results from the CAMS trial.

Journal Article J Consult Clin Psychol · April 2014 OBJECTIVE: We sought to examine predictors and moderators of treatment outcomes among 488 youths ages 7-17 years (50% female; 74% ≤ 12 years) meeting Diagnostic and Statistical Manual of Mental Disorders (4th ed., text rev.; American Psychiatric Associatio ... Full text Link to item Cite

Naturalistic follow-up of youths treated for pediatric anxiety disorders.

Journal Article JAMA Psychiatry · March 2014 IMPORTANCE: Pediatric anxiety disorders are highly prevalent and impairing and are considered gateway disorders in that they predict adult psychiatric problems. Although they can be effectively treated in the short term, data are limited on the long-term o ... Full text Link to item Cite

24- and 36-week outcomes for the Child/Adolescent Anxiety Multimodal Study (CAMS).

Journal Article J Am Acad Child Adolesc Psychiatry · March 2014 OBJECTIVE: We report active treatment group differences on response and remission rates and changes in anxiety severity at weeks 24 and 36 for the Child/Adolescent Anxiety Multimodal Study (CAMS). METHOD: CAMS youth (N = 488; 74% ≤ 12 years of age) with DS ... Full text Link to item Cite

A probabilistic and individualized approach for predicting treatment gains: an extension and application to anxiety disordered youth.

Journal Article Behav Ther · January 2014 The objective of this study was to extend the probability of treatment benefit method by adding treatment condition as a stratifying variable, and illustrate this extension of the methodology using the Child and Adolescent Anxiety Multimodal Study data. Th ... Full text Link to item Cite

Assessing anxiety in youth with the multidimensional anxiety scale for children.

Journal Article J Clin Child Adolesc Psychol · 2014 The present study examined the psychometric properties, including discriminant validity and clinical utility, of the youth self-report and parent-report forms of the Multidimensional Anxiety Scale for Children (MASC) among youth with anxiety disorders. The ... Full text Link to item Cite

The therapeutic relationship in cognitive-behavioral therapy and pharmacotherapy for anxious youth.

Journal Article J Consult Clin Psychol · October 2013 OBJECTIVE: We examined the therapeutic relationship with cognitive-behavioral therapists and with pharmacotherapists for youth from the Child/Adolescent Anxiety Multimodal Study (Walkup et al., 2008). The therapeutic relationship was examined in relation t ... Full text Link to item Cite

Benefits of child-focused anxiety treatments for parents and family functioning.

Journal Article Depress Anxiety · September 2013 BACKGROUND: To examine (1) changes in parent (global psychological distress, trait anxiety) and family (dysfunction, burden) functioning following 12 weeks of child-focused anxiety treatment, and (2) whether changes in these parent and family factors were ... Full text Link to item Cite

Therapist Factors and Outcomes in CBT for Anxiety in Youth.

Journal Article Prof Psychol Res Pr · April 2013 This study examined the relationship between therapist factors and child outcomes in anxious youth who received cognitive-behavioral therapy (CBT) as part of the Child-Adolescent Anxiety Multimodal Study (CAMS). Of the 488 youth who participated in the CAM ... Full text Link to item Cite

Remission of generalized anxiety disorder after 6 months of open-label treatment with venlafaxine XR.

Journal Article Psychother Psychosom · 2013 BACKGROUND: Remission has become one of the leading outcome criteria in clinical trials. Data collected by this research group assessed the rate of remission after 6 months of treatment of generalized anxiety disorder (GAD) with venlafaxine XR, to search f ... Full text Link to item Cite

Defining treatment response and remission in child anxiety: signal detection analysis using the pediatric anxiety rating scale.

Journal Article J Am Acad Child Adolesc Psychiatry · January 2013 OBJECTIVE: To determine optimal Pediatric Anxiety Rating Scale (PARS) percent reduction and raw score cut-offs for predicting treatment response and remission among children and adolescents with anxiety disorders. METHOD: Data were from a subset of youth ( ... Full text Link to item Cite

SMARTer discontinuation trial designs for developing an adaptive treatment strategy.

Journal Article J Child Adolesc Psychopharmacol · October 2012 OBJECTIVE: Developing evidenced-based practices for the management of childhood psychiatric disorders requires research studies that address how to treat children during both the acute phase of the disorder and beyond. Given the selection of a medication f ... Full text Link to item Cite

Psychopharmacologic treatment of children and adolescents with anxiety disorders.

Journal Article Child Adolesc Psychiatr Clin N Am · July 2012 Over the last decade, psychopharmacologic treatments for pediatric anxiety disorders have been developed and increasingly subjected to randomized, controlled trials. The authors summarize the data concerning the use of tricyclic antidepressants (TCAs), sel ... Full text Link to item Cite

Childhood anxiety: lessons learned.

Journal Article Child Adolesc Psychiatr Clin N Am · July 2012 Full text Link to item Cite

Establishing the neurobiologic basis of treatment in children and adolescents with generalized anxiety disorder.

Journal Article Depress Anxiety · April 2012 Generalized anxiety disorder (GAD) is associated with significant morbidity in children and adolescents, yet only recently have the neuropharmacology and neurophysiology of this condition been studied in youth. Accumulating data suggest structural and func ... Full text Link to item Cite

Tricyclic Antidepressants and Monoamine Oxidase Inhibitors for the Treatment of Child and Adolescent Psychiatric Disorders

Chapter · February 17, 2012 Tricyclic Antidepressants (TCAs) and Monoamine Oxidase Inhibitors (MAOIs) remain useful pharmacotherapies for pediatric psychiatric disorders despite the fact that they are no longer used as first line medications. In pediatric populations, evidence suppor ... Full text Cite

Short-term dynamic psychotherapy versus pharmacotherapy for major depressive disorder: a randomized, placebo-controlled trial.

Journal Article J Clin Psychiatry · January 2012 OBJECTIVE: To determine whether supportive-expressive psychotherapy (SET), a form of dynamic psychotherapy, and pharmacotherapy + clinical management (MED) for major depressive disorder (MDD) are more effective than pill-placebo + clinical management (PBO) ... Full text Link to item Cite

Dr Barber and colleagues reply

Journal Article Journal of Clinical Psychiatry · January 1, 2012 Full text Cite

Remission after acute treatment in children and adolescents with anxiety disorders: findings from the CAMS.

Journal Article J Consult Clin Psychol · December 2011 OBJECTIVE: To report on remission rates in anxious youth who participated in the Child/Adolescent Anxiety Multimodal Study (CAMS). The CAMS, a multisite clinical trial, randomized 488 children and adolescents (ages 7-17 years; 79% Caucasian; 50% female) wi ... Full text Link to item Cite

Screening parents during child evaluations: exploring parent and child psychopathology in the same clinic.

Journal Article J Am Acad Child Adolesc Psychiatry · May 2011 OBJECTIVE: Children of depressed and/or anxious parents are at increased risk for developing psychiatric disorders. Little research has focused on screening parents bringing their children for psychiatric evaluation, and few studies have included fathers o ... Full text Link to item Cite

Time to relapse after 6 and 12 months' treatment of generalized anxiety disorder with venlafaxine extended release.

Journal Article Arch Gen Psychiatry · December 2010 CONTEXT: Generalized anxiety disorder (GAD) is a chronic disorder in need of reliable data to guide long-term treatment. OBJECTIVES: To assess the benefits of 6 and 12 months' treatment of GAD with venlafaxine hydrochloride extended release (XR) in patient ... Full text Link to item Cite

Clinical characteristics of anxiety disordered youth.

Journal Article J Anxiety Disord · April 2010 Reports the characteristics of a large, representative sample of treatment-seeking anxious youth (N=488). Participants, aged 7-17 years (mean 10.7 years), had a principal DSM-IV diagnosis of separation anxiety disorder (SAD), generalized anxiety disorder ( ... Full text Link to item Cite

Child/Adolescent Anxiety Multimodal Study (CAMS): rationale, design, and methods.

Journal Article Child Adolesc Psychiatry Ment Health · January 5, 2010 OBJECTIVE: To present the design, methods, and rationale of the Child/Adolescent Anxiety Multimodal Study (CAMS), a recently completed federally-funded, multi-site, randomized placebo-controlled trial that examined the relative efficacy of cognitive-behavi ... Full text Link to item Cite

Childhood anxiety disorders: Best treatment options and practice

Chapter · January 1, 2010 Introduction Growing up with an anxiety disorder that interferes with everyday life activities and enjoyment can be a painful and exhausting experience, both for the child and for his or her caregivers. Unfortunately, anxiety disorders often are not identi ... Full text Cite

Cognitive behavioral therapy, sertraline, or a combination in childhood anxiety.

Journal Article N Engl J Med · December 25, 2008 BACKGROUND: Anxiety disorders are common psychiatric conditions affecting children and adolescents. Although cognitive behavioral therapy and selective serotonin-reuptake inhibitors have shown efficacy in treating these disorders, little is known about the ... Full text Link to item Cite

Attention bias toward threat in pediatric anxiety disorders.

Journal Article J Am Acad Child Adolesc Psychiatry · October 2008 OBJECTIVE: To examine attention bias toward threat faces in a large sample of anxiety-disordered youths using a well-established visual probe task. METHOD: Study participants included 101 children and adolescents (ages 7-18 years) with generalized anxiety ... Full text Link to item Cite

Influence of gender on the clinical presentation of generalized anxiety disorder, and response to treatment with Pregabalin

Conference European Psychiatry · April 2008 Full text Cite

The varied manifestations of anxiety disorder

Journal Article Psychiatric Times · February 1, 2008 Cite

A Randomized controlled trial of venlafaxine ER versus placebo in pediatric social anxiety disorder.

Journal Article Biol Psychiatry · November 15, 2007 BACKGROUND: Social anxiety disorder, which occurs in 2% to 5% of children and adolescents, is associated with significant distress and functional impairment. METHODS: The objective of the randomized, masked controlled trial conducted in 48 academic and com ... Full text Link to item Cite

Efficacy and safety of extended-release venlafaxine in the treatment of generalized anxiety disorder in children and adolescents: two placebo-controlled trials.

Journal Article Am J Psychiatry · February 2007 OBJECTIVE: The authors evaluated the efficacy, safety, and tolerability of extended-release venlafaxine in the treatment of pediatric generalized anxiety disorder. METHOD: Two randomized, double-blind, placebo-controlled trials were conducted at 59 sites i ... Full text Link to item Cite

Social anxiety disorder in children and adolescents: epidemiology, diagnosis, and treatment.

Journal Article Paediatr Drugs · 2007 Social anxiety disorder (SOC) is characterized by marked and persistent fear of one or more social performance situations in which the person is exposed to unfamiliar people or to possible scrutiny. The person fears that she or he might act in a way that w ... Full text Link to item Cite

Selegiline transdermal system for the treatment of major depressive disorder: an 8-week, double-blind, placebo-controlled, flexible-dose titration trial.

Journal Article J Clin Psychiatry · September 2006 OBJECTIVE: This study investigated the efficacy, safety, and tolerability of the selegiline transdermal system (STS) administered in a dose range of 6 mg/24 hours to 12 mg/24 hours for treating major depressive disorder (MDD). METHOD: Patients meeting DSM- ... Full text Link to item Cite

The psychometric properties of the MASC in a pediatric psychiatric sample.

Journal Article J Anxiety Disord · 2006 The goals of this study were twofold: to examine the psychometric properties of the Multidimensional Anxiety Scale for Children (MASC) in a clinical sample of 193 children and adolescents who had received a diagnosis of major depressive or anxiety disorder ... Full text Link to item Cite

Open-label pilot study of ziprasidone for refractory generalized anxiety disorder.

Journal Article J Clin Psychopharmacol · October 2005 Full text Link to item Cite

Generalized anxiety disorder: acute and chronic treatment.

Journal Article CNS Spectr · October 2004 Clinical and epidemiological data suggest that generalized anxiety disorder (GAD) is a chronic illness causing patients to suffer for many years leading to significant distress in daily life functioning. The literature suggests the several conclusions. GAD ... Full text Link to item Cite

Paroxetine in the treatment of generalised anxiety disorder.

Journal Article Expert Opin Pharmacother · August 2004 Paroxetine is a selective serotonin re-uptake inhibitor useful in the treatment of a wide range of psychiatric disorders. Generalised anxiety disorder (GAD) is characterised by excessive persistent anxiety and worry about a number of events and activities ... Full text Link to item Cite

49th Annual Meeting of the American Academy of Child & Adolescent Psychiatry. 22-27 October 2002, San Francisco, CA, USA.

Journal Article Expert Opin Pharmacother · April 2003 The diverse programme covered recent advances in developmental neurobiology, genetics, psychotherapy and pharmacotherapy. Presentations included clinical consultation breakfasts, with experts in their specialities, clinical case conferences, media theatre ... Full text Link to item Cite

Ziprasidone-associated mania: a case series and review of the mechanism.

Journal Article Bipolar Disord · February 2003 Atypical antipsychotics are now commonly used in the treatment of bipolar disorder, as they have been shown to have effects on mania as well as psychosis. Shortly after the introduction of atypical antipsychotics, several cases of associated hypomania and ... Full text Link to item Cite

Efficacy and safety of nefazadone in the treatment of adolescents with major depressive disorder

Conference JOURNAL OF CHILD AND ADOLESCENT PSYCHOPHARMACOLOGY · December 1, 2002 Link to item Cite

Desipramine toxicity with terbinafine.

Journal Article Am J Psychiatry · March 2002 Full text Link to item Cite

Placebo-controlled trial of sertraline in the treatment of children with generalized anxiety disorder.

Journal Article Am J Psychiatry · December 2001 OBJECTIVE: The study compared the safety and efficacy of sertraline, a selective serotonin reuptake inhibitor, and placebo in the treatment of generalized anxiety disorder in children and adolescents. METHOD: The study subjects were 22 children and adolesc ... Full text Link to item Cite

What is generalized anxiety disorder?

Journal Article J Clin Psychiatry · 2001 Generalized, persistent, and free-floating anxiety was first described by Freud in 1894, although the diagnostic term generalized anxiety disorder (GAD) was not included in classification systems until 1980 (Diagnostic and Statistical Manual for Mental Dis ... Link to item Cite

Assessment of Psychiatric Comorbidity in Children Infected with Human Immunodeficiency Virus, Type 1

Conference Pediatric Research · April 1999 Full text Cite