Skip to main content

The extracellular matrix mechanics in the vasculature

Publication ,  Journal Article
Wang, D; Brady, T; Santhanam, L; Gerecht, S
Published in: Nature Cardiovascular Research
August 1, 2023

Mechanical stimuli from the extracellular matrix (ECM) modulate vascular differentiation, morphogenesis and dysfunction of the vasculature. With innovation in measurements, we can better characterize vascular microenvironment mechanics in health and disease. Recent advances in material sciences and stem cell biology enable us to accurately recapitulate the complex and dynamic ECM mechanical microenvironment for in vitro studies. These biomimetic approaches help us understand the signaling pathways in disease pathologies, identify therapeutic targets, build tissue replacement and activate tissue regeneration. This Review analyzes how ECM mechanics regulate vascular homeostasis and dysfunction. We highlight approaches to examine ECM mechanics at tissue and cellular levels, focusing on how mechanical interactions between cells and the ECM regulate vascular phenotype, especially under certain pathological conditions. Finally, we explore the development of biomaterials to emulate, measure and alter the physical microenvironment of pathological ECM to understand cell–ECM mechanical interactions toward the development of therapeutics.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Nature Cardiovascular Research

DOI

EISSN

2731-0590

Publication Date

August 1, 2023

Volume

2

Issue

8

Start / End Page

718 / 732
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Wang, D., Brady, T., Santhanam, L., & Gerecht, S. (2023). The extracellular matrix mechanics in the vasculature. Nature Cardiovascular Research, 2(8), 718–732. https://doi.org/10.1038/s44161-023-00311-0
Wang, D., T. Brady, L. Santhanam, and S. Gerecht. “The extracellular matrix mechanics in the vasculature.” Nature Cardiovascular Research 2, no. 8 (August 1, 2023): 718–32. https://doi.org/10.1038/s44161-023-00311-0.
Wang D, Brady T, Santhanam L, Gerecht S. The extracellular matrix mechanics in the vasculature. Nature Cardiovascular Research. 2023 Aug 1;2(8):718–32.
Wang, D., et al. “The extracellular matrix mechanics in the vasculature.” Nature Cardiovascular Research, vol. 2, no. 8, Aug. 2023, pp. 718–32. Scopus, doi:10.1038/s44161-023-00311-0.
Wang D, Brady T, Santhanam L, Gerecht S. The extracellular matrix mechanics in the vasculature. Nature Cardiovascular Research. 2023 Aug 1;2(8):718–732.

Published In

Nature Cardiovascular Research

DOI

EISSN

2731-0590

Publication Date

August 1, 2023

Volume

2

Issue

8

Start / End Page

718 / 732