Scholars@Duke
Ruhan Wei

Ruhan Wei

Assistant Professor of Pathology
Pathology
ruhan.wei@duke.edu
40 Duke Medicine Circle, Durham NC, NC 27710

Selected Publications

Deciphering the multifaceted mechanism of Shuang Huang Lian in treating upper respiratory tract infections: A metabolomics-based network pharmacology approach

Journal Article Phytomedicine Plus · February 1, 2025 Background and purpose: Shuang Huang Lian (SHL), a traditional Chinese medicine (TCM) formula consisting of extracts from Lonicerae japonicae flos, Forsythiae fructus, and Scutellariae radix, is widely recognized for its efficacy in treating upper respirat ... Full text Cite

Challenges of insulin-like growth factor-1 testing.

Journal Article Crit Rev Clin Lab Sci · August 2024 Insulin-like growth factor 1 (IGF-1), primarily synthesized in the liver, was initially discovered due to its capacity to replicate the metabolic effects of insulin. Subsequently, it emerged as a key regulator of the actions of growth hormone (GH), managin ... Full text Link to item Cite

Evaluation of Age and Sex Differences in Contemporary versus High-Sensitivity Troponin I Measurement in Hospitalized Patients.

Journal Article J Clin Med · April 21, 2024 Background: With the transition from the contemporary (cTnI) to high-sensitivity troponin assay (hs-cTnI), concerns have arisen regarding the diagnostic differences between these two assays due to analytical distinctions. This study aims to evaluate the ag ... Full text Open Access Link to item Cite

Relationship between TSH and free thyroxine in outpatient cancer patient population.

Journal Article Endocrine · November 2023 BACKGROUND: The inverse log-linear relationship between Thyroid-stimulating hormone (TSH) and free thyroxine (FT4) is well established and reliably used for evaluation of hypothalamus-pituitary-thyroid (HPT) axis function. However, there are limited data r ... Full text Link to item Cite

A novel role of RNase L in the development of nonalcoholic steatohepatitis.

Journal Article FASEB J · September 2023 Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease and affects about 25% of the population globally. NAFLD has the potential to cause significant liver damage in many patients because it can progress to nonalcoholic steatohep ... Full text Link to item Cite

Autoverification-based algorithms to detect preanalytical errors: Two examples.

Journal Article Clin Biochem · May 2023 The preanalytical phase of testing accounts for the majority of the errors. Software-based quality rules, such as autoverification, can assist in preanalytical error detection; therefore, preventing erroneous results from being reported. Two autoverificati ... Full text Open Access Link to item Cite

The Androstenedione Roche Elecsys immunoassay has superior comparability to the LC-MS/MS assay than the Siemens Immulite immunoassay

Journal Article Practical Laboratory Medicine · August 1, 2022 Androstenedione (ASD) is a biomarker used in the diagnostic workup of hyperandrogenism, congenital adrenal hyperplasia, premature adrenarche, and polycystic ovary syndrome (PCOS). The Elecsys ASD competitive electrochemiluminescence immunoassay (Roche Diag ... Full text Open Access Cite

Evaluation of the Clinical Performance of 7 Serological Assays for SARS-CoV-2 for Use in Clinical Laboratories.

Journal Article J Appl Lab Med · July 7, 2021 BACKGROUND: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) serological assays have emerged as a response to the global pandemic, warranting studies evaluating their clinical performance. This study investigated 7 commercially available SARS-C ... Full text Open Access Link to item Cite

RNase L Is Involved in Liposaccharide-Induced Lung Inflammation.

Journal Article Viruses · January 7, 2020 RNase L mediates interferon (IFN) function during viral infection and cell proliferation. Furthermore, the role of RNase L in the regulation of gene expression, cell apoptosis, autophagy, and innate immunity has been well established in the last decade. Ti ... Full text Open Access Link to item Cite

Cobalt(II) Diphenylazodioxide Complexes Induce Apoptosis in SK-HEP-1 Cells

Journal Article ACS Omega · September 10, 2019 The cobalt(II) complex salts [Co(bpy)(az)2](PF6)2 and [Co(az)4](PF6), each bearing the unusual cis-N,N-diphenylazodioxide ligand, were both screened as possible anticancer agents against SK-HEP-1 liver cancer cells. Both compounds were found to induce subs ... Full text Open Access Cite