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Sharon Gerecht

Paul M. Gross Distinguished Professor
Biomedical Engineering

Selected Publications

Collagen VI deposition mediates stromal T cell trapping through inhibition of T cell motility in the prostate tumor microenvironment.

Journal Article Matrix Biology : Journal of the International Society for Matrix Biology · August 2023 The tumor extracellular matrix (ECM) is a barrier to anti-tumor immunity in solid tumors by disrupting T cell-tumor cell interaction underlying the need for elucidating mechanisms by which specific ECM proteins impact T cell motility and activity within th ... Full text Cite

Vascular stiffening in aging females with a hypertension-induced HIF2A gain-of-function mutation.

Journal Article Bioengineering & Translational Medicine · March 2023 Pulmonary arterial hypertension (PAH) is more prevalent in females than males; the causes of this sex difference have not been adequately explored. Gain-of-function (GOF) mutations in hypoxia-inducible factor 2α (HIF2A) lead to PAH and thrombotic consequen ... Full text Cite

BEYOND THE ENDOTHELIUM: THE ROLE OF MURAL CELLS IN VASCULAR BIOLOGY: In vitro systems to study endothelial/pericyte cell interactions.

Journal Article Vascular Biology (Bristol, England) · February 2023 The vasculature is crucial for tissue development and survival, and the stability of blood vessels to perform these functions relies on the interplay between endothelial cells (ECs) and mural cells. Pericytes are a subtype of mural cells found in the micro ... Full text Cite

Engineering of the microenvironment to accelerate vascular regeneration.

Journal Article Trends in Molecular Medicine · January 2023 Blood vessels are crucial for tissue development, functionality, and homeostasis and are typically a determinant in the progression of healing and regeneration. The tissue microenvironment provides physicochemical cues that affect cellular function, and th ... Full text Cite

Looking on the horizon; potential and unique approaches to developing radiation countermeasures for deep space travel.

Journal Article Life Sci Space Res (Amst) · November 2022 Future lunar missions and beyond will require new and innovative approaches to radiation countermeasures. The Translational Research Institute for Space Health (TRISH) is focused on identifying and supporting unique approaches to reduce risks to human heal ... Full text Link to item Cite

Off-the-shelf, heparinized small diameter vascular graft limits acute thrombogenicity in a porcine model.

Journal Article Acta Biomaterialia · October 2022 Thrombogenicity poses a challenge to the clinical translation of engineered grafts. Previously, small-diameter vascular grafts (sdVG) composed of fibrin hydrogel microfiber tubes (FMT) with an external poly(ε-caprolactone) (PCL) sheath supported long-term ... Full text Cite

Engineering Smooth Muscle to Understand Extracellular Matrix Remodeling and Vascular Disease.

Journal Article Bioengineering (Basel, Switzerland) · September 2022 The vascular smooth muscle is vital for regulating blood pressure and maintaining cardiovascular health, and the resident smooth muscle cells (SMCs) in blood vessel walls rely on specific mechanical and biochemical signals to carry out these functions. Any ... Full text Cite

Stiffening Matrix Induces Age-Mediated Microvascular Phenotype Through Increased Cell Contractility and Destabilization of Adherens Junctions.

Journal Article Advanced Science (Weinheim, Baden Wurttemberg, Germany) · August 2022 Aging is a major risk factor in microvascular dysfunction and disease development, but the underlying mechanism remains largely unknown. As a result, age-mediated changes in the mechanical properties of tissue collagen have gained interest as drivers of en ... Full text Cite

Tissue Engineering Approaches to Uncover Therapeutic Targets for Endothelial Dysfunction in Pathological Microenvironments.

Journal Article International Journal of Molecular Sciences · July 2022 Endothelial cell dysfunction plays a central role in many pathologies, rendering it crucial to understand the underlying mechanism for potential therapeutics. Tissue engineering offers opportunities for in vitro studies of endothelial dysfunction in pathol ... Full text Cite

Hypoxia-induced blood-brain barrier dysfunction is prevented by pericyte-conditioned media via attenuated actomyosin contractility and claudin-5 stabilization.

Journal Article Faseb Journal : Official Publication of the Federation of American Societies for Experimental Biology · May 2022 The blood-brain barrier (BBB) regulates molecular and cellular entry from the cerebrovasculature into the surrounding brain parenchyma. Many diseases of the brain are associated with dysfunction of the BBB, where hypoxia is a common stressor. However, the ... Full text Cite

Intrinsic epigenetic control of angiogenesis in induced pluripotent stem cell-derived endothelium regulates vascular regeneration.

Journal Article Npj Regenerative Medicine · May 2022 Human-induced pluripotent stem cell-derived endothelial cells (iECs) provide opportunities to study vascular development and regeneration, develop cardiovascular therapeutics, and engineer model systems for drug screening. The differentiation and character ... Full text Cite