Skip to main content
Journal cover image

Perivascular cells in blood vessel regeneration.

Publication ,  Journal Article
Wanjare, M; Kusuma, S; Gerecht, S
Published in: Biotechnology journal
April 2013

Vascular engineering seeks to design and construct functional blood vessels comprising endothelial cells (ECs) and perivascular cells (PCs), with the ultimate goal of clinical translation. While EC behavior has been extensively investigated, PCs play an equally significant role in the development of novel regenerative strategies, providing functionality and stability to vessels. The two major classes of PCs are vascular smooth muscle cells (vSMCs) and pericytes; vSMCs can be further sub-classified as either contractile or synthetic. The inclusion of these cell types is crucial for successful regeneration of blood vessels. Furthermore, understanding distinctions between vSMCs and pericytes will enable improved therapeutics in a tissue-specific manner. Here we focus on the approaches and challenges facing the use of PCs in vascular regeneration, including their characteristics, stem cell sources, and interactions with ECs. Finally, we discuss biochemical and microRNA (miR) regulators of PC behavior and engineering approaches that mimic various cues affecting PC function.

Duke Scholars

Published In

Biotechnology journal

DOI

EISSN

1860-7314

ISSN

1860-6768

Publication Date

April 2013

Volume

8

Issue

4

Start / End Page

434 / 447

Related Subject Headings

  • Tissue Engineering
  • Regeneration
  • Pericytes
  • Muscle, Smooth, Vascular
  • Humans
  • Biotechnology
  • Animals
  • 3106 Industrial biotechnology
  • 3101 Biochemistry and cell biology
  • 1004 Medical Biotechnology
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Wanjare, M., Kusuma, S., & Gerecht, S. (2013). Perivascular cells in blood vessel regeneration. Biotechnology Journal, 8(4), 434–447. https://doi.org/10.1002/biot.201200199
Wanjare, Maureen, Sravanti Kusuma, and Sharon Gerecht. “Perivascular cells in blood vessel regeneration.Biotechnology Journal 8, no. 4 (April 2013): 434–47. https://doi.org/10.1002/biot.201200199.
Wanjare M, Kusuma S, Gerecht S. Perivascular cells in blood vessel regeneration. Biotechnology journal. 2013 Apr;8(4):434–47.
Wanjare, Maureen, et al. “Perivascular cells in blood vessel regeneration.Biotechnology Journal, vol. 8, no. 4, Apr. 2013, pp. 434–47. Epmc, doi:10.1002/biot.201200199.
Wanjare M, Kusuma S, Gerecht S. Perivascular cells in blood vessel regeneration. Biotechnology journal. 2013 Apr;8(4):434–447.
Journal cover image

Published In

Biotechnology journal

DOI

EISSN

1860-7314

ISSN

1860-6768

Publication Date

April 2013

Volume

8

Issue

4

Start / End Page

434 / 447

Related Subject Headings

  • Tissue Engineering
  • Regeneration
  • Pericytes
  • Muscle, Smooth, Vascular
  • Humans
  • Biotechnology
  • Animals
  • 3106 Industrial biotechnology
  • 3101 Biochemistry and cell biology
  • 1004 Medical Biotechnology