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Sharon Gerecht

Paul M. Gross Distinguished Professor
Biomedical Engineering

Overview


Dr. Gerecht is an internationally recognized pioneer in stem cells and vascular biology and engineering. Gerecht’s research group studies how the microenvironment regulates cellular responses, with the long-term goal of developing countermeasures and therapeutics. We emulate mechanical and physical stressors toward understanding tissue function, reliance, and homeostasis. We use that information to uncover pathways in injury and disease development to guide tissue healing and regeneration. We focus on blood vessels and their multifaceted roles in tissue performance, aging, and disease. 

Current Appointments & Affiliations


Paul M. Gross Distinguished Professor · 2022 - Present Biomedical Engineering, Pratt School of Engineering
Professor of Biomedical Engineering · 2022 - Present Biomedical Engineering, Pratt School of Engineering
Chair of the Department of Biomedical Engineering · 2024 - Present Biomedical Engineering, Pratt School of Engineering
Member of the Duke Cancer Institute · 2022 - Present Duke Cancer Institute, Institutes and Centers

In the News


Published September 30, 2024
Nursing, Pratt Collaborate to Tackle Health Challenges
Published July 18, 2023
Taking Academic Leadership to the Next Level
Published May 18, 2022
University Awards 24 New Distinguished Professorships

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Recent Publications


Cytoplasmic anillin and Ect2 promote RhoA/myosin II-dependent confined migration and invasion.

Journal Article Nature materials · September 2025 Cell migration in mechanically confined environments is a crucial step of metastatic cancer progression. Nonetheless, the molecular components and processes mediating such behaviour are still not fully understood. Here we demonstrate that a pool of the sca ... Full text Cite

Endothelial-Pericyte Interactions Regulate Angiogenesis Via VEGFR2 Signaling During Retinal Development and Disease.

Journal Article Investigative ophthalmology & visual science · September 2025 PurposeEndothelial-pericyte interaction disruption causes vascular dropout and pathological angiogenesis, severely impacting visual function in ocular microvascular diseases. This study examines VEGF receptor 2 (VEGFR2) signaling in endothelial-pe ... Full text Cite

Cell-Material Interactions in Vascular Tissue Engineering

Journal Article Accounts of Materials Research · May 23, 2025 The vascular system, encompassing blood and lymphatic vessels, is essential for nutrient transport, waste elimination, and homeostasis regulation. Composed of endothelial cells and mural cells, such as smooth muscle cells and pericytes, the vasculature is ... Full text Cite
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Recent Grants


iPediHeart: Interdisciplinary Research Training Program for Pediatric Heart Disease

Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 2025 - 2030

Targeting Stiffness-Enhanced Ferroptosis to Overcome Chemoresistance in UPS

ResearchCo Investigator · Awarded by The Paula Takacs Foundation For Sarcoma Research · 2026 - 2027

Persistent Injury Activated EC in Fibrosis

FellowshipPrincipal Investigator · Awarded by American Heart Association · 2026 - 2027

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Education, Training & Certifications


Israel Institute of Technology (Israel) · 2004 Ph.D.