Skip to main content
construction release_alert
Scholars@Duke will be undergoing maintenance April 11-15. Some features may be unavailable during this time.
cancel
Studies in Mechanobiology, Tissue Engineering and Biomaterials

The Integrated Role of Biomaterials and Stem Cells in Vascular Regeneration

Publication ,  Chapter
Sun, G; Kusuma, S; Gerecht, S
January 1, 2010

A healthy vascular system is essential for maintaining normal blood supply and circulation in the body, while ischemia can lead to limb amputation or even death. Vascular regeneration engineering holds the promise of permanent, effective treatments for many vascular diseases. However, many challenges also remain to bring the therapy to the clinic, as the formation of blood vessels is a complicated process. One major challenge facing vascular engineering is developing the ability to maintain large masses of viable and functional cells during in vitro culture and following their transfer from in vitro conditions into the patient. This chapter introduces the cells being studied for vascular differentiation and regeneration and introduces the biomaterials being investigated for vascular engineering, including their sources, properties, and different scaffold types. We then discuss recent approaches to engineering microenvironments, including proper signaling cues and biodegradable scaffolds that will guide the development of these cells into vessels suitable for cell-based vascular therapy. These functional biomaterials may be used as environments to stimulate the generation of blood vessels, to deliver cells to angiogenic areas of the vasculature, or to promote differentiation from progenitor cells into mature vascular cells.

Duke Scholars

DOI

Publication Date

January 1, 2010

Volume

2

Start / End Page

195 / 223
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Sun, G., Kusuma, S., & Gerecht, S. (2010). The Integrated Role of Biomaterials and Stem Cells in Vascular Regeneration. In Studies in Mechanobiology, Tissue Engineering and Biomaterials (Vol. 2, pp. 195–223). https://doi.org/10.1007/8415_2010_9
Sun, G., S. Kusuma, and S. Gerecht. “The Integrated Role of Biomaterials and Stem Cells in Vascular Regeneration.” In Studies in Mechanobiology, Tissue Engineering and Biomaterials, 2:195–223, 2010. https://doi.org/10.1007/8415_2010_9.
Sun G, Kusuma S, Gerecht S. The Integrated Role of Biomaterials and Stem Cells in Vascular Regeneration. In: Studies in Mechanobiology, Tissue Engineering and Biomaterials. 2010. p. 195–223.
Sun, G., et al. “The Integrated Role of Biomaterials and Stem Cells in Vascular Regeneration.” Studies in Mechanobiology, Tissue Engineering and Biomaterials, vol. 2, 2010, pp. 195–223. Scopus, doi:10.1007/8415_2010_9.
Sun G, Kusuma S, Gerecht S. The Integrated Role of Biomaterials and Stem Cells in Vascular Regeneration. Studies in Mechanobiology, Tissue Engineering and Biomaterials. 2010. p. 195–223.

DOI

Publication Date

January 1, 2010

Volume

2

Start / End Page

195 / 223