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Nicole DePasquale

Assistant Professor in Medicine
Medicine, General Internal Medicine

Selected Publications


Elevated Amyloid-β PET Scan and Cognitive and Functional Decline in Mild Cognitive Impairment and Dementia of Uncertain Etiology.

Journal Article J Alzheimers Dis · 2024 BACKGROUND: Elevated amyloid-β (Aβ) on positron emission tomography (PET) scan is used to aid diagnosis of Alzheimer's disease (AD), but many prior studies have focused on patients with a typical AD phenotype such as amnestic mild cognitive impairment (MCI ... Full text Link to item Cite

Association of Age and Gender With Concerns About Live Donor Kidney Transplantation Among Black Individuals.

Conference Transplant Proc · December 2023 Black individuals are less likely to receive live donor kidney transplantation (LDKT) compared to others. This may be partly related to their concerns about LDKT, which can vary based on age and gender. We conducted a cross-sectional, secondary analysis of ... Full text Link to item Cite

"I know that my role is going to change": a mixed-methods study of the relationship between amyloid-β PET scan results and caregiver burden.

Journal Article Aging Clin Exp Res · February 2023 BACKGROUND: Caregiver burden consists of disease specific and perceived stressors, respectively referred to as objective and subjective indicators of burden, and is associated with negative outcomes. Previous research has found that care partners to person ... Full text Link to item Cite

Association of Perceived Neighborhood Health With Hypertension Self-care.

Journal Article JAMA Netw Open · February 1, 2023 IMPORTANCE: Hypertension self-management is recommended for optimal blood pressure (BP) control, but self-identified residential contextual factors that hinder hypertension self-care are understudied. OBJECTIVE: To quantify perceived neighborhood health an ... Full text Link to item Cite

Advance directives among cognitively impaired persons who had an amyloid PET scan and their care partners: a mixed-methods study.

Journal Article BMC Palliat Care · November 6, 2022 BACKGROUND: Little research exists on the role of β-amyloid PET scans as part of Alzheimer's diagnostic tests and documentation of end-of-life preferences for persons with cognitive impairment. The study objectives were to examine the association of amyloi ... Full text Link to item Cite

Receipt and Sharing of Information to Improve Knowledge About Living Donor Kidney Transplant among Transplant Candidates with Advanced Chronic Kidney Disease.

Journal Article Prog Transplant · September 2022 Introduction: Knowledge about living donor kidney transplant (LDKT) is associated with greater access. Yet, little is known about factors associated with high living donor transplant knowledge. Research Questions: Is receipt of LDKT information from health ... Full text Link to item Cite

Decisional Conflict About Kidney Failure Treatment Modalities Among Adults With Advanced CKD.

Journal Article Kidney Med · September 2022 RATIONALE & OBJECTIVE: Choosing from multiple kidney failure treatment modalities can create decisional conflict, but little is known about this experience before decision implementation. We explored decisional conflict about treatment for kidney failure a ... Full text Link to item Cite

Making the Informal Formal: Discussing and Completing Advance Care Plans in Care Dyads with Cognitive Impairment.

Journal Article J Palliat Care · July 2022 Background: Discussing advance care planning (ACP) with care partners may be a steppingstone to the completion of advance directives (ADs) for persons with cognitive impairment (PwCIs). Objectives: To examine whether PwCI-reported occurrence of and PwCI-ca ... Full text Link to item Cite

Unintended Consequences of COVID-19 Social Distancing Among Older Adults With Kidney Disease.

Journal Article J Gerontol A Biol Sci Med Sci · April 1, 2022 BACKGROUND: While social distancing policies protect older adults with advanced chronic kidney disease (CKD) from exposure to COVID-19, reduced social interaction may also have unintended consequences. METHODS: To identify subgroups of patients at risk for ... Full text Link to item Cite

Disparities in Discussions about Kidney Replacement Therapy in CKD Care.

Journal Article Kidney360 · January 27, 2022 Participants who identified as female and Black reported more thorough discussions of dialysis than transplant.Participants with low incomes and education reported more thorough discussions of dialysis than transplant. ... Full text Link to item Cite

Amyloid-β PET Scan Results Disclosure and Care-Partner Emotional Well-Being Over Time.

Journal Article J Alzheimers Dis · 2022 BACKGROUND: Diagnostic tests, such as amyloid-β positron emission tomography (PET) scans, can increase appropriate therapeutic management for the underlying causes of cognitive decline. To evaluate the full utility of this diagnostic tool, information is n ... Full text Link to item Cite

The potential of mHealth for older adults on dialysis and their care partners: What's been done and where do we go from here?

Journal Article Front Nephrol · 2022 Self-care, or the dynamic, daily process of becoming actively involved in one's own care, is paramount to prevent and manage complications of end-stage kidney disease. However, many older dialysis patients face distinctive challenges to adequate engagement ... Full text Link to item Cite

African Americans' discussions about living-donor kidney transplants with family or friends: Who, what, and why not?

Journal Article Clin Transplant · April 2021 BACKGROUND: Although discussions with family or friends can improve access to living-donor kidney transplantation (LDKT), they remain an understudied step in the LDKT process. METHODS: Among 300 African American transplant candidates, we examined how socio ... Full text Link to item Cite

Midlife Children's and Older Mothers' Depressive Symptoms: Empathic Mother-Child Relationships as a Key Moderator.

Journal Article Fam Relat · December 2020 OBJECTIVE: This study aimed to evaluate the link between midlife children's and older mothers' depressive symptoms, whether this link is exacerbated in highly empathic mother-child relationships (i.e., shared strong feelings of being loved, cared for, and ... Full text Link to item Cite

Family-supportive supervisor behaviour positively affects work behaviour and nonwork well-being among men in long-term care.

Journal Article J Nurs Manag · October 2020 AIMS: This study examined whether family-supportive supervisor behavior is associated with work behavior (safety compliance and organizational citizenship behavior) and nonwork well#x2010;being (family time adequacy, time in bed and sleep quality) among me ... Full text Link to item Cite

Mechanisms Through Which a Family Caregiver Coaching Intervention Might Reduce Anxiety Among Children in Military Households.

Journal Article Matern Child Health J · October 2020 OBJECTIVES: Children of injured or disabled veterans and service members may be at risk for mental health and adjustment problems due to household stress. Yet, there are few widely available interventions to address the needs of this population. Reducing d ... Full text Link to item Cite

"I Wish Someone Had Told Me That Could Happen": A Thematic Analysis of Patients' Unexpected Experiences With End-Stage Kidney Disease Treatment.

Journal Article J Patient Exp · August 2020 BACKGROUND: Preparedness regarding prognosis and treatment options enables patients to cope with uncertainties, make value-based treatment decisions, and set treatment goals. Yet, little is known about the expectedness of end-stage kidney disease (ESKD) pa ... Full text Link to item Cite

Essential Long-Term Care Workers Commonly Hold Second Jobs and Double- or Triple-Duty Caregiving Roles.

Journal Article J Am Geriatr Soc · August 2020 OBJECTIVES: Long-term care (LTC) facilities are particularly dangerous places for the spread of COVID-19 given that they house vulnerable high-risk populations. Transmission-based precautions to protect residents, employees, and families alike must account ... Full text Open Access Link to item Cite

Associations of perceived information adequacy and knowledge with pursuit of live donor kidney transplants and living donor inquiries among African American transplant candidates.

Journal Article Clin Transplant · March 2020 We studied associations between perceived adequacy of live donor kidney transplant (LDKT) information or knowledge with pursuit of LDKT or receipt of live donor inquiries among 300 African American kidney transplant candidates. Participants reported via qu ... Full text Link to item Cite

The Relationship between Subjective Cognitive Impairment and Activity Participation: A Systematic Review.

Conference Act Adapt Aging · 2020 This systematic review synthesizes current evidence to determine how subjective cognitive impairment (SCI) relates to physical, cognitive, and social activity participation in older adults. Nine peer-reviewed articles were reviewed and appraised for eviden ... Full text Link to item Cite

Elevated Amyloid-β PET Scan and Cognitive and Functional Decline in Mild Cognitive Impairment and Dementia of Uncertain Etiology.

Journal Article J Alzheimers Dis · 2024 BACKGROUND: Elevated amyloid-β (Aβ) on positron emission tomography (PET) scan is used to aid diagnosis of Alzheimer's disease (AD), but many prior studies have focused on patients with a typical AD phenotype such as amnestic mild cognitive impairment (MCI ... Full text Link to item Cite

Association of Age and Gender With Concerns About Live Donor Kidney Transplantation Among Black Individuals.

Conference Transplant Proc · December 2023 Black individuals are less likely to receive live donor kidney transplantation (LDKT) compared to others. This may be partly related to their concerns about LDKT, which can vary based on age and gender. We conducted a cross-sectional, secondary analysis of ... Full text Link to item Cite

"I know that my role is going to change": a mixed-methods study of the relationship between amyloid-β PET scan results and caregiver burden.

Journal Article Aging Clin Exp Res · February 2023 BACKGROUND: Caregiver burden consists of disease specific and perceived stressors, respectively referred to as objective and subjective indicators of burden, and is associated with negative outcomes. Previous research has found that care partners to person ... Full text Link to item Cite

Association of Perceived Neighborhood Health With Hypertension Self-care.

Journal Article JAMA Netw Open · February 1, 2023 IMPORTANCE: Hypertension self-management is recommended for optimal blood pressure (BP) control, but self-identified residential contextual factors that hinder hypertension self-care are understudied. OBJECTIVE: To quantify perceived neighborhood health an ... Full text Link to item Cite

Advance directives among cognitively impaired persons who had an amyloid PET scan and their care partners: a mixed-methods study.

Journal Article BMC Palliat Care · November 6, 2022 BACKGROUND: Little research exists on the role of β-amyloid PET scans as part of Alzheimer's diagnostic tests and documentation of end-of-life preferences for persons with cognitive impairment. The study objectives were to examine the association of amyloi ... Full text Link to item Cite

Receipt and Sharing of Information to Improve Knowledge About Living Donor Kidney Transplant among Transplant Candidates with Advanced Chronic Kidney Disease.

Journal Article Prog Transplant · September 2022 Introduction: Knowledge about living donor kidney transplant (LDKT) is associated with greater access. Yet, little is known about factors associated with high living donor transplant knowledge. Research Questions: Is receipt of LDKT information from health ... Full text Link to item Cite

Decisional Conflict About Kidney Failure Treatment Modalities Among Adults With Advanced CKD.

Journal Article Kidney Med · September 2022 RATIONALE & OBJECTIVE: Choosing from multiple kidney failure treatment modalities can create decisional conflict, but little is known about this experience before decision implementation. We explored decisional conflict about treatment for kidney failure a ... Full text Link to item Cite

Making the Informal Formal: Discussing and Completing Advance Care Plans in Care Dyads with Cognitive Impairment.

Journal Article J Palliat Care · July 2022 Background: Discussing advance care planning (ACP) with care partners may be a steppingstone to the completion of advance directives (ADs) for persons with cognitive impairment (PwCIs). Objectives: To examine whether PwCI-reported occurrence of and PwCI-ca ... Full text Link to item Cite

Unintended Consequences of COVID-19 Social Distancing Among Older Adults With Kidney Disease.

Journal Article J Gerontol A Biol Sci Med Sci · April 1, 2022 BACKGROUND: While social distancing policies protect older adults with advanced chronic kidney disease (CKD) from exposure to COVID-19, reduced social interaction may also have unintended consequences. METHODS: To identify subgroups of patients at risk for ... Full text Link to item Cite

Disparities in Discussions about Kidney Replacement Therapy in CKD Care.

Journal Article Kidney360 · January 27, 2022 Participants who identified as female and Black reported more thorough discussions of dialysis than transplant.Participants with low incomes and education reported more thorough discussions of dialysis than transplant. ... Full text Link to item Cite

Amyloid-β PET Scan Results Disclosure and Care-Partner Emotional Well-Being Over Time.

Journal Article J Alzheimers Dis · 2022 BACKGROUND: Diagnostic tests, such as amyloid-β positron emission tomography (PET) scans, can increase appropriate therapeutic management for the underlying causes of cognitive decline. To evaluate the full utility of this diagnostic tool, information is n ... Full text Link to item Cite

The potential of mHealth for older adults on dialysis and their care partners: What's been done and where do we go from here?

Journal Article Front Nephrol · 2022 Self-care, or the dynamic, daily process of becoming actively involved in one's own care, is paramount to prevent and manage complications of end-stage kidney disease. However, many older dialysis patients face distinctive challenges to adequate engagement ... Full text Link to item Cite

African Americans' discussions about living-donor kidney transplants with family or friends: Who, what, and why not?

Journal Article Clin Transplant · April 2021 BACKGROUND: Although discussions with family or friends can improve access to living-donor kidney transplantation (LDKT), they remain an understudied step in the LDKT process. METHODS: Among 300 African American transplant candidates, we examined how socio ... Full text Link to item Cite

Midlife Children's and Older Mothers' Depressive Symptoms: Empathic Mother-Child Relationships as a Key Moderator.

Journal Article Fam Relat · December 2020 OBJECTIVE: This study aimed to evaluate the link between midlife children's and older mothers' depressive symptoms, whether this link is exacerbated in highly empathic mother-child relationships (i.e., shared strong feelings of being loved, cared for, and ... Full text Link to item Cite

Family-supportive supervisor behaviour positively affects work behaviour and nonwork well-being among men in long-term care.

Journal Article J Nurs Manag · October 2020 AIMS: This study examined whether family-supportive supervisor behavior is associated with work behavior (safety compliance and organizational citizenship behavior) and nonwork well#x2010;being (family time adequacy, time in bed and sleep quality) among me ... Full text Link to item Cite

Mechanisms Through Which a Family Caregiver Coaching Intervention Might Reduce Anxiety Among Children in Military Households.

Journal Article Matern Child Health J · October 2020 OBJECTIVES: Children of injured or disabled veterans and service members may be at risk for mental health and adjustment problems due to household stress. Yet, there are few widely available interventions to address the needs of this population. Reducing d ... Full text Link to item Cite

"I Wish Someone Had Told Me That Could Happen": A Thematic Analysis of Patients' Unexpected Experiences With End-Stage Kidney Disease Treatment.

Journal Article J Patient Exp · August 2020 BACKGROUND: Preparedness regarding prognosis and treatment options enables patients to cope with uncertainties, make value-based treatment decisions, and set treatment goals. Yet, little is known about the expectedness of end-stage kidney disease (ESKD) pa ... Full text Link to item Cite

Essential Long-Term Care Workers Commonly Hold Second Jobs and Double- or Triple-Duty Caregiving Roles.

Journal Article J Am Geriatr Soc · August 2020 OBJECTIVES: Long-term care (LTC) facilities are particularly dangerous places for the spread of COVID-19 given that they house vulnerable high-risk populations. Transmission-based precautions to protect residents, employees, and families alike must account ... Full text Open Access Link to item Cite

Associations of perceived information adequacy and knowledge with pursuit of live donor kidney transplants and living donor inquiries among African American transplant candidates.

Journal Article Clin Transplant · March 2020 We studied associations between perceived adequacy of live donor kidney transplant (LDKT) information or knowledge with pursuit of LDKT or receipt of live donor inquiries among 300 African American kidney transplant candidates. Participants reported via qu ... Full text Link to item Cite

The Relationship between Subjective Cognitive Impairment and Activity Participation: A Systematic Review.

Conference Act Adapt Aging · 2020 This systematic review synthesizes current evidence to determine how subjective cognitive impairment (SCI) relates to physical, cognitive, and social activity participation in older adults. Nine peer-reviewed articles were reviewed and appraised for eviden ... Full text Link to item Cite

Hypertension Self-management in Socially Disadvantaged African Americans: the Achieving Blood Pressure Control Together (ACT) Randomized Comparative Effectiveness Trial.

Journal Article J Gen Intern Med · January 2020 BACKGROUND: Effective hypertension self-management interventions are needed for socially disadvantaged African Americans, who have poorer blood pressure (BP) control compared to others. OBJECTIVE: We studied the incremental effectiveness of contextually ad ... Full text Link to item Cite

Perspectives of African-American Family Members about Kidney Failure Treatment.

Journal Article Nephrol Nurs J · 2020 Understanding African-American families' experiences with treatment for kidney failure is necessary for informing the delivery of family-centered care and the design of appropriate interventions. This qualitative study explored treatment-related questions, ... Link to item Cite

Tonight's Sleep Predicts Tomorrow's Fatigue: A Daily Diary Study of Long-Term Care Employees With Nonwork Caregiving Roles.

Journal Article Gerontologist · November 16, 2019 BACKGROUND AND OBJECTIVES: Long-term care employees and employees with nonwork caregiving roles are at high risk for sleep problems and fatigue. Little is known, however, about relationships between sleep and fatigue among long-term care employees who occu ... Full text Link to item Cite

Predictors of Secondary Role Strains Among Spousal Caregivers of Older Adults With Functional Disability.

Journal Article Gerontologist · May 17, 2019 BACKGROUND AND OBJECTIVES: Aging spouses commonly care for a partner with functional disability, but little is known about how spousal caregiving may impact different life domains. This study evaluated how caregiving characteristics are associated with sec ... Full text Link to item Cite

Unpaid Caregiving Roles and Sleep Among Women Working in Nursing Homes: A Longitudinal Study.

Journal Article Gerontologist · May 17, 2019 BACKGROUND AND OBJECTIVES: Although sleep is a critical health outcome providing insight into overall health, well-being, and role functioning, little is known about the sleep consequences of simultaneously occupying paid and unpaid caregiving roles. This ... Full text Link to item Cite

Family Members' Experiences With Dialysis and Kidney Transplantation.

Journal Article Kidney Med · 2019 RATIONALE & OBJECTIVE: Understanding whether family members' experiences with patients' treatment for end-stage kidney disease (ESKD) were expected could guide the development of family-centered interventions that enhance the preparedness of patients and t ... Full text Link to item Cite

Health Behavior Among Men With Multiple Family Roles: The Moderating Effects of Perceived Partner Relationship Quality

Journal Article American Journal of Men's Health · November 2018 Men in the United States are increasingly involved in their children’s lives and currently represent 40% of informal caregivers to dependent relatives or friends aged 18 years and older. Yet much more is known about the health effects of varying f ... Full text Cite

Double- and Triple-Duty Caregiving Men: An Examination of Subjective Stress and Perceived Schedule Control

Journal Article Journal of Applied Gerontology · April 2018 Based on the stress process model of family caregiving, this study examined subjective stress appraisals and perceived schedule control among men employed in the long-term care industry (workplace-only caregivers) who concurrently occupied unpaid ... Full text Cite

Subjective cognitive impairment and quality of life: a systematic review.

Journal Article Int Psychogeriatr · December 2017 BACKGROUND: Older adults with subjective cognitive impairment (SCI) experience increased affective symptoms, reduced engagement in a range of activities, as well as more functional problems when compared to those without SCI. These associations suggest tha ... Full text Link to item Cite

The Psychosocial Implications of Managing Work and Family Caregiving Roles: Gender Differences Among Information Technology Professionals

Journal Article Journal of Family Issues · August 2017 An increasing number of adults, both men and women, are simultaneously managing work and family caregiving roles. Guided by the stress process model, we investigate whether 823 employees occupying diverse family caregiving roles (child caregiving ... Full text Cite

Family care work: a policy-relevant research agenda

Journal Article International Journal of Care and Caring · March 2017 This article addresses the need for policy-relevant research agendas on family care in transaction with formal care and public as well as organisational norms and policies in light of the crisis in caregiving for older adults. We propose a combined ... Full text Cite

Relationship Quality Between Older Fathers and Middle-Aged Children: Associations With Both Parties’ Subjective Well-Being

Journal Article The Journals of Gerontology Series B: Psychological Sciences and Social Sciences · August 12, 2016 Full text Cite

Combining Formal and Informal Caregiving Roles: The Psychosocial Implications of Double- and Triple-Duty Care

Journal Article The Journals of Gerontology Series B: Psychological Sciences and Social Sciences · March 2016 Full text Cite

Improving urban African Americans' blood pressure control through multi-level interventions in the Achieving Blood Pressure Control Together (ACT) study: a randomized clinical trial.

Journal Article Contemp Clin Trials · July 2014 BACKGROUND: Given their high rates of uncontrolled blood pressure, urban African Americans comprise a particularly vulnerable subgroup of persons with hypertension. Substantial evidence has demonstrated the important role of family and community support in ... Full text Link to item Cite

Effectiveness of educational and social worker interventions to activate patients' discussion and pursuit of preemptive living donor kidney transplantation: a randomized controlled trial.

Journal Article Am J Kidney Dis · March 2013 BACKGROUND: Many patients with chronic kidney disease (CKD) have difficulty becoming actively engaged in the pursuit of preemptive living donor kidney transplantation. STUDY DESIGN: The Talking About Live Kidney Donation (TALK) Study was a randomized contr ... Full text Link to item Cite

Selecting renal replacement therapies: what do African American and non-African American patients and their families think others should know? A mixed methods study.

Journal Article BMC Nephrol · January 14, 2013 BACKGROUND: Little is known regarding the types of information African American and non-African American patients with chronic kidney disease (CKD) and their families need to inform renal replacement therapy (RRT) decisions. METHODS: In 20 structured group ... Full text Open Access Link to item Cite

The Talking about Live Kidney Donation (TALK) Social Worker Intervention: Putting it into Practice

Journal Article Journal of Nephrology Social Work · 2013 Featured Publication Live kidney transplantation (LKT) is underutilized among patients with kidney disease. Social workers may be particularly effective in helping patients and their families overcome barriers to considering and/or pursuing LKT because of their expertise in he ... Link to item Cite

Development of a decision aid to inform patients' and families' renal replacement therapy selection decisions.

Journal Article BMC Med Inform Decis Mak · December 1, 2012 BACKGROUND: Few educational resources have been developed to inform patients' renal replacement therapy (RRT) selection decisions. Patients progressing toward end stage renal disease (ESRD) must decide among multiple treatment options with varying characte ... Full text Open Access Link to item Cite

Feasibility and acceptability of the TALK social worker intervention to improve live kidney transplantation.

Journal Article Health Soc Work · November 2012 Featured Publication Live kidney transplantation (LKT) is underused by patients with end-stage renal disease. Easily implementable and effective interventions to improve patients' early consideration of LKT are needed. The Talking About Live Kidney Donation (TALK) social worke ... Full text Link to item Cite

The providing resources to enhance African American patients' readiness to make decisions about kidney disease (PREPARED) study: protocol of a randomized controlled trial.

Journal Article BMC Nephrol · October 12, 2012 BACKGROUND: Living related kidney transplantation (LRT) is underutilized, particularly among African Americans. The effectiveness of informational and financial interventions to enhance informed decision-making among African Americans with end stage renal ... Full text Open Access Link to item Cite

Protocol of a randomized controlled trial of culturally sensitive interventions to improve African Americans' and non-African Americans' early, shared, and informed consideration of live kidney transplantation: the Talking About Live Kidney Donation (TALK) Study.

Journal Article BMC Nephrol · July 8, 2011 BACKGROUND: Live kidney transplantation (LKT) is underutilized, particularly among ethnic/racial minorities. The effectiveness of culturally sensitive educational and behavioral interventions to encourage patients' early, shared (with family and health car ... Full text Link to item Cite

Social and Behavior Change Interventions Landscaping Study: A global review

Report · 2011 This report summarizes programmatic and research implications from the past decade of research (2000-2010) on health-related social and behavior change interventions in developed and developing countries. We conducted a search for peer-reviewed literature ... Cite