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Hydrogels to model 3D in vitro microenvironment of tumor vascularization.

Publication ,  Journal Article
Song, H-HG; Park, KM; Gerecht, S
Published in: Advanced drug delivery reviews
December 2014

A growing number of failing clinical trials for cancer therapy are substantiating the need to upgrade the current practice in culturing tumor cells and modeling tumor angiogenesis in vitro. Many attempts have been made to engineer vasculature in vitro by utilizing hydrogels, but the application of these tools in simulating in vivo tumor angiogenesis is still very new. In this review, we explore current use of hydrogels and their design parameters to engineer vasculogenesis and angiogenesis and to evaluate the angiogenic capability of cancerous cells and tissues. By coupling these hydrogels with other technologies such as lithography and three-dimensional printing, one can create an advanced microvessel model as microfluidic channels to more accurately capture the native angiogenesis process.

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Published In

Advanced drug delivery reviews

DOI

EISSN

1872-8294

ISSN

0169-409X

Publication Date

December 2014

Volume

79-80

Start / End Page

19 / 29

Related Subject Headings

  • Tumor Microenvironment
  • Tissue Engineering
  • Pharmacology & Pharmacy
  • Neovascularization, Pathologic
  • Neoplasms
  • Models, Biological
  • Microfluidics
  • In Vitro Techniques
  • Hydrogels
  • Humans
 

Citation

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Song, H.-H., Park, K. M., & Gerecht, S. (2014). Hydrogels to model 3D in vitro microenvironment of tumor vascularization. Advanced Drug Delivery Reviews, 7980, 19–29. https://doi.org/10.1016/j.addr.2014.06.002
Song, Hyun-Ho Greco, Kyung Min Park, and Sharon Gerecht. “Hydrogels to model 3D in vitro microenvironment of tumor vascularization.Advanced Drug Delivery Reviews 79–80 (December 2014): 19–29. https://doi.org/10.1016/j.addr.2014.06.002.
Song H-HG, Park KM, Gerecht S. Hydrogels to model 3D in vitro microenvironment of tumor vascularization. Advanced drug delivery reviews. 2014 Dec;79–80:19–29.
Song, Hyun-Ho Greco, et al. “Hydrogels to model 3D in vitro microenvironment of tumor vascularization.Advanced Drug Delivery Reviews, vol. 79–80, Dec. 2014, pp. 19–29. Epmc, doi:10.1016/j.addr.2014.06.002.
Song H-HG, Park KM, Gerecht S. Hydrogels to model 3D in vitro microenvironment of tumor vascularization. Advanced drug delivery reviews. 2014 Dec;79–80:19–29.

Published In

Advanced drug delivery reviews

DOI

EISSN

1872-8294

ISSN

0169-409X

Publication Date

December 2014

Volume

79-80

Start / End Page

19 / 29

Related Subject Headings

  • Tumor Microenvironment
  • Tissue Engineering
  • Pharmacology & Pharmacy
  • Neovascularization, Pathologic
  • Neoplasms
  • Models, Biological
  • Microfluidics
  • In Vitro Techniques
  • Hydrogels
  • Humans