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Nilakshee Bhattacharya

Research & Dev Engineer III
Pratt School of Engineering

Overview


Nilakshee is the CryoEM Manager for the cryo-electron microscopy facility housed within SMIF. She serves as the primary contact for the Thermo Fisher Krios G2i 300 keV and the 100 keV cryo-TEM instruments.

She holds a M.S. in Molecular Biology from Colorado State University and a Ph.D. in Biochemistry from Florida State University.

With over fifteen years of experience in the field of cryo-electron microscopy, Nilakshee’s expertise spans vitrified sample preparation, data collection, and data processing. Her research interests and technical strengths lie in single-particle analysis and tomography.

Nilakshee joined SMIF in 2020 and currently leads the cryoEM team, overseeing facility operations, training, and project development.

Current Appointments & Affiliations


Research & Dev Engineer III Pratt School of Engineering

Recent Publications


Maize Streak Virus: Single and Gemini Capsid Architecture

Journal Article Viruses · November 29, 2024 Geminiviridae are ssDNA plant viruses whose control has both economical and agricultural importance. Their capsids assemble into two distinct architectural forms: (i) a T = 1 icosahedral and (ii) a unique twinned quasi-isometric capsid. Described h ... Full text Cite

Structural and Biophysical Analysis of Adeno-Associated Virus Serotype 2 Capsid Assembly Variants

Journal Article Journal of Virology · July 27, 2023 Adeno-associated viruses (AAVs) have been shown to be useful vectors for gene therapy applications. Consequently, AAV has been approved as a biologic for the treatment of several monogenic disorders, and many additional clinical trials are ongoing. ... Full text Cite

Characterization of the Serpentine Adeno-Associated Virus (SAAV) Capsid Structure: Receptor Interactions and Antigenicity

Journal Article Journal of Virology · June 8, 2022 AAVs are widely studied therapeutic gene delivery vectors. However, preexisting antibodies and their detrimental effect on therapeutic efficacy are a primary challenge encountered during clinical trials. ... Full text Cite
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