Journal ArticleViruses · November 29, 2024
Geminiviridae are ssDNA plant viruses whose control has both economical and agricultural importance. Their capsids assemble into two distinct architectural forms: (i) a T = 1 icosahedral and (ii) a unique twinned quasi-isometric capsid. Described h ...
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Journal ArticleJournal of Virology · July 27, 2023
Adeno-associated viruses (AAVs) have been shown to be useful vectors for gene therapy applications. Consequently, AAV has been approved as a biologic for the treatment of several monogenic disorders, and many additional clinical trials are ongoing. ...
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Journal ArticleJournal of Virology · June 8, 2022
AAVs are widely studied therapeutic gene delivery vectors. However, preexisting antibodies and their detrimental effect on therapeutic efficacy are a primary challenge encountered during clinical trials. ...
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Journal ArticleJournal of Virology · September 9, 2021
There are 13 distinct Adeno-associated virus (AAV) serotypes that are structurally homologous and whose capsid proteins (VP1 to −3) are similar in amino acid sequence. However, AAV9 is one of the most commonly studied and is used as a gene therapy ...
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Journal ArticleViruses · February 20, 2021
Human bocavirus 1 (HBoV1) has gained attention as a gene delivery vector with its ability to infect polarized human airway epithelia and 5.5 kb genome packaging capacity. Gorilla bocavirus 1 (GBoV1) VP3 shares 86% amino acid sequence identity with ...
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Journal ArticleViruses · January 13, 2021
The capsid structures of most Adeno-associated virus (AAV) serotypes, already assigned to an antigenic clade, have been previously determined. This study reports the remaining capsid structures of AAV7, AAV11, AAV12, and AAV13 determined by cryo-el ...
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Journal ArticleJ Control Release · December 10, 2020
Adeno-associated virus (AAV) is a promising vector for gene therapy, but its broad tropism can be detrimental if the transgene being delivered is harmful when expressed ubiquitously in the body, i.e. in non-target tissues. Delivering the transgene of inter ...
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Journal ArticleMolecular therapy. Methods & clinical development · December 2020
Affinity-based purification of adeno-associated virus (AAV) vectors has replaced density-based methods for vectors used in clinical settings. This method utilizes camelid single-domain antibodies recognizing AAV capsids. These include AVB Sepharose (AVB) a ...
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Journal ArticleProceedings of the National Academy of Sciences · August 18, 2020
SignificanceParvoviruses (PVs) are ssDNA viruses, with T = 1 icosahedral symmetry, infecting deuterostome and protostome animals. Most PVs have a highly conserved phospholipase A2 domain (PLA2) in the N-terminal ...
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Journal ArticleJournal of Virology · February 28, 2020
Recombinant adeno-associated virus vectors (rAAVs), based on AAV8 and AAVrh.10, have been utilized in multiple clinical trials to treat different monogenetic diseases. The closely related AAVrh.39 has also shown promise
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Journal ArticleThe EMBO Journal · March 12, 2015
Abstract
In mammalian cells, cargo‐laden secretory vesicles leave the endoplasmic reticulum (
ER
...
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